Frank Bergmann

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint [Pancreatic acinar neoplasms : Comparative molecular characterization]
    F Bergmann
    Pathologisches Institut, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Deutschland
    Pathologe 37:191-195. 2016
  2. doi request reprint Acinar cell carcinomas of the pancreas: a molecular analysis in a series of 57 cases
    Frank Bergmann
    Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 224, D 69120, Heidelberg, Germany
    Virchows Arch 465:661-72. 2014
  3. doi request reprint [Gastroenteropancreatic neuroendocrine neoplasms. Role of biopsies]
    F Bergmann
    Pathologisches Institut, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Deutschland
    Pathologe 34:221-5. 2013
  4. pmc The impact of MFG-E8 in chronic pancreatitis: potential for future immunotherapy?
    Jan G D'Haese
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str, 22, Munich, D 81675, Germany
    BMC Gastroenterol 13:14. 2013
  5. pmc Neoadjuvant chemoradiation with Gemcitabine for locally advanced pancreatic cancer
    Daniel Habermehl
    Department of Radiation Oncology, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Radiat Oncol 7:28. 2012
  6. pmc Mononuclear cells modulate the activity of pancreatic stellate cells which in turn promote fibrosis and inflammation in chronic pancreatitis
    Christoph W Michalski
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    J Transl Med 5:63. 2007
  7. pmc Low expression of aldehyde dehydrogenase 1A1 (ALDH1A1) is a prognostic marker for poor survival in pancreatic cancer
    Christoph Kahlert
    Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    BMC Cancer 11:275. 2011
  8. pmc Molecular characterisation of pancreatic ductal adenocarcinoma in patients under 40
    F Bergmann
    Institute of Pathology and Department of Surgery, University of Heidelberg, Heidelberg, Germany
    J Clin Pathol 59:580-4. 2006
  9. ncbi request reprint Early undifferentiated pancreatic carcinoma with osteoclastlike giant cells: direct evidence for ductal evolution
    Frank Bergmann
    Institute of Pathology, University of Heidelberg, Germany
    Am J Surg Pathol 31:1919-25. 2007
  10. doi request reprint Fundamental differences in the neural invasion behavior of pancreatic endocrine tumors: relevance for local recurrence rates?
    Frank Bergmann
    Institute of Pathology, University of Heidelberg, D 69120 Heidelberg, Germany
    Hum Pathol 40:50-7. 2009

Detail Information

Publications83

  1. ncbi request reprint [Pancreatic acinar neoplasms : Comparative molecular characterization]
    F Bergmann
    Pathologisches Institut, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Deutschland
    Pathologe 37:191-195. 2016
    ....
  2. doi request reprint Acinar cell carcinomas of the pancreas: a molecular analysis in a series of 57 cases
    Frank Bergmann
    Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 224, D 69120, Heidelberg, Germany
    Virchows Arch 465:661-72. 2014
    ..Furthermore, EGFR, MGMT, HSP90, and L1CAM may be useful as therapeutic markers and predictors of response to therapy in a subset of PACs...
  3. doi request reprint [Gastroenteropancreatic neuroendocrine neoplasms. Role of biopsies]
    F Bergmann
    Pathologisches Institut, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Deutschland
    Pathologe 34:221-5. 2013
    ..Finally, using the stomach as an example, biopsies may also be successfully used to investigate neuroendocrine precursor lesions which may harbor prognostic significance. ..
  4. pmc The impact of MFG-E8 in chronic pancreatitis: potential for future immunotherapy?
    Jan G D'Haese
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str, 22, Munich, D 81675, Germany
    BMC Gastroenterol 13:14. 2013
    ..Accumulating evidence suggests an immunomodulatory link between MFG-E8 and the pro-inflammatory chemokine fractalkine, which may determine the severity of pain, fibrosis, and inflammation in chronic pancreatitis (CP)...
  5. pmc Neoadjuvant chemoradiation with Gemcitabine for locally advanced pancreatic cancer
    Daniel Habermehl
    Department of Radiation Oncology, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Radiat Oncol 7:28. 2012
    ..To evaluate efficacy and secondary resectability in patients with locally advanced pancreatic cancer (LAPC) treated with neoadjuvant chemoradiotherapy (CRT)...
  6. pmc Mononuclear cells modulate the activity of pancreatic stellate cells which in turn promote fibrosis and inflammation in chronic pancreatitis
    Christoph W Michalski
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    J Transl Med 5:63. 2007
    ..Interactions between mononuclear cells and activated pancreatic myofibroblasts (pancreatic stellate cells; PSC) may contribute to inflammation and fibrosis in chronic pancreatitis (CP)...
  7. pmc Low expression of aldehyde dehydrogenase 1A1 (ALDH1A1) is a prognostic marker for poor survival in pancreatic cancer
    Christoph Kahlert
    Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    BMC Cancer 11:275. 2011
    ..Recently, ALDH1A1 has been described as a prognostic marker in a pancreatic cancer tissue microarray. The aim of this study was to reevaluate the expression of ALDH1A1 as a prognostic marker on whole-mount tissue sections...
  8. pmc Molecular characterisation of pancreatic ductal adenocarcinoma in patients under 40
    F Bergmann
    Institute of Pathology and Department of Surgery, University of Heidelberg, Heidelberg, Germany
    J Clin Pathol 59:580-4. 2006
    ..Pancreatic ductal adenocarcinoma (PDAC) rarely affects people under 40...
  9. ncbi request reprint Early undifferentiated pancreatic carcinoma with osteoclastlike giant cells: direct evidence for ductal evolution
    Frank Bergmann
    Institute of Pathology, University of Heidelberg, Germany
    Am J Surg Pathol 31:1919-25. 2007
    ..Therefore, we suggest that the tumor should be considered as an anaplastic variant of pancreatic ductal adenocarcinoma...
  10. doi request reprint Fundamental differences in the neural invasion behavior of pancreatic endocrine tumors: relevance for local recurrence rates?
    Frank Bergmann
    Institute of Pathology, University of Heidelberg, D 69120 Heidelberg, Germany
    Hum Pathol 40:50-7. 2009
    ..This phenomenon may explain the low rate of local relapses after tumor resection in pancreatic endocrine tumors despite the high frequency of neural invasion...
  11. doi request reprint Expression of L1CAM, COX-2, EGFR, c-KIT and Her2/neu in anaplastic pancreatic cancer: putative therapeutic targets?
    Frank Bergmann
    Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D 69120 Heidelberg, Germany
    Histopathology 56:440-8. 2010
    ..As additional therapeutic options have not yet been investigated in undifferentiated pancreatic cancer, the aim was to analyse the expression of putative therapeutic targets that have shown promising results in various other neoplasms...
  12. doi request reprint Discovered on gastrointestinal stromal tumor 1 (DOG1) is expressed in pancreatic centroacinar cells and in solid-pseudopapillary neoplasms--novel evidence for a histogenetic relationship
    Frank Bergmann
    Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D 69120 Heidelberg, Germany
    Hum Pathol 42:817-23. 2011
    ....
  13. doi request reprint Re-resection for isolated local recurrence of pancreatic cancer is feasible, safe, and associated with encouraging survival
    Oliver Strobel
    Department of Surgery, University Hospital Heidelberg, Heidelberg, Germany
    Ann Surg Oncol 20:964-72. 2013
    ..Around 30% of patients have isolated local recurrence (ILR) without evidence of metastases. In spite of localized disease these patients usually only receive palliative chemotherapy and have a short survival...
  14. ncbi request reprint Expression and potential function of the CXC chemokine CXCL16 in pancreatic ductal adenocarcinoma
    Moritz N Wente
    Department of General Surgery, University of Heidelberg, D 69120 Heidelberg, Germany
    Int J Oncol 33:297-308. 2008
    ....
  15. pmc Sequential biphasic changes in claudin1 and claudin4 expression are correlated to colorectal cancer progression and liver metastasis
    Rania Georges
    Toxicology and Chemotherapy Unit, German Cancer Research Center DKFZ, Heidelberg, Germany
    J Cell Mol Med 16:260-72. 2012
    ..This modulation is reflected by significant changes in claudin expression in human primary and metastatic CRC...
  16. doi request reprint Expression of galectin-3 in pancreatic ductal adenocarcinoma
    Matthias M Gaida
    Institute of Pathology, University of Heidelberg, 69120, Heidelberg, Germany
    Pathol Oncol Res 18:299-307. 2012
    ..In conclusion, galectin-3 is expressed in PDAC tissues suggesting a role in tumor development; however, no relationship between expression and clinical findings could be established...
  17. doi request reprint Expression pattern and functional relevance of epidermal growth factor receptor and cyclooxygenase-2: novel chemotherapeutic targets in pancreatic endocrine tumors?
    Frank Bergmann
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Am J Gastroenterol 104:171-81. 2009
    ....
  18. ncbi request reprint Solid type clear cell carcinoma of the pancreas: differential diagnosis of an unusual case and review of the literature
    Martin Loos
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Virchows Arch 450:719-26. 2007
    ..Despite metastatic behavior, the tumor displayed a more favorable course than conventional pancreatic ductal adenocarcinoma. We suggest that this tumor be called solid type clear cell carcinoma of the pancreas...
  19. doi request reprint Pancreatic cancer surgery in the new millennium: better prediction of outcome
    Werner Hartwig
    Department of General Surgery, University of Heidelberg, Germany
    Ann Surg 254:311-9. 2011
    ..This analysis aimed to determine prognostic parameters in a patient cohort with resected pancreatic adenocarcinoma with a special focus on the revised R1-definition...
  20. doi request reprint Actinin-4 expression in primary and metastasized pancreatic ductal adenocarcinoma
    Thilo Welsch
    Department of General, Visceral, and Transplant Surgery, University of Heidelberg, Heidelberg, Germany
    Pancreas 38:968-76. 2009
    ..The present study analyzed the expression of actinin-4 in the pancreas, in localized and metastasized pancreatic ductal adenocarcinoma (PDAC), and the correlation with clinical outcome...
  21. ncbi request reprint CXCL14 expression and potential function in pancreatic cancer
    Moritz N Wente
    Department of Surgery, University of Heidelberg, D 69120 Heidelberg, Germany
    Cancer Lett 259:209-17. 2008
    ..In conclusion, CXCL14 might play a pivotal role in the pathobiology of pancreatic cancer, probably by regulating cancer invasion...
  22. doi request reprint MHC class II expression in pancreatic tumors: a link to intratumoral inflammation
    Matthias M Gaida
    Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, Heidelberg, Germany
    Virchows Arch 460:47-60. 2012
    ..Our findings suggest that MHC class II expression on pancreatic tumor cells is induced by the intratumoral inflammatory reaction in pancreatic tumors...
  23. doi request reprint Most pancreatic cancer resections are R1 resections
    Irene Esposito
    Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany
    Ann Surg Oncol 15:1651-60. 2008
    ..Although general guidelines for the processing of pancreatic specimens have been established, there is currently no widely accepted standardized protocol for pathological examination, especially with respect to resection margins...
  24. ncbi request reprint Microcystic tubulopapillary carcinoma of the pancreas: a new tumor entity?
    Irene Esposito
    Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120, Heidelberg, Germany
    Virchows Arch 444:447-53. 2004
    ..These data suggest that the neoplasm most likely represents a new pancreatic tumor entity, which we would like to refer to as microcystic tubulopapillary tumor...
  25. ncbi request reprint Hypothetical progression model of pancreatic cancer with origin in the centroacinar-acinar compartment
    Irene Esposito
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Pancreas 35:212-7. 2007
    ..The aim of the study was to find support for either of the 2 models through the analysis of a large panel of human pancreatic tissues...
  26. doi request reprint Expression and therapeutic relevance of heat-shock protein 90 in pancreatic endocrine tumors
    Philipp Mayer
    Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D 69120 Heidelberg, Germany
    Endocr Relat Cancer 19:217-32. 2012
    ..HSP90 is expressed in the vast majority of PET and its inhibition reveals significant treatment effects in vitro. Thus, HSP90 qualifies as a promising new target...
  27. ncbi request reprint Elevated L1CAM expression in precursor lesions and primary and metastastic tissues of pancreatic ductal adenocarcinoma
    Frank Bergmann
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Oncol Rep 24:909-15. 2010
    ..Furthermore, its broad expression in primary tumors as well as in metastases of PDAC patients provide a rationale to further explore the value of L1CAM as a therapeutic target in the treatment of this highly malignant tumor...
  28. pmc Chemoradiation in patients with isolated recurrent pancreatic cancer - therapeutical efficacy and probability of re-resection
    Daniel Habermehl
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, 69120, Germany
    Radiat Oncol 8:27. 2013
    ..In the present retrospective analysis we analysed the therapeutic outcome of a set of patients, who were treated with chemoradiation (CRT) for recurrent pancreatic cancer (RPC) in a single institution...
  29. doi request reprint Polymorphonuclear neutrophils promote dyshesion of tumor cells and elastase-mediated degradation of E-cadherin in pancreatic tumors
    Matthias M Gaida
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Eur J Immunol 42:3369-80. 2012
    ....
  30. doi request reprint Clinicopathologic characteristics of patients with resected multifocal intraductal papillary mucinous neoplasm of the pancreas
    Stefan Fritz
    Department of General and Visceral Surgery, University of Heidelberg, Germany
    Surgery 152:S74-80. 2012
    ..This study evaluated the clinicopathologic characteristics of patients with surgically resected, multifocal intraductal papillary mucinous neoplasm of the pancreas...
  31. doi request reprint Resection after neoadjuvant therapy for locally advanced, "unresectable" pancreatic cancer
    Oliver Strobel
    Department of Surgery, University Hospital Heidelberg, Heidelberg, Germany
    Surgery 152:S33-42. 2012
    ..Many patients present with locally advanced cancers deemed unresectable. We sought to assess the results of exploration after neoadjuvant therapy for locally advanced possibly unresectable pancreatic cancer...
  32. ncbi request reprint Regulation of osteopontin and related proteins in rat CC531 colorectal cancer cells
    Rania Georges
    Toxicology and Chemotherapy Unit, German Cancer Research Center DKFZ, D 69120 Heidelberg, Germany
    Int J Oncol 37:249-56. 2010
    ..Whereas TGF-beta1 induced over-expression of OPN and Runx2 in hepatocytes, it did not exert the same effect on hepatocytes co-cultured with CC531 cells, indicating that this response was abrogated by CC531 cells...
  33. doi request reprint Anaplastic pancreatic cancer: Presentation, surgical management, and outcome
    Oliver Strobel
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Surgery 149:200-8. 2011
    ..The available data are focused on pathologic and molecular features, and little is known about the clinical presentation and management. The outcome of operative exploration and resection is unknown...
  34. doi request reprint Comparative analysis of tumorbiology and CD133 positivity in primary and recurrent pancreatic ductal adenocarcinoma
    Thilo Welsch
    Department of General, Visceral and Transplant Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    Clin Exp Metastasis 26:701-11. 2009
    ..The apical membrane CD133 positivity of normal and inflammatorily altered ductal structures and its lack in tumor cells bring the role of CD133 as a specific CSC marker in PDAC into question...
  35. doi request reprint Survival data justifies resection for pancreatic metastases
    Oliver Strobel
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Ann Surg Oncol 16:3340-9. 2009
    ..This study was designed to evaluate perioperative and follow-up results after resection for pancreatic metastases and to define prognostic factors...
  36. ncbi request reprint Pancreatic Cancer Surgery: The New R-status Counts
    Oliver Strobel
    Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany Institute of Pathology Heidelberg, Heidelberg, Germany National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany
    Ann Surg . 2016
    ..To assess the relevance of resection margin status for survival outcome after resection and adjuvant therapy for pancreatic cancer...
  37. doi request reprint Small (Sendai negative) branch-duct IPMNs: not harmless
    Stefan Fritz
    Department of General and Visceral Surgery, University of Heidelberg, Heidelberg, Germany
    Ann Surg 256:313-20. 2012
    ..The aim of this study was to evaluate existing management guidelines for branch-duct intraductal papillary mucinous neoplasms (IPMNs)...
  38. pmc Overexpression of cellular inhibitor of apoptosis protein 2 is an early event in the progression of pancreatic cancer
    Irene Esposito
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    J Clin Pathol 60:885-95. 2007
    ..To determine the role of two antiapoptotic proteins of the inhibitor of apoptosis protein family, cellular inhibitor of apoptosis protein 1 (cIAP1) and cellular inhibitor of apoptosis protein 2 (cIAP2), in human pancreatic carcinogenesis...
  39. doi request reprint LigaSure for pancreatic sealing during distal pancreatectomy
    Werner Hartwig
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg, 69120, Germany
    World J Surg 34:1066-70. 2010
    ..Pancreatic fistula is an unresolved problem after distal pancreatectomy. The current study investigated the safety of LigaSure for distal pancreatic resection in a porcine model...
  40. pmc Autoimmune pancreatocholangitis, non-autoimmune pancreatitis and primary sclerosing cholangitis: a comparative morphological and immunological analysis
    Irene Esposito
    Institute of Pathology, Technische Universitat Munchen, Munich, Germany
    PLoS ONE 3:e2539. 2008
    ..Aim of this study was the comprehensive evaluation of a series of AIPC patients, who were diagnosed and treated in a European institution between January 2003 and July 2006...
  41. ncbi request reprint Differential diagnosis of non-epithelial tumors of the pancreas: malignant non-epithelial pancreatic tumor with focal pigmentation
    Frank Bergmann
    Institute of Pathology, University of Heidelberg, Germany
    Virchows Arch 444:190-3. 2004
    ....
  42. doi request reprint Acinar cell carcinoma of the pancreas: is resection justified even in limited metastatic disease?
    Werner Hartwig
    Department of General Surgery, University of Heidelberg, Germany
    Am J Surg 202:23-7. 2011
    ..The aim of the present study was to investigate the role of surgery in ACC with limited metastatic disease...
  43. doi request reprint Enucleation: A treatment alternative for branch duct intraductal papillary mucinous neoplasms
    Joerg Kaiser
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Surgery . 2016
    ..The present study aimed to evaluate enucleation as an alternative operative approach for branch-duct intraductal papillary mucinous neoplasms to exclude and prevent malignancy...
  44. doi request reprint Main-duct Intraductal Papillary Mucinous Neoplasm: High Cancer Risk in Duct Diameter of 5 to 9 mm
    Thilo Hackert
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany Department of Diagnostic and Interventional Radiology, University of Heidelberg, Heidelberg, Germany Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Ann Surg 262:875-80; discussion 880-1. 2015
    ..Aim of the present study was to analyze cancer risk in patients with an MPD diameter of less than 10 mm...
  45. doi request reprint Pancreatic main-duct involvement in branch-duct IPMNs: an underestimated risk
    Stefan Fritz
    Department of General, Visceral and Transplantation Surgery Department of Diagnostic and Interventional Radiology Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Ann Surg 260:848-55; discussion 855-6. 2014
    ..This study aimed to analyze a large single-center population of resected intraductal papillary mucinous neoplasms (IPMN) of the pancreas with respect to risk factors of malignant transformation...
  46. doi request reprint Alcohol exacerbates LPS-induced fibrosis in subclinical acute pancreatitis
    Haitao Gu
    Department of General, Visceral, and Transplantation Surgery, University Clinic Heidelberg, Heidelberg, Germany
    Am J Pathol 183:1508-17. 2013
    ..We suggest that multiple, subclinical, acute pancreatitis episodes can accumulate in fibrosis during the development of chronic pancreatitis, even if there is no history of acute pancreatitis...
  47. doi request reprint Lack of CCR7 expression is rate limiting for lymphatic spread of pancreatic ductal adenocarcinoma
    Jan Sperveslage
    Institute of Pathology, University of Tubingen, Tubingen, Germany
    Int J Cancer 131:E371-81. 2012
    ..Lymph vessel invasion by CCR7 expressing PDAC cells may be additionally enhanced by upregulation of CCL21 in tumor-associated lymph vessels, representing a previously unknown factor of lymphatic spread...
  48. doi request reprint A novel animal model of severe pancreatitis in mice and its differences to the rat
    Werner Hartwig
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Surgery 144:394-403. 2008
    ..The aim of the present study was to establish this new model in mice and to compare it with the rat model...
  49. doi request reprint Pancreatic adenocarcinoma: number of positive nodes allows to distinguish several N categories
    Oliver Strobel
    Department of Surgery Division of Biostatistics and Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany and Department of Surgery, Ludwig Maximilians University, Munich, Germany
    Ann Surg 261:961-9. 2015
    ..To determine the prognostic value of PLN and LNR based on a large series with standardized lymphadenectomy and pathological workup...
  50. doi request reprint Total pancreatectomy for primary pancreatic neoplasms: renaissance of an unpopular operation
    Werner Hartwig
    Department of General, Visceral, and Transplantation Surgery Division of Biostatistics and Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Ann Surg 261:537-46. 2015
    ..To assess the long-term survival and quality of life in total pancreatectomies and to identify risk factors for perioperative morbidity and mortality...
  51. doi request reprint Prognostic impact of CA 19-9 on outcome after neoadjuvant chemoradiation in patients with locally advanced pancreatic cancer
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    Ann Surg Oncol 21:2801-7. 2014
    ..To asses the impact of CA 19-9 and weight loss/gain on outcome after neoadjuvant chemoradiation (CRT) in patients with locally advanced pancreatic cancer (LAPC)...
  52. pmc Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma
    Darjus Felix Tschaharganeh
    Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany
    Gastroenterology 144:1530-1542.e12. 2013
    ..However, the oncogenic mechanisms of YAP activity are unclear...
  53. pmc Prognostic significance of erythropoietin in pancreatic adenocarcinoma
    Thilo Welsch
    Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany
    PLoS ONE 6:e23151. 2011
    ..Erythropoietin (Epo) administration has been reported to have tumor-promoting effects in anemic cancer patients. We investigated the prognostic impact of endogenous Epo in patients with pancreatic ductal adenocarcinoma (PDAC)...
  54. ncbi request reprint Metastasis of rectal adenocarcinoma to the pancreas. Two case reports and a review of the literature
    Jeannine Bachmann
    Department of General Surgery, University of Heidelberg, Germany
    JOP 8:214-22. 2007
    ..The vast majority of pancreatic tumors are of pancreatic origin. Nonetheless, a variety of extrapancreatic tumors can involve the pancreas and may manifest with different clinicopathological characteristics...
  55. ncbi request reprint Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway
    Frank Bergmann
    Department of General Pathology, Institute of Pathology, University of Heidelberg, 69120 Heidelberg, Germany
    Oncol Rep 24:1535-9. 2010
    ..The data further suggest that CD should be considered in patients with small bowel adenocarcinoma, particularly when the tumors display MSI...
  56. ncbi request reprint Osteopontin but not osteonectin favors the metastatic growth of pancreatic cancer cell lines
    Maria Zhivkova-Galunska
    Toxicology and Chemotherapy Unit, German Cancer Research Center, Heidelberg, Germany
    Cancer Biol Ther 10:54-64. 2010
    ..In accordance with the latter finding downregulation of osteonectin was coupled with increased proliferation. This evidence supports a protumorigenic role of osteopontin and points to an antitumorigenic role of osteonectin in PDAC...
  57. pmc Cannabinoids ameliorate pain and reduce disease pathology in cerulein-induced acute pancreatitis
    Christoph W Michalski
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Gastroenterology 132:1968-78. 2007
    ..Moreover, the therapeutic potential of cannabinoids in pancreatitis has not been addressed...
  58. ncbi request reprint Oligoclonal T-cell populations in an inflammatory pseudotumor of the pancreas possibly related to autoimmune pancreatitis: an immunohistochemical and molecular analysis
    Irene Esposito
    Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120, Heidelberg, Germany
    Virchows Arch 444:119-26. 2004
    ..The relation of the pancreatic IPT to autoimmune pancreatitis is emphasized...
  59. pmc Intraductal papillary mucinous neoplasms of the pancreas: radiological predictors of malignant transformation and the introduction of bile duct dilation to current guidelines
    Albert Strauss
    1 Radiology Department, University Hospital Heidelberg, Heidelberg, Germany
    Br J Radiol 89:20150853. 2016
    ..To evaluate the current guidelines as a model to predict malignancy and to determine further radiological predictors of malignancy in intraductal papillary mucinous neoplasms (IPMNs)...
  60. pmc Pancreatic metastasis of Merkel cell carcinoma and concomitant insulinoma: case report and literature review
    Jeannine Bachmann
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    World J Surg Oncol 3:58. 2005
    ..In many patients, a local recurrence after resection of the primary tumour and even distant metastases can be found...
  61. pmc Pancreatic metastasis from gastric carcinoma: a case report
    Moritz N Wente
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    World J Surg Oncol 2:43. 2004
    ..The pancreas is a rare but occasionally favored target for metastasis. Metastatic lesions in the pancreas have been described for various primary cancers, such as carcinomas of the lung, the breast, renal cell carcinoma and sarcomas...
  62. pmc The neurotrophic factor artemin influences the extent of neural damage and growth in chronic pancreatitis
    Güralp O Ceyhan
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Gut 56:534-44. 2007
    ..Artemin was recently shown to eliminate neuropathic pain and reverse neurochemical damage after nerve injury. The role of artemin and its receptor GFRalpha3 was investigated in patients with chronic pancreatitis...
  63. pmc Increased expression of ALCAM/CD166 in pancreatic cancer is an independent prognostic marker for poor survival and early tumour relapse
    C Kahlert
    Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Br J Cancer 101:457-64. 2009
    ..Although the expression of ALCAM is a valuable prognostic and predictive marker in several types of epithelial tumours, its role as a prognostic marker in pancreatic cancer has not yet been reported...
  64. ncbi request reprint Tenascin C and annexin II expression in the process of pancreatic carcinogenesis
    I Esposito
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    J Pathol 208:673-85. 2006
    ..Pancreatic stellate cells are identified as a source of TNC in pancreatic tissues, possibly under the influence of soluble factors released by the tumour cells...
  65. pmc Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma
    I Esposito
    Institute of Pathology, University of Heidelberg, 69120 Heidelberg, Germany
    J Clin Pathol 57:630-6. 2004
    ..Inflammatory cells contribute to the growth and spread of human malignancies by producing molecules that enhance tumour invasiveness...
  66. doi request reprint Identification of Novel Serum Autoantibodies for Differential Diagnosis of Autoimmune Pancreatitis and Pancreatic Ductal Adenocarcinoma
    Klaus Felix
    From the Department of General Surgery, University of Heidelberg, Heidelberg Department of Plant Biochemistry, Dahlem Centre of Plant Sciences, Freie Universitat Berlin, Berlin Functional Proteome Analysis, German Cancer Research Center DKFZ and Institute of Pathology, University of Heidelberg, Heidelberg and Department of General, Visceral, Transplantations, Vascular and Thorax Surgery, Ludwig Maximilian University of Munich, Munich, Germany
    Pancreas 45:1309-19. 2016
    ..The aims were to characterize the autoantibody profiles in AIP and pancreatic ductal adenocarcinoma (PDAC) and to identify circulating autoantibodies that could be diagnostic markers differentiating PDAC and the AIP subtypes...
  67. doi request reprint Correlation of Histological Vessel Characteristics and Diffusion-Weighted Imaging Intravoxel Incoherent Motion-Derived Parameters in Pancreatic Ductal Adenocarcinomas and Pancreatic Neuroendocrine Tumors
    Miriam Klau
    From the Department of Diagnostic and Interventional Radiology, and Institute of Pathology, University of Heidelberg, Heidelberg, Germany Department of Medical and Biological Informatics, DKFZ, Heidelberg, Germany Department of Surgery, University of Heidelberg, Heidelberg, Germany Diagnostic Munich, Munich, Germany and Department of Radiology, University of Basel, Basel, Switzerland
    Invest Radiol 50:792-7. 2015
    ..To investigate the correlation between intravoxel incoherent motion (IVIM) model-derived parameters and histologically determined microvascularity in pancreatic ductal adenocarcinomas (PDACs) and pancreatic neuroendocrine tumors (PNETs)...
  68. ncbi request reprint Large-cell neuroendocrine carcinoma of the major duodenal papilla: case report
    Mark Hartel
    Department of General Surgery, Institute of Pathology, University of Heidelberg, Germany
    Gastrointest Endosc 60:838-41. 2004
  69. doi request reprint Immunogenicity of SEREX-identified antigens and disease outcome in pancreatic cancer
    A Heller
    Department of Surgery, University Hospital Heidelberg, Heidelberg, Germany
    Cancer Immunol Immunother 59:1389-400. 2010
    ....
  70. pmc Identification of a tumor-reactive T-cell repertoire in the immune infiltrate of patients with resectable pancreatic ductal adenocarcinoma
    Isabel Poschke
    Division of Molecular Oncology of Gastrointestinal Tumors, German Cancer Research Center, Heidelberg, Germany
    Oncoimmunology 5:e1240859. 2016
    ..Until now, T-cell therapy has been scarcely pursued in PDA, due to the prevailing view that it represents a poorly immunogenic tumor...
  71. doi request reprint Radical surgery with total mesorectal excision in patients with T1 rectal cancer
    Yakup Kulu
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Ann Surg Oncol 22:2051-8. 2015
    ..The aim of our study was to investigate whether the identification of these patients is possible through existing selection criteria...
  72. doi request reprint Targeting heat shock protein 90 with non-quinone inhibitors: a novel chemotherapeutic approach in human hepatocellular carcinoma
    Marco Breinig
    Department of General Pathology, University Hospital Heidelberg, Heidelberg, Germany
    Hepatology 50:102-12. 2009
    ..PU-H71 showed potent and prolonged in vivo Hsp90 inhibitory activity and reduced tumor growth without causing toxicity...
  73. doi request reprint Cardiac amyloidosis induces up-regulation of Deleted in Malignant Brain Tumors 1 (DMBT1)
    Hanna Müller
    Division of Neonatology, Department of Pediatrics, University of Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Cardiovasc Pathol 22:195-202. 2013
    ..The purpose of this study was to examine the role of innate defense components, i.e., Deleted in Malignant Brain Tumors 1 (DMBT1) and the complement system, in different types of cardiac amyloidosis...
  74. doi request reprint Islet cells contribute to pancreatic carcinogenesis in an animal model
    Mohamed El-Ghamari
    Surgical Department, University of Heidelberg, Heidelberg, Germany
    Pancreas 40:242-6. 2011
    ..This occurrence would suggest that pancreatrophic carcinogens are metabolized by islet cells...
  75. ncbi request reprint Origin and development of the precursor lesions in experimental pancreatic cancer in rats
    Dale E Bockman
    Departments of General Surgery, University of Heidelberg, Germany
    Lab Invest 83:853-9. 2003
    ..The results raise the question whether the transdifferentiated cells in the tubular complexes of patients with chronic pancreatitis are more susceptible to carcinogenic influences, resulting in the increased rate of pancreatic cancer...
  76. doi request reprint Preoperative tissue diagnosis for tumours of the pancreas
    W Hartwig
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany
    Br J Surg 96:5-20. 2009
    ..Preoperative biopsy of pancreatic lesions suspected of malignancy is controversial...
  77. ncbi request reprint Biological and clinical significance of cytogenetic abnormalities in low-risk and high-risk gastrointestinal stromal tumors
    Bastian Gunawan
    Institute of Pathology, Georg August University Gottingen, Germany
    Hum Pathol 33:316-21. 2002
    ....
  78. doi request reprint Clinical significance and regulation of the costimulatory molecule B7-H1 in pancreatic cancer
    Martin Loos
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    Cancer Lett 268:98-109. 2008
    ..Our findings also suggest a dual role of IFN-gamma in antitumor response. Through induction of B7-H1 in pancreatic cancer cells IFN-gamma might contribute to the evasion of antitumor immunity...
  79. pmc 15-lipoxygenase-1 production is lost in pancreatic cancer and overexpression of the gene inhibits tumor cell growth
    Rene Hennig
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Neoplasia 9:917-26. 2007
    ..Thus, induction of 15-LOX-1 expression may be an attractive option for the prevention and treatment of pancreatic cancer...
  80. pmc Cannabinoids in pancreatic cancer: correlation with survival and pain
    Christoph W Michalski
    Department of General Surgery, Technische Universität Munich, Munich, Germany
    Int J Cancer 122:742-50. 2008
    ..Therefore, changes in the levels of endocannabinoid metabolizing enzymes and cannabinoid receptors on pancreatic cancer cells may affect prognosis and pain status of PDAC patients...
  81. pmc Cannabinoids reduce markers of inflammation and fibrosis in pancreatic stellate cells
    Christoph W Michalski
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    PLoS ONE 3:e1701. 2008
    ..While cannabinoids have been shown to ameliorate liver fibrosis, their effects in chronic pancreatitis and on pancreatic stellate cells (PSC) are unknown...
  82. pmc Extrapulmonary sarcoidosis of liver and pancreas: a case report and review of literature
    Hermann Harder
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg at Mannheim, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    World J Gastroenterol 13:2504-9. 2007
    ..An extensive literature review of systemic sarcoidosis, focusing on reported cases with unusual presentation of sarcoidosis in the liver and the pancreas, its diagnosis, treatment, and prognosis was made...
  83. ncbi request reprint Leptospirosis in travelers returning from the Dominican Republic
    Martin P Grobusch
    Department of Parasitology, Institute of Tropical Medicine, Tubingen University, Germany
    J Travel Med 10:55-8. 2003