Genomes and Genes
Affiliation: University of Freiburg
- The Bcl-2 protein family: sensors and checkpoints for life-or-death decisionsChristoph Borner
Institute of Molecular Medicine and Cell Research, Albert Ludwigs University, Freiburg, Germany
Mol Immunol 39:615-47. 2003..This review provides a snapshot on where we are on this journey and how we may exploit our knowledge on this family of proteins to unveil the mysteries of immune regulation...
- Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membraneThomas Kaufmann
Institute of Molecular Medicine and Cell Research, Albert Ludwigs University Freiburg, D 79106 Freiburg, Germany
J Cell Biol 160:53-64. 2003..These data define a new targeting sequence for the MOM and propose that Bcl-2 acts on several intracellular membranes whereas Bcl-x(L) specifically functions on the MOM...
- TNFα-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formationJisen Huai
Institute of Molecular Medicine and Cell Research ZBMZ, Albert Ludwigs University Freiburg, Stefan Meier Strasse 17, D 79104 Freiburg, Germany
J Cell Sci 126:4015-25. 2013..Thus, after MOMP, active caspase-3 exerts a feedback action on complex I to produce ROS. ROS then provoke LMP, cathepsin release and further caspase activation to amplify TNFα apoptosis signaling. ..
- Bcl-w(edding) with mitochondriaThomas Kaufmann
Institute of Molecular Medicine and Cell Research, Zentrale Klinische Forschung ZKF, Albert Ludwigs University Freiburg, Breisacherstrasse 66, 79106 Freiburg, Germany
Trends Cell Biol 14:8-12. 2004..Here, we discuss the importance of this finding for a better understanding of the action mode of Bcl-w and other Bcl-2-family members...
- Bcl-2 family members: integrators of survival and death signals in physiology and pathology [corrected]Anna Schinzel
Institute for Molecular Medicine and Cell Research, Albert Ludwigs University Freiburg, Breisachertstrasse 66, D 79106 Fribourg, Germany
Biochim Biophys Acta 1644:95-105. 2004..Furthermore, we will discuss the posttranslational modifications which regulate these events...
- Preprotein transport machineries of yeast mitochondrial outer membrane are not required for Bax-induced release of intermembrane space proteinsLuiza K Sanjuán Szklarz
Institut fur Biochemie und Molekularbiologie, Zentrum für Biochemie und Molekulare Zellforschung, Universitat Freiburg, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
J Mol Biol 368:44-54. 2007..Inactivation of the known protein import and sorting machineries of the outer membrane does not impair the function of Bax at the mitochondria...
- Interleukin-1β enhances FasL-induced caspase-3/-7 activity without increasing apoptosis in primary mouse hepatocytesAnna Lutz
Department of Pharmaceutical Biology and Biotechnology, Albert Ludwigs University Freiburg, Freiburg, Germany
PLoS ONE 9:e115603. 2014....
- Phylogenetically Distant Viruses Use the Same BH3-Only Protein Puma to Trigger Bax/Bak-Dependent Apoptosis of Infected Mouse and Human CellsEmanuela Papaianni
Department of Biological and Environmental Sciences, University of Messina, Via F Stagno D Alcontres 31, I 98166, Messina, Italy The Institute of Translational Pharmacology, CNR, Via Fosso del Cavaliere 100, I 00133, Rome, Italy Institute of Molecular Medicine and Cell Research, Albert Ludwigs University of Freiburg, Stefan Meier Strasse 17, D 79104, Freiburg, Germany
PLoS ONE 10:e0126645. 2015..Our data suggest that viruses use a Puma protein-dependent mechanism to trigger MOMP and apoptosis in host cells. ..
- A novel mitochondrial MAVS/Caspase-8 platform links RNA virus-induced innate antiviral signaling to Bax/Bak-independent apoptosisSouhayla El Maadidi
Institute of Molecular Medicine and Cell Research, Albert Ludwigs University Freiburg, D 79104 Freiburg, Germany
J Immunol 192:1171-83. 2014..Thus, after RNA virus infection MAVS does not only elicit a type I antiviral response but also recruits caspase-8 to mitochondria to mediate caspase-3 activation and apoptosis in a Bax/Bak-independent manner. ..
- Volatile anesthetics induce caspase-dependent, mitochondria-mediated apoptosis in human T lymphocytes in vitroTorsten Loop
Division of Experimental Anesthesiology, Institute of Molecular Medicine, University Hospital, Hugstetterstrasse 55, D 79106 Freiburg, Germany
Anesthesiology 102:1147-57. 2005..The current work was undertaken to examine whether volatile anesthetics induce apoptosis in human T lymphocytes and what apoptotic signaling pathway might be used...
- Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosisChristoph M Schempp
Department of Dermatology, University of Freiburg, Hauptstrasse 7, D 79104 Freiburg, Germany
Oncogene 21:1242-50. 2002....
- Cytosolic Bax: does it require binding proteins to keep its pro-apoptotic activity in check?Sandra Vogel
Institute of Molecular Medicine and Cell Research, Center for Biochemistry and Molecular Cell Research, Albert Ludwigs University, Freiburg, Germany
J Biol Chem 287:9112-27. 2012..We propose that in most healthy cells, cytosolic endogenous Bax is a monomeric protein that does not necessarily need a binding partner to keep its pro-apoptotic activity in check...
- Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signalingTobias B Huber
Renal Division Molecular Medicine, University Hospital Freiburg, D 79106 Freiburg, Germany
Mol Cell Biol 23:4917-28. 2003....
- Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytesDorothee Walter
Institute of Molecular Medicine and Cell Research, ZBMZ, Albert Ludwigs University Freiburg, Freiburg, Germany
Hepatology 48:1942-53. 2008..Moreover, the switch is specific for FasL-induced apoptosis as collagen-plated Bid-deficient hepatocytes are protected from tumor necrosis factor alpha/actinomycin D (TNFalpha/ActD)-induced apoptosis...
- SPATA2 promotes CYLD activity and regulates TNF-induced NF-κB signaling and cell deathLisa Schlicher
Institute of Molecular Medicine and Cell Research, Albert Ludwigs University Freiburg, Freiburg, Germany Spemann Graduate School of Biology and Medicine SGBM, Albert Ludwigs University of Freiburg, Freiburg, Germany BIOSS, Centre for Biological Signaling Studies, Freiburg, Germany
EMBO Rep 17:1485-1497. 2016..Thus, this study identifies SPATA2 as an important factor in the TNF signaling pathway with a substantial role for the effects mediated by the cytokine...
- Tumor necrosis factor α sensitizes primary murine hepatocytes to Fas/CD95-induced apoptosis in a Bim- and Bid-dependent mannerKathrin Schmich
Department of Pharmaceutical Biology and Biotechnology, Albert Ludwigs University of Freiburg, Freiburg, Germany
Hepatology 53:282-92. 2011..Finally, our results are physiologically relevant because TNFα also induces sensitivity to agonistic anti-Fas-induced liver damage...
- Caspase-3 feeds back on caspase-8, Bid and XIAP in type I Fas signaling in primary mouse hepatocytesKarine Sá Ferreira
Institute of Molecular Medicine and Cell Research, University of Freiburg, Freiburg, Germany
Apoptosis 17:503-15. 2012..Thus, potent, selective caspase-3 inhibitors are useful tools to understand complex signaling circuitries in apoptosis...
- Conformational control of Bax localization and apoptotic activity by Pro168Anna Schinzel
Institute of Molecular Medicine and Cell Research, Center for Biochemistry and Molecular Cell Research, Albert Ludwigs University Freiburg, Stefan Meier Strasse 17, D 79104 Freiburg, Germany
J Cell Biol 164:1021-32. 2004..Moreover, the mutants have their NH2 termini exposed. We propose that Pro168 links the NH2 and the COOH terminus of Bax and is required for COOH-terminal release and mitochondrial targeting once this link is broken...
- Non-caspase proteases: triggers or amplifiers of apoptosis?Karen Schrader
Institute of Molecular Medicine and Cell Research ZBMZ, Albert Ludwigs University Freiburg, Stefan Meier Str 17, 79104, Freiburg, Germany
Cell Mol Life Sci 67:1607-18. 2010..This review shall provide evidence for such a concept...
- Bcl-x(S) induces an NGF-inhibitable cytochrome c releaseLiora Lindenboim
Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Israel
Exp Cell Res 297:392-403. 2004....
- Role of Bcl-2 expression for productive herpes simplex virus 2 replicationMaria Teresa Sciortino
Department of Microbiological, Genetic and Molecular Sciences, University of Messina, Salita Sperone 31, 98166 Messina, Italy
Virology 356:136-46. 2006..Overall, our data indicate that Bcl-2 expression acts as a regulator of HSV-2 replication...
- Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitisChristian Gianinazzi
Institute for Infectious Diseases, University of Bern, Friedbuhlstrasse 51, 3010 Bern, Switzerland
Acta Neuropathol 105:499-507. 2003..Taken together, the present results identify caspase-3 as a key effector of neuronal apoptosis in pneumococcal meningitis...
- RIP death domain structural interactions implicated in TNF-mediated proliferation and survivalJuilee Thakar
Department of Bioinformatics, Biocenter, Am Hubland, University of Wuerzburg, Wuerzburg, Germany
Proteins 63:413-23. 2006....
- Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on PumaPaul G Ekert
Children s Cancer Centre, Murdoch Children s Research Centre, Royal Children s Hospital, Flemington Rd, Parkville, Victoria 3052, Australia
Blood 108:1461-8. 2006..Inhibition of the PI3 kinase pathway promoted apoptosis in the presence or absence of IL-3 and did not require Bad, Bim, or Puma, suggesting IL-3 receptor survival signals and PI3 kinase survival signals are independent...
- The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in miceJulian Pardo
Metschnikoff Laboratory, Max Planck Institut fur Immunbiologie, D 79108 Freiburg, Germany
J Cell Biol 174:509-19. 2006..The elucidation of the molecular basis opens new strategies for the development of therapeutic regimens to combat A. fumigatus and related fungal infections...