Thomas Brabletz

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. doi request reprint EMT and MET in metastasis: where are the cancer stem cells?
    Thomas Brabletz
    Department of General and Visceral Surgery, Comprehensive Cancer Center and BIOSS Centre for Biological Signalling Studies, University of Freiburg Medical Center, Hugstetter Str 55, 79106 Freiburg, Germany
    Cancer Cell 22:699-701. 2012
  2. doi request reprint To differentiate or not--routes towards metastasis
    Thomas Brabletz
    Department of General and Visceral Surgery and Comprehensive Cancer Center, University of Freiburg Medical Center, Hugstetter Str 55, 79106 Freiburg, Germany
    Nat Rev Cancer 12:425-36. 2012
  3. doi request reprint Gastrointestinal stem cells in development and cancer
    S Brabletz
    Department of Visceral Surgery and Comprehensive Cancer Centre, University Medical Centre Freiburg, Germany
    J Pathol 217:307-17. 2009
  4. pmc The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer?
    Simone Brabletz
    Department of Visceral Surgery, University of Freiburg, Hugstetterstrasse 55, 79106 Freiburg, Germany
    EMBO Rep 11:670-7. 2010
  5. pmc MicroRNAs coordinately regulate protein complexes
    Steffen Sass
    MIPS, Institute for Bioinformatics and System Biology, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstädter Landstraße 1, D 85764 Neuherberg, Germany
    BMC Syst Biol 5:136. 2011
  6. doi request reprint E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer
    Otto Schmalhofer
    Department of Visceral Surgery, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany
    Cancer Metastasis Rev 28:151-66. 2009
  7. doi request reprint The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
    Ulrich Wellner
    Department of Visceral Surgery, University of Freiburg, 79106 Freiburg, Germany
    Nat Cell Biol 11:1487-95. 2009
  8. pmc The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells
    Simone Brabletz
    Department of Visceral Surgery, University of Freiburg, Freiburg, Germany
    EMBO J 30:770-82. 2011
  9. pmc A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    Ulrike Burk
    Department of Visceral Surgery, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    EMBO Rep 9:582-9. 2008
  10. doi request reprint A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer
    Bogdan Tiberius Preca
    Department of General and Visceral Surgery, Medical Center University of Freiburg, Faculty of Medicine, Freiburg, Germany
    Oncotarget . 2017

Collaborators

Detail Information

Publications21

  1. doi request reprint EMT and MET in metastasis: where are the cancer stem cells?
    Thomas Brabletz
    Department of General and Visceral Surgery, Comprehensive Cancer Center and BIOSS Centre for Biological Signalling Studies, University of Freiburg Medical Center, Hugstetter Str 55, 79106 Freiburg, Germany
    Cancer Cell 22:699-701. 2012
    ..Moreover, although EMT has been associated with stemness properties, one study indicates that they are not necessarily linked...
  2. doi request reprint To differentiate or not--routes towards metastasis
    Thomas Brabletz
    Department of General and Visceral Surgery and Comprehensive Cancer Center, University of Freiburg Medical Center, Hugstetter Str 55, 79106 Freiburg, Germany
    Nat Rev Cancer 12:425-36. 2012
    ..This simplified classification integrates clinically relevant aspects of dormancy, metastatic tropism and therapy resistance, and implies perspectives on treatment strategies against metastasis...
  3. doi request reprint Gastrointestinal stem cells in development and cancer
    S Brabletz
    Department of Visceral Surgery and Comprehensive Cancer Centre, University Medical Centre Freiburg, Germany
    J Pathol 217:307-17. 2009
    ....
  4. pmc The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer?
    Simone Brabletz
    Department of Visceral Surgery, University of Freiburg, Hugstetterstrasse 55, 79106 Freiburg, Germany
    EMBO Rep 11:670-7. 2010
    ....
  5. pmc MicroRNAs coordinately regulate protein complexes
    Steffen Sass
    MIPS, Institute for Bioinformatics and System Biology, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstädter Landstraße 1, D 85764 Neuherberg, Germany
    BMC Syst Biol 5:136. 2011
    ..Interactions between targets of co-expressed miRNAs (including miRNA clusters) have not yet been systematically investigated...
  6. doi request reprint E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer
    Otto Schmalhofer
    Department of Visceral Surgery, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany
    Cancer Metastasis Rev 28:151-66. 2009
    ....
  7. doi request reprint The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
    Ulrich Wellner
    Department of Visceral Surgery, University of Freiburg, 79106 Freiburg, Germany
    Nat Cell Biol 11:1487-95. 2009
    ..Thus, targeting the ZEB1-miR-200 feedback loop might form the basis of a promising treatment for fatal tumours, such as pancreatic cancer...
  8. pmc The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells
    Simone Brabletz
    Department of Visceral Surgery, University of Freiburg, Freiburg, Germany
    EMBO J 30:770-82. 2011
    ..These findings explain increased Notch signalling in some types of cancers, where mutations in Notch pathway genes are rare. Moreover, they indicate an additional way how ZEB1 exerts its tumour progressing functions...
  9. pmc A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    Ulrike Burk
    Department of Visceral Surgery, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    EMBO Rep 9:582-9. 2008
    ..Alternatively, depending on the environmental trigger, this loop might switch and induce epithelial differentiation, and thus explain the strong intratumorous heterogeneity observed in many human cancers...
  10. doi request reprint A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer
    Bogdan Tiberius Preca
    Department of General and Visceral Surgery, Medical Center University of Freiburg, Faculty of Medicine, Freiburg, Germany
    Oncotarget . 2017
    ..In combination with the previously identified ZEB1/ESRP1/CD44s feedback loop, we found a novel autocrine mechanism how ZEB1 is accelerating EMT...
  11. pmc ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types
    Waltraut Lehmann
    Department of General and Visceral Surgery, University of Freiburg Medical Center, Hugstetter Strasse 55, 79106 Freiburg, Germany
    Nat Commun 7:10498. 2016
    ..This gene set is a predictor of poor survival, therapy resistance and increased metastatic risk in breast cancer, indicating the clinical relevance of our findings. ..
  12. pmc The ZEB1/miR-200c feedback loop regulates invasion via actin interacting proteins MYLK and TKS5
    Vignesh Sundararajan
    Department of Visceral Surgery, University Medical Center Freiburg, Freiburg, Germany
    Oncotarget 6:27083-96. 2015
    ..In summary, TKS5 and MYLK represent two mediators of invasive behavior of cancer cells that are regulated by the ZEB1/miR-200 feedback loop. ..
  13. pmc The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors
    Kerstin Mock
    Department of Visceral Surgery, University Medical Center Freiburg, Freiburg, Germany
    Oncotarget 6:14399-412. 2015
    ..Consequently, ZEB1 stimulates BMP-inhibitor mediated osteoclast differentiation. These findings suggest that ZEB1 is not only driving EMT, but also contributes to the formation of osteolytic bone metastases in breast cancer. ..
  14. pmc ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat
    Simone Meidhof
    Department of General and Visceral Surgery, University of Freiburg Medical Center, Freiburg, Germany Spemann Graduate School of Biology and Medicine SGBM, Albert Ludwigs University Freiburg, Freiburg, Germany Faculty of Biology, Albert Ludwigs University Freiburg, Freiburg, Germany
    EMBO Mol Med 7:831-47. 2015
    ..Our data encourage the application of mechanism-based combinations of selected epigenetic drugs with standard chemotherapy for the rational treatment of aggressive solid tumors, such as pancreatic cancer. ..
  15. doi request reprint The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer
    Simone Spaderna
    Department of Visceral Surgery, University of Freiburg, Freiburg, Germany
    Cancer Res 68:537-44. 2008
    ..Thus, by linking EMT, loss of polarity, and metastasis, ZEB1 is a crucial promoter of malignant tumor progression...
  16. doi request reprint A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells
    Bogdan Tiberius Preca
    Department of Visceral Surgery, University Medical Center Freiburg, D 79106, Freiburg, Germany
    Int J Cancer 137:2566-77. 2015
    ..This renders tumor cell stemness independent of external stimuli, as ZEB1 downregulates ESRP1, further promoting CD44s isoform synthesis. ..
  17. pmc Roadblocks to translational advances on metastasis research
    Thomas Brabletz
    1 Department of General and Visceral Surgery, Comprehensive Cancer Center and BIOSS Centre for Biological Signalling Studies, University of Freiburg Medical Center, Freiburg, Germany 2
    Nat Med 19:1104-9. 2013
    ....
  18. doi request reprint Native promoter reporters validate transcriptional targets
    Otto Schmalhofer
    Department of Surgery, University of Freiburg, Germany
    Methods Mol Biol 468:111-28. 2008
    ..In this chapter, we describe how to generate such reporter plasmids using the MMP7 promoter as an example...
  19. pmc ZEB1 in Pancreatic Cancer
    Ulrich Wellner
    Department of General and Visceral Surgery, University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
    Cancers (Basel) 2:1617-28. 2010
    ..ZEB1 has also been shown to be associated with drug resistance of pancreatic cancer cells. This article reviews the biological functions of ZEB1 with a focus on pancreatic cancer. ..
  20. doi request reprint ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer
    Juliane Strietz
    Department of Visceral Surgery, University Hospital Freiburg, German Cancer Consortium DKTK, Freiburg, Germany
    Oncotarget . 2016
    ..ERN1 and ALPK1 are potential targets for therapeutic development...
  21. doi request reprint Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition
    Ulf D Kahlert
    Division of Stereotactic Neurosurgery, Department of General Neurosurgery, University Medical Center Freiburg, Freiburg, Germany
    Cancer Lett 325:42-53. 2012
    ..These findings suggest that canonical WNT/β-catenin pathway is a critical regulator of GBM invasion and may represent a potential therapeutic target...