Marco Averbeck

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Differential regulation of hyaluronan metabolism in the epidermal and dermal compartments of human skin by UVB irradiation
    Marco Averbeck
    Department of Dermatology, Venerology and Allergology, Leipzig University Medical Center, Leipzig, Germany
    J Invest Dermatol 127:687-97. 2007
  2. ncbi request reprint Hyaluronan fragments induce cytokine and metalloprotease upregulation in human melanoma cells in part by signalling via TLR4
    Verena Voelcker
    Department of Dermatology, Venerology and Allergology, Leipzig University, Leipzig, Germany
    Exp Dermatol 17:100-7. 2008
  3. ncbi request reprint Immunologic principles of allergic disease
    Marco Averbeck
    Clinic for Dermatology, Venerology and Allergology, Leipzig University, Leipzig, Germany
    J Dtsch Dermatol Ges 5:1015-28. 2007
  4. ncbi request reprint Switch in syndecan-1 and syndecan-4 expression controls maturation associated dendritic cell motility
    Marco Averbeck
    Department of Dermatology, Venerology and Allergology, Leipzig University, Leipzig, Germany
    Exp Dermatol 16:580-9. 2007
  5. ncbi request reprint In situ profiling and quantification of cytokines released during ultraviolet B-induced inflammation by combining dermal microdialysis and protein microarrays
    Marco Averbeck
    Department of Dermatology, Venerology and Allergology, University of Leipzig, Germany
    Exp Dermatol 15:447-54. 2006
  6. ncbi request reprint Early cytoskeletal rearrangement during dendritic cell maturation enhances synapse formation and Ca(2+) signaling in CD8(+) T cells
    Marco Averbeck
    Department of Dermatology, University of Leipzig, Leipzig, Germany
    Eur J Immunol 34:2708-19. 2004
  7. ncbi request reprint Induction of CD4+ T cell apoptosis as a consequence of impaired cytoskeletal rearrangement in UVB-irradiated dendritic cells
    Tina Wachter
    Department of Dermatology, Albert Ludwigs Universitat, Freiburg, Germany
    J Immunol 171:776-82. 2003
  8. doi request reprint Dermal hyaluronan is rapidly reduced by topical treatment with glucocorticoids
    Carl Gebhardt
    Department of Dermatology, Venerology and Allergology, University of Leipzig, Leipzig, Germany
    J Invest Dermatol 130:141-9. 2010
  9. ncbi request reprint Dermal fibroblasts induce maturation of dendritic cells
    Anja Saalbach
    Department of Dermatology, Venerology, and Allergology, Medical Faculty of Leipzig University, Leipzig, Germany
    J Immunol 178:4966-74. 2007
  10. doi request reprint ADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells
    Ulf Anderegg
    Department of Dermatology, Venerology and Allergology, Leipzig University Medical Center, Leipzig, Germany
    J Invest Dermatol 129:1471-82. 2009

Detail Information

Publications23

  1. ncbi request reprint Differential regulation of hyaluronan metabolism in the epidermal and dermal compartments of human skin by UVB irradiation
    Marco Averbeck
    Department of Dermatology, Venerology and Allergology, Leipzig University Medical Center, Leipzig, Germany
    J Invest Dermatol 127:687-97. 2007
    ..These data demonstrate that there is a complex temporal and spatial regulation of HA-metabolism in skin in response to UVB irradiation...
  2. ncbi request reprint Hyaluronan fragments induce cytokine and metalloprotease upregulation in human melanoma cells in part by signalling via TLR4
    Verena Voelcker
    Department of Dermatology, Venerology and Allergology, Leipzig University, Leipzig, Germany
    Exp Dermatol 17:100-7. 2008
    ....
  3. ncbi request reprint Immunologic principles of allergic disease
    Marco Averbeck
    Clinic for Dermatology, Venerology and Allergology, Leipzig University, Leipzig, Germany
    J Dtsch Dermatol Ges 5:1015-28. 2007
    ..Subsequent immigration of CD4(+) Th2 cells provides anti-inflammatory mechanisms leading to resolution of the inflammatory response and tissue repair...
  4. ncbi request reprint Switch in syndecan-1 and syndecan-4 expression controls maturation associated dendritic cell motility
    Marco Averbeck
    Department of Dermatology, Venerology and Allergology, Leipzig University, Leipzig, Germany
    Exp Dermatol 16:580-9. 2007
    ....
  5. ncbi request reprint In situ profiling and quantification of cytokines released during ultraviolet B-induced inflammation by combining dermal microdialysis and protein microarrays
    Marco Averbeck
    Department of Dermatology, Venerology and Allergology, University of Leipzig, Germany
    Exp Dermatol 15:447-54. 2006
    ..We conclude that the combination of dermal microdialysis and protein microarray offers a powerful tool to analyze in real-time the complex and rapidly changing interstitial protein milieu during cutaneous inflammatory responses...
  6. ncbi request reprint Early cytoskeletal rearrangement during dendritic cell maturation enhances synapse formation and Ca(2+) signaling in CD8(+) T cells
    Marco Averbeck
    Department of Dermatology, University of Leipzig, Leipzig, Germany
    Eur J Immunol 34:2708-19. 2004
    ..These data indicate that already very early after receiving a maturation stimulus, DC display enhanced cytoskeletal activity resulting in the rapid formation of immunological synapses and effective CD8(+) T cell stimulation...
  7. ncbi request reprint Induction of CD4+ T cell apoptosis as a consequence of impaired cytoskeletal rearrangement in UVB-irradiated dendritic cells
    Tina Wachter
    Department of Dermatology, Albert Ludwigs Universitat, Freiburg, Germany
    J Immunol 171:776-82. 2003
    ..In conclusion, UVBR of DC impairs their cytoskeletal rearrangement and induces apoptosis in CD4(+) T cells by disruption of early DC-T cell interaction, resulting in a reduced Ca(2+) influx in T cells...
  8. doi request reprint Dermal hyaluronan is rapidly reduced by topical treatment with glucocorticoids
    Carl Gebhardt
    Department of Dermatology, Venerology and Allergology, University of Leipzig, Leipzig, Germany
    J Invest Dermatol 130:141-9. 2010
    ..This may reflect an initiation of skin atrophy in response to topically applied GCs...
  9. ncbi request reprint Dermal fibroblasts induce maturation of dendritic cells
    Anja Saalbach
    Department of Dermatology, Venerology, and Allergology, Medical Faculty of Leipzig University, Leipzig, Germany
    J Immunol 178:4966-74. 2007
    ....
  10. doi request reprint ADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells
    Ulf Anderegg
    Department of Dermatology, Venerology and Allergology, Leipzig University Medical Center, Leipzig, Germany
    J Invest Dermatol 129:1471-82. 2009
    ....
  11. ncbi request reprint Vaccinia virus impairs directional migration and chemokine receptor switch of human dendritic cells
    Jens Y Humrich
    University Hospital of Erlangen Nuremberg, Department of Dermatology, Erlangen, Germany
    Eur J Immunol 37:954-65. 2007
    ..This study shows that VV targets directional migration of professional antigen-presenting cells at multiple functional levels, revealing a potent viral strategy of immune escape...
  12. ncbi request reprint Ultraviolet-B irradiation enhances melanoma cell motility via induction of autocrine interleukin 8 secretion
    Carl Gebhardt
    Department of Dermatology, Venerology and Allergology, University of Leipzig, Leipzig, Germany
    Exp Dermatol 16:636-43. 2007
    ..Our findings are consistent with the hypothesis that UVB is not only involved in the initiation of melanoma, but may also be important for some aspects of tumor progression...
  13. doi request reprint Lysophosphatidylcholine-mediated functional inactivation of syndecan-4 results in decreased adhesion and motility of dendritic cells
    Johannes Bühligen
    Department of Dermatology, Venerology and Allergology, Universitatsklinikum Leipzig, Leipzig, Germany
    J Cell Physiol 225:905-14. 2010
    ..Thus, these DC are defective in adhesion and migration. Based on our results, we hypothesize that LysoPC released during apoptosis might delay DC migration to lymphoid organs and thus prevent autoimmunity...
  14. pmc Targeting dendritic cells with CD44 monoclonal antibodies selectively inhibits the proliferation of naive CD4+ T-helper cells by induction of FAS-independent T-cell apoptosis
    Christian Termeer
    Department of Dermatology, University of Freiburg, Germany
    Immunology 109:32-40. 2003
    ..Taken together, we found that perturbation of distinct epitopes of CD44 on DC interfere with early Ca2+ signalling events during the activation of CD4+ T cells, resulting in T-cell apoptosis...
  15. doi request reprint Critical role for syndecan-4 in dendritic cell migration during development of allergic airway inflammation
    Tobias Polte
    1 Department of Environmental Immunology, UFZ Helmholtz Centre for Environmental Research Leipzig Halle, Permoserstrasse 15, Leipzig 04318, Germany 2 Department of Dermatology, Venerology and Allergology, Leipzig University Medical Center, Leipzig 04103, Germany
    Nat Commun 6:7554. 2015
    ..Our results demonstrate that SDC4 plays an important role in asthma induction and indicate SDC4 as possible target for therapeutic intervention in this disease. ..
  16. doi request reprint A case of cutaneous Rosai-Dorfman disease refractory to imatinib therapy
    Carl Gebhardt
    Department of Dermatology, Venereology, and Allergology, Universitätsklinikum Leipzig Anstalt öffentlichen Rechts, Philipp Rosenthal Strasse 23 25, 04103 Leipzig, Germany
    Arch Dermatol 145:571-4. 2009
    ..Rosai-Dorfman disease is a non-Langerhans cell histiocytosis that recently has been treated successfully with imatinib mesylate in a patient with a systemic variant of the disease...
  17. ncbi request reprint Hyperforin acts as an angiogenesis inhibitor
    Christoph M Schempp
    Department of Dermatology, University of Freiburg, Germany
    Planta Med 71:999-1004. 2005
    ..These data suggest that, in addition to the induction of tumor cell apoptosis, hyperforin can also suppress angiogenesis by a direct, non-toxic effect on endothelial cells...
  18. pmc Mature monocyte-derived dendritic cells respond more strongly to CCL19 than to CXCL12: consequences for directional migration
    Jens Y Humrich
    Department of Dermatology, University Hospital of Erlangen, Germany
    Immunology 117:238-47. 2006
    ....
  19. ncbi request reprint The signal-to-noise ratio as a measure of HA oligomer concentration: a MALDI-TOF MS study
    Katja Busse
    University of Leipzig, Faculty of Medicine, Institute of Medical Physics and Biophysics, Hartelstr 16 18, D 04107 Leipzig, Germany
    Carbohydr Res 341:1065-70. 2006
    ..However, the detection limits depend considerably on the size of the HA oligomer with larger oligomers being less sensitively detectable. The advantages and drawbacks of the S/N ratio as concentration measure are discussed...
  20. doi request reprint More than just a filler - the role of hyaluronan for skin homeostasis
    Ulf Anderegg
    Department of Dermatology, Venerology and Allergology, University of Leipzig, Leipzig, Germany
    Exp Dermatol 23:295-303. 2014
    ..This review provides an update on HA-based structures, expression, metabolism and its regulation, function and pharmacological targeting of HA in skin. ..
  21. doi request reprint Histology of saphenous veins after treatment with the ClariVein® device - an ex-vivo experiment
    Michael Kendler
    Clinic and Polyclinic for Dermatology, Venereology, and Allergology, University Hospital of Leipzig AöR, Philipp Rosenthal Straße 23, Leipzig, Germany
    J Dtsch Dermatol Ges 11:348-52. 2013
    ..The ClariVein® catheter is a new endoluminal mechanico-chemical obliteration technique which can be used without tumescent anesthesia. It is still unclear what changes the mechanical tip of the catheter has on the walls of the vein...
  22. doi request reprint Local anesthesia in dermatology
    Tino Wetzig
    Department of Dermatology, Venereology and Allergy, University of Leipzig, Germany
    J Dtsch Dermatol Ges 8:1007-17; quiz 1018. 2010
    ..For dermatologists, the knowledge of mode of action and toxicity of local anesthetics, as well as the emergency management of their potential complications, is essential...
  23. pmc Lifetime-dependent effects of bisphenol A on asthma development in an experimental mouse model
    Susanne Petzold
    UFZ Helmholtz Centre for Environmental Research Leipzig Halle, Department of Environmental Immunology, Leipzig, Germany Department of Dermatology, Venerology and Allergology, Leipzig University Medical Center, Leipzig, Germany
    PLoS ONE 9:e100468. 2014
    ..The aim of this study was to investigate age-dependent effects of BPA on the asthma risk using a murine model to explain the controversial results reported till date...