Sabine Andre

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. doi request reprint Lectins: getting familiar with translators of the sugar code
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University, Veterinarstr 13, 80539 Munich, Germany
    Molecules 20:1788-823. 2015
  2. pmc Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes
    Jennifer A Belisle
    Department of Obstetrics and Gynecology, University of Wisconsin Madison, Madison, WI, USA
    Mol Cancer 9:118. 2010
  3. ncbi request reprint Evidence for lectin activity of a plant receptor-like protein kinase by application of neoglycoproteins and bioinformatic algorithms
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University, Veterinarstr 13, 80539 Munchen, Germany
    Biochim Biophys Acta 1725:222-32. 2005
  4. doi request reprint From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, D 80539 Munich, Germany
    Biol Chem 390:557-65. 2009
  5. ncbi request reprint Tumor suppressor p16INK4a--modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Germany
    FEBS J 274:3233-56. 2007
  6. ncbi request reprint Substitutions in the N-glycan core as regulators of biorecognition: the case of core-fucose and bisecting GlcNAc moieties
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Veterinarstrasse 13, D 80539 Munich, Germany
    Biochemistry 46:6984-95. 2007
  7. ncbi request reprint Branching mode in complex-type triantennary N-glycans as regulatory element of their ligand properties
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University, Veterinaerstr 13, 80539 Munich, Germany
    Biochim Biophys Acta 1760:768-82. 2006
  8. ncbi request reprint Introduction of extended LEC14-type branching into core-fucosylated biantennary N-glycan
    Sabine Andre
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat Munchen, Germany
    FEBS J 272:1986-98. 2005
  9. ncbi request reprint Determination of modulation of ligand properties of synthetic complex-type biantennary N-glycans by introduction of bisecting GlcNAc in silico, in vitro and in vivo
    Sabine Andre
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat Munich, Germany
    Eur J Biochem 271:118-34. 2004
  10. ncbi request reprint Persubstituted cyclodextrin-based glycoclusters as inhibitors of protein-carbohydrate recognition using purified plant and mammalian lectins and wild-type and lectin-gene-transfected tumor cells as targets
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Veterinarstr 13, D 80539 Munich, Germany
    Bioconjug Chem 15:87-98. 2004

Collaborators

Detail Information

Publications51

  1. doi request reprint Lectins: getting familiar with translators of the sugar code
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University, Veterinarstr 13, 80539 Munich, Germany
    Molecules 20:1788-823. 2015
    ....
  2. pmc Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes
    Jennifer A Belisle
    Department of Obstetrics and Gynecology, University of Wisconsin Madison, Madison, WI, USA
    Mol Cancer 9:118. 2010
    ..In a previous study we demonstrated that sMUC16 binds to specific subset of NK cells. Here, we identify the csMUC16/sMUC16 binding partner expressed on immune cells...
  3. ncbi request reprint Evidence for lectin activity of a plant receptor-like protein kinase by application of neoglycoproteins and bioinformatic algorithms
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University, Veterinarstr 13, 80539 Munchen, Germany
    Biochim Biophys Acta 1725:222-32. 2005
    ..These results give further research direction to define physiological ligands, plant/bacterial rhamnose-containing saccharides and rhamnose-mimetic glycans or peptides being potential candidates...
  4. doi request reprint From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, D 80539 Munich, Germany
    Biol Chem 390:557-65. 2009
    ..These modifications are thus molecular switches...
  5. ncbi request reprint Tumor suppressor p16INK4a--modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Germany
    FEBS J 274:3233-56. 2007
    ..This mechanism establishes a new aspect of p16(INK4a) functionality...
  6. ncbi request reprint Substitutions in the N-glycan core as regulators of biorecognition: the case of core-fucose and bisecting GlcNAc moieties
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Veterinarstrasse 13, D 80539 Munich, Germany
    Biochemistry 46:6984-95. 2007
    ..Moreover, our data inspire us to devise new, non-natural modifications to realize the full potential of glycoengineering for diagnostic and therapeutic purposes...
  7. ncbi request reprint Branching mode in complex-type triantennary N-glycans as regulatory element of their ligand properties
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University, Veterinaerstr 13, 80539 Munich, Germany
    Biochim Biophys Acta 1760:768-82. 2006
    ..This part of the study is relevant for rational glycoengineering of pharmaproteins. In general, our study supports the concept to view details of N-glycan structure, here branching, as a means to modulate ligand properties...
  8. ncbi request reprint Introduction of extended LEC14-type branching into core-fucosylated biantennary N-glycan
    Sabine Andre
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat Munchen, Germany
    FEBS J 272:1986-98. 2005
    ..The results argue in favor of the concept of viewing substitutions as molecular switches for lectin-binding affinity. Moreover, they have potential relevance for glycoengineering of reagents in tumor imaging...
  9. ncbi request reprint Determination of modulation of ligand properties of synthetic complex-type biantennary N-glycans by introduction of bisecting GlcNAc in silico, in vitro and in vivo
    Sabine Andre
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat Munich, Germany
    Eur J Biochem 271:118-34. 2004
    ..Synthetic glycan tailoring provides a versatile approach to the preparation of newly substituted glycans with favorable ligand properties for medical applications...
  10. ncbi request reprint Persubstituted cyclodextrin-based glycoclusters as inhibitors of protein-carbohydrate recognition using purified plant and mammalian lectins and wild-type and lectin-gene-transfected tumor cells as targets
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Veterinarstr 13, D 80539 Munich, Germany
    Bioconjug Chem 15:87-98. 2004
    ..This type of chemical scaffold with favorable pharmacologic properties might thus be exploited for the design of galectin- and ligand-type-selective glycoclusters...
  11. doi request reprint Cyclic neoglycodecapeptides: how to increase their inhibitory activity and selectivity on lectin/toxin binding to a glycoprotein and cells
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University, Munich, Germany
    J Pept Sci 17:427-37. 2011
    ..Cyclic neoglycodecapeptides thus warrant further study as lectin-directed pharmaceuticals...
  12. ncbi request reprint alpha2,3/alpha2,6-Sialylation of N-glycans: non-synonymous signals with marked developmental regulation in bovine reproductive tracts
    Hans Christian Siebert
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University, Veterinarstr 13, 80539 Munchen, Germany
    Biochimie 88:399-410. 2006
    ..They give each disaccharide its own characteristic meaning as signal in the sugar code...
  13. ncbi request reprint Unique conformer selection of human growth-regulatory lectin galectin-1 for ganglioside GM1 versus bacterial toxins
    Hans Christian Siebert
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat Munchen, Veterinarstrasse 13, 80539 Munchen, Germany
    Biochemistry 42:14762-73. 2003
    ..In principle, our methodology can be applied in studies aimed at blocking galectin functionality in malignancy and beyond glycosciences...
  14. doi request reprint Unique chicken tandem-repeat-type galectin: implications of alternative splicing and a distinct expression profile compared to those of the three proto-type proteins
    Herbert Kaltner
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat Munchen, Veterinarstrasse 13, D 80539 Munchen, Germany
    Biochemistry 48:4403-16. 2009
    ..Overall, we extend the network of CGs to a tandem-repeat-type protein and provide a detailed characterization from gene and protein structures to expression...
  15. ncbi request reprint First demonstration of differential inhibition of lectin binding by synthetic tri- and tetravalent glycoclusters from cross-coupling of rigidified 2-propynyl lactoside
    Sabine Andre
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat Munchen, Veterinarstr 13, 80539 Munchen, Germany
    Org Biomol Chem 1:3909-16. 2003
    ..These data underline the feasibility of galectin-type target selectivity by compound design despite using an identical headgroup (lactose) in synthesis...
  16. doi request reprint Synthesis of bivalent lactosides and their activity as sensors for differences between lectins in inter- and intrafamily comparisons
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Veterinarstr 13, 80539 Munich, Germany
    Bioorg Med Chem Lett 22:313-8. 2012
    ..Two of the bivalent probes can be considered as sensors for interlectin differences. Most pronounced were the selectivities of N-glycosyl 1,2,3-triazole derivatives for the chimera-type galectin and its proteolytically truncated version...
  17. doi request reprint Chicken GRIFIN: A homodimeric member of the galectin network with canonical properties and a unique expression profile
    Gabriel García Caballero
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Veterinarstr 13, 80539 Munich, Germany
    Biochimie 128:34-47. 2016
    ....
  18. ncbi request reprint Carbohydrate chain of ganglioside GM1 as a ligand: identification of the binding strategies of three 15 mer peptides and their divergence from the binding modes of growth-regulatory galectin-1 and cholera toxin
    Hans Christian Siebert
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat Munchen, Veterinarstrasse 13, 80539 Munchen, Germany
    Chemistry 12:388-402. 2005
    ....
  19. doi request reprint Toward comprehensive analysis of the galectin network in chicken: unique diversity of galectin-3 and comparison of its localization profile in organs of adult animals to the other four members of this lectin family
    Herbert Kaltner
    Faculty of Veterinary Medicine, Institute of Physiological Chemistry, Ludwig Maximilians University, Veterinarstrasse 13, Munich, Germany
    Anat Rec (Hoboken) 294:427-44. 2011
    ..This information on CG-3 completes the description of the panel of CGs, hereby setting the stage for detailed comparative analysis of the entire CG family, e.g., in embryogenesis...
  20. doi request reprint Negative regulation of RPE cell attachment by carbohydrate-dependent cell surface binding of galectin-3 and inhibition of the ERK-MAPK pathway
    Claudia S Alge-Priglinger
    Department of Ophthalmology, Ludwig Maximilians University, Mathildenstrasse 8, Munich, Germany
    Biochimie 93:477-88. 2011
    ..Further investigation at this pathway may disclose a promising nouveau perspective for treatment and prophylaxis of early PVR...
  21. doi request reprint Calix[n]arene-based glycoclusters: bioactivity of thiourea-linked galactose/lactose moieties as inhibitors of binding of medically relevant lectins to a glycoprotein and cell-surface glycoconjugates and selectivity among human adhesion/growth-regulatory g
    Sabine Andre
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat, Veterinarstrasse 13, 80539 Munchen, Germany
    Chembiochem 9:1649-61. 2008
    ..The results thus revealed bioactivity of galactose-/lactose-presenting calix[n]arenes for medically relevant lectins and selectivity within the family of adhesion/growth-regulatory human galectins...
  22. doi request reprint Merging carbohydrate chemistry with lectin histochemistry to study inhibition of lectin binding by glycoclusters in the natural tissue context
    Sabine Andre
    Faculty of Veterinary Medicine, Institute of Physiological Chemistry, Ludwig Maximilians University Munich, Munich, Germany
    Histochem Cell Biol 145:185-99. 2016
    ..Testing glycoclusters in lectin histochemistry will especially be attractive in cases of multi-target recognition (glycans, proteins and lipids) by a tissue lectin. ..
  23. ncbi request reprint Prototype chicken galectins revisited: characterization of a third protein with distinctive hydrodynamic behaviour and expression pattern in organs of adult animals
    Herbert Kaltner
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat Munchen, Veterinarstr 13, D 80539 Munchen, Germany
    Biochem J 409:591-9. 2008
    ..Overall, the results reveal a network of three prototype galectins in chicken...
  24. ncbi request reprint The sugar code: functional lectinomics
    Hans Joachim Gabius
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat Munchen, Veterinarstr 13, D 80539, Munich, Germany
    Biochim Biophys Acta 1572:165-77. 2002
    ....
  25. doi request reprint Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes
    Sabine Andre
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat, Veterinarstr 13, 80539 Munchen, Germany
    Chem Commun (Camb) 47:6126-8. 2011
    ..In detail, aromatic substituents were introduced at the 2-N or 3'-positions of N-acetyllactosamine and the products conjugated to two types of calix[n]arenes (n = 4, 6) via thiourea-linker chemistry...
  26. doi request reprint Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Veterinarstr 13, 80539 Munich, Germany
    Org Biomol Chem 7:4715-25. 2009
    ..The applied strategy for the cell assays is proposed to be of general importance in the quest to identify medically relevant lectin inhibitors...
  27. ncbi request reprint Glycosyldisulfides from dynamic combinatorial libraries as O-glycoside mimetics for plant and endogenous lectins: their reactivities in solid-phase and cell assays and conformational analysis by molecular dynamics simulations
    Sabine Andre
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat Munchen, Veterinarstr 13, D 80539 Munchen, Germany
    Bioorg Med Chem 14:6314-26. 2006
    ..The presented evidence defines glycosyldisulfides as biologically active ligands for lectins...
  28. ncbi request reprint Identification of peptide ligands for malignancy- and growth-regulating galectins using random phage-display and designed combinatorial peptide libraries
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University, Veterinarstr 13, 80539 Munchen, Germany
    Bioorg Med Chem 13:563-73. 2005
    ..Identification of peptide ligands for galectins with and without glycomimetic properties is thus possible. Our study documents the potential to combine the two library-based approaches for structural optimization of lead peptides...
  29. ncbi request reprint Chemical biology of the sugar code
    Hans Joachim Gabius
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat, Veterinarstrasse 13, 80539 Munich, Germany
    Chembiochem 5:740-64. 2004
    ....
  30. ncbi request reprint Suitability of binary mixtures of water with aprotic solvents to turn hydroxyl protons of carbohydrate ligands into conformational sensors in NOE and transferred NOE experiments
    Hans Christian Siebert
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat Munchen, Veterinarstr 13, 80539 Munchen, Germany
    J Biomol NMR 25:197-215. 2003
    ..Our experiments reveal that binary mixtures have favorable properties for the conformational analysis of the free- and bound-state topologies of bioactive ligands...
  31. ncbi request reprint Association of galectin-1- but not galectin-3-dependent parameters with proliferation activity in human neuroblastomas and small cell lung carcinomas
    Hans Joachim Gabius
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat, Munich, Germany
    Anticancer Res 22:405-10. 2002
    ..Owing to this capacity they might affect tumor growth when expression is adapted adequately...
  32. doi request reprint Carbamate-linked lactose: design of clusters and evidence for selectivity to block binding of human lectins to (neo)glycoproteins with increasing degree of branching and to tumor cells
    Sabine Andre
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat, Veterinarstrasse 13, 80539 Munchen, Germany
    Bioconjug Chem 20:1716-28. 2009
    ..The reported bioactivity and the delineation of its modulation by structural parameters of lectins and glycans set instructive examples for the further design of selective inhibitors and assay procedures...
  33. doi request reprint Cell-type-specific expression of murine multifunctional galectin-3 and its association with follicular atresia/luteolysis in contrast to pro-apoptotic galectins-1 and -7
    Michaela Lohr
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University, Munich, Germany
    Histochem Cell Biol 130:567-81. 2008
    ..This study demonstrates cell-type specificity and cycle-associated regulation for galectin-3 with increased presence in atretic preantral follicles and in late stages of luteolysis...
  34. ncbi request reprint Determination of structural and functional overlap/divergence of five proto-type galectins by analysis of the growth-regulatory interaction with ganglioside GM1 in silico and in vitro on human neuroblastoma cells
    Sabine Andre
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat, Munich, Germany
    Int J Cancer 114:46-57. 2005
    ..Moreover, the given strategy for comparative computational analysis of extended binding sites has implications for the rational design of galectin-type-specific ligands...
  35. doi request reprint Galectins as tools for glycan mapping in histology: comparison of their binding profiles to the bovine zona pellucida by confocal laser scanning microscopy
    Felix A Habermann
    Institute of Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, Ludwig Maximilians University, Veterinarstr 13, 80539, Munich, Germany
    Histochem Cell Biol 135:539-52. 2011
    ..Our results encourage further comparative analysis and research to trace the underlying structural and/or topological properties...
  36. ncbi request reprint Playing Modular Puzzle with Adhesion/Growth-Regulatory Galectins: Design and Testing of a Hybrid to Unravel Structure-Activity Relationships
    Anna Kristin Ludwig
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Veterinarstr 13, 80539 Munchen, Germany
    Protein Pept Lett 23:1003-1012. 2016
    ..Tested as agglutinin, the hybrid was potent, excelling wild-type control galectins. The chimera-type design can thus serve as platform for tuning crosslinking activity...
  37. ncbi request reprint Unique sequence and expression profiles of rat galectins-5 and -9 as a result of species-specific gene divergence
    Martin Lensch
    Institute for Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Veterinarstr 13, D 80539 Munich, Germany
    Int J Biochem Cell Biol 38:1741-58. 2006
    ..The presented results on galectin-5 relative to galectin-9 intimate distinct functions especially in erythropoiesis and imply currently unknown mechanisms to compensate its absence from the galectin network in other mammals...
  38. ncbi request reprint Describing topology of bound ligand by transferred nuclear Overhauser effect spectroscopy and molecular modeling
    Hans Christian Siebert
    Institute of Physiological Chemistry, Ludwig Maximilians University, Veterinarstrasse 13, Munich D 80539, Germany
    Methods Enzymol 362:417-34. 2003
  39. doi request reprint Galectin-related protein: An integral member of the network of chicken galectins: 2. From expression profiling to its immunocyto- and histochemical localization and application as tool for ligand detection
    Herbert Kaltner
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Veterinarstr 13, 80539, Munich, Germany
    Biochim Biophys Acta 1860:2298-312. 2016
    ..Galectin-related protein (GRP), present in vertebrates, is special within this family of adhesion/growth-regulatory proteins due to its strong positive selection and loss of canonical lectin activity...
  40. ncbi request reprint Discovery of galectin ligands in fully randomized combinatorial one-bead-one-compound (glyco)peptide libraries
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Veterinarstr 13, 80539 Munich, Germany
    Bioorg Med Chem Lett 17:793-8. 2007
    ..The various data obtained define the library approach as a facile route for the discovery of selective (glyco)peptide-based galectin inhibitors...
  41. doi request reprint From lectin structure to functional glycomics: principles of the sugar code
    Hans Joachim Gabius
    Institute of Physiological Chemistry, Ludwig Maximilians University Munich, Munchen, Germany
    Trends Biochem Sci 36:298-313. 2011
    ..Experimentally, the strategic combination of methods to monitor distinct aspects of the lectin-glycan interplay offers a promising perspective to answer this question...
  42. ncbi request reprint Down-regulation of the epidermal growth factor receptor by altering N-glycosylation: emerging role of β1,4-galactosyltransferases
    Hans J Gabius
    Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Veterinarstr 13, D 80539 Munich, Germany
    Anticancer Res 32:1565-72. 2012
    ..Blocking N-glycosylation of the epidermal growth factor receptor (EGFR) by tunicamycin inhibits its cellular accumulation. Due to the toxic potential of this drug, finding less drastic routes to reduce EGFR expression is desirable...
  43. pmc Inhibition of human retinal pigment epithelial cell attachment, spreading, and migration by the human lectin galectin-1
    Claudia S Alge-Priglinger
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
    Mol Vis 15:2162-73. 2009
    ..The role of the endogenous lectin, galectin-1, in attachment, spreading, and migration of human RPE cells was investigated from a therapeutic perspective...
  44. doi request reprint Network monitoring of adhesion/growth-regulatory galectins: localization of the five canonical chicken proteins in embryonic and maturing bone and cartilage and their introduction as histochemical tools
    Herbert Kaltner
    Faculty of Veterinary Medicine, Institute of Physiological Chemistry, Ludwig Maximilians University Munich, 80539, Munich, Germany
    Anat Rec (Hoboken) 298:2051-70. 2015
    ..Thus, complete network analysis irrespective of its degree of complexity is mandatory...
  45. ncbi request reprint Analysis of protein-carbohydrate interaction at the lower size limit of the protein part (15-mer peptide) by NMR spectroscopy, electrospray ionization mass spectrometry, and molecular modeling
    Hans Christian Siebert
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat Munchen, Veterinarstrasse 13, 80539 Munchen, Germany
    Biochemistry 41:9707-17. 2002
    ..We have thereby proven effectiveness of our approach to analyze even low-affinity interactions (not restricted to carbohydrates as ligands). It will be useful to evaluate the impact of rational manipulation of lead peptide sequences...
  46. doi request reprint Structural significance of galectin design: impairment of homodimer stability by linker insertion and partial reversion by ligand presence
    Sabine Vértesy
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat, Veterinär straße 13, 80539 Munchen, Germany
    Protein Eng Des Sel 28:199-210. 2015
    ..Dynamic changes in the spatial presentation of the two lectin domains in the context of a tandem-repeat display can alter counterreceptor targeting relative to the fixed positions found in the proto-type galectin homodimer. ..
  47. doi request reprint The glycobiology of the CD system: a dictionary for translating marker designations into glycan/lectin structure and function
    Hans Joachim Gabius
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians Universitat Munchen, Veterinärstraße 13, 80539 Munich, Germany Electronic address
    Trends Biochem Sci 40:360-76. 2015
    ..Glycans presented on proteins or lipids and receptors for carbohydrate structures (lectins) are part of the CD list. Our review presents biochemical and biomedical highlights of the respective CD entries. ..
  48. doi request reprint Combining glycocluster synthesis with protein engineering: an approach to probe into the significance of linker length in a tandem-repeat-type lectin (galectin-4)
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Veterinarstr 13, 80539 Munich, Germany
    Carbohydr Res 389:25-38. 2014
    ..The testing of glycoclusters is suggested as a general strategy to help to delineate the significance of distinct structural features of lectins beyond their contact sites to the glycan. ..
  49. doi request reprint Bi- to tetravalent glycoclusters presenting GlcNAc/GalNAc as inhibitors: from plant agglutinins to human macrophage galactose-type lectin (CD301) and galectins
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Veterinarstr 13, 80539 Munich, Germany
    Org Biomol Chem 13:4190-203. 2015
    ..Evidently, the valency and spatial display of α-GalNAc residues is a key factor to design potent and selective inhibitors for this lectin. ..
  50. doi request reprint Studies on Unprocessed and Acid-Treated Arabinogalactan from Larch as an Inhibitor of Glycan Binding of a Plant Toxin and Biomedically Relevant Human Lectins
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Munchen, Germany
    Planta Med 81:1146-53. 2015
    ..Larch arabinogalactan, tested as a model, will thus most likely not impair (ga)lectin functionality physiologically. ..
  51. doi request reprint Thio- and selenoglycosides as ligands for biomedically relevant lectins: valency-activity correlations for benzene-based dithiogalactoside clusters and first assessment for (di)selenodigalactosides
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University, Veterinarstr 13, 80539 Munich, Germany
    Bioorg Med Chem Lett 25:931-5. 2015
    ..This result directs attention to further studies to relate Se-dependent alterations in bond angle and length as well as van der Waals radius to binding properties of selenoglycosides to biomedically relevant lectins. ..