N Bornfeld

Summary

Affiliation: University of Essen
Country: Germany

Publications

  1. ncbi request reprint [Analysis of ocular surface alterations following proton beam radiation in eyes with conjunctival malignant melanoma]
    H Westekemper
    Zentrum für Augenheilkunde, Universitatsklinikum, Hufelandstrasse 55, 45122 Essen
    Ophthalmologe 103:588-95. 2006
  2. pmc Assessment of the effect of iris colour and having children on 5-year risk of death after diagnosis of uveal melanoma: a follow-up study
    Andrea Schmidt-Pokrzywniak
    Institute of Clinical Epidemiology, Medical Faculty, University of Halle Wittenberg, Magdeburger Str 8, 06097 Halle, Germany
    BMC Ophthalmol 14:42. 2014
  3. pmc A case-control study: occupational cooking and the risk of uveal melanoma
    Andrea Schmidt-Pokrzywniak
    Institute of Clinical Epidemiology, Medical Faculty, University of Halle Wittenberg, Halle, Germany
    BMC Ophthalmol 10:26. 2010
  4. ncbi request reprint [Capillary hemangioma of the retina in cases of von Hippel-Lindau syndrome. New therapeutic directions]
    N Bornfeld
    Zentrum für Augenheilkunde, Universitatsklinikum Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Ophthalmologe 104:114-8. 2007
  5. ncbi request reprint [Age-related macular degeneration--new options for therapy?]
    N Bornfeld
    Zentrum für Augenheilkunde, Universitatsklinikum Essen
    Klin Monbl Augenheilkd 222:379-80. 2005
  6. ncbi request reprint [Retinoblastoma]
    N Bornfeld
    Zentrum für Augenheilkunde, Universitatsklinikum Essen
    Ophthalmologe 103:59-76; quiz 77-8. 2006
  7. doi request reprint [Diagnosis and treatment of retinoblastoma: current strategies for effective tumour control and preservation of vision]
    P Temming
    Klinik für Kinderheilkunde III, Universitatsklinikum Essen, Germany
    Klin Monbl Augenheilkd 230:232-42. 2013
  8. doi request reprint Current concepts for diagnosis and treatment of retinoblastoma in Germany: aiming for safe tumor control and vision preservation
    P Temming
    Department of Pediatric Hematology and Oncology, University Hospital Essen, Essen, Germany
    Klin Padiatr 224:339-47. 2012
  9. doi request reprint [Uveal melanoma: current insights into clinical relevance of genetic testing]
    C H Metz
    Klinik fur Augenheilkunde, Universitatsklinikum Essen, Universitat Duisburg Essen, Hufelandstrasse 55, Essen
    Klin Monbl Augenheilkd 230:686-91. 2013
  10. pmc Thermochemotherapy in hereditary retinoblastoma
    A O Schueler
    Department of Ophthalmology, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Br J Ophthalmol 87:90-5. 2003

Detail Information

Publications42

  1. ncbi request reprint [Analysis of ocular surface alterations following proton beam radiation in eyes with conjunctival malignant melanoma]
    H Westekemper
    Zentrum für Augenheilkunde, Universitatsklinikum, Hufelandstrasse 55, 45122 Essen
    Ophthalmologe 103:588-95. 2006
    ..In extended tumours, ocular surface problems can result after therapy. In this study we examined ocular surface integrity of ten patients who underwent proton beam radiation between 1996 and 2002...
  2. pmc Assessment of the effect of iris colour and having children on 5-year risk of death after diagnosis of uveal melanoma: a follow-up study
    Andrea Schmidt-Pokrzywniak
    Institute of Clinical Epidemiology, Medical Faculty, University of Halle Wittenberg, Magdeburger Str 8, 06097 Halle, Germany
    BMC Ophthalmol 14:42. 2014
    ..Furthermore, we assess of the effect of iris colour and having children on 5-year risk of death after diagnosis of uveal melanoma. Therefore, we assess the performance of an individual prediction model of survival from uveal melanoma...
  3. pmc A case-control study: occupational cooking and the risk of uveal melanoma
    Andrea Schmidt-Pokrzywniak
    Institute of Clinical Epidemiology, Medical Faculty, University of Halle Wittenberg, Halle, Germany
    BMC Ophthalmol 10:26. 2010
    ..They found a positive association between cooks and the risk of uveal melanoma. In our study we examine whether cooks or people who worked in cook related jobs have an increased uveal melanoma risk...
  4. ncbi request reprint [Capillary hemangioma of the retina in cases of von Hippel-Lindau syndrome. New therapeutic directions]
    N Bornfeld
    Zentrum für Augenheilkunde, Universitatsklinikum Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Ophthalmologe 104:114-8. 2007
    ..The treatment of juxtapapillary angiomas is still a therapeutic dilemma. Vitreoretinal surgery should be confined to advanced stages with tractional detachment or when no other treatment option is available to salvage the eye...
  5. ncbi request reprint [Age-related macular degeneration--new options for therapy?]
    N Bornfeld
    Zentrum für Augenheilkunde, Universitatsklinikum Essen
    Klin Monbl Augenheilkd 222:379-80. 2005
  6. ncbi request reprint [Retinoblastoma]
    N Bornfeld
    Zentrum für Augenheilkunde, Universitatsklinikum Essen
    Ophthalmologe 103:59-76; quiz 77-8. 2006
    ..Molecular genetic research on the origin of retinoblastomas has substantially helped in our understanding of the origin of malignant tumors in general, as well as to the key role of the Rb-1 gene as a tumor suppressor...
  7. doi request reprint [Diagnosis and treatment of retinoblastoma: current strategies for effective tumour control and preservation of vision]
    P Temming
    Klinik für Kinderheilkunde III, Universitatsklinikum Essen, Germany
    Klin Monbl Augenheilkd 230:232-42. 2013
    ..This article was translated and modified and was primarily published in Klin Padiatr 2012; 224: 339-347...
  8. doi request reprint Current concepts for diagnosis and treatment of retinoblastoma in Germany: aiming for safe tumor control and vision preservation
    P Temming
    Department of Pediatric Hematology and Oncology, University Hospital Essen, Essen, Germany
    Klin Padiatr 224:339-47. 2012
    ..Multicenter clinical trials are being developed to evaluate evidence-based treatment concepts for localized and metastasized retinoblastoma to improve survival rates and quality of life of children with retinoblastoma...
  9. doi request reprint [Uveal melanoma: current insights into clinical relevance of genetic testing]
    C H Metz
    Klinik fur Augenheilkunde, Universitatsklinikum Essen, Universitat Duisburg Essen, Hufelandstrasse 55, Essen
    Klin Monbl Augenheilkd 230:686-91. 2013
    ..Moreover relatives of these patients should be offered a screening for BAP1 mutation. ..
  10. pmc Thermochemotherapy in hereditary retinoblastoma
    A O Schueler
    Department of Ophthalmology, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Br J Ophthalmol 87:90-5. 2003
    ..The aim of this study was to identify safe indications, the complications as well as the limitations of this new treatment for retinoblastoma...
  11. pmc Ruthenium-106 plaque brachytherapy for symptomatic vasoproliferative tumours of the retina
    G Anastassiou
    Augenklinik, Universitatsklinikum Essen, 45122 Essen, Germany
    Br J Ophthalmol 90:447-50. 2006
    ..To investigate the safety and efficacy of beta ray brachytherapy in treatment of vasoproliferative tumours of the retina (VTR)...
  12. doi request reprint [New developments in molecular genetics and treatment of retinoblastoma]
    N Bornfeld
    Zentrum für Augenheilkunde, Universitatsklinikum Essen
    Klin Monbl Augenheilkd 228:593-8. 2011
    ..The excellent prognosis for retinoblastomas in countries with a well developed health system is contrasted by the miserable prognosis for retinoblastomas in developing countries, which must be changed by a joint effort of all centres...
  13. doi request reprint [Value of transretinal tumor biopsy as diagnostic and predictive instrument]
    E Biewald
    Zentrum für Augenheilkunde, Universitatsklinikum Essen, Deutschland
    Ophthalmologe 110:882-4. 2013
    ..This review will focus on the various biopsy techniques and indications for this method. ..
  14. pmc Prognostic significance of chromosome 3 alterations determined by microsatellite analysis in uveal melanoma: a long-term follow-up study
    S Thomas
    Department of Ophthalmology, University Hospital of Essen, Hufelandstrasse 55, Essen, Germany
    Br J Cancer 106:1171-6. 2012
    ..The strong association of metastatic disease with M3 offers the opportunity for molecular prognostic testing of UM patients...
  15. doi request reprint [TTF-1 (8G7G3/1) positive colon adenocarcinoma: diagnostic implications]
    H G Reis
    Institut für Pathologie und Neuropathologie, Universitatsklinikum Essen, Universitat Duisburg Essen, Hufelandstr 55, 45122, Essen, Deutschland
    Pathologe 32:349-51. 2011
    ..We report on a patient with TTF-1 (clone 8G7G3/1) positive adenocarcinoma of the colon with metastases to the eye and lung and discuss TTF-1 based diagnostic considerations...
  16. doi request reprint [Intraocular medulloepithelioma - series of 10 cases and review of the literature]
    M Holdt
    Zentrum für Augenheilkunde, Universitatsklinikum Essen
    Klin Monbl Augenheilkd 226:1017-22. 2009
    ..Metastasis did not occur, but epiretinal tumor seeding did occur in one patient. In one of the 3 not enucleated eyes, ruthenium-106 brachytherapy could salvage the tumor containing eye...
  17. ncbi request reprint Expression of Fas and Fas ligand in uveal melanoma: biological implication and prognostic value
    G Anastassiou
    Department of Ophthalmology, University Hospital, University of Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    J Pathol 194:466-72. 2001
    ..The clinical relevance of this observation is limited, as more predictive parameters have been described for uveal melanoma...
  18. ncbi request reprint Partial deletions of the long and short arm of chromosome 3 point to two tumor suppressor genes in uveal melanoma
    F Tschentscher
    Institut fur Humangenetik, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Cancer Res 61:3439-42. 2001
    ..5 Mb in 3p25. This SRO does not overlap with the VHL gene. Our finding suggests a role for two tumor suppressor genes in metastasizing uveal melanoma and may explain the loss of an entire chromosome 3 in these tumors...
  19. pmc Expression of VLA-2, VLA-3, and alpha(v) integrin receptors in uveal melanoma: association with microvascular architecture of the tumour and prognostic value
    G Anastassiou
    Department of Ophthalmology, Medical Faculty, University of Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Br J Ophthalmol 84:899-902. 2000
    ..There is some evidence that interactions between the tumour cells and the extracellular matrix are responsible for the shape of these patterns...
  20. ncbi request reprint [Endoresection of large uveal melanomas after pretreatment by single-dose stereotactic convergence irradiation with the leksell gamma knife--first experience on 46 cases]
    H Schilling
    Universitäts Augenklinik Essen
    Klin Monbl Augenheilkd 223:513-20. 2006
    ..The aim of this non-comparative, consecutive case series is to evaluate the short-term results after endoresection of large uveal melanomas in combination with pretreatment with stereotactic gamma knife radiosurgery...
  21. ncbi request reprint Expression of the cell adhesion molecules ICAM-1, VCAM-1 and NCAM in uveal melanoma: a clinicopathological study
    G Anastassiou
    Department of Ophthalmology, Biometry and Epidemiology, Medical Faculty, University of Essen, Germany
    Oncology 58:83-8. 2000
    ..NCAM and VCAM-1 expression was not related to metastasis. Our results show that the loss of ICAM-1 expression is associated with an increased risk of metastasis within the first 5 years after diagnosis...
  22. ncbi request reprint ["Talking Eyes" versus "Silent Ophthalmoscopy"?]
    B Jurklies
    Universitats Augenklinik, Essen
    Klin Monbl Augenheilkd 222:317-8. 2005
  23. ncbi request reprint [Corneoretinal dystrophy (Bietti)-- Long-term course of one patient over a period of 30 years, and interindividual variability of clinical and electrophysiological findings in two patients]
    B Jurklies
    Universitäts Augenklinik Essen, Hufelandstrasse 55, 45122 Essen Direktor der Abteilung für Erkrankungen des hinteren Augenabschnittes Prof Dr N Bornfeld, E mail
    Klin Monbl Augenheilkd 218:562-9. 2001
    ..A tapetoretinal dystrophy with crystalline deposits of the retina and limbal cornea was described by Bietti in 1937. To date, only a few cases with long-term follow up have been reported...
  24. ncbi request reprint Monitoring retinal function in neovascular maculopathy using multifocal electroretinography - early and long-term correlation with clinical findings
    B Jurklies
    University Eye Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Graefes Arch Clin Exp Ophthalmol 240:244-64. 2002
    ..To objectively investigate and longitudinally monitor retinal function in patients with choroidal neovascularization (CNV) due to exudative age-related macular degeneration (AMD) and myopia using multifocal electroretinography (mfERG)...
  25. pmc Photodynamic therapy using verteporfin in circumscribed choroidal haemangioma
    B Jurklies
    Department of Ophthalmology, Univ Hospital Essen, Germany Department of Ophthalmology, Univ Hospital Lübeck, Germany
    Br J Ophthalmol 87:84-9. 2003
    ..To investigate the safety and efficacy of photodynamic therapy with verteporfin in patients with choroidal haemangioma...
  26. pmc High resolution magnetic resonance imaging of retinoblastoma
    A O Schueler
    Department of Ophthalmology, Universitatsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Br J Ophthalmol 87:330-5. 2003
    ..Parameters studied were appearance of retinoblastoma, choroidal and scleral infiltration, extraocular extension, optic nerve infiltration, and vitreous seeding...
  27. ncbi request reprint Whole-body fluorine-18 fluordeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in staging of advanced uveal melanoma
    L S Freudenberg
    Department of Nuclear Medicine, University Hospital, Essen, Germany
    Surv Ophthalmol 49:537-40. 2004
    ..Furthermore, PET revealed an unknown otherwise undetected vital liver metastasis. We conclude that combined FDG-PET/CT has potential to further improve staging and therapy planning in patients with advanced uveal melanoma...
  28. doi request reprint [New therapeutic strategies for retinoblastoma: non-systemic chemotherapy]
    E Biewald
    Klinik für Erkrankungen des hinteren Augenabschnittes, Zentrum für Augenheilkunde, Universitätsklinikum Essen AöR, Universitat Duisburg Essen, Hufelandstr 55, 45147, Essen, Deutschland
    Ophthalmologe 111:379-82. 2014
    ..Therefore, new non-systemic chemotherapy strategies, such as the intra-arterial or intravitreal administration of melphalan are being revised with the aim of reducing systemic side effects. ..
  29. doi request reprint Bilateral Bartonella henselae neuroretinitis with stellate maculopathy in a 6-year-old boy
    C H D Metz
    University of Duisburg Essen, Essen, Germany
    Infection 40:191-4. 2012
    ..Bartonella henselae, the cause of cat-scratch disease in humans, may lead to characteristic vision-threatening ocular findings, which importantly indicate diagnosis...
  30. ncbi request reprint [Endoscopic resection of malignant melanomas of the uvea after preoperative stereotactic single dose convergence irradiation with the Leksell gamma knife]
    N Bornfeld
    Universitatsklinikum Essen, Zentrum für Augenheilkunde, Abteilung für Erkrankungen des hinteren Augenabschnitts, Hufelandstrasse 55, 45122 Essen
    Ophthalmologe 99:338-44. 2002
    ..Tumor-destroying, single-dose convergence irradiation (radiosurgery) of such tumors applied shortly before endoresection can represent a possible therapeutic alternative in these types of cases...
  31. doi request reprint Photodynamic therapy with verteporfin in paediatric and young adult patients: long-term treatment results of choroidal neovascularisations
    A Lipski
    Department of Ophthalmology, University Hospital Essen, D 45122 Essen, Germany
    Br J Ophthalmol 92:655-60. 2008
    ..The aim of this study is to highlight the applicability of photodynamic therapy using verteporfin (PDT) in these patients...
  32. ncbi request reprint [Clinical findings in autosomal recessive syndrome of blue cone hypersensitivity]
    B Jurklies
    , Hufelandstrasse 55, 45122 Essen
    Ophthalmologe 98:285-93. 2001
    ..These unusual ERG findings may be due to a depressed rod system and an increased number of S-cone photoreceptors, postreceptoral circuits, and S-cone sensitive ganglion cells...
  33. ncbi request reprint [The Position of the Retinological Society, the German Ophthalmological Society and the Professional Association of Ophthalmologists--comments on the current therapy for neovascular AMD]
    D Pauleikhoff
    Augenabteilung des St Franziskus Krankenhauses, Munster
    Klin Monbl Augenheilkd 222:381-8. 2005
    ..Referring to these data, expert guidance is required to supply ophthalmologists with expertise in the management of AMD to select and use the most appropriate therapies in the treatment of neovascular AMD...
  34. ncbi request reprint High-dose chemotherapy with autologous stem cell rescue in children with retinoblastoma
    B Kremens
    Department of Pediatrics, University Hospitals of Essen, Germany
    Bone Marrow Transplant 31:281-4. 2003
    ..It may control occult CNS disease. The necessity to irradiate these children and the curative potential of this strategy for patients with bulky CNS disease remain to be determined...
  35. ncbi request reprint [Malignant and non-malignant uveitis-masquerade syndromes in childhood]
    A Schuler
    Universitats Augenklinik, Gesamthochschule Duisburg Essen, Essen
    Klin Monbl Augenheilkd 224:477-82. 2007
    ..In case of doubt in childhood, an examination under anaesthesia and, if necessary, further imaging diagnostics should be performed in order to avoid with certainty a false diagnosis having possibly serious consequences...
  36. doi request reprint [Primary pars plana vitrectomy. Techniques, indications, and results]
    H Heimann
    St Paul s Eye Unit, Royal Liverpool University Hospital, Liverpool
    Ophthalmologe 105:19-26. 2008
    ..In contrast, primary vitrectomy does not seem to offer an advantage over scleral buckling in phakic patients...
  37. ncbi request reprint Age at diagnosis of isolated unilateral retinoblastoma does not distinguish patients with and without a constitutional RB1 gene mutation but is influenced by a parent-of-origin effect
    A Schuler
    Department of Ophthalmology, University of Duisburg Essen, Germany
    Eur J Cancer 41:735-40. 2005
    ..Our findings suggest that, at least in some patients, age at diagnosis is modified by a parent-of-origin effect...
  38. ncbi request reprint [Blocking nociceptive afferents by retrobulbar bupivacaine does not decrease nausea and vomiting after propofol-remifentanil anaesthesia]
    D Muller
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen
    Anasthesiol Intensivmed Notfallmed Schmerzther 38:689-94. 2003
    ....
  39. ncbi request reprint [Development of an epiretinal prosthesis for stimulation of the human retina]
    M Feucht
    Augenklinik, Universitat Hamburg
    Ophthalmologe 102:688-91. 2005
    ..Initial results of acute epiretinal stimulation using an epiretinal implant in legally blind patients demonstrate that acute epiretinal stimulation of the human retina is feasible and safe...
  40. doi request reprint Are low inflammatory reactions involved in exudative age-related macular degeneration? Morphological and immunhistochemical analysis of AMD associated with basal deposits
    A Lommatzsch
    Department of Ophthalmology and Ophtha Lab, St Franziskus Hospital Münster, Munster, Germany
    Graefes Arch Clin Exp Ophthalmol 246:803-10. 2008
    ..Therefore, analysis of BLD composition may provide further information concerning the pathogenesis of BLD and CNV in age-related macular degeneration (AMD)...
  41. ncbi request reprint The possible role of radiofrequency radiation in the development of uveal melanoma
    A Stang
    Institute for Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Essen, Germany
    Epidemiology 12:7-12. 2001
    ..This is the first study describing an association between radiofrequency radiation exposure and uveal melanoma. Several methodologic limitations prevent our results from providing clear evidence on the hypothesized association...
  42. ncbi request reprint [Malignant melanoma of the uvea. Current status and prospects]
    N Bornfeld
    Ophthalmologe 99:325-6. 2002