Christoph Borner

Summary

Affiliation: University of Freiburg
Country: Germany

Publications

  1. ncbi request reprint The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions
    Christoph Borner
    Institute of Molecular Medicine and Cell Research, Albert Ludwigs University, Freiburg, Germany
    Mol Immunol 39:615-47. 2003
  2. pmc Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane
    Thomas Kaufmann
    Institute of Molecular Medicine and Cell Research, Albert Ludwigs University Freiburg, D 79106 Freiburg, Germany
    J Cell Biol 160:53-64. 2003
  3. doi request reprint TNFα-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formation
    Jisen Huai
    Institute of Molecular Medicine and Cell Research ZBMZ, Albert Ludwigs University Freiburg, Stefan Meier Strasse 17, D 79104 Freiburg, Germany
    J Cell Sci 126:4015-25. 2013
  4. ncbi request reprint Bcl-w(edding) with mitochondria
    Thomas Kaufmann
    Institute of Molecular Medicine and Cell Research, Zentrale Klinische Forschung ZKF, Albert Ludwigs University Freiburg, Breisacherstrasse 66, 79106 Freiburg, Germany
    Trends Cell Biol 14:8-12. 2004
  5. ncbi request reprint Bcl-2 family members: integrators of survival and death signals in physiology and pathology [corrected]
    Anna Schinzel
    Institute for Molecular Medicine and Cell Research, Albert Ludwigs University Freiburg, Breisachertstrasse 66, D 79106 Fribourg, Germany
    Biochim Biophys Acta 1644:95-105. 2004
  6. ncbi request reprint Preprotein transport machineries of yeast mitochondrial outer membrane are not required for Bax-induced release of intermembrane space proteins
    Luiza K Sanjuán Szklarz
    Institut fur Biochemie und Molekularbiologie, Zentrum für Biochemie und Molekulare Zellforschung, Universitat Freiburg, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
    J Mol Biol 368:44-54. 2007
  7. pmc Interleukin-1β enhances FasL-induced caspase-3/-7 activity without increasing apoptosis in primary mouse hepatocytes
    Anna Lutz
    Department of Pharmaceutical Biology and Biotechnology, Albert Ludwigs University Freiburg, Freiburg, Germany
    PLoS ONE 9:e115603. 2014
  8. pmc Phylogenetically Distant Viruses Use the Same BH3-Only Protein Puma to Trigger Bax/Bak-Dependent Apoptosis of Infected Mouse and Human Cells
    Emanuela Papaianni
    Department of Biological and Environmental Sciences, University of Messina, Via F Stagno D Alcontres 31, I 98166, Messina, Italy The Institute of Translational Pharmacology, CNR, Via Fosso del Cavaliere 100, I 00133, Rome, Italy Institute of Molecular Medicine and Cell Research, Albert Ludwigs University of Freiburg, Stefan Meier Strasse 17, D 79104, Freiburg, Germany
    PLoS ONE 10:e0126645. 2015
  9. doi request reprint A novel mitochondrial MAVS/Caspase-8 platform links RNA virus-induced innate antiviral signaling to Bax/Bak-independent apoptosis
    Souhayla El Maadidi
    Institute of Molecular Medicine and Cell Research, Albert Ludwigs University Freiburg, D 79104 Freiburg, Germany
    J Immunol 192:1171-83. 2014
  10. ncbi request reprint Volatile anesthetics induce caspase-dependent, mitochondria-mediated apoptosis in human T lymphocytes in vitro
    Torsten Loop
    Division of Experimental Anesthesiology, Institute of Molecular Medicine, University Hospital, Hugstetterstrasse 55, D 79106 Freiburg, Germany
    Anesthesiology 102:1147-57. 2005

Collaborators

Detail Information

Publications25

  1. ncbi request reprint The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions
    Christoph Borner
    Institute of Molecular Medicine and Cell Research, Albert Ludwigs University, Freiburg, Germany
    Mol Immunol 39:615-47. 2003
    ..This review provides a snapshot on where we are on this journey and how we may exploit our knowledge on this family of proteins to unveil the mysteries of immune regulation...
  2. pmc Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane
    Thomas Kaufmann
    Institute of Molecular Medicine and Cell Research, Albert Ludwigs University Freiburg, D 79106 Freiburg, Germany
    J Cell Biol 160:53-64. 2003
    ..These data define a new targeting sequence for the MOM and propose that Bcl-2 acts on several intracellular membranes whereas Bcl-x(L) specifically functions on the MOM...
  3. doi request reprint TNFα-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formation
    Jisen Huai
    Institute of Molecular Medicine and Cell Research ZBMZ, Albert Ludwigs University Freiburg, Stefan Meier Strasse 17, D 79104 Freiburg, Germany
    J Cell Sci 126:4015-25. 2013
    ..Thus, after MOMP, active caspase-3 exerts a feedback action on complex I to produce ROS. ROS then provoke LMP, cathepsin release and further caspase activation to amplify TNFα apoptosis signaling. ..
  4. ncbi request reprint Bcl-w(edding) with mitochondria
    Thomas Kaufmann
    Institute of Molecular Medicine and Cell Research, Zentrale Klinische Forschung ZKF, Albert Ludwigs University Freiburg, Breisacherstrasse 66, 79106 Freiburg, Germany
    Trends Cell Biol 14:8-12. 2004
    ..Here, we discuss the importance of this finding for a better understanding of the action mode of Bcl-w and other Bcl-2-family members...
  5. ncbi request reprint Bcl-2 family members: integrators of survival and death signals in physiology and pathology [corrected]
    Anna Schinzel
    Institute for Molecular Medicine and Cell Research, Albert Ludwigs University Freiburg, Breisachertstrasse 66, D 79106 Fribourg, Germany
    Biochim Biophys Acta 1644:95-105. 2004
    ..Furthermore, we will discuss the posttranslational modifications which regulate these events...
  6. ncbi request reprint Preprotein transport machineries of yeast mitochondrial outer membrane are not required for Bax-induced release of intermembrane space proteins
    Luiza K Sanjuán Szklarz
    Institut fur Biochemie und Molekularbiologie, Zentrum für Biochemie und Molekulare Zellforschung, Universitat Freiburg, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
    J Mol Biol 368:44-54. 2007
    ..Inactivation of the known protein import and sorting machineries of the outer membrane does not impair the function of Bax at the mitochondria...
  7. pmc Interleukin-1β enhances FasL-induced caspase-3/-7 activity without increasing apoptosis in primary mouse hepatocytes
    Anna Lutz
    Department of Pharmaceutical Biology and Biotechnology, Albert Ludwigs University Freiburg, Freiburg, Germany
    PLoS ONE 9:e115603. 2014
    ....
  8. pmc Phylogenetically Distant Viruses Use the Same BH3-Only Protein Puma to Trigger Bax/Bak-Dependent Apoptosis of Infected Mouse and Human Cells
    Emanuela Papaianni
    Department of Biological and Environmental Sciences, University of Messina, Via F Stagno D Alcontres 31, I 98166, Messina, Italy The Institute of Translational Pharmacology, CNR, Via Fosso del Cavaliere 100, I 00133, Rome, Italy Institute of Molecular Medicine and Cell Research, Albert Ludwigs University of Freiburg, Stefan Meier Strasse 17, D 79104, Freiburg, Germany
    PLoS ONE 10:e0126645. 2015
    ..Our data suggest that viruses use a Puma protein-dependent mechanism to trigger MOMP and apoptosis in host cells. ..
  9. doi request reprint A novel mitochondrial MAVS/Caspase-8 platform links RNA virus-induced innate antiviral signaling to Bax/Bak-independent apoptosis
    Souhayla El Maadidi
    Institute of Molecular Medicine and Cell Research, Albert Ludwigs University Freiburg, D 79104 Freiburg, Germany
    J Immunol 192:1171-83. 2014
    ..Thus, after RNA virus infection MAVS does not only elicit a type I antiviral response but also recruits caspase-8 to mitochondria to mediate caspase-3 activation and apoptosis in a Bax/Bak-independent manner. ..
  10. ncbi request reprint Volatile anesthetics induce caspase-dependent, mitochondria-mediated apoptosis in human T lymphocytes in vitro
    Torsten Loop
    Division of Experimental Anesthesiology, Institute of Molecular Medicine, University Hospital, Hugstetterstrasse 55, D 79106 Freiburg, Germany
    Anesthesiology 102:1147-57. 2005
    ..The current work was undertaken to examine whether volatile anesthetics induce apoptosis in human T lymphocytes and what apoptotic signaling pathway might be used...
  11. ncbi request reprint Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis
    Christoph M Schempp
    Department of Dermatology, University of Freiburg, Hauptstrasse 7, D 79104 Freiburg, Germany
    Oncogene 21:1242-50. 2002
    ....
  12. pmc Cytosolic Bax: does it require binding proteins to keep its pro-apoptotic activity in check?
    Sandra Vogel
    Institute of Molecular Medicine and Cell Research, Center for Biochemistry and Molecular Cell Research, Albert Ludwigs University, Freiburg, Germany
    J Biol Chem 287:9112-27. 2012
    ..We propose that in most healthy cells, cytosolic endogenous Bax is a monomeric protein that does not necessarily need a binding partner to keep its pro-apoptotic activity in check...
  13. pmc Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling
    Tobias B Huber
    Renal Division Molecular Medicine, University Hospital Freiburg, D 79106 Freiburg, Germany
    Mol Cell Biol 23:4917-28. 2003
    ....
  14. pmc Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes
    Dorothee Walter
    Institute of Molecular Medicine and Cell Research, ZBMZ, Albert Ludwigs University Freiburg, Freiburg, Germany
    Hepatology 48:1942-53. 2008
    ..Moreover, the switch is specific for FasL-induced apoptosis as collagen-plated Bid-deficient hepatocytes are protected from tumor necrosis factor alpha/actinomycin D (TNFalpha/ActD)-induced apoptosis...
  15. pmc SPATA2 promotes CYLD activity and regulates TNF-induced NF-κB signaling and cell death
    Lisa Schlicher
    Institute of Molecular Medicine and Cell Research, Albert Ludwigs University Freiburg, Freiburg, Germany Spemann Graduate School of Biology and Medicine SGBM, Albert Ludwigs University of Freiburg, Freiburg, Germany BIOSS, Centre for Biological Signaling Studies, Freiburg, Germany
    EMBO Rep 17:1485-1497. 2016
    ..Thus, this study identifies SPATA2 as an important factor in the TNF signaling pathway with a substantial role for the effects mediated by the cytokine...
  16. doi request reprint Tumor necrosis factor α sensitizes primary murine hepatocytes to Fas/CD95-induced apoptosis in a Bim- and Bid-dependent manner
    Kathrin Schmich
    Department of Pharmaceutical Biology and Biotechnology, Albert Ludwigs University of Freiburg, Freiburg, Germany
    Hepatology 53:282-92. 2011
    ..Finally, our results are physiologically relevant because TNFα also induces sensitivity to agonistic anti-Fas-induced liver damage...
  17. doi request reprint Caspase-3 feeds back on caspase-8, Bid and XIAP in type I Fas signaling in primary mouse hepatocytes
    Karine Sá Ferreira
    Institute of Molecular Medicine and Cell Research, University of Freiburg, Freiburg, Germany
    Apoptosis 17:503-15. 2012
    ..Thus, potent, selective caspase-3 inhibitors are useful tools to understand complex signaling circuitries in apoptosis...
  18. pmc Conformational control of Bax localization and apoptotic activity by Pro168
    Anna Schinzel
    Institute of Molecular Medicine and Cell Research, Center for Biochemistry and Molecular Cell Research, Albert Ludwigs University Freiburg, Stefan Meier Strasse 17, D 79104 Freiburg, Germany
    J Cell Biol 164:1021-32. 2004
    ..Moreover, the mutants have their NH2 termini exposed. We propose that Pro168 links the NH2 and the COOH terminus of Bax and is required for COOH-terminal release and mitochondrial targeting once this link is broken...
  19. doi request reprint Non-caspase proteases: triggers or amplifiers of apoptosis?
    Karen Schrader
    Institute of Molecular Medicine and Cell Research ZBMZ, Albert Ludwigs University Freiburg, Stefan Meier Str 17, 79104, Freiburg, Germany
    Cell Mol Life Sci 67:1607-18. 2010
    ..This review shall provide evidence for such a concept...
  20. ncbi request reprint Bcl-x(S) induces an NGF-inhibitable cytochrome c release
    Liora Lindenboim
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Israel
    Exp Cell Res 297:392-403. 2004
    ....
  21. ncbi request reprint Role of Bcl-2 expression for productive herpes simplex virus 2 replication
    Maria Teresa Sciortino
    Department of Microbiological, Genetic and Molecular Sciences, University of Messina, Salita Sperone 31, 98166 Messina, Italy
    Virology 356:136-46. 2006
    ..Overall, our data indicate that Bcl-2 expression acts as a regulator of HSV-2 replication...
  22. ncbi request reprint Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis
    Christian Gianinazzi
    Institute for Infectious Diseases, University of Bern, Friedbuhlstrasse 51, 3010 Bern, Switzerland
    Acta Neuropathol 105:499-507. 2003
    ..Taken together, the present results identify caspase-3 as a key effector of neuronal apoptosis in pneumococcal meningitis...
  23. ncbi request reprint RIP death domain structural interactions implicated in TNF-mediated proliferation and survival
    Juilee Thakar
    Department of Bioinformatics, Biocenter, Am Hubland, University of Wuerzburg, Wuerzburg, Germany
    Proteins 63:413-23. 2006
    ....
  24. ncbi request reprint Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma
    Paul G Ekert
    Children s Cancer Centre, Murdoch Children s Research Centre, Royal Children s Hospital, Flemington Rd, Parkville, Victoria 3052, Australia
    Blood 108:1461-8. 2006
    ..Inhibition of the PI3 kinase pathway promoted apoptosis in the presence or absence of IL-3 and did not require Bad, Bim, or Puma, suggesting IL-3 receptor survival signals and PI3 kinase survival signals are independent...
  25. pmc The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice
    Julian Pardo
    Metschnikoff Laboratory, Max Planck Institut fur Immunbiologie, D 79108 Freiburg, Germany
    J Cell Biol 174:509-19. 2006
    ..The elucidation of the molecular basis opens new strategies for the development of therapeutic regimens to combat A. fumigatus and related fungal infections...