Kerstin Amann

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi request reprint Blood pressure-independent effect of long-term treatment with the soluble heme-independent guanylyl cyclase activator HMR1766 on progression in a model of noninflammatory chronic renal damage
    Kerstin Benz
    Department of Pediatrics, University of Erlangen, Erlangen, Germany
    Kidney Blood Press Res 30:224-33. 2007
  2. doi request reprint Intrauterine growth restriction leads to a dysregulation of Wilms' tumour supressor gene 1 (WT1) and to early podocyte alterations
    Carlos Menendez-Castro
    Department of Pediatrics and Adolescent Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Nephrol Dial Transplant 28:1407-17. 2013
  3. pmc The mitogen-activated protein kinase p38α regulates tubular damage in murine anti-glomerular basement membrane nephritis
    Ralf Muller
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Bavaria, Germany
    PLoS ONE 8:e56316. 2013
  4. doi request reprint Early glomerular alterations in genetically determined low nephron number
    Kerstin Benz
    Department of Pediatrics, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Physiol Renal Physiol 300:F521-30. 2011
  5. doi request reprint Cardiovascular and renal effects of high salt diet in GDNF+/- mice with low nephron number
    Julia Schlote
    Department of Pathology, IZKF Nachwuchsgruppe, Department of Nephrology and Hypertension, Department of Pediatrics, University of Erlangen Nurnberg, Germany
    Kidney Blood Press Res 37:379-91. 2013
  6. doi request reprint The proteasome inhibitor bortezomib prevents lupus nephritis in the NZB/W F1 mouse model by preservation of glomerular and tubulointerstitial architecture
    Nadine Hainz
    Nephropathology, Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Nephron Exp Nephrol 120:e47-58. 2012
  7. doi request reprint Intrauterine growth restriction promotes vascular remodelling following carotid artery ligation in rats
    Carlos Menendez-Castro
    Department of Pediatrics and Adolescent Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    Clin Sci (Lond) 123:437-44. 2012
  8. doi request reprint Diabetes mellitus negatively affects peri-implant bone formation in the diabetic domestic pig
    Cornelius von Wilmowsky
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    J Clin Periodontol 38:771-9. 2011
  9. pmc Early and late postnatal myocardial and vascular changes in a protein restriction rat model of intrauterine growth restriction
    Carlos Menendez-Castro
    Department of Pediatrics and Adolescent Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    PLoS ONE 6:e20369. 2011
  10. pmc Podocytes are nonhematopoietic professional antigen-presenting cells
    Andreas Goldwich
    Department of Immunemodulation at the Dermatology, University Hospital Erlangen, Erlangen, Germany
    J Am Soc Nephrol 24:906-16. 2013

Detail Information

Publications124 found, 100 shown here

  1. ncbi request reprint Blood pressure-independent effect of long-term treatment with the soluble heme-independent guanylyl cyclase activator HMR1766 on progression in a model of noninflammatory chronic renal damage
    Kerstin Benz
    Department of Pediatrics, University of Erlangen, Erlangen, Germany
    Kidney Blood Press Res 30:224-33. 2007
    ..6 +/- 9). The results document beneficial BP-independent HMR1766 effects on kidney structure and urinary albumin excretion in a noninflammatory model of renal failure and may argue for a novel therapeutic principle...
  2. doi request reprint Intrauterine growth restriction leads to a dysregulation of Wilms' tumour supressor gene 1 (WT1) and to early podocyte alterations
    Carlos Menendez-Castro
    Department of Pediatrics and Adolescent Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Nephrol Dial Transplant 28:1407-17. 2013
    ..We hypothesized that IUGR induces early podocyte alterations based on a dysregulation of Wilms' tumour suppressor gene 1 (WT1), a key player of nephrogenesis and mediator of podocyte integrity...
  3. pmc The mitogen-activated protein kinase p38α regulates tubular damage in murine anti-glomerular basement membrane nephritis
    Ralf Muller
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Bavaria, Germany
    PLoS ONE 8:e56316. 2013
    ..Full protection from nephritis is however not achieved as renal failure and structural damage still occurs...
  4. doi request reprint Early glomerular alterations in genetically determined low nephron number
    Kerstin Benz
    Department of Pediatrics, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Physiol Renal Physiol 300:F521-30. 2011
    ....
  5. doi request reprint Cardiovascular and renal effects of high salt diet in GDNF+/- mice with low nephron number
    Julia Schlote
    Department of Pathology, IZKF Nachwuchsgruppe, Department of Nephrology and Hypertension, Department of Pediatrics, University of Erlangen Nurnberg, Germany
    Kidney Blood Press Res 37:379-91. 2013
    ..To test the suggested association of low nephron number and later development of renal and cardiovascular disease we investigated the effects of high sodium diet in heterozygous GDNF+/- mice...
  6. doi request reprint The proteasome inhibitor bortezomib prevents lupus nephritis in the NZB/W F1 mouse model by preservation of glomerular and tubulointerstitial architecture
    Nadine Hainz
    Nephropathology, Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Nephron Exp Nephrol 120:e47-58. 2012
    ..In extension to our previously published data we here analyzed the potential renoprotective mechanisms of bortezomib (BZ) in experimental lupus nephritis by focusing on morphological changes...
  7. doi request reprint Intrauterine growth restriction promotes vascular remodelling following carotid artery ligation in rats
    Carlos Menendez-Castro
    Department of Pediatrics and Adolescent Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    Clin Sci (Lond) 123:437-44. 2012
    ..We conclude that IUGR aggravates atherosclerotic vascular remodelling induced by a second injury later in life...
  8. doi request reprint Diabetes mellitus negatively affects peri-implant bone formation in the diabetic domestic pig
    Cornelius von Wilmowsky
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    J Clin Periodontol 38:771-9. 2011
    ..The aim of the present study was to investigate the effect of diabetes on peri-implant bone formation in an animal model of human bone repair...
  9. pmc Early and late postnatal myocardial and vascular changes in a protein restriction rat model of intrauterine growth restriction
    Carlos Menendez-Castro
    Department of Pediatrics and Adolescent Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    PLoS ONE 6:e20369. 2011
    ..Hence, altered matrix composition of the vascular wall and the myocardium may predispose IUGR animals to cardiovascular disease later in life...
  10. pmc Podocytes are nonhematopoietic professional antigen-presenting cells
    Andreas Goldwich
    Department of Immunemodulation at the Dermatology, University Hospital Erlangen, Erlangen, Germany
    J Am Soc Nephrol 24:906-16. 2013
    ..In conclusion, podocytes participate in the antigen-specific activation of adaptive immune responses, providing a potential target for immunotherapies of inflammatory kidney diseases and transplant rejection...
  11. doi request reprint Effects of adrenomedullin on the glomerular adrenomedullin system in a rat model of anti-thy1 glomerulonephritis
    Bettina Geissler
    Kinder und Jugendklinik, Erlangen, Germany
    Nephron Exp Nephrol 115:e80-8. 2010
    ..Adrenomedullin (ADM) has antiproliferative effects on glomerular mesangial cells. The study was performed to determine changes in glomerular gene expression of the ADM system by ADM treatment in anti-Thy1 glomerulonephritis (GN)...
  12. pmc Darbepoetin alpha reduces oxidative stress and chronic inflammation in atherosclerotic lesions of apo E deficient mice in experimental renal failure
    Nicole Arend
    Department of Internal Medicine Nephrology, University of Erlangen Nurnberg, Erlangen, Germany
    PLoS ONE 9:e88601. 2014
    ..Therefore, this study evaluates the effects of Darbepoetin on markers of oxidative stress and chronic inflammation in atherosclerotic lesions in apo E knockout mice with renal dysfunction...
  13. doi request reprint Activated ERK1/2 increases CD44 in glomerular parietal epithelial cells leading to matrix expansion
    Sebastian S Roeder
    Division of Nephrology, University of Washington, Seattle, Washington, USA Friedrich Alexander Universität Erlangen Nürnberg FAU, Erlangen, Germany
    Kidney Int . 2016
    ..Thus, pERK is a regulator of CD44 expression, and increased CD44 expression leads to a pro-sclerotic and migratory parietal epithelial cell phenotype...
  14. doi request reprint Kidney injury is independent of endothelial HIF-1α
    Joanna Kalucka
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nürnberg FAU, Ulmenweg 18, 91054, Erlangen, Germany
    J Mol Med (Berl) 93:891-904. 2015
    ..This has implications for the development of pharmacological strategies targeting the endothelial hypoxic response pathways...
  15. doi request reprint Structural renal changes in obesity and diabetes
    Kerstin Amann
    Department of Nephropathology, Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Semin Nephrol 33:23-33. 2013
    ..This review specifically addresses the pathogenesis and morphology of renal functional and particularly structural changes in obesity and associated renal disease such as diabetic nephropathy...
  16. pmc A complex microdeletion 17q12 phenotype in a patient with recurrent de novo membranous nephropathy
    Bernward Hinkes
    Department of Pediatrics, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    BMC Nephrol 13:27. 2012
    ..Repeatedly she suffered from kidney transplant failure caused by consuming membranous nephropathy...
  17. doi request reprint High frequency of autoantibody-secreting cells and long-lived plasma cells within inflamed kidneys of NZB/W F1 lupus mice
    Charlotte Starke
    Department of Internal Medicine 3, Clinical Research Group, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Immunol 41:2107-12. 2011
    ..Moreover, the frequencies of IgG-secreting cells specific for the autoantigens dsDNA and nucleolin were higher in the kidneys compared with those in the spleen and bone marrow...
  18. ncbi request reprint Untreated 'blow-in' fracture of the orbital floor causing a mucocele: report of an unusual late complication
    Emeka Nkenke
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Germany
    J Craniomaxillofac Surg 33:255-9. 2005
    ..To date, there is only minimal knowledge on long-term complications of blow-in fractures that have remained untreated. The present case report describes a late complication of an untreated blow-in fracture of the orbital floor...
  19. ncbi request reprint Arterialisation of the portal vein as a model for the induction of hepatic fibrosis: description of microsurgical models in the rat
    Volker Muller
    Department of Surgery, University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Transpl Int 17:822-33. 2005
    ..After a brief period of learning the microsurgical techniques, the surgeon can limit clamping times and achieve good results with these techniques...
  20. ncbi request reprint Expression of bone morphogenic protein 2/4, transforming growth factor-beta1, and bone matrix protein expression in healing area between vascular tibia grafts and irradiated bone-experimental model of osteonecrosis
    Stefan Schultze-Mosgau
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Glueckstrasse 11, Erlangen 91054, Germany
    Int J Radiat Oncol Biol Phys 61:1189-96. 2005
    ..Therefore, the aim of the present in vivo study was to analyze the expression of BMP2/4, TGF-beta(1), collagen I, and osteocalcin in the transition area between the bone graft and the graft bed after RT...
  21. ncbi request reprint Submental cutaneous sinus tract as a result of progressive peri-implantitis: a case report
    Emeka Nkenke
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    J Periodontol 75:1417-23. 2004
    ....
  22. ncbi request reprint Effects of portal vein arterialization on regeneration and morphology in liver transplantation: investigations using the rat model
    Volker Muller
    Department of Surgery, University of Erlangen Nuremberg, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Transplantation 78:1159-65. 2004
    ..The present study investigates the effects of the arterialized portal vein on the function, morphology, and regenerative behavior of the liver...
  23. ncbi request reprint Adrenomedullin reduces mesangial cell number and glomerular inflammation in experimental mesangioproliferative glomerulonephritis
    Christian Plank
    Department of Pediatrics, University Erlangen Nuremberg, Germany
    Kidney Int 68:1086-95. 2005
    ..Whether or not treatment with ADM can reduce MC proliferation in vivo [i.e., in mesangioproliferative glomerulonephritis (GN)] is unknown. We tested the hypothesis that ADM substitution reduces MC proliferation in GN...
  24. pmc HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury
    Johannes Schödel
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Am J Pathol 174:1663-74. 2009
    ..These results implicate the non-uniform expression of HIF-regulating enzymes that modify the hypoxic response in the kidney under both regional and temporal conditions...
  25. ncbi request reprint Thrombotic microangiopathy as a complication in a patient with focal segmental glomerulosclerosis
    Kerstin Benz
    Klinik fur Kinder und Jugendliche, Friedrich Alexander Universitat Erlangen Nurnberg, Loschgestrasse 15, 91054, Erlangen, Germany
    Pediatr Nephrol 22:2125-8. 2007
    ..In conclusion, severe hypertension in chronic kidney disease can lead to target organ damage and thrombotic microangiopathy, which may further worsen renal function...
  26. ncbi request reprint Thrombospondin-1 is an endogenous activator of TGF-beta in experimental diabetic nephropathy in vivo
    Christoph Daniel
    Department of Nephrology and Hypertension, University Erlangen Nurnberg, Loschgestr 8, 91054 Erlangen, Germany
    Diabetes 56:2982-9. 2007
    ..Recent studies by our group demonstrated that thrombospondin-1 (TSP-1) is the major activator of latent TGF-beta in experimental glomerulonephritis in the rat, but its role in diabetic nephropathy in vivo is unknown...
  27. ncbi request reprint Low birth weight, but not postnatal weight gain, aggravates the course of nephrotic syndrome
    Christian Plank
    Department of Paediatrics, Kinder and Jugendklinik, University of Erlangen Nuremberg, Loschgestrasse 15, 91056 Erlangen, Germany
    Pediatr Nephrol 22:1881-9. 2007
    ..Independently of birth weight, weight gain in the first 2 years of life did not influence the course of disease...
  28. ncbi request reprint Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure
    Wanja M Bernhardt
    Department of Nephrology and Hypertension, Nikolaus Fiebiger Center for Molecular Medicine, Friedrich Alexander University Erlangen Nuremberg, Loschgestrasse, Erlangen, Germany
    J Am Soc Nephrol 17:1970-8. 2006
    ..In conclusion, the data provide proof of principle that preconditional activation of the HIF system protects against ischemic injury. Inhibiting the activity of HIF hydroxylases therefore seems to have considerable clinical perspectives...
  29. ncbi request reprint Nonhypotensive dose of beta-adrenergic blocker ameliorates capillary deficits in the hearts of rats with moderate renal failure
    Kerstin Amann
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10, 91054 Erlangen, Germany
    Virchows Arch 449:207-14. 2006
    ....
  30. ncbi request reprint Restricted-expressed proliferation-associated protein (Repp86) expression in squamous cell carcinoma of the oral cavity
    Matthias Fenner
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    Strahlenther Onkol 181:755-61. 2005
    ....
  31. ncbi request reprint Impaired myocardial capillarogenesis and increased adaptive capillary growth in FGF2-deficient mice
    Kerstin Amann
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Lab Invest 86:45-53. 2006
    ..These data demonstrate that two intact Fgf2 genes are necessary for normal capillary development after birth, whereas FGF2 seems to be dispensable for adaptive myocardial capillary growth in the adult mouse...
  32. ncbi request reprint Low nephron number--a new cardiovascular risk factor in children?
    Kerstin Amann
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    Pediatr Nephrol 19:1319-23. 2004
    ..Therefore, it is important to identify children at risk as early as possible in order to treat them early and to prevent the development of end-organ damage. This could be an important goal for pediatrics in the near future...
  33. ncbi request reprint Characterization of the renal phenotype in a mouse model of Marfan syndrome
    Andrea Hartner
    Department of Pediatrics, University of Erlangen Nurnberg, Loschgestrasse 15, 91054 Erlangen, Germany
    Virchows Arch 445:382-8. 2004
    ..Alterations in renal histology were only subtle with a reduced glomerular volume and mesangial area likely due to a reduced mesangial cell volume...
  34. ncbi request reprint Restricted expression of mouse GCMa/Gcm1 in kidney and thymus
    Said Hashemolhosseini
    Institut fur Biochemie, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Mech Dev 118:175-8. 2002
    ..In thymus, mGCMa is restricted to few small clusters of cells, in kidney to the S3 segment of proximal tubules. mGCMa expression is primarily postnatal, arguing for a role in organ function rather than organ development...
  35. ncbi request reprint Cardiovascular changes in renal failure
    Karin Tyralla
    Department of Pathology, University of Erlangen, Germany
    Blood Purif 20:462-5. 2002
    ....
  36. ncbi request reprint Hyperphosphatemia aggravates cardiac fibrosis and microvascular disease in experimental uremia
    Kerstin Amann
    Department of Pathology, Erlangen, Germany
    Kidney Int 63:1296-301. 2003
    ....
  37. ncbi request reprint Why is coronary heart disease of uraemic patients so frequent and so devastating?
    Kerstin Amann
    Department of Pathology, University of Erlangen Nurnberg, Germany
    Nephrol Dial Transplant 18:631-40. 2003
    ..He was a very intelligent and cultured person, and a man of great style who enjoyed a wide range of hobbies and interests in addition to his medical work. All his colleagues and friends mourn his passing...
  38. ncbi request reprint Cardiomyocyte loss in experimental renal failure: prevention by ramipril
    Kerstin Amann
    Department of Pathology, University of Erlangen, Erlangen, Germany
    Kidney Int 63:1708-13. 2003
    ..It was the aim of the present study in short-term experimental renal failure (1) to characterize cardiomyocyte volume and number and (2) to study whether they are affected by the angiotensin-converting enzyme (ACE) inhibitor ramipril...
  39. ncbi request reprint In Vivo TGF-beta 3 expression during wound healing in irradiated tissue. An experimental study
    Stefan Schultze-Mosgau
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nurnberg, Erlangen, Germany
    Strahlenther Onkol 179:410-6. 2003
    ..The objective of the in vivo study was therefore to analyze the expression profile of TGF-beta(3) in the graft bed and in the transition area between the graft and the graft bed after irradiation and/or after surgery...
  40. ncbi request reprint Effect of antioxidant therapy with dl-alpha-tocopherol on cardiovascular structure in experimental renal failure
    Kerstin Amann
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, D 91054 Erlangen, Germany
    Kidney Int 62:877-84. 2002
    ..Furthermore, uremia is a state of increased oxygen stress. It was the purpose of this study to examine whether these findings are interrelated...
  41. ncbi request reprint Dialysis-associated acquired cystic kidney disease imitating autosomal dominant polycystic kidney disease in a patient receiving long-term peritoneal dialysis
    Daniel Neureiter
    Department of Pathology, University of Erlangen, Heidelberg, Germany
    Nephrol Dial Transplant 17:500-3. 2002
  42. ncbi request reprint Improved free vascular graft survival in an irradiated surgical site following topical application of rVEGF
    Stefan Schultze-Mosgau
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    Int J Radiat Oncol Biol Phys 57:803-12. 2003
    ..An experimental in vivo model was used to study the possible role of rVEGF for reduction of wound healing disorders and the promotion of neovascularization...
  43. ncbi request reprint Transforming growth factor-beta receptor-II up-regulation during wound healing in previously irradiated graft beds in vivo
    Stefan Schultze-Mosgau
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    Wound Repair Regen 11:297-305. 2003
    ..Exogenous blocking or TGFbetaR-II inhibitors could therefore represent a new therapeutic approach for improving wound healing after preoperative radiotherapy...
  44. ncbi request reprint Transforming growth factor beta1 and beta2 (TGFbeta2 / TGFbeta2) profile changes in previously irradiated free flap beds
    Stefan Schultze-Mosgau
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    Head Neck 24:33-41. 2002
    ....
  45. ncbi request reprint Anti-TGFbeta1 antibody for modulation of expression of endogenous transforming growth factor beta 1 to prevent fibrosis after plastic surgery in rats
    Stefan Schultze-Mosgau
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Glueckstrasse 11, Erlangen 91054, Germany
    Br J Oral Maxillofac Surg 42:112-9. 2004
    ..The results indicate that anti-TGFbeta1 might improve the healing of free flaps in the graft beds of patients who are prone to excessive fibrosis...
  46. doi request reprint PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury
    Gui Wei He
    Department of Medicine 1, Friedrich Alexander University, Erlangen, Germany
    Gut . 2016
    ..The aim of this study was to identify molecular mechanisms that drive hepatocyte cell death in the pathogenesis of acute liver injury...
  47. doi request reprint Complex reinnervation pattern after unilateral renal denervation in rats
    Kristina Rodionova
    Department of Internal Medicine 4, Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremburg, Erlangen, Germany
    Am J Physiol Regul Integr Comp Physiol 310:R806-18. 2016
    ..These results suggest a long-term net surplus of afferent influence on the DNX kidney may be contributing to the blood pressure lowering effect of DNX. ..
  48. doi request reprint Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease
    Isabel N Schellinger
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA VA Palo Alto Health Care System, Palo Alto, California, USA Heart Center, Georg August University Gottingen, Gottingen, Germany German Center for Cardiovascular Research DZHK, Gottingen, Germany
    Kidney Int . 2016
    ..Thus, impaired ischemia-induced angiogenesis in rats with CKD can be improved by HIF stabilization, even if started after onset of ischemia...
  49. doi request reprint BRONJ-related jaw bone is associated with increased Dlx-5 and suppressed osteopontin-implication in the site-specific alteration of angiogenesis and bone turnover by bisphosphonates
    Falk Wehrhan
    Department of Oral and Maxillofacial Surgery, Friedrich Alexander University of Erlangen, Glueckstrasse 11, 91054, Erlangen, Germany
    Clin Oral Investig 19:1289-98. 2015
    ....
  50. doi request reprint Hypoxia regulates the sperm associated antigen 4 (SPAG4) via HIF, which is expressed in renal clear cell carcinoma and promotes migration and invasion in vitro
    Karl Xaver Knaup
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany Nikolaus Fiebiger Center, University of Erlangen Nuremberg, Erlangen, Germany
    Mol Carcinog 53:970-8. 2014
    ..Together, SPAG4 could possibly play a role in the invasion capability and growth of renal tumors and could represent an interesting target for clinical intervention...
  51. doi request reprint Recurrent adult-type rhabdomyoma: a rare differential diagnosis of "swellings in the masticatory muscle"
    Tilo Schlittenbauer
    From the Department of Oral and Maxillofacial Surgery and Institute of Pathology, University Hospital Erlangen, Erlangen, Germany
    J Craniofac Surg 24:e504-7. 2013
    ..Adult-type rhabdomyoma of the cheek and masticatory area are exceptionally rare with no more than 3 cases reported to date. ..
  52. doi request reprint Impairment of podocyte function by diphtheria toxin--a new reversible proteinuria model in mice
    Andreas Goldwich
    Department of Immunemodulation at the Dermatology, University Hospital Erlangen, Erlangen, Germany
    Lab Invest 92:1674-85. 2012
    ..We suggest DTx-induced transient kidney dysfunction as a new reversible model of experimental podocyte injury, which could be used as an additional approach to complement studies in human...
  53. doi request reprint Beneficial effects of integrin αvβ3-blocking RGD peptides in early but not late phase of experimental glomerulonephritis
    Kerstin Amann
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Nephrol Dial Transplant 27:1755-68. 2012
    ..The aim of the study was to clarify if blockade of αvβ3 integrin with the specific αvβ3-blocking cyclic peptide RGDdFV (cRGD) has beneficial effects on the course of this disease...
  54. doi request reprint Fetal programming of renal function
    Jorg Dotsch
    Department of Pediatrics, University of Cologne, Kerpener Str 62, 50937 Cologne, Germany
    Pediatr Nephrol 27:513-20. 2012
    ..g., changes in endothelial function) alterations. It appears likely that the outcomes of fetal programming may be influenced or modified postnatally, for example, by the amount of nutrients given at critical times...
  55. pmc Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts
    Ruth E Schietke
    Interdisciplinary Centre for Clinical Research, University Erlangen Nuremberg, Erlangen, Germany
    PLoS ONE 7:e31034. 2012
    ..However, HIF-2α overexpression alone is insufficient to induce tumors. Thus, our data bear implications for renal tumorigenesis, epithelial differentiation and renal repair mechanisms...
  56. doi request reprint Selective stabilization of HIF-1α in renal tubular cells by 2-oxoglutarate analogues
    Gunnar Schley
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Germany
    Am J Pathol 181:1595-606. 2012
    ....
  57. doi request reprint Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells
    Johannes Schödel
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Kidney Int 78:857-67. 2010
    ..Thus, FIH1 appears to be a suppressor of oxygen-dependent genes in the kidney, operating through HIF-dependent and -independent mechanisms...
  58. pmc High-dose enalapril treatment reverses myocardial fibrosis in experimental uremic cardiomyopathy
    Karin Tyralla
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    PLoS ONE 6:e15287. 2011
    ..It is unclear, however, to what extent ACE-inhibitors can also reverse existing cardiovascular alterations. Therefore, we investigated the effect of high dose enalapril treatment on these alterations...
  59. ncbi request reprint Sensory neurons with afferents from hind limbs: enhanced sensitivity in secondary hypertension
    Peter Linz
    Department of Internal Medicine 4 Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Hypertension 47:527-31. 2006
    ..We speculate that this observation may indicate an increased activity of these neurons, their axons, and neurotransmitters in the control of resistance vessels in hypertension...
  60. doi request reprint Long-term treatment of sirolimus but not cyclosporine ameliorates diabetic nephropathy in the rat
    Sandra Wittmann
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    Transplantation 87:1290-9. 2009
    ..We evaluated whether sirolimus (SRL) or cyclosporine A (CsA) therapy would be a superior immunosuppressant in streptozotocin-induced diabetic nephropathy...
  61. ncbi request reprint The apolipoprotein e knockout mouse: a model documenting accelerated atherogenesis in uremia
    Moriz Buzello
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    J Am Soc Nephrol 14:311-6. 2003
    ..In conclusion, even mild renal dysfunction, i.e., after uninephrectomy, causes a dramatic increase in plaque size and aggressive morphology (foam cell rich soft plaques) in the animal model of the Apoe-/- mouse...
  62. ncbi request reprint Glomerular and renal vascular structural changes in alpha8 integrin-deficient mice
    Christian S Haas
    Department of Internal Medicine IV and Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    J Am Soc Nephrol 14:2288-96. 2003
    ..The compensatory mechanisms involved will be the subject of future research...
  63. ncbi request reprint OS 29-03 INCREASED NEUROKININ RELEASE FROM AFFERENT RENAL NERVES IS ACCOMPANIED BY DECREASED AFFERENT ELECTRIC ACTIVITY
    Tilmann Ditting
    1Department of Nephrology and Hypertension, University of Erlangen, Germany 2Division of Nephropathology, University of Erlangen, Germany
    J Hypertens 34:e253. 2016
    ..Hence, we hypothesized that augmented effects of CGRP in renal inflammation occur with increased afferent renal nerve activity...
  64. doi request reprint Expression of transforming growth factor beta 1-related signaling proteins in irradiated vessels
    Raimund H M Preidl
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nurnberg, Glückstraße 11, 91054, Erlangen, Germany
    Strahlenther Onkol 191:518-24. 2015
    ....
  65. doi request reprint Cellular FLICE-like inhibitory protein secures intestinal epithelial cell survival and immune homeostasis by regulating caspase-8
    Nadine Wittkopf
    Department of Medicine 1, Friedrich Alexander University, Erlangen, Germany
    Gastroenterology 145:1369-79. 2013
    ..Dysregulation of epithelial cell death has been implicated in barrier dysfunction and in the pathogenesis of intestinal inflammation. We investigated mechanisms of cell-death regulation in the intestinal epithelium of mice...
  66. doi request reprint Benign mesenchymal tumours and tumour-like lesions in end-stage renal disease
    Maike Büttner
    Institute of Pathology, Department of Nephropathology, University Hospital of Erlangen, Krankenhausstraße 8 10, Erlangen, Germany
    Histopathology 62:229-36. 2013
    ..A few haemangiomas have been reported in end-stage renal disease (ESRD) but, to date, no study has focused on the frequency and morphological spectrum of mesenchymal lesions in ESRD...
  67. doi request reprint PEG matrix enables cell-mediated local BMP-2 gene delivery and increased bone formation in a porcine critical size defect model of craniofacial bone regeneration
    Falk Wehrhan
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    Clin Oral Implants Res 23:805-13. 2012
    ..This study addressed the suitability of a polyethylene glycol (PEG) matrix as scaffold for cell-mediated local BMP-2 gene transfer in a calvarial critical size defect (CSD) model...
  68. pmc Unexpected recovery from longterm renal failure in severe diffuse proliferative lupus nephritis
    Sophia Ross
    Department of Pediatric Nephrology, University of Erlangen Nurnberg, Loschgestr 15, Erlangen D 91054, Germany
    BMC Nephrol 13:81. 2012
    ..Complete remission can be obtained, however, at least in the young when chronic lesions are absent and adequate anti-inflammatory therapy is immediately initiated...
  69. doi request reprint Oligohydramnios associated with sonographically normal kidneys
    Ulrike John
    Department of Pediatrics, University of Jena, Germany
    Urology 79:1155-7. 2012
    ..The diagnosis was confirmed by 2 heterozygous nonsense mutations of the ACE gene. Because the recurrence rate of RTD is 25% for the autosomal recessive trait, knowledge and genetic diagnosis of the disease is important for the parents...
  70. doi request reprint Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1
    Tina Gimm
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    FASEB J 24:4443-58. 2010
    ..HIG2 could be detected in atherosclerotic arteries and fatty liver disease, suggesting that this ubiquitously inducible HIF-1 target gene may play an important functional role in diseases associated with pathological lipid accumulation...
  71. doi request reprint White matter angiopathy is common in pediatric patients with intractable focal epilepsies
    Michelle Hildebrandt
    Neuropathological Reference Center for Epilepsy Surgery, Friedrich Alexander University Erlangen Nuremburg, Erlangen, Germany
    Epilepsia 49:804-15. 2008
    ..In the present study, we investigated pathomorphological abnormalities of blood vessels in a cohort of young patients with chronic intractable seizures submitted to an epilepsy surgery program...
  72. doi request reprint The implications of fetal programming of glomerular number and renal function
    Jorg Dotsch
    Department of Pediatric Nephrology, University of Erlangen Nuremberg, Loschgestrasse 15, 91054, Erlangen, Germany
    J Mol Med (Berl) 87:841-8. 2009
    ..g. changes in endothelial function). It also appears likely that the outcomes of fetal programming may be influenced postnatally, for example, by the amount of nutrients given at critical times...
  73. ncbi request reprint Glomerular regeneration is delayed in nephritic alpha 8-integrin-deficient mice: contribution of alpha 8-integrin to the regulation of mesangial cell apoptosis
    Andrea Hartner
    Hospital for Children and Adolescents, Erlangen, Germany
    Am J Nephrol 28:168-78. 2008
    ..We tested the hypothesis that alpha(8)-integrin is essential for the healing process after mesangioproliferative glomerulonephritis...
  74. doi request reprint Batf-dependent Th17 cells critically regulate IL-23 driven colitis-associated colon cancer
    Elise Punkenburg
    Department of Medicine 1, University Hospital Erlangen, University of Erlangen Nuremberg, Kussmaul Campus for Medical Research, Erlangen, Germany Max Eder Research Group supported by the German Cancer Aid, University Hospital Erlangen, Erlangen, Germany
    Gut 65:1139-50. 2016
    ..IBDs have an increased risk for development of colorectal cancer (CRC). Here, we aimed at the characterisation of the functional role of Th17-associated transcription factors in sporadic and colitis-associated colon cancer in vivo...
  75. pmc Comparison of different normalization strategies for the analysis of glomerular microRNAs in IgA nephropathy
    Clemens L Bockmeyer
    Department of Nephropathology, Friedrich Alexander University FAU Erlangen Nuremberg, Erlangen, Germany
    Sci Rep 6:31992. 2016
    ..It should be considered that significant differences could be missed using one particular normalization method. As a starting point for glomerular miRNA studies in IgA nephropathy we provide a library of miRNAs. ..
  76. pmc Cell cycle re-entry sensitizes podocytes to injury induced death
    Manuel Hagen
    a Department of Nephropathology, Friedrich Alexander University FAU Erlangen Nürnberg, Erlangen, Germany
    Cell Cycle 15:1929-37. 2016
    ..Therefore, this model is appropriate for testing new podocyte protective substances that can be used for therapy. ..
  77. pmc CD163+ M2c-like macrophages predominate in renal biopsies from patients with lupus nephritis
    Gregor Olmes
    Department of Nephropathology, Institute of Pathology, Friedrich Alexander University Erlangen Nürnberg FAU, Krankenhausstr 8 10, 91054, Erlangen, Germany
    Arthritis Res Ther 18:90. 2016
    ..Here we investigated whether the differentiation in M1- or M2-like macrophages depends on the stage of lupus nephritis and whether this correlates with clinical parameters...
  78. pmc Changes in glomerular parietal epithelial cells in mouse kidneys with advanced age
    Sebastian S Roeder
    Division of Nephrology, University of Washington, Seattle, Washington Friedrich Alexander Universität Erlangen Nürnberg FAU, Erlangen, Germany
    Am J Physiol Renal Physiol 309:F164-78. 2015
    ....
  79. pmc Renal leishmaniasis as unusual cause of nephrotic syndrome in an HIV patient
    Kerstin Amann
    Abt für Nephropathologie, Pathologisches Institut, Universitatsklinikum Erlangen, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    J Am Soc Nephrol 23:586-90. 2012
    ..The case presents several remarkable clinical, pathologic, and therapeutic aspects that may be important for daily clinical practice...
  80. pmc Long-term evaluation of a selective retrograde coronary venous perfusion model in pigs (Sus scrofa domestica)
    Frank Harig
    Center of Cardiac Surgery, University Hospital Erlangen, Erlangen, Germany
    Comp Med 61:150-7. 2011
    ..Venous retroperfusion is an effective technique to achieve long-term survival after acute occlusion of the left anterior descending artery in a pig model. In this model, proximal ligation of vena cordis magna is essential...
  81. doi request reprint Establishment of a streptozotocin-induced diabetic domestic pig model and a systematic evaluation of pathological changes in the hard and soft tissue over a 12-month period
    Cornelius von Wilmowsky
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    Clin Oral Implants Res 21:709-17. 2010
    ..Therefore, a diabetic animal model with high degree of similarities with humans, which is suitable for the systematic evaluation of biomaterials and medical devices, is needed...
  82. doi request reprint Endothelin in diabetic renal disease
    Kerstin Benz
    Departments for Pediatrics and Nephropathology, University of Erlangen Nurnberg, Erlangen, Germany
    Contrib Nephrol 172:139-48. 2011
    ..Thus, it appears currently of great scientific and clinical interest to shed some light on the role of the ET system and its blockade in diabetic nephropathy...
  83. doi request reprint Changes in 11beta-hydroxysteroid dehydrogenase type 2 expression in a low-protein rat model of intrauterine growth restriction
    Iris Ostreicher
    Department of Pediatrics and Adolescent Medicine, University Erlangen Nuremberg, Erlangen, Germany
    Nephrol Dial Transplant 25:3195-203. 2010
    ....
  84. doi request reprint CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity
    Julia Jellusova
    Department of Genetics, University of Erlangen, Erlangen, Germany
    J Immunol 184:3618-27. 2010
    ..These resulted in a moderate form of immune complex glomerulonephritis. These results show that Siglec-G and CD22 have partly compensatory functions and together are crucial in maintaining the B cell tolerance...
  85. doi request reprint Thrombotic microangiopathy: new insights
    Kerstin Benz
    Department of Pediatrics, University of Erlangen Nurnberg, Erlangen, Germany
    Curr Opin Nephrol Hypertens 19:242-7. 2010
    ....
  86. ncbi request reprint Statin treatment reduces glomerular inflammation and podocyte damage in rat deoxycorticosterone-acetate-salt hypertension
    Andrea Hartner
    Hospital for Children and Adolescents, Erlangen, Germany
    J Hypertens 27:376-85. 2009
    ..We examined the effects of fluvastatin treatment on the development of kidney injury in experimental deoxycorticosterone-acetate (DOCA)-salt hypertension...
  87. ncbi request reprint Laryngotracheal growth following cricotracheal resection combined with laminotomy. An experimental study on rabbits
    Mark Weidenbecher
    Department of Otolaryngology Head and Neck Surgery, University of of Erlangen Nuremberg, Erlangen, Germany
    Ann Otol Rhinol Laryngol 112:697-703. 2003
    ..Cricotracheal resection together with partial resection of the cricoid plate, however, leads to an unstable situation with an impaired airway...
  88. doi request reprint [Inflammatory myofibroblastic tumor of the lymph node with paraneoplastic thrombosis and eosinophilia]
    Ali Behzad
    Medizinische Klinik 5 Hämatologie and Internistische Onkologie, Universitatsklinikum Erlangen, Erlangen, Germany
    Med Klin (Munich) 105:232-6. 2010
    ..Anti-inflammatory medication with ibuprofen was subsequently initiated. Imaging and clinical examination at 3 months after discharge revealed no relapse and no signs of a paraneoplastic syndrome...
  89. ncbi request reprint Interforaminal implant therapy using a split skin graft--treatment outcome after 13 years
    Matthias Karl
    Department of Prosthodontics, University of Erlangen Nuremberg, Glueckstrasse 11, Erlangen, Germany
    Quintessence Int 40:191-4. 2009
    ..For the patient under examination, an acceptable level of oral rehabilitation was achieved using a split skin graft. The follow-up investigation showed stable conditions for both the implants and the graft...
  90. ncbi request reprint Cross-talk between the kidney and the cardiovascular system
    Kerstin Amann
    Department Pathology, Friedrich Alexander University Erlangen, Erlangen, Germany
    J Am Soc Nephrol 17:2112-9. 2006
    ..The most interesting unifying concept, however, is deranged fetal programming linking nephron underdosing to the increased cardiovascular risk...
  91. pmc Autonomic renal denervation ameliorates experimental glomerulonephritis
    Roland Veelken
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    J Am Soc Nephrol 19:1371-8. 2008
    ....
  92. ncbi request reprint Myocyte loss in early left ventricular hypertrophy of experimental renovascular hypertension
    Moriz Buzello
    Department of Pathology, University of Heidelberg, Germany
    Virchows Arch 442:364-71. 2003
    ..These observations document that experimental renovascular hypertension induces a rapidly developing LVH characterized by marked cardiac remodeling and substantial loss of cadiomyocytes...
  93. ncbi request reprint Plasminogen activator inhibitor-I-related regulation of procollagen I (alpha1 and alpha2) by antitransforming growth factor-beta1 treatment during radiation-impaired wound healing
    Stefan Schultze-Mosgau
    Department of Oral and Maxillofacial Surgery Plastic Surgery, Freidrich Schiller University of Jena, Jena, Germany
    Int J Radiat Oncol Biol Phys 64:280-8. 2006
    ..It is not known whether anti-TGF-beta1 treatment specifically inhibits alpha(I)-procollagen synthesis. We used an experimental wound healing study to address anti-TGF-beta1-associated influence on alpha(I)-procollagen synthesis...
  94. ncbi request reprint Transforming growth factor beta 1 dependent regulation of Tenascin-C in radiation impaired wound healing
    Falk Wehrhan
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Germany
    Radiother Oncol 72:297-303. 2004
    ..The aim of the study was to clarify the question whether Tenascin-C expression is elevated in radiation impaired wounds and whether anti-TGF beta(1)-treatment is capable to influence Tenascin-C and NF kappa B expression...
  95. ncbi request reprint Exogenous modulation of TGF-beta(1) influences TGF-betaR-III-associated vascularization during wound healing in irradiated tissue
    Falk Wehrhan
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Germany
    Strahlenther Onkol 180:526-33. 2004
    ..The aim of the study was to analyze the influence of anti-TGF-beta(1) treatment on TGF-betaR-III-associated vascularization in the transition area between irradiated graft bed and graft...
  96. ncbi request reprint Increased infarct size in uremic rats: reduced ischemia tolerance?
    Ralf Dikow
    University Hospital of Heidelberg, Bergheimerstrasse 561, 69115 Heidelberg, Germany
    J Am Soc Nephrol 15:1530-6. 2004
    ..The findings could explain the high rate of death from MI in patients with impaired renal function...
  97. ncbi request reprint Smad-3 and Smad-7 expression following anti-transforming growth factor beta 1 (TGFbeta1)-treatment in irradiated rat tissue
    Stefan Schultze-Mosgau
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Glueckstrasse 11, 91054 Erlangen, Germany
    Radiother Oncol 70:249-59. 2004
    ....
  98. ncbi request reprint Effect of endothelin blockade on early cardiovascular remodeling in the one-clip-two-kidney hypertension of the rat
    Tobias Saam
    Department of Nephrology, University of Heidelberg, Germany
    Kidney Blood Press Res 26:325-32. 2003
    ..The effects of ET(A) receptor blockade (ET(A)-RB) on vascular remodeling and their potential relation to BP lowering, have not been clarified...
  99. ncbi request reprint 1,25-Dihydroxyvitamin D3 decreases podocyte loss and podocyte hypertrophy in the subtotally nephrectomized rat
    Alexander Kuhlmann
    Department of Pathology, Universitiy of Erlangen Nuremberg, Krankenhausstr 8 10, D 91054 Erlangen, Germany
    Am J Physiol Renal Physiol 286:F526-33. 2004
    ..This notion is suggested by less evidence of podocyte injury, decreased podocytes loss, and abrogation of podocyte hypertrophy, findings that may also explain less pronounced albuminuria and glomerulosclerosis...
  100. ncbi request reprint Reversal of glomerulosclerosis after high-dose enalapril treatment in subtotally nephrectomized rats
    Marcin Adamczak
    Department of Internal Medicine, University of Heidelberg, Germany
    J Am Soc Nephrol 14:2833-42. 2003
    ..The study confirms that high-dose ACE inhibitor treatment causes partial reversal of glomerular as well as interstitial lesions in subtotally nephrectomized rats...
  101. ncbi request reprint Beneficial and adverse renal and vascular effects of the vasopeptidase inhibitor omapatrilat in renovascular hypertensive rats
    Ulrich O Wenzel
    University Hospital of Hamburg Eppendorf, Department of Medicine, Division of Nephrology, Pav 61, Martinistrasse 52, D 20246 Hamburg, Germany
    Nephrol Dial Transplant 18:2005-13. 2003
    ....