Martin Bidlingmaier

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint What endocrinologists should know about growth hormone measurements
    Martin Bidlingmaier
    Endocrine Research Laboratories, Medizinische Klinik Innenstadt, Ludwig Maximilians University, Ziemssenstrasse 1, Munich 80336, Germany
    Endocrinol Metab Clin North Am 36:101-8. 2007
  2. ncbi request reprint Growth hormone assays: current methodologies and their limitations
    Martin Bidlingmaier
    Endocrine Research Laboratories, Medizinische Klinik Innenstadt, Ludwig Maximilians University, Ziemssenstr 1, 80336 Munich, Germany
    Pituitary 10:115-9. 2007
  3. ncbi request reprint Comparative pharmacokinetics and pharmacodynamics of a new sustained-release growth hormone (GH), LB03002, versus daily GH in adults with GH deficiency
    Martin Bidlingmaier
    Medizinische Klinik Innenstadt, Ludwig Maximilians Universitat, Ziemssenstrasse 1, 80336 Munich, Germany
    J Clin Endocrinol Metab 91:2926-30. 2006
  4. doi request reprint Serum IGF-I is not a reliable pharmacodynamic marker of exogenous growth hormone activity in mice
    Maximilian Bielohuby
    Endocrine Research Unit, Medizinische Klinik Innenstadt, Ludwig Maximilians University, D 80336 Munich, Germany
    Endocrinology 152:4764-76. 2011
  5. doi request reprint Growth hormone
    Martin Bidlingmaier
    Medizinische Klinik Innenstadt, Ludwig Maximilians University, Ziemssenstr 1, 80336, Munich, Germany
    Handb Exp Pharmacol . 2010
  6. doi request reprint Influence of pre-analytical conditions on the measurement of components of the GH/IGF axis in rats
    Maximilian Bielohuby
    Endocrine Research Unit, Medizinische Klinik und Poliklinik IV, Klinikum der LMU, Munich, Germany
    Growth Horm IGF Res 23:141-8. 2013
  7. pmc Mental health in the aged: prevalence, covariates and related neuroendocrine, cardiovascular and inflammatory factors of successful aging
    Maria E Lacruz
    Institut für Epidemiologie Helmholtz Zentrum München, Munchen, Germany
    BMC Med Res Methodol 10:36. 2010
  8. doi request reprint Measurement of human growth hormone by immunoassays: current status, unsolved problems and clinical consequences
    Martin Bidlingmaier
    Endocrine Research Laboratories, Medizinische Klinik Innenstadt, Ludwig Maximilians University, Munich, Germany
    Growth Horm IGF Res 20:19-25. 2010
  9. doi request reprint Detecting growth hormone abuse in athletes
    Martin Bidlingmaier
    Endocrine Research Laboratories, Medizinische Klinik Innenstadt, Ludwig Maximilians University, Munich, Germany
    Endocrinol Metab Clin North Am 39:25-32, vii. 2010
  10. doi request reprint Pitfalls of insulin-like growth factor I assays
    Martin Bidlingmaier
    Medizinische Klinik Innenstadt, Ludwig Maximilian University, Munich, Germany
    Horm Res 71:30-3. 2009

Detail Information

Publications88

  1. ncbi request reprint What endocrinologists should know about growth hormone measurements
    Martin Bidlingmaier
    Endocrine Research Laboratories, Medizinische Klinik Innenstadt, Ludwig Maximilians University, Ziemssenstrasse 1, Munich 80336, Germany
    Endocrinol Metab Clin North Am 36:101-8. 2007
    ..This article focuses on the molecular, structural, and methodologic background of the heterogeneity of assay results and on possible next steps toward standardization...
  2. ncbi request reprint Growth hormone assays: current methodologies and their limitations
    Martin Bidlingmaier
    Endocrine Research Laboratories, Medizinische Klinik Innenstadt, Ludwig Maximilians University, Ziemssenstr 1, 80336 Munich, Germany
    Pituitary 10:115-9. 2007
    ..This review provides an overview on GH assays used in clinical practice, their limitations and the potential next steps towards standardization...
  3. ncbi request reprint Comparative pharmacokinetics and pharmacodynamics of a new sustained-release growth hormone (GH), LB03002, versus daily GH in adults with GH deficiency
    Martin Bidlingmaier
    Medizinische Klinik Innenstadt, Ludwig Maximilians Universitat, Ziemssenstrasse 1, 80336 Munich, Germany
    J Clin Endocrinol Metab 91:2926-30. 2006
    ..LB03002 is a novel sustained-release GH preparation administered once weekly...
  4. doi request reprint Serum IGF-I is not a reliable pharmacodynamic marker of exogenous growth hormone activity in mice
    Maximilian Bielohuby
    Endocrine Research Unit, Medizinische Klinik Innenstadt, Ludwig Maximilians University, D 80336 Munich, Germany
    Endocrinology 152:4764-76. 2011
    ..Total body weight, lean body mass, and liver weight may be more reliable phenotypic indicators in these models...
  5. doi request reprint Growth hormone
    Martin Bidlingmaier
    Medizinische Klinik Innenstadt, Ludwig Maximilians University, Ziemssenstr 1, 80336, Munich, Germany
    Handb Exp Pharmacol . 2010
    ..Because the "marker method" and the "isoform method" have a different window of opportunity for detection, complementary use of both tests could be a way to increase the likelihood of detecting cheating athletes...
  6. doi request reprint Influence of pre-analytical conditions on the measurement of components of the GH/IGF axis in rats
    Maximilian Bielohuby
    Endocrine Research Unit, Medizinische Klinik und Poliklinik IV, Klinikum der LMU, Munich, Germany
    Growth Horm IGF Res 23:141-8. 2013
    ..Furthermore, we explored if short term fasting, age and circadian rhythmicity have an impact upon the concentrations of IGF-I, IGFBP-2 and IGFBP-3 in rats...
  7. pmc Mental health in the aged: prevalence, covariates and related neuroendocrine, cardiovascular and inflammatory factors of successful aging
    Maria E Lacruz
    Institut für Epidemiologie Helmholtz Zentrum München, Munchen, Germany
    BMC Med Res Methodol 10:36. 2010
    ..Specifically, we aim to identify predictors of successful aging and to elucidate bio-psychosocial mechanisms that maintain mental health and successful adaptation despite adverse experiences of life and aging...
  8. doi request reprint Measurement of human growth hormone by immunoassays: current status, unsolved problems and clinical consequences
    Martin Bidlingmaier
    Endocrine Research Laboratories, Medizinische Klinik Innenstadt, Ludwig Maximilians University, Munich, Germany
    Growth Horm IGF Res 20:19-25. 2010
    ..This review summarizes current practices for GH measurement with respect to the methods used, their limitations and the clinical consequences of the existing heterogeneity in GH immunoassay results...
  9. doi request reprint Detecting growth hormone abuse in athletes
    Martin Bidlingmaier
    Endocrine Research Laboratories, Medizinische Klinik Innenstadt, Ludwig Maximilians University, Munich, Germany
    Endocrinol Metab Clin North Am 39:25-32, vii. 2010
    ..A more widespread use of these tests in out-of-competition controls will enhance the likelihood to detect GH doping...
  10. doi request reprint Pitfalls of insulin-like growth factor I assays
    Martin Bidlingmaier
    Medizinische Klinik Innenstadt, Ludwig Maximilian University, Munich, Germany
    Horm Res 71:30-3. 2009
    ..With IGF-I assays, interference from binding proteins is an important variable affecting assay results...
  11. doi request reprint Problems with GH assays and strategies toward standardization
    Martin Bidlingmaier
    Endocrine Research Laboratories, Medizinische Klinik, Innenstadt, Ludwig Maximilians University, Ziemssenstreet 1, 80336 Munich, Germany
    Eur J Endocrinol 159:S41-4. 2008
    ....
  12. ncbi request reprint Technology insight: detecting growth hormone abuse in athletes
    Martin Bidlingmaier
    Endocrine Research Laboratories, Medizinische Klinik Innenstadt Medical Department, Klinikum der Universitat, Ludwig Maximilians University, Munich, Germany
    Nat Clin Pract Endocrinol Metab 3:769-77. 2007
    ..Used in a complementary way in an out-of-competition setting, these methods are a powerful tool with which to detect growth hormone abuse in sports...
  13. doi request reprint Lack of influence of somatic mutations on steroid gradients during adrenal vein sampling in aldosterone-producing adenoma patients
    Andrea Oßwald
    Medizinische Klinik und Poliklinik IV, Ludwig Maximilians Universitat Munchen, Klinikum der Universitat Munchen, Ziemssenstr 1, D 80336 Munich, Germany
    Eur J Endocrinol 169:657-63. 2013
    ..These and other recently identified genetic modifiers (ATP1A1 and ATP2B3) might affect the final diagnosis and treatment of the affected patients...
  14. doi request reprint Lack of dietary carbohydrates induces hepatic growth hormone (GH) resistance in rats
    Maximilian Bielohuby
    Endocrine Research Unit, Medizinische Klinik Innenstadt, Ludwig Maximilians University, Munich, Germany
    Endocrinology 152:1948-60. 2011
    ..In conclusion, lack of carbohydrates in LC-HFD induces hepatic GH resistance. Furthermore, central feedback mechanisms of the GH/IGF system are impaired with extreme, ketogenic LC-HFD...
  15. doi request reprint Low-carbohydrate high-fat diets in combination with daily exercise in rats: effects on body weight regulation, body composition and exercise capacity
    Samantha J Caton
    Endocrine Research Unit, Medizinische Klinik und Poliklinik IV, Klinikum der LMU, Munich, Germany
    Physiol Behav 106:185-92. 2012
    ....
  16. doi request reprint Quality of life in patients with primary aldosteronism: gender differences in untreated and long-term treated patients and associations with treatment and aldosterone
    Heike E Kunzel
    Medizinische Klinik Innenstadt, Klinikum der Ludwig Maximilians Universität München, Ziemssenstr 1, D 80336 MUnchen, Germany
    J Psychiatr Res 46:1650-4. 2012
    ..Untreated and mineralocorticoid antagonist treated patients report the lowest readings. Females were found to be more impaired than males in QoL. MRA treatment seems to affect the MCS of female patients...
  17. ncbi request reprint Role of placental growth hormone in the alteration of maternal arterial resistance in pregnancy
    Barbara Schiessl
    Prenatal Medicine Unit, Department of Obstetrics and Gynecology, Ludwig Maximilians University, Munich, Germany
    J Reprod Med 52:313-6. 2007
    ..To investigate the relation between arterial resistance and placental growth hormone (hGH-V) levels in the maternal circulation...
  18. ncbi request reprint Automated 22-kD growth hormone-specific assay without interference from Pegvisomant
    Jenny Manolopoulou
    Endocrine Research Laboratories, Medizinische Klinik und Poliklinik IV, Ludwig Maximilians University, Munich, Germany
    Clin Chem 58:1446-56. 2012
    ..A recent consensus conference established criteria for standardization and evaluation of GH assays. Following consensus recommendations, we developed a new GH assay on an automated analyzer (IDS-iSYS, Immunodiagnostic Systems)...
  19. pmc Dataset of the associations of aldosterone to renin ratio with MR-proANP and MR-proADM
    Cornelia Then
    Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig Maximilians Universität, Munich, Germany Clinical Cooperation Group Diabetes, Ludwig Maximilians Universität München and Helmholtz Zentrum München, Munich, Germany
    Data Brief 8:1395-9. 2016
    ..2016) [1] and describes the association of the aldosterone to renin ratio with midregional-pro atrial natriuretic peptide (MR-proANP) and midregional-pro adrenomedullin (MR-proADM) in 1261 participants from the KORA F4 cohort. ..
  20. doi request reprint Gender differences in anxiety and depressive symptoms in patients with primary hyperaldosteronism: a cross-sectional study
    Konstantina Apostolopoulou
    Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig Maximilians Universität München, Munchen, Germany
    World J Biol Psychiatry 15:26-35. 2014
    ..Primary hyperaldosteronism (PA) is associated with a marked aldosterone excess. Prior studies on PA describe an increased prevalence of anxiety and sub-threshold depressive symptoms in these patients...
  21. doi request reprint Aldosterone excess impairs first phase insulin secretion in primary aldosteronism
    Evelyn Fischer
    Medizinische Klinik und Poliklinik IV, Klinikum der Universitat Munchen, Ziemssenstrasse 1, 80336 Munchen, Germany
    J Clin Endocrinol Metab 98:2513-20. 2013
    ..Primary aldosteronism (PA) represents the most frequent cause of secondary arterial hypertension. Conflicting data have been published regarding the effect of aldosterone excess on glucose metabolism...
  22. doi request reprint Prolonged zona glomerulosa insufficiency causing hyperkalemia in primary aldosteronism after adrenalectomy
    Evelyn Fischer
    Medizinische Klinik und Poliklinik IV, Klinikum der Universitat Munchen, Ziemssenstr 1, 80336 Munchen, Germany
    J Clin Endocrinol Metab 97:3965-73. 2012
    ..Unilateral adrenalectomy is the therapy of choice in aldosterone-producing adenoma (APA). Zona glomerulosa (ZG) insufficiency causing hyperkalemia after adrenalectomy has been described in case reports...
  23. ncbi request reprint A new nonisotopic, highly sensitive assay for the measurement of human placental growth hormone: development and clinical implications
    Zida Wu
    Neuroendocrine Unit, Medizinische Klinik Innenstadt, Klinikum der Ludwig Maximilians University, 80336 Munich, Germany
    J Clin Endocrinol Metab 88:804-11. 2003
    ..In addition, the results indicate that maternal weight has a major impact on circulating concentrations of hGH-V...
  24. doi request reprint Risk factors associated with a low glomerular filtration rate in primary aldosteronism
    Martin Reincke
    Medizinische Klinik Innenstadt, Ludwig Maximilians Universitat Munchen, 80336 Munchen, Germany
    J Clin Endocrinol Metab 94:869-75. 2009
    ..Primary aldosteronism (PA) is associated with vascular end organ damage...
  25. doi request reprint Adrenal vein sampling using rapid cortisol assays in primary aldosteronism is useful in centers with low success rates
    Matthias J Betz
    Department of Medicine, University Hospital Innenstadt, Ludwig Maximilians University, Ziemssenstrasse 1, D 80336 Munich, Germany
    Eur J Endocrinol 165:301-6. 2011
    ..We hypothesized that rapid (intraprocedure) cortisol measurement can improve performance in a center with initially low AVS success rate...
  26. doi request reprint Gender-, strain-, and inheritance-dependent variation in aldosterone secretion in mice
    Ariadni Spyroglou
    Endocrine Research Unit, Medizinische Klinik und Poliklinik IV, Klinikum der Universitat Munchen, LMU, Ziemssenstrasse 1, D 80336 Munich, Germany
    J Endocrinol 215:375-81. 2012
    ....
  27. pmc Isoenergetic feeding of low carbohydrate-high fat diets does not increase brown adipose tissue thermogenic capacity in rats
    Matthias J Betz
    Endocrine Research Unit, Medizinische Klinik und Poliklinik IV, Klinikum der LMU, Munich, Germany
    PLoS ONE 7:e38997. 2012
    ..We studied brown adipose tissue (BAT) morphology and function following exposure to different LC-HF diets...
  28. ncbi request reprint Reboxetine acutely stimulates cortisol, ACTH, growth hormone and prolactin secretion in healthy male subjects
    Cornelius Schule
    Department of Psychiatry, University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Psychoneuroendocrinology 29:185-200. 2004
    ..Mean arterial blood pressure and heart rate were significantly increased by reboxetine, too. Our results suggest that besides COR, ACTH and GH secretion, the release of PRL is also under the control of the noradrenergic systems in man...
  29. doi request reprint Carbohydrate content of post-operative diet influences the effect of vertical sleeve gastrectomy on body weight reduction in obese rats
    Maximilian Bielohuby
    Endocrine Research Unit, Medizinische Klinik Innenstadt, LMU, Ziemssenstr 1, 80336 Munich, Germany
    Obes Surg 22:140-51. 2012
    ..We therefore investigated if post-surgical consumption of different diets can affect the outcome of VSG...
  30. doi request reprint High-sensitivity chemiluminescence immunoassays for detection of growth hormone doping in sports
    Martin Bidlingmaier
    Medizinische Klinik Innenstadt, Ludwig Maximilians University, Munich, Germany
    Clin Chem 55:445-53. 2009
    ..We developed and validated selective immunoassays for isoform analysis with potential utility for screening and confirmation in doping tests...
  31. pmc CT mapping of the vertebral level of right adrenal vein
    Christoph Degenhart
    Institute for Clinical Radiology, Ludwig Maximilians University Hospital Munich, Munich, Germany
    Diagn Interv Radiol 21:60-6. 2015
    ..We aimed to evaluate the accuracy of multidetector computed tomography (MDCT) venous mapping for the localization of the right adrenal veins (RAV) in patients suffering from primary aldosteronism...
  32. ncbi request reprint Worsening of lipid metabolism after successful treatment of primary aldosteronism
    Christian Adolf
    Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig Maximilians Universität, Ziemssenstr 1, 80336, Munich, Germany
    Endocrine 54:198-205. 2016
    ..024). Treatment of PA is associated with a deterioration of lipid parameters despite stable BMI and improved fasting plasma glucose and blood pressure. This effect can be explained by renal dysfunction following ADX or MRA therapy...
  33. doi request reprint Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets
    Maximilian Bielohuby
    Endocrine Research Unit, Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig Maximilians Universität LMU Munich, Germany
    Am J Physiol Endocrinol Metab 305:E1059-70. 2013
    ..Therefore, use of LC-HF diets for weight loss or other therapeutic purposes should be balanced against potentially harmful metabolic side effects...
  34. doi request reprint Chronic growth hormone excess is associated with increased aldosterone: a study in patients with acromegaly and in growth hormone transgenic mice
    Maximilian Bielohuby
    Medizinische Klinik Innenstadt Klinikum der Universität, Ziemssenstr 1, 80336 Munich, Germany
    Exp Biol Med (Maywood) 234:1002-9. 2009
    ..The underlying mechanism is likely to be independent of renin, excess IGF-I, or adrenal aldosterone synthase expression...
  35. doi request reprint Observational study mortality in treated primary aldosteronism: the German Conn's registry
    Martin Reincke
    Medizinische Klinik und Poliklinik IV, Campus Innnestadt, Klinikum der Universitat Munchen, Ziemssenstr 1, 80336 Munchen, Germany
    Hypertension 60:618-24. 2012
    ..05). These data indicate that cardiovascular mortality is increased in patients treated for PA, whereas all-cause mortality is not different from matched hypertensive controls...
  36. doi request reprint Utilization of a mutagenesis screen to generate mouse models of hyperaldosteronism
    Ariadni Spyroglou
    Department of Medicine, Endocrine Research, University Hospital Innenstadt, Ziemssenstr 1, D 80336 Munich, Germany
    Endocrinology 152:326-31. 2011
    ..Taken together, our data demonstrate the feasibility of a phenotype-driven mutagenesis screen to detect and establish mutant mouse lines with a phenotype of chronic hyperaldosteronism...
  37. doi request reprint Blunted diurnal cortisol pattern is associated with frailty: a cross-sectional study of 745 participants aged 65 to 90 years
    Hamimatunnisa Johar
    Institute of Epidemiology II H J, R T E, B T, A P, M H, K H L, Helmholtz Zentrum Munchen, German Research Centre for Environmental Health, 85764 Neuherberg, Germany Medizinische Klinik und Poliklinik IV M B, M R, Klinikum der Ludwig Maximilians Universität München, 80336 Munich, Germany and Department of Psychosomatic Medicine and Psychotherapy K H L, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munich, Germany
    J Clin Endocrinol Metab 99:E464-8. 2014
    ..Hypothalamic-pituitary-adrenal axis dysregulation is a plausible candidate pathway contributing to frailty. Thus, we sought to examine the associations of diurnal cortisol secretion with frailty in older adults...
  38. pmc The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms
    Timo D Müller
    Institute for Diabetes and Obesity, Helmholtz Center Munich and Division of Metabolic Diseases, Department of Medicine, Technical University Munich, Munich, Germany
    Nat Commun 4:1968. 2013
    ..Together, our data suggest that Gpr83 modulates ghrelin action but also indicate that Gpr83 regulates systemic metabolism through other ghrelin-independent pathways...
  39. doi request reprint New detection methods of growth hormone and growth factors
    Martin Bidlingmaier
    Endocrine Research Laboratories, Medizinische Klinik und Poliklinik IV, Ludwig Maximilians University, Munich, Germany muenchen de
    Endocr Dev 23:52-9. 2012
    ....
  40. doi request reprint Induction of ketosis in rats fed low-carbohydrate, high-fat diets depends on the relative abundance of dietary fat and protein
    Maximilian Bielohuby
    Ludwig Maximilians University, Endocrine Research Unit, Ziemssenstrasse 1 80336, Munich, Germany
    Am J Physiol Endocrinol Metab 300:E65-76. 2011
    ..LC-HFDs must be high in fat, but also low in protein contents to be clearly ketogenic. Independent of the macronutrient composition, LC-HFD-induced weight loss is not due to increased EE and LA...
  41. doi request reprint Low-carbohydrate high-fat diets: regulation of energy balance and body weight regain in rats
    Samantha J Caton
    Neuroendocrine Unit, Medizinische Klinik Innenstadt, Ludwig Maximilians University, Munich, Germany
    Obesity (Silver Spring) 17:283-9. 2009
    ..Moreover, when the LC-HFD ceases and a high-carbohydrate diet follows, more body weight is regained as compared to when the LC-HFD is consumed, in the absence of increased energy intake...
  42. doi request reprint Effects of low-carbohydrate, high-fat diets on apparent digestibility of minerals and trace elements in rats
    Lena Frommelt
    Chair of Animal Nutrition and Dietetics, Ludwig Maximilians University, Munich, Germany
    Nutrition 30:869-75. 2014
    ..The aim of this study was to determine mineral digestibility by total collection method in LCHF diets compared with a chow diet and a standard high-fat diet (HFD, high in fat and carbohydrates)...
  43. doi request reprint Short term regulation of aldosterone secretion after stimulation and suppression experiments in mice
    Ariadni Spyroglou
    Department of Medicine, Endocrine Research, University Hospital Innenstadt, Ludwig Maximilians University, Munich, Germany
    J Mol Endocrinol 42:407-13. 2009
    ..These data suggest that acute regulation of aldosterone synthesis is accompanied by fast transcriptional modulation of steroidogenic enzymes and transcription factors that are likely to be involved in aldosterone secretion...
  44. doi request reprint Low-dose ghrelin infusion--evidence against a hormonal role in food intake
    Florian Lippl
    Division of Gastroenterology, Medizinische Klinik Campus Innenstadt, Klinikum der LMU, Munich, Germany
    Regul Pept 174:26-31. 2012
    ..These data do not favour a hormonal role of peripheral ghrelin in the regulation of food intake...
  45. doi request reprint Spontaneous remission of idiopathic aldosteronism after long-term treatment with spironolactone: results from the German Conn's Registry
    Evelyn Fischer
    Medizinische Klinik Innenstadt, Klinikum der Ludwig Maximilians Universität München, Munich, Germany
    Clin Endocrinol (Oxf) 76:473-7. 2012
    ..Primary aldosteronism (PA) is mainly caused by aldosterone-producing adenoma and idiopathic bilateral adrenal hyperplasia (IHA). Recently, spontaneous resolution of IHA has been described...
  46. doi request reprint Short-term exposure to low-carbohydrate, high-fat diets induces low bone mineral density and reduces bone formation in rats
    Maximilian Bielohuby
    Endocrine Research Unit, Medizinische Klinik Innenstadt, Ludwig Maximilians University, Munich, Germany
    J Bone Miner Res 25:275-84. 2010
    ..This might indicate a lower rate of mesenchymal stem cells differentiating into osteoblasts, thus explaining reduced bone formation with LC-HF diets...
  47. doi request reprint Total adrenal volume but not testicular adrenal rest tumor volume is associated with hormonal control in patients with 21-hydroxylase deficiency
    Nicole Reisch
    Department of Endocrinology and Metabolism, Medizinische Klinik Innenstadt, University Hospital Munich, D 80336 Munich, Germany
    J Clin Endocrinol Metab 95:2065-72. 2010
    ..Patients with 21-hydroxylase deficiency (21-OHD) have been shown to develop adrenal adenomas and, in males, testicular adrenal rest tumors (TARTs) at a high percentage...
  48. ncbi request reprint Plasma- and urine concentrations of nitrite/nitrate and cyclic Guanosinemonophosphate in intrauterine growth restricted and preeclamptic pregnancies
    Barbara Schiessl
    Department of Obstetrics and Gynaecology, Fetal Medicine Unit, Ludwig Maximilians University, 80337 Munich, Germany
    Arch Gynecol Obstet 274:150-4. 2006
    ..In the presented study we analyzed the urine and plasma concentrations of nitrite/nitrate, the stable endproducts of NO and its second messenger, cyclic Guanosinemonophosphate (cGMP) in normal, preeclamptic and IUGR pregnancies...
  49. doi request reprint Altered relation of the renin-aldosterone system and vasoactive peptides in type 2 diabetes: The KORA F4 study
    Cornelia Then
    Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig Maximilians Universität, Munich, Germany Clinical Cooperation Group Diabetes, Ludwig Maximilians Universität München and Helmholtz Zentrum München, Munich, Germany Electronic address
    Atherosclerosis 252:88-96. 2016
    ....
  50. doi request reprint Effects of low carbohydrate diets on energy and nitrogen balance and body composition in rats depend on dietary protein-to-energy ratio
    Lena Frommelt
    Animal Nutrition, Ludwig Maximilians University, Munich, Germany
    Nutrition 30:863-8. 2014
    ..Truly ketogenic rodent diets are low in carbohydrates but also low in protein. The aim of this study was to differentiate effects of ketosis, low carbohydrate (LC) and/or low-protein intake on energy and nitrogen metabolism...
  51. ncbi request reprint Automated chemiluminescence-immunoassay for aldosterone during dynamic testing: comparison to radioimmunoassays with and without extraction steps
    Caroline Schirpenbach
    Ludwig Maximilians University, Medizinische Klinik Innenstadt, Munich, Germany
    Clin Chem 52:1749-55. 2006
    ..Our aim was to compare concentrations reported by 4 assays for samples obtained after saline infusion during dynamic testing...
  52. ncbi request reprint Quantification of the soluble leptin receptor in human blood by ligand-mediated immunofunctional assay
    Zida Wu
    Medical Clinic, University Hospital Innenstadt, Ludwig Maximilians University, Ziemssenstrasse 1, 80336 Munich, Germany
    J Clin Endocrinol Metab 87:2931-9. 2002
    ....
  53. ncbi request reprint Evaluation of a salivary based combined dexamethasone/CRH test in patients with major depression
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Psychoneuroendocrinology 27:385-99. 2002
    ....
  54. ncbi request reprint The influence of mirtazapine on anterior pituitary hormone secretion in healthy male subjects
    Cornelius Schule
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Psychopharmacology (Berl) 163:95-101. 2002
    ..This special mechanism of action may be characterized by a distinct pharmacoendocrinological profile...
  55. doi request reprint High prevalence of reduced fecundity in men with congenital adrenal hyperplasia
    Nicole Reisch
    Endocrinology and Metabolism, University Hospital München, D 80336 MUnchen, Germany
    J Clin Endocrinol Metab 94:1665-70. 2009
    ..Testicular adrenal rest tumors (TARTs) are regarded to contribute to the high prevalence of subfertility in males with congenital adrenal hyperplasia (CAH)...
  56. doi request reprint Growth hormone binding protein - physiological and analytical aspects
    Katharina Schilbach
    Endocrine Laboratory, Medizinische Klinik und Poliklinik IV, Klinikum der Universitat Munchen, Ziemssenstr 1, 80336, Munich, Germany Electronic address
    Best Pract Res Clin Endocrinol Metab 29:671-83. 2015
    ..In clinical practice, measurement of GHBP can be helpful to differentiate between GH deficiency and GH insensitivity, particularly if GHBP is absent. ..
  57. doi request reprint ACTH after 15 min distinguishes between Cushing's disease and ectopic Cushing's syndrome: a proposal for a short and simple CRH test
    Katrin Ritzel
    Medizinische Klinik und Poliklinik IVKlinikum der Universität München, Ziemssenstraße 1, D 80336 Munich, GermanyDepartment of NeurosurgeryUniversity of Tuebingen, Tuebingen, GermanyInstitut für klinische RadiologieKlinikum der Ludwig Maximilians Universität München, Munich, Germany
    Eur J Endocrinol 173:197-204. 2015
    ....
  58. doi request reprint Reference intervals for insulin-like growth factor-1 (igf-i) from birth to senescence: results from a multicenter study using a new automated chemiluminescence IGF-I immunoassay conforming to recent international recommendations
    Martin Bidlingmaier
    Endocrine Research Laboratories M Bid, M Bie, Medizinische Klinik und Poliklinik IV, Klinikum der Universitat Munchen, 80336 Munich, Germany Metabolic Center N F, H W, Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany Helmholtz Zentrum München German Research Center for Environmental Health GmbH R T E, A D, Institute of Epidemiology II, 85764 Neuherberg, Germany Department of Endocrinology, Diabetes, and Nutrition J S, A F H P, A M A, Charite University Medicine Berlin, 10117 Berlin, Germany Experimental and Clinical Research Center J S, Charité University Medicine Berlin and Max Delbrück Centre Berlin Buch, 13125 Berlin, Germany Center for Cardiovascular Research J S, A M A, Charite University Medicine Berlin, 10115 Berlin, Germany Children s Clinic Randers O D W, DK 8900 Randers, Denmark Göteborg Pediatric Growth Research Center J R, the Sahlgrenska Academy at University of Gothenburg, 41685 Gothenburg, Sweden Center for Pediatric Research A K, Hospital for Children and Adolescents
    J Clin Endocrinol Metab 99:1712-21. 2014
    ..A recent consensus conference defined criteria for validation of IGF-I assays and for establishment of normative data...
  59. doi request reprint Commentary on the Endocrine Society Practice Guidelines: Consequences of adjustment of antihypertensive medication in screening of primary aldosteronism
    Evelyn Fischer
    Medizinische Klinik, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    Rev Endocr Metab Disord 12:43-8. 2011
    ..Such recommendation, therefore, must include a note of caution because of possibly deleterious side effects...
  60. doi request reprint The relationship between alexithymia and salivary cortisol levels in somatoform disorders
    Francisco Pedrosa Gil
    Psychosomatic Out Patient Clinic, Department of Internal Medicine, Ludwig Maximilians University, Munich, Germany
    Nord J Psychiatry 62:366-73. 2008
    ..001 for AUC-G and AUC-I. However, the two groups did not differ in terms of their mean morning cortisol levels (P>0.05). The results suggest that pre-existing hypocortisolism might possibly be associated with SFD...
  61. ncbi request reprint Decreasing resistance in the maternal uterine and peripheral arterial system is apparently unrelated to plasma and urinary levels of nitrite/nitrate and cyclic-guanosinmonophosohate during the course of normal pregnancies
    Barbara Schiessl
    Department of Obstetrics and Gynaecology, Prenatal Medicine Unit, Ludwig Maximilians University, Munich, Germany
    J Perinat Med 31:281-6. 2003
    ....
  62. doi request reprint Predicting metabolisable energy in commercial rat diets: physiological fuel values may be misleading
    Maximilian Bielohuby
    Neuroendocrine Unit, Medizinische Klinik Innenstadt, Ludwig Maximilians University, Munich, Germany
    Br J Nutr 103:1525-33. 2010
    ..If the equation for pig feed cannot be applied we suggest using the lower modified Atwater factors instead of the 'original' Atwater factors to estimate the ME of a diet...
  63. pmc The diagnosis and treatment of primary hyperaldosteronism in Germany: results on 555 patients from the German Conn Registry
    Caroline Schirpenbach
    Medizinische Klinik Innenstadt, Klinikum der Ludwig Maximilians Universität München, Germany
    Dtsch Arztebl Int 106:305-11. 2009
    ..As many as 12% of patients with hypertension have the characteristic laboratory constellation of Conn's syndrome. Its diagnosis and treatment have not been standardized...
  64. doi request reprint Low-carbohydrate, high-fat diets have sex-specific effects on bone health in rats
    Ayse Zengin
    Endocrine Research Unit, Medizinische Klinik und Poliklinik IV, Klinikum der Universitat Munchen, Ziemssenstrasse 1, 80336, Munich, Germany
    Eur J Nutr 55:2307-20. 2016
    ..Therefore, we investigated whether sex-specific effects of LC-HF diets on bone health exist...
  65. pmc Targeting heterogeneity of adrenocortical carcinoma: Evaluation and extension of preclinical tumor models to improve clinical translation
    Constanze Hantel
    Endocrine Research Unit, Medizinische Klinik und Poliklinik IV, Ludwig Maximilians Universitat, Munich, Germany
    Oncotarget 7:79292-79304. 2016
    ..In summary, we provide evidence for a novel patient-derived tumor model with the potential to improve clinical prediction of novel therapeutic strategies for patients with ACC...
  66. doi request reprint Obesity in MENX Rats Is Accompanied by High Circulating Levels of Ghrelin and Improved Insulin Sensitivity
    Tobias Wiedemann
    Institute of Pathology, Helmholtz Center Munich, German Research Center for Environmental Health, Technical University Munich, Munich, Germany
    Diabetes 65:406-20. 2016
    ..This model might aid in identifying new therapeutic approaches for obesity and obesity-related diseases, including type 2 diabetes. ..
  67. pmc Validation of serum IGF-I as a biomarker to monitor the bioactivity of exogenous growth hormone agonists and antagonists in rabbits
    Maximilian Bielohuby
    Endocrine Research Unit, Medizinische Klinik und Poliklinik IV, Ludwig Maximilians University, 80336 Munich, Germany
    Dis Model Mech 7:1263-73. 2014
    ..Unlike in rodents, the IGF-I response to treatment with recombinant human GH or a GHA closely mimics the pharmacodynamics seen in humans, suggesting that rabbits are a suitable new model to test human GH agonists and antagonists. ..
  68. doi request reprint Coexisting Prolactinoma and Primary Aldosteronism: Is There a Pathophysiological Link?
    Tracy Ann Williams
    Medizinische Klinik und Poliklinik IV T A W, A S D, A R, E F, M B, J S, F B, M R and Klinische Radiologie M Tr, L G, Klinikum der Ludwig Maximilians Universität München, 80336 Munich, Germany Division of Internal Medicine and Hypertension T A W, J B, F V, P M, Department of Medical Sciences, University of Turin, 10126 Turin, Italy and Department of Endocrinology M Th, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Clin Endocrinol Metab 100:E1262-9. 2015
    ..Coexisting prolactinoma-primary aldosteronism (PA) is infrequently reported...
  69. pmc Effects of a high-caloric diet and physical exercise on brain metabolite levels: a combined proton MRS and histologic study
    Matthias K Auer
    1 RG Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany 2 RG Animal Models in Psychiatry, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany
    J Cereb Blood Flow Metab 35:554-64. 2015
    ..The observed effects seem to be independent of neuroinflammation. ..
  70. doi request reprint Pitfalls of insulin-like growth factor-i and growth hormone assays
    Riia K Junnila
    Endocrine Research Unit, Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig Maximilians Universität LMU, Ziemssenstr 1, Munich 80336, Germany
    Endocrinol Metab Clin North Am 44:27-34. 2015
    ..This review discusses common pitfalls in the measurement of GH and IGF-I and guides laboratories in their analyses of these hormones. ..
  71. doi request reprint Diastrophic dysplasia sulfate transporter (SLC26A2) is expressed in the adrenal cortex and regulates aldosterone secretion
    Ariadni Spyroglou
    Endocrine Research Unit, Medizinische Klinik und Poliklinik IV, Klinikum der Universitat Munchen, Ziemssenstr 1, D 80336 Munich, Germany
    Hypertension 63:1102-9. 2014
    ..In summary, these findings point toward a possible effect of SLC26A2 in the regulation of aldosterone secretion potentially involved in the pathogenesis of primary aldosteronism. ..
  72. ncbi request reprint Endocrinological effects of mirtazapine in healthy volunteers
    Cornelius Schule
    Psychiatric Hospital, University of Munich, Munich, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 26:1253-61. 2002
    ....
  73. ncbi request reprint Ghrelin drives GH secretion during fasting in man
    Alex F Muller
    Division of Endocrinology, Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Eur J Endocrinol 146:203-7. 2002
    ....
  74. ncbi request reprint Pharmacokinetics and pharmacodynamics of GH: dependence on route and dosage of administration
    Alexandra Keller
    Hospital for Children and Adolescents, University of Leipzig, Oststr 21 25, D 04317 Leipzig, Germany
    Eur J Endocrinol 156:647-53. 2007
    ..We examined pharmacokinetics, pharmacodynamics, and 20 kDa GH after injection of rhGH at different doses and routes of administration...
  75. ncbi request reprint The diagnosis of partial growth hormone deficiency in adults with a putative insult to the hypothalamo-pituitary axis
    Robert D Murray
    Department of Endocrinology, Christie Hospital National Health Service Trust, Wilmslow Road, Manchester, United Kingdom
    J Clin Endocrinol Metab 92:1705-9. 2007
    ..Given the inherent problems in the diagnosis of severe GHD, the situation is likely to be even more difficult in individuals with GHI...
  76. ncbi request reprint How robust are laboratory measures of growth hormone status?
    Christian J Strasburger
    Division of Clinical Endocrinology, Department of Medicine, Charite University Medicine, Berlin, Germany
    Horm Res 64:1-5. 2005
    ..Since these parameters are used in establishing diagnoses and in monitoring GH-related diseases, the endocrinologist should be aware of the specifications and limitations of the analytical methods available...
  77. ncbi request reprint Efficacy of 12-month treatment with the GH receptor antagonist pegvisomant in patients with acromegaly resistant to long-term, high-dose somatostatin analog treatment: effect on IGF-I levels, tumor mass, hypertension and glucose tolerance
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, Federico II University of Naples, Italy
    Eur J Endocrinol 154:467-77. 2006
    ..We aimed to investigate the efficacy of pegvisomant in patients with acromegaly resistant to long-term (> or = 24-month), high-dose treatment with octreotide-LAR (40 mg/month) or lanreotide (120 mg/month)...
  78. ncbi request reprint Identification of a monoclonal antibody against the leptin receptor that acts as an antagonist and blocks human monocyte and T cell activation
    Mehdi Fazeli
    Division of Clinical Sciences North, University of Sheffield, Sheffield S5 7AU, UK
    J Immunol Methods 312:190-200. 2006
    ..In conclusion, this study has identified a mAb to the human leptin receptor which inhibits leptin signalling and acts as a leptin antagonist in vitro...
  79. ncbi request reprint The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    Michael A Cowley
    The Vollum Institute, Oregon Health and Science University, Portland, OR 97201, USA
    Neuron 37:649-61. 2003
    ..We propose that at these sites, release of ghrelin may stimulate the release of orexigenic peptides and neurotransmitters, thus representing a novel regulatory circuit controlling energy homeostasis...
  80. ncbi request reprint Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats
    Mads Tang-Christensen
    Pharmacology, Rheoscience A S, Glerupvej 2, DK 2610 Roedovre, Denmark
    Endocrinology 145:4645-52. 2004
    ..Expanding the current model of food intake control to include mechanisms regulating physical activity may promote our understanding of two major etiological factors causing obesity...
  81. ncbi request reprint Short stature caused by a biologically inactive mutant growth hormone (GH-C53S)
    Amélie Besson
    University Children s Hospital, Pediatric Endocrinology and Metabolism, Inselspital, University of Bern, CH 3010 Bern, Switzerland
    J Clin Endocrinol Metab 90:2493-9. 2005
    ..In conclusion, we have demonstrated that GH-C53S is a bioinactive GH at the physiological range and that the disulfide bridge Cys-53 to Cys-163 is required for mediating the biological effects of GH...
  82. ncbi request reprint Indications, limitations and pitfalls in the determination of human growth hormone, IGF-I and their binding proteins
    Zvi Laron
    Endocrinology and Diabetes Research Unit, Schneider Children s Medical Center of Israel, WHO Collaborating Center for the Study of Diabetes in Youth, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Pediatr Endocrinol Rev 5:555-69. 2007
    ....
  83. ncbi request reprint Preanalytical stability of adrenocorticotropic hormone depends on time to centrifugation rather than temperature
    Nicole Reisch
    Clin Chem 53:358-9. 2007
  84. ncbi request reprint Sample pre-treatment determines the clinical usefulness of acid-labile subunit immunoassays in the diagnosis of growth hormone deficiency and acromegaly
    Katherine M Morrison
    Department of Pediatrics and Population Health Research Institute, McMaster University Medical Centre, Room 3G52, 1200 Main St W Hamilton, Ontario, Canada L8N 3Z5
    Eur J Endocrinol 156:331-9. 2007
    ..The usefulness of measuring the GH-dependent acid-labile subunit (ALS) in the management of GH deficiency (GHD) and acromegaly remains in question and is investigated in this study, comparing several different immunoassays for ALS...
  85. ncbi request reprint Ectopic growth hormone-releasing hormone secretion by a metastatic bronchial carcinoid tumor: a case with a non hypophysial intracranial tumor that shrank during long acting octreotide treatment
    Patricia Fainstein Day
    Department of Endocrinology and Nuclear Medicine, Hospital Italiano, Gascón 450 1187, Buenos Aires, Argentina
    Pituitary 10:311-9. 2007
    ..Total regression of pituitary enlargement was also observed. No changes were observed in lung and liver metastases. After 24 months of therapy the patient is asymptomatic and living a full and active life...
  86. ncbi request reprint Treatment of acromegaly with pegvisomant during pregnancy: maternal and fetal effects
    Susan Riddle Brian
    Department of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Clin Endocrinol Metab 92:3374-7. 2007
    ..Our objective was to describe the first case of the successful use of pegvisomant during pregnancy in a woman with acromegaly...
  87. ncbi request reprint Increased acylated plasma ghrelin, but improved lipid profiles 24-h after consumption of carob pulp preparation rich in dietary fibre and polyphenols
    Sindy Gruendel
    Dietary Fibre and the Metabolic Syndrome Research Group, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Br J Nutr 98:1170-7. 2007
    ..However, elevated glucose levels after carob fibre consumption need to be addressed in future studies...
  88. ncbi request reprint Systemic response of the GH/IGF-I axis in timely versus delayed fracture healing
    Stefan Weiss
    Stiftung Orthopädische Universitätsklinik, University of Heidelberg, Germany
    Growth Horm IGF Res 18:205-12. 2008
    ..An impairment of the GH/IGF-I axis might be involved in the biochemical mechanisms determining delayed or failed fracture healing...