Christian Bogdan

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. ncbi request reprint Production of interferon-gamma by myeloid cells--fact or fancy?
    Christian Bogdan
    Department of Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University of Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    Trends Immunol 27:282-90. 2006
  2. pmc NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs
    Ulrike Schleicher
    Institute of Medical Microbiology and Hygiene, University of Freiburg, D 79104 Freiburg, Germany
    J Exp Med 204:893-906. 2007
  3. ncbi request reprint Immunoregulatory and antimicrobial activities of myeloid cells
    Christian Bogdan
    Abteilung für Mikrobiologie und Hygiene, Institut fur Medizinische Mikrobiologie und Hygiene, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    Eur J Immunol 37:303-5. 2007
  4. ncbi request reprint The role of type I interferons in non-viral infections
    Christian Bogdan
    Institute of Medical Microbiology and Hygiene, Department of Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    Immunol Rev 202:33-48. 2004
  5. ncbi request reprint TLR9 signaling is essential for the innate NK cell response in murine cutaneous leishmaniasis
    Jan Liese
    Institute of Medical Microbiology and Hygiene, Department of Medical Microbiology and Hygiene, University Clinic of Freiburg, Freiburg, Germany
    Eur J Immunol 37:3424-34. 2007
  6. doi request reprint The elimination of Anaplasma phagocytophilum requires CD4+ T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms
    Katharina Birkner
    Department of Medical Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    Eur J Immunol 38:3395-410. 2008
  7. pmc Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo
    Gyorgy Fejer
    Max Planck Institute for Immunobiology, Freiburg, Germany
    PLoS Pathog 4:e1000208. 2008
  8. doi request reprint The innate immune response against Leishmania parasites
    Jan Liese
    Department of Medical Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University Clinic Freiburg, Freiburg, Germany
    Immunobiology 213:377-87. 2008
  9. pmc Impairment of gamma interferon signaling in human neutrophils infected with Anaplasma phagocytophilum
    Uta Bussmeyer
    Institute of Medical Microbiology and Hygiene, University of Luebeck, Ratzeburger Allee 160, Luebeck D 23538, Germany
    Infect Immun 78:358-63. 2010
  10. ncbi request reprint Characterization of rifampicin-resistant clinical Helicobacter pylori isolates from Germany
    Erik Glocker
    National Reference Center for Helicobacter pylori, Department of Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University Hospital Freiburg, Freiburg, Germany
    J Antimicrob Chemother 59:874-9. 2007

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Production of interferon-gamma by myeloid cells--fact or fancy?
    Christian Bogdan
    Department of Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University of Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    Trends Immunol 27:282-90. 2006
    ..We also discuss the possible function of intracellular IFN-gamma in macrophages and the evidence for a protective role of myeloid IFN-gamma in vivo...
  2. pmc NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs
    Ulrike Schleicher
    Institute of Medical Microbiology and Hygiene, University of Freiburg, D 79104 Freiburg, Germany
    J Exp Med 204:893-906. 2007
    ....
  3. ncbi request reprint Immunoregulatory and antimicrobial activities of myeloid cells
    Christian Bogdan
    Abteilung für Mikrobiologie und Hygiene, Institut fur Medizinische Mikrobiologie und Hygiene, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    Eur J Immunol 37:303-5. 2007
    ..180 scientists recently met at the 20th Annual meeting of the European Macrophage and Dendritic Cell Society to discuss the interaction between interferons, myeloid cells, TLR, killing mechanisms and microbial pathogens...
  4. ncbi request reprint The role of type I interferons in non-viral infections
    Christian Bogdan
    Institute of Medical Microbiology and Hygiene, Department of Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    Immunol Rev 202:33-48. 2004
    ..This review summarizes the current knowledge on the production and function of IFN-alpha/beta during non-viral infections in vitro and in vivo...
  5. ncbi request reprint TLR9 signaling is essential for the innate NK cell response in murine cutaneous leishmaniasis
    Jan Liese
    Institute of Medical Microbiology and Hygiene, Department of Medical Microbiology and Hygiene, University Clinic of Freiburg, Freiburg, Germany
    Eur J Immunol 37:3424-34. 2007
    ..We conclude that TLR9 signaling is essential for NK cell activation, but dispensable for a protective T cell response to L. major in vivo...
  6. doi request reprint The elimination of Anaplasma phagocytophilum requires CD4+ T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms
    Katharina Birkner
    Department of Medical Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    Eur J Immunol 38:3395-410. 2008
    ..These findings provide a novel paradigm for the control of an intracellular pathogen, which appears to be strikingly different from the CD4(+) T cell-, IL-12-, and IFN-gamma-dependent immunity to other intracellular bacteria...
  7. pmc Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo
    Gyorgy Fejer
    Max Planck Institute for Immunobiology, Freiburg, Germany
    PLoS Pathog 4:e1000208. 2008
    ..The hypersensitivity to components of the microbial flora and invading pathogens may in part explain the toxic side effects of adenoviral gene therapy and contribute to the pathogenesis of adenoviral disease...
  8. doi request reprint The innate immune response against Leishmania parasites
    Jan Liese
    Department of Medical Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University Clinic Freiburg, Freiburg, Germany
    Immunobiology 213:377-87. 2008
    ....
  9. pmc Impairment of gamma interferon signaling in human neutrophils infected with Anaplasma phagocytophilum
    Uta Bussmeyer
    Institute of Medical Microbiology and Hygiene, University of Luebeck, Ratzeburger Allee 160, Luebeck D 23538, Germany
    Infect Immun 78:358-63. 2010
    ..Since IFN-gamma activates various antibacterial effector mechanisms of PMN, the impaired IFN-gamma signaling in infected cells likely contributes to the survival of A. phagocytophilum inside PMN and to HGA disease development...
  10. ncbi request reprint Characterization of rifampicin-resistant clinical Helicobacter pylori isolates from Germany
    Erik Glocker
    National Reference Center for Helicobacter pylori, Department of Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University Hospital Freiburg, Freiburg, Germany
    J Antimicrob Chemother 59:874-9. 2007
    ....
  11. ncbi request reprint The role of epithelial Toll-like receptor expression in host defense and microbial tolerance
    Mathias W Hornef
    Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany
    J Endotoxin Res 11:124-8. 2005
    ..Recent findings suggest that the role of epithelial cells in the maintenance of stable microbial colonization of host surfaces and the immediate host response to infectious challenges might have to be revised...
  12. doi request reprint Translational repression of inducible NO synthase in macrophages by l-arginine depletion is not associated with an increased phosphorylation of eIF2alpha
    Till König
    Department of Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University Clinic of Freiburg, Germany
    Immunobiology 214:822-7. 2009
    ..Alternative modes of translational repression of iNOS need to be considered...
  13. ncbi request reprint Analysis of the antimicrobial activity of local anaesthetics used for dental analgesia
    Klaus Pelz
    Institut fuer Mikrobiologie und Hygiene, Albert Ludwigs Universitaet Freiburg, D 79104 Freiburg, Germany
    J Med Microbiol 57:88-94. 2008
    ..Due to the results obtained with nosocomial strains (Escherichia coli, S. aureus and Pseudomonas), disinfection of the mucous membranes should be performed routinely in immunocompromised patients, regardless of the anaesthetic used...
  14. pmc Detection of "Candidatus Neoehrlichia mikurensis" in two patients with severe febrile illnesses: evidence for a European sequence variant
    Friederike D von Loewenich
    Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    J Clin Microbiol 48:2630-5. 2010
    ..16S rRNA and groEL gene sequencing provided evidence of three groups of sequence variants...
  15. pmc Cytokine-mediated control of lipopolysaccharide-induced activation of small intestinal epithelial cells
    Michael Lotz
    Department of Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University Clinic of Freiburg, Freiburg, Germany
    Immunology 122:306-15. 2007
    ..In conclusion, cytokines such as IL-4 and IL-13 affect intestinal epithelial cells and exhibit a modulating activity on Toll-like receptor-4-mediated epithelial cell activation...
  16. ncbi request reprint Macrophage and dendritic cells. Editorial
    Christian Bogdan
    Immunobiology 212:677. 2007
  17. ncbi request reprint Type I IFN modulates host defense and late hyperinflammation in septic peritonitis
    Heike Weighardt
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    J Immunol 177:5623-30. 2006
    ..The results suggest that type I IFN exerts predominantly adverse effects under these conditions...
  18. pmc Lymphadenopathy in a novel mouse model of Bartonella-induced cat scratch disease results from lymphocyte immigration and proliferation and is regulated by interferon-alpha/beta
    Stefanie Kunz
    Immunologie und Hygiene, Universitatsklinikum Erlangen, Wasserturmstrasse 3 5, Erlangen, Germany
    Am J Pathol 172:1005-18. 2008
    ..These data demonstrate that the lymphadenopathy of human CSD can be reproduced and studied in a mouse model and provide the first insights into the underlying immunological mechanisms...
  19. doi request reprint Mechanisms and consequences of persistence of intracellular pathogens: leishmaniasis as an example
    Christian Bogdan
    Microbiology Institute Clinical Microbiology, Immunology and Hygiene, University Clinic of Erlangen, Erlangen, Germany
    Cell Microbiol 10:1221-34. 2008
    ..Parasites of the genus Leishmania have been particular helpful in unravelling some of the basic processes and form therefore the centre of the discussion...
  20. pmc Hydrolytic reactivity trends among potential prodrugs of the O2-glycosylated diazeniumdiolate family. Targeting nitric oxide to macrophages for antileishmanial activity
    Carlos A Valdez
    Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    J Med Chem 51:3961-70. 2008
    ....
  21. pmc Innate immune response to Anaplasma phagocytophilum contributes to hepatic injury
    Diana G Scorpio
    Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Department of Molecular and Comparative Pathobiology, 720 Rutland Avenue, Ross 459, Baltimore, Maryland 21205, USA
    Clin Vaccine Immunol 13:806-9. 2006
    ..We show that despite evasion of these host responses, phox, NOS2, TNF, and MyD88 are activated and contribute to inflammation and hepatic injury more than A. phagocytophilum itself...
  22. ncbi request reprint Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock
    Marina Karaghiosoff
    Institute of Animal Breeding and Genetics, Veterinary University of Vienna, A 1210 Vienna, Austria
    Nat Immunol 4:471-7. 2003
    ..IFN-beta-null but not STAT1-null mice were also resistant to high dose LPS treatment. Together, these data suggest that Tyk2 and IFN-beta are essential effectors in LPS induced lethality...
  23. ncbi request reprint Organ-specific and stage-dependent control of Leishmania major infection by inducible nitric oxide synthase and phagocyte NADPH oxidase
    Martin Blos
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Immunol 33:1224-34. 2003
    ..These results demonstrate that iNOS and phox are both required for the control of L. major in vivo and display unexpected organ- and stage-specific anti-leishmanial effects...
  24. ncbi request reprint Human granulocytic ehrlichiosis in Germany: evidence from serological studies, tick analyses, and a case of equine ehrlichiosis
    Friederike D von Loewenich
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, D 91054 Erlangen, Germany
    Ann N Y Acad Sci 990:116-7. 2003
  25. pmc High diversity of ankA sequences of Anaplasma phagocytophilum among Ixodes ricinus ticks in Germany
    Friederike D von Loewenich
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Erlangen, Germany
    J Clin Microbiol 41:5033-40. 2003
    ..Based on this unexpected sequence heterogeneity, we propose to use the ankA gene for further phylogenetic analyses of A. phagocytophilum and to investigate the biology and pathogenicity of strains that differ in the ankA gene...
  26. ncbi request reprint Control of Leishmania major in the absence of Tyk2 kinase
    Ulrike Schleicher
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Immunol 34:519-29. 2004
    ..Thus, Tyk2 is required for the IL-12 response of NK cells and CD8(+) T cells in L. major-infected mice, but not for the generation of Th1 cells and the ultimate control of the disease...
  27. ncbi request reprint The control of Leishmania (Leishmania) major by TNF in vivo is dependent on the parasite strain
    Uwe Ritter
    Interdisziplinäres Zentrum für Klinische Forschung der Universität Erlangen Nürnberg, Glückstrasse 6, 91054 Erlangen, Germany
    Microbes Infect 6:559-65. 2004
    ..L.) major strain, which most likely explains the previously published discrepant results on the role of TNF in leishmaniasis...
  28. ncbi request reprint Protection against progressive leishmaniasis by IFN-beta
    Jochen Mattner
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 172:7574-82. 2004
    ..These results identify IFN-beta as a novel cytokine with a strong, dose-dependent protective effect against progressive cutaneous leishmaniasis that results from IL-12- and STAT4-dependent as well as -independent events...
  29. ncbi request reprint Frontline: control of Anaplasma phagocytophilum, an obligate intracellular pathogen, in the absence of inducible nitric oxide synthase, phagocyte NADPH oxidase, tumor necrosis factor, Toll-like receptor (TLR)2 and TLR4, or the TLR adaptor molecule MyD88
    Friederike D von Loewenich
    Institute of Clinical Microbiology, Immunology, and Hygiene, University of Erlangen, Erlangen, Germany
    Eur J Immunol 34:1789-97. 2004
    ..phagocytophilum. From these data we conclude that effector mechanisms that are crucial to the defense against numerous other intracellular pathogens are dispensable for the control of A. phagocytophilum...
  30. ncbi request reprint Minute numbers of contaminant CD8+ T cells or CD11b+CD11c+ NK cells are the source of IFN-gamma in IL-12/IL-18-stimulated mouse macrophage populations
    Ulrike Schleicher
    Institute of Clinical Microbiology, Immunologu and Hygiene, University of Erlangen, Germany
    Blood 105:1319-28. 2005
    ....
  31. ncbi request reprint NKT cells mediate organ-specific resistance against Leishmania major infection
    Jochen Mattner
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen Nuremberg, Germany
    Microbes Infect 8:354-62. 2006
    ..Thus, NKT cells fulfill organ-specific protective functions during infection with L. major, but are not essential for parasite control...
  32. ncbi request reprint TNF but not Fas ligand provides protective anti-L. major immunity in C57BL/6 mice
    Patricia Wilhelm
    Interdisziplinäres Zentrum für Klinische Forschung der Universität Erlangen Nürnberg, Nachwuchsgruppe 1, Nikolaus Fiebiger Zentrum, Erlangen, Germany
    Microbes Infect 7:1461-8. 2005
    ..Thus, TNF, but not FasL is essential for the control of L. major BNI. The discrepancy between these and other published data are most likely due to the use of different strains of the pathogen...
  33. ncbi request reprint Innate immune tissue injury and murine HGA: tissue injury in the murine model of granulocytic anaplasmosis relates to host innate immune response and not pathogen load
    Diana G Scorpio
    Department of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Ann N Y Acad Sci 1063:425-8. 2005
    ..Our hypothesis is that the innate immune response to A. phagocytophilum results in inflammatory histopathology, but does not control the pathogen...
  34. pmc Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells
    Michael Lotz
    Department for Medical Microbiology and Hygiene, University Clinic of Freiburg, 79104 Freiburg, Germany
    J Exp Med 203:973-84. 2006
    ..Thus, unlike intestinal macrophages, IECs acquire TLR tolerance immediately after birth by exposure to exogenous endotoxin to facilitate microbial colonization and the development of a stable intestinal host-microbe homeostasis...
  35. pmc Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity
    Mauritius Menges
    Department of Dermatology, University of Erlangen, Erlangen 91052, Germany
    J Exp Med 195:15-21. 2002
    ..In conclusion, this study describes that stimulation by TNF-alpha results in incompletely matured DCs (semi-mature DCs) which induce peptide-specific IL-10-producing T cells in vivo and prevent EAE...