T Aigner

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi request reprint Gene expression in chondrocytes assessed with use of microarrays
    Thomas Aigner
    Department of Pathology, University of Erlangen Nurnberg, Germany
    J Bone Joint Surg Am 85:117-23. 2003
  2. ncbi request reprint Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis
    Thomas Aigner
    Osteoarticular and Arthritis Research, Institute of Pathology, University of Leipzig, Liebigstrasse 26, D 04103 Leipzig, Germany
    Arthritis Rheum 54:3533-44. 2006
  3. ncbi request reprint Functional genomics of osteoarthritis: on the way to evaluate disease hypotheses
    Thomas Aigner
    Department of Pathology, Osteoarticular and Arthritis Research, University of Erlangen Nurnberg, Erlangen, Germany
    Clin Orthop Relat Res . 2004
  4. pmc Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage
    Mathias Gebauer
    Aventis Pharma Deutschland, Functional Genomics, Sanofi Aventis, Frankfurt, Germany
    Arthritis Res Ther 7:R274-84. 2005
  5. ncbi request reprint Genomics of osteoarthritis
    Thomas Aigner
    Cartilage Research Group, Department of Pathology, University of Erlangen Nurnberg, Erlangen Germany
    Curr Opin Rheumatol 15:634-40. 2003
  6. ncbi request reprint Roles of chondrocytes in the pathogenesis of osteoarthritis
    Thomas Aigner
    Cartilage Research Group, Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Curr Opin Rheumatol 14:578-84. 2002
  7. ncbi request reprint Apoptosis and cellular vitality: issues in osteoarthritic cartilage degeneration
    T Aigner
    University of Erlangen Nurnberg, Erlangen, Germany
    Arthritis Rheum 46:1986-96. 2002
  8. ncbi request reprint Functional genomics of osteoarthritis
    Thomas Aigner
    Cartilage Research, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10D 91054 Erlangen, FRG, Germany
    Pharmacogenomics 3:635-50. 2002
  9. ncbi request reprint Towards a new understanding and classification of chondrogenic neoplasias of the skeleton--biochemistry and cell biology of chondrosarcoma and its variants
    T Aigner
    Cartilage Research, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    Virchows Arch 441:219-30. 2002
  10. ncbi request reprint Molecular pathology and pathobiology of osteoarthritic cartilage
    T Aigner
    Institute of Pathology, University of Erlangen Nurnberg, Germany
    Cell Mol Life Sci 59:5-18. 2002

Detail Information

Publications113 found, 100 shown here

  1. ncbi request reprint Gene expression in chondrocytes assessed with use of microarrays
    Thomas Aigner
    Department of Pathology, University of Erlangen Nurnberg, Germany
    J Bone Joint Surg Am 85:117-23. 2003
    ..This has been shown to be true for the analysis of known genes as well as the discovery of new genes of interest...
  2. ncbi request reprint Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis
    Thomas Aigner
    Osteoarticular and Arthritis Research, Institute of Pathology, University of Leipzig, Liebigstrasse 26, D 04103 Leipzig, Germany
    Arthritis Rheum 54:3533-44. 2006
    ..The present study was therefore initiated in order to identify differentially expressed disease-related genes and potential therapeutic targets...
  3. ncbi request reprint Functional genomics of osteoarthritis: on the way to evaluate disease hypotheses
    Thomas Aigner
    Department of Pathology, Osteoarticular and Arthritis Research, University of Erlangen Nurnberg, Erlangen, Germany
    Clin Orthop Relat Res . 2004
    ..However, the expression pattern of the plethora of expressed genes will paint a picture (network) of disease context, maybe even more pushing forward our understanding of complex diseases such as osteoarthritis...
  4. pmc Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage
    Mathias Gebauer
    Aventis Pharma Deutschland, Functional Genomics, Sanofi Aventis, Frankfurt, Germany
    Arthritis Res Ther 7:R274-84. 2005
    ..Activation, the reinitiation of proliferative activity and the loss of a stable phenotype are three major changes in osteoarthritic chondrocytes that are highly significantly correlated with the repression of Tob1 expression...
  5. ncbi request reprint Genomics of osteoarthritis
    Thomas Aigner
    Cartilage Research Group, Department of Pathology, University of Erlangen Nurnberg, Erlangen Germany
    Curr Opin Rheumatol 15:634-40. 2003
    ....
  6. ncbi request reprint Roles of chondrocytes in the pathogenesis of osteoarthritis
    Thomas Aigner
    Cartilage Research Group, Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Curr Opin Rheumatol 14:578-84. 2002
    ..Methodologically, the past year has seen the first steps of functional genomics in osteoarthritis research, providing new insights into the cell biology of this condition...
  7. ncbi request reprint Apoptosis and cellular vitality: issues in osteoarthritic cartilage degeneration
    T Aigner
    University of Erlangen Nurnberg, Erlangen, Germany
    Arthritis Rheum 46:1986-96. 2002
  8. ncbi request reprint Functional genomics of osteoarthritis
    Thomas Aigner
    Cartilage Research, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10D 91054 Erlangen, FRG, Germany
    Pharmacogenomics 3:635-50. 2002
    ..However, care must be taken not to over or misinterpret results and some major challenges must be overcome in order to properly utilize the potential of this technology in the field of osteoarthritis...
  9. ncbi request reprint Towards a new understanding and classification of chondrogenic neoplasias of the skeleton--biochemistry and cell biology of chondrosarcoma and its variants
    T Aigner
    Cartilage Research, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    Virchows Arch 441:219-30. 2002
    ....
  10. ncbi request reprint Molecular pathology and pathobiology of osteoarthritic cartilage
    T Aigner
    Institute of Pathology, University of Erlangen Nurnberg, Germany
    Cell Mol Life Sci 59:5-18. 2002
    ..Gene expression mapping in situ and gene expression profiling allows characterization of the osteoarthritic cellular phenotype, a key determinant for understanding and manipulating the osteoarthritic disease process...
  11. ncbi request reprint The C5 domain of Col6A3 is cleaved off from the Col6 fibrils immediately after secretion
    T Aigner
    Cartilage Research Group, Department of Pathology, University of Erlangen Nurnberg, Erlangen, Federal Republic of Germany
    Biochem Biophys Res Commun 290:743-8. 2002
    ....
  12. ncbi request reprint Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology
    T Aigner
    Cartilage Research, Department of Pathology, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 44:2777-89. 2001
    ..To understand changes in gene expression levels that occur during osteoarthritic (OA) cartilage degeneration, using complementary DNA (cDNA)-array technology...
  13. pmc Cell differentiation and matrix gene expression in mesenchymal chondrosarcomas
    T Aigner
    Institute of Pathology, the University of Erlangen Nürnberg, Erlangen, Germany
    Am J Pathol 156:1327-35. 2000
    ....
  14. ncbi request reprint SOX9 expression does not correlate with type II collagen expression in adult articular chondrocytes
    Thomas Aigner
    Cartilage Research, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, Erlangen 91504, Germany
    Matrix Biol 22:363-72. 2003
    ..However, SOX9 might still be involved in maintaining the chondrocytic phenotype in normal and osteoarthritic cartilage...
  15. ncbi request reprint Apoptosis in osteoarthritis
    Thomas Aigner
    Osteoarticular and Arthritis Research, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    Rheum Dis Clin North Am 30:639-53, xi. 2004
    ....
  16. ncbi request reprint Collagens--major component of the physiological cartilage matrix, major target of cartilage degeneration, major tool in cartilage repair
    T Aigner
    Cartilage Research, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10, 91054 Erlangen, Germany
    Adv Drug Deliv Rev 55:1569-93. 2003
    ..Thus, collagens are not only major constituents of connective tissues in terms of integrity and function, they are also major targets of tissue destruction and regeneration and might become major tools to achieve tissue repair...
  17. ncbi request reprint Gene expression profiling of serum- and interleukin-1 beta-stimulated primary human adult articular chondrocytes--a molecular analysis based on chondrocytes isolated from one donor
    Thomas Aigner
    Osteoarticular and Arthritis Research, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10, D 91054 Erlangen, FRG
    Cytokine 31:227-40. 2005
    ..In contrast, IL-1beta did not appear to be a good model for mimicking catabolic gene alterations in degenerating chondrocytes...
  18. ncbi request reprint [Neoplastic chondroneogenesis as a characteristic of mesenchymal chondrosarcomas]
    C M Schörle
    Schwerpunkt Knorpelforschung Osteoarthrose, Pathologisches Institut, Universitat Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen
    Orthopade 31:544-50. 2002
    ..The results characterize mesenchymal chondrosarcomas as skeletal malignancies that arise from undifferentiated chondroprogenitor cells and have the potential to undergo all steps of chondrocytic differentiation...
  19. ncbi request reprint Cell biology and matrix biochemistry of chondromyxoid fibroma
    S Soder
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10, D 91054 Erlangen, Germany
    Am J Clin Pathol 116:271-7. 2001
    ..This justifies chondromyxoid fibroma as a specific neoplastic entity, both clinically and biologically...
  20. ncbi request reprint Chondroblastoma is an osteoid-forming, but not cartilage-forming neoplasm
    T Aigner
    Institute of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, D 91054 Erlangen, Germany
    J Pathol 189:463-9. 1999
    ..This study did not show chondroid matrix formation or chondroblastic cell differentiation in chondroblastomas, suggesting that chondroblastoma should be classified as a specific bone-forming, rather than cartilage-forming neoplasm...
  21. ncbi request reprint Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage: a study of proliferation, programmed cell death (apoptosis), and viability of chondrocytes in normal and osteoarthritic human knee carti
    T Aigner
    Department of Pathology, University of Erlangen-Nuremberg, Erlangen, Germany
    Arthritis Rheum 44:1304-12. 2001
    ..They also show that, contrary to previous suggestions, apoptotic cell death is not a widespread phenomenon in aging or OA cartilage...
  22. ncbi request reprint Type II collagen, but not aggrecan expression, distinguishes clear cell chondrosarcoma and chondroblastoma
    S Soder
    Department of Pathology, University of Leipzig, Leipzig, FRG
    Pathology 38:35-8. 2006
    ..Thus, it can be difficult both radiographically and histologically to distinguish these neoplasms. So far there are no immunohistochemical markers available that have been shown to be helpful in differentiating these neoplasms...
  23. ncbi request reprint Phenotypic characterization of chondrosarcoma-derived cell lines
    C M Schörle
    Osteoarticular and Arthritis Research, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10, D 91054 Erlangen, Germany
    Cancer Lett 226:143-54. 2005
    ..Thus, the investigated cell lines are of limited value as substitute of primary chondrocytes but might have a much higher potential to investigate the behavior of neoplastic chondrocytes, i.e. chondrosarcoma biology...
  24. ncbi request reprint CDRAP is expressed in adult articular cartilage, but its expression is not significantly regulated in osteoarthritic chondrocytes
    J Rose
    Osteoarticular and Arthritis Research, Department of Pathology, University of Erlangen Nurnberg, Germany
    Clin Exp Rheumatol 24:573-5. 2006
    ..In this study we assessed the differential in vivo mRNA expression levels of CDRAP, a potential marker of cartilage degeneration...
  25. ncbi request reprint Regulation of anabolic and catabolic gene expression in normal and osteoarthritic adult human articular chondrocytes by osteogenic protein-1
    Z Fan
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10, D 91054 Erlangen, Germany
    Clin Exp Rheumatol 22:103-6. 2004
    ....
  26. ncbi request reprint Molecular phenotyping of human chondrocyte cell lines T/C-28a2, T/C-28a4, and C-28/I2
    F Finger
    University of Erlangen Nurnberg, Erlangen, Germany
    Arthritis Rheum 48:3395-403. 2003
    ....
  27. ncbi request reprint MMP-9/gelatinase B is a gene product of human adult articular chondrocytes and increased in osteoarthritic cartilage
    S Soder
    Institute of Pathology, University of Leipzig, Germany
    Clin Exp Rheumatol 24:302-4. 2006
    ....
  28. ncbi request reprint Comparative analysis of imbalances in genomic DNA and mRNA expression levels in chondrosarcoma-derived cell line FSCP-1
    C M Schörle
    Cartilage Research, Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Int J Oncol 25:1651-60. 2004
    ..However, genes such as c-myc might represent significant exceptions potentially relevant for the clinico-biological behavior of the neoplasms...
  29. ncbi request reprint Isolation of RNA from small human articular cartilage specimens allows quantification of mRNA expression levels in local articular cartilage defects
    A Gehrsitz
    Cartilage Research Group, Institute of Pathology, , Erlangen, Germany
    J Orthop Res 19:478-81. 2001
    ..We were able to analyse the expression levels of several genes in parallel including aggrecan and type II collagen...
  30. pmc Matrix gene expression analysis and cellular phenotyping in chordoma reveals focal differentiation pattern of neoplastic cells mimicking nucleus pulposus development
    D Gottschalk
    Department of Pathology, , Erlangen, Germany
    Am J Pathol 158:1571-8. 2001
    ..Our study firmly establishes a focal real chondrocytic phenotype of neoplastic cells in chordomas. Chondroid chordoma is neither a low-grade chondrosarcoma nor a misnomer as discussed previously...
  31. pmc DNA methylation is not likely to be responsible for aggrecan down regulation in aged or osteoarthritic cartilage
    E Poschl
    Department of Experimental Medicine, University of Erlangen Nurnberg, Glückstr 6, 91054 Erlangen, Germany
    Ann Rheum Dis 64:477-80. 2005
    ..Expression of aggrecan is reduced during aging and osteoarthritic cartilage degeneration. CpG methylation may have a role in the down regulation of aggrecan transcriptions...
  32. ncbi request reprint Immunolocalization of matrix proteins in different human cartilage subtypes
    L Wachsmuth
    Department of Pathology, University of Erlangen Nurnberg, Germany
    Histol Histopathol 21:477-85. 2006
    ..In this study, we present a biochemical profile of the major cartilage types of the human body which is important for understanding the physiology and the pathophysiology of cartilages...
  33. ncbi request reprint Ultrastructural localization of type VI collagen in normal adult and osteoarthritic human articular cartilage
    S Soder
    Cartilage Research, Department of Pathology, University of Erlangen Nurnberg, Germany
    Osteoarthritis Cartilage 10:464-70. 2002
    ..Additionally, we were interested in its ultrastructural appearance in normal and osteoarthritic cartilage...
  34. ncbi request reprint Mesenchymal chondrosarcoma: an immunohistochemical study of 10 cases examining prognostic significance of proliferative activity and cellular differentiation
    W Nussbeck
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Pathology 36:230-3. 2004
    ..The prognosis is unpredictable, and the identification of prognostic markers that could aid in determining the behaviour of this tumour would be helpful. There are few studies in the literature that have attempted to address this issue...
  35. ncbi request reprint Osteophyte development--molecular characterization of differentiation stages
    K Gelse
    Cartilage Research, Department of Pathology, University of Erlangen Nurnberg, Federal Republic of Germany
    Osteoarthritis Cartilage 11:141-8. 2003
    ..Our focus was to identify different steps of osteophyte development via analysis of expression patterns of marker genes of chondrocytic differentiation...
  36. doi request reprint DNA methylation is not responsible for p21WAF1/CIP1 down-regulation in osteoarthritic chondrocytes
    S Sesselmann
    Institute of Pathology, University Hospital Erlangen, Krankenhausstr 12, 91054 Erlangen, Germany
    Osteoarthritis Cartilage 17:507-12. 2009
    ..p21(WAF1/CIP1) was previously suggested to be down-regulated in OA chondrocytes and is known to be regulated by epigenetic modulation...
  37. ncbi request reprint MMP-2/gelatinase A is a gene product of human adult articular chondrocytes and is increased in osteoarthritic cartilage
    S Duerr
    Osteoarticular and Arthritis Research, Department of Pathology, University of Erlangen Nurnberg, Germany
    Clin Exp Rheumatol 22:603-8. 2004
    ....
  38. ncbi request reprint Osteoarthritis: aging of matrix and cells--going for a remedy
    T Aigner
    Institute of Pathology, University of Leipzig, Liebigstr 26, D 04301 Leipzig, FRG
    Curr Drug Targets 8:325-31. 2007
    ..However, this review intends to open up the idea that age-related changes are less a fate, but rather a challenge for therapeutic intervention which can be taken...
  39. doi request reprint Comparison of histological parameters for the diagnosis of eosinophilic oesophagitis versus gastro-oesophageal reflux disease on oesophageal biopsy material
    S Mueller
    Institute of Pathology, University of Munich, Munich, Germany
    Histopathology 53:676-84. 2008
    ..The aim was to compare histological parameters for the diagnosis of EO versus GORD on routinely taken biopsy specimens...
  40. ncbi request reprint Role of growth factors in rabbit articular cartilage repair by chondrocytes in agarose
    J Weisser
    Institute of Pathology, University of Jena, Germany
    Osteoarthritis Cartilage 9:S48-54. 2001
    ..Therefore, we have explored the possibility whether chondrocytes embedded into agarose gels provided better graft tissues in a repair model of full thickness defects in rabbit joint cartilage...
  41. ncbi request reprint Fibroblast-mediated delivery of growth factor complementary DNA into mouse joints induces chondrogenesis but avoids the disadvantages of direct viral gene transfer
    K Gelse
    Department of Experimental Medicine I, University of Erlangen-Nuremberg, Erlangen, Germany
    Arthritis Rheum 44:1943-53. 2001
    ..CONCLUSION: Our results indicate that cell-mediated gene transfer provides sufficient BMP-2 levels in the joint to induce cartilage formation while avoiding inadvertent vector spread and immune reactions...
  42. pmc YKL-39 (chitinase 3-like protein 2), but not YKL-40 (chitinase 3-like protein 1), is up regulated in osteoarthritic chondrocytes
    T Knorr
    Cartilage Research, Department of Pathology, University of Erlangen Nurnberg, FRG
    Ann Rheum Dis 62:995-8. 2003
    ..To investigate quantitatively the mRNA expression levels of YKL-40, an established marker of rheumatoid and osteoarthritic cartilage degeneration in synovial fluid and serum, and a closely related molecule YKL-39, in articular chondrocytes...
  43. ncbi request reprint Tenascin: a sensitive and specific diagnostic marker of minimal collagenous colitis
    S Muller
    Department of Pathology, University of Erlangen Nurnberg, Germany
    Virchows Arch 438:435-41. 2001
    ..Tenascin immunostaining is a simple and safe tool to complement conventional histological diagnostics in clinically and histopathologically unclear cases of diarrhea...
  44. ncbi request reprint [Characterisation and differentiation of chondroblastomas and chondromyxoidfibromas - presence and expression of collagen types I and II]
    C M Schörle
    Pathologisches Institut, Universitat Erlangen Nurnberg, Erlangen, Germany
    Z Orthop Ihre Grenzgeb 140:208-13. 2002
    ..Aim of this study was to analyse the biochemical composition of the matrix of these tumour entities in order to further characterise the cellular phenotypes of these neoplasms using typical cell biological marker genes...
  45. ncbi request reprint Targets to tackle--the pathophysiology of the disease
    N Schmitz
    Department of Pathology, University of Leipzig, Liebigstrasse 26, 04103 Leipzig, Germany
    Curr Drug Targets 11:521-7. 2010
    ..It is evident that there is a great need for the development of disease modifying agents in order to improve quality of life as well as to relieve the community of the enormous socio-economic burden of the disease...
  46. doi request reprint Efficient non-viral transfection of primary human adult chondrocytes in a high-throughput format
    J Haag
    Institute of Pathology, University Hospital Leipzig, Leipzig, Germany
    Osteoarthritis Cartilage 17:813-7. 2009
    ..The development of a reliable high-throughput transfection protocol for primary human articular chondrocytes...
  47. doi request reprint Basic methods in histopathology of joint tissues
    N Schmitz
    Institute of Pathology, University of Leipzig, Liebigstrasse 26, D 04103 Leipzig, Germany
    Osteoarthritis Cartilage 18:S113-6. 2010
    ....
  48. doi request reprint [Osteoarthritis. Etiology, typing, staging and histological grading]
    S Soder
    Pathologisches Institut, Universitatsklinikum Erlangen, Krankenhausstr 8 10, 91054, Erlangen
    Pathologe 32:183-92. 2011
    ..Differentiating between primary osteoarthritis and secondary degenerative changes, e.g., due to previously unknown rheumatoid disease, bone necrosis or an infection of the joint, is of particular clinical interest...
  49. ncbi request reprint IL-1beta and BMPs--interactive players of cartilage matrix degradation and regeneration
    T Aigner
    Institute of Pathology, University of Leipzig, 04103 Leipzig, Germany
    Eur Cell Mater 12:49-56; discussion 56. 2006
    ..Thus, it might be neither the aim of osteoarthritis therapy to foster anabolism nor to knock down catabolism, but the balance of anabolic-catabolic activities as a total might need proper titration and balancing...
  50. ncbi request reprint Bone morphogenetic protein-7 expression and activity in the human adult normal kidney is predominantly localized to the distal nephron
    P Wetzel
    Osteoarticular and Arthritis Research, Department of Pathology, University of Erlangen Nurnberg, Erlangen, FRG
    Kidney Int 70:717-23. 2006
    ..These findings suggest that BMP-7 plays a physiological role mostly in this part of the kidney. Still, as reported previously, PTCs are responsive to BMP-7, but presumably not in an autocrine or paracrine mode in normal adult kidneys...
  51. ncbi request reprint MMP-8 is only a minor gene product of human adult articular chondrocytes of the knee
    S Stremme
    Department of Pathology, University of Erlangen, Nurnberg, Germany
    Clin Exp Rheumatol 21:205-9. 2003
    ..The objective of this study was to determine the quantitative expression as well as distribution levels in normal and osteoarthritic cartilage and synovium and in cultured articular chondrocytes with and without stimulation by Il-1 beta...
  52. ncbi request reprint Hypoxia-inducible factor 1alpha is involved in the prostaglandin metabolism of osteoarthritic cartilage through up-regulation of microsomal prostaglandin E synthase 1 in articular chondrocytes
    C Grimmer
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 56:4084-94. 2007
    ....
  53. doi request reprint SOX gene expression in human osteoarthritic cartilage
    Jochen Haag
    Institute of Pathology, University Hospital Leipzig, Leipzig, Germany
    Pathobiology 75:195-9. 2008
    ..Therefore, the aim of the present study was to present a thorough analysis of SOX gene expression in normal and osteoarthritic human adult cartilage...
  54. ncbi request reprint Bone morphogenetic protein and transforming growth factor beta inhibitory Smads 6 and 7 are expressed in human adult normal and osteoarthritic cartilage in vivo and are differentially regulated in vitro by interleukin-1beta
    Martina Kaiser
    Osteoarticular and Artheritis Research, Dept, or Pathology, University of Erlangen Nuremberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    Arthritis Rheum 50:3535-40. 2004
    ....
  55. ncbi request reprint Hepatocyte growth factor/scatter factor is not a potent regulator of anabolic and catabolic gene expression in adult human articular chondrocytes
    Brigitte Bau
    Osteoarticular and Arthritis Research, Department of Pathology, University of Erlangen Nurnberg, Erlangen D 91054, Germany
    Biochem Biophys Res Commun 316:984-90. 2004
    ....
  56. ncbi request reprint Freshly isolated osteoarthritic chondrocytes are catabolically more active than normal chondrocytes, but less responsive to catabolic stimulation with interleukin-1beta
    Zhiyong Fan
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, D 91054 Erlangen, Germany
    Arthritis Rheum 52:136-43. 2005
    ..Determination of whether there was a difference in reactivity between normal and osteoarthritic chondrocytes was also a goal of this study...
  57. ncbi request reprint Collagens--structure, function, and biosynthesis
    K Gelse
    Cartilage Research, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10, D 91054 Erlangen, Germany
    Adv Drug Deliv Rev 55:1531-46. 2003
    ....
  58. ncbi request reprint Highly enhanced expression of the disintegrin metalloproteinase MDC15 (metargidin) in rheumatoid synovial tissue
    B B Böhm
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 44:2046-54. 2001
    ....
  59. doi request reprint Histopathology atlas of animal model systems - overview of guiding principles
    T Aigner
    Institute of Pathology, Medical Center Coburg, Ketschendorferstr 33, 96450 Coburg, Germany
    Osteoarthritis Cartilage 18:S2-6. 2010
    ..Use of such systems, independently or in conjunction with other systems in parallel, should facilitate comparability of results across animal model studies...
  60. ncbi request reprint [B-cell lymphoma of the testes]
    V Zugor
    Urologische Klinik mit Poliklinik, Friedrich Alexander Universitat Erlangen Nurnberg, Krankenhausstrasse 12, 91054, Erlangen, Germany
    Urologe A 45:1308-11. 2006
    ..This article presents two adults aged 67 and 75 years with histologically proven B-cell lymphoma of the testes and discusses the characteristics of this relatively rare clinical picture as well as treatment and prognosis...
  61. pmc Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels
    Claudia Grimmer
    Division of Orthopedic Rheumatology, Department of Orthopedic Surgery im Waldkrankenhaus St Marien, University of Erlangen Nuremberg, Rathsbergerstrasse 57, D 91054 Erlangen, Germany
    Am J Pathol 169:491-502. 2006
    ....
  62. ncbi request reprint Parosteal lipoma of the thigh with cartilaginous and osseous differentiation: an osteochondrolipoma
    Tilman Rau
    Department of Pathology, Friedrich Alexander University of Erlangen Nuremberg, D 91054 Erlangen, Germany
    Ann Diagn Pathol 10:279-82. 2006
    ..Such a multidirectional potential was recently well established in vitro in stem cells present in adult adipocytic tissue...
  63. ncbi request reprint Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis--structure, chaos and senescence
    Thomas Aigner
    Institute of Pathology, University of Leipzig, Germany
    Nat Clin Pract Rheumatol 3:391-9. 2007
    ..Thus, anti-aging strategies might complement existing therapeutic targets related to anabolism, catabolism, inflammation, and apoptosis-processes that are integral to the pathogenesis of osteoarthritis...
  64. pmc Osteomyelitis of the ulna caused by Porphyromonas gingivalis
    Heike Welkerling
    Department of Orthopaedic Surgery, Friedrich Alexander University Erlangen Nürnberg Rathsberger Strasse 57, 91054 Erlangen, Germany
    J Clin Microbiol 44:3835-7. 2006
    ..No microorganism could be grown from an intraoperative tissue specimen, but bacterial 16S rRNA genes were detected by broad-range PCR, revealing Porphyromonas gingivalis as the causative agent of osteomyelitis...
  65. ncbi request reprint Analysis of differential gene expression in healthy and osteoarthritic cartilage and isolated chondrocytes by microarray analysis
    Thomas Aigner
    Cartilege Research, Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Methods Mol Med 100:109-28. 2004
    ..However, care has to be taken not to over- and misinterpret results, and some major challenges must be overcome in order to utilize the potential of this technology properly in the field of osteoarthritis...
  66. ncbi request reprint ADAMTS-1, a gene product of articular chondrocytes in vivo and in vitro, is downregulated by interleukin 1beta
    Lydia Wachsmuth
    Cartilage Research Unit, Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    J Rheumatol 31:315-20. 2004
    ....
  67. ncbi request reprint Down-regulation of the GTPase RhoB might be involved in the pre-apoptotic phenotype of osteoarthritic chondrocytes
    Pia M Gebhard
    Cartilage Research, Department of Pathology, University of Erlangen Nurnberg, FRG
    Front Biosci 9:827-33. 2004
    ....
  68. ncbi request reprint Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities
    Martin Zenker
    Institute of Human Genetics, Schwabachanlage 10, 91054 Erlangen, Germany
    Hum Mol Genet 13:2625-32. 2004
    ..In addition, components of the molecular interface between GBM and podocyte foot processes come in the focus as potential candidates for isolated and syndromic CNS...
  69. ncbi request reprint Quantification of expression levels of cellular differentiation markers does not support a general shift in the cellular phenotype of osteoarthritic chondrocytes
    Pia Margarethe Gebhard
    Cartilage Research, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, FRG, Germany
    J Orthop Res 21:96-101. 2003
    ..The largely unchanged ratios of collagen subtypes investigated indicate that no general shift in the cellular phenotype does occur in osteoarthritic cartilage as suggested by previous investigations...
  70. ncbi request reprint [Metastatic alveolar soft tissue sarcoma in a 26-year-old patient]
    Sabine Zirlik
    Medizinische Klinik I mit Poliklinik der Friedrich Alexander Universität Erlangen Nürnberg, Erlangen
    Med Klin (Munich) 99:682-3. 2004
  71. ncbi request reprint Achondrogenesis Type IA (Houston-Harris): a still-unresolved molecular phenotype
    Thomas Aigner
    Institute of Pathology, Liebigstrasse 26, Leipzig, Germany
    Pediatr Dev Pathol 10:328-34. 2007
    ..Presumably, as a consequence of this event, processes of chondrocyte maturation and differentiation and endochondral bone formation are severely affected in this case of achondrogenesis type IA...
  72. ncbi request reprint Functional genomics, evo-devo and systems biology: a chance to overcome complexity?
    Thomas Aigner
    Institute of Pathology, University of Leipzig, Leipzig, Germany
    Curr Opin Rheumatol 19:463-70. 2007
    ..This review addresses the key question of how to integrate a high complexity of processes and data to a unifying picture of disease processes and progression relevant for osteoarthritis...
  73. ncbi request reprint Phenotypic characterization of human chondrocyte cell line C-20/A4: a comparison between monolayer and alginate suspension culture
    Florian Finger
    Osteoarticular and Arthritis Research, Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Cells Tissues Organs 178:65-77. 2004
    ..These results indicate that immortalized chondrocyte cell lines, rather than substituting for primary chondrocytes, may serve as models for extending findings on chondrocyte function not achievable by the use of primary chondrocytes...
  74. ncbi request reprint Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro
    Brigitte Bau
    Cartilage Research, Department of Pathology, University of Erlangen Nuremberg, Krankenhausstrasse 8 10, D 91054 Erlangen, Germany
    Arthritis Rheum 46:2648-57. 2002
    ....
  75. ncbi request reprint Role of mitogen-activated protein kinases and NFkappaB on IL-1beta-induced effects on collagen type II, MMP-1 and 13 mRNA expression in normal articular human chondrocytes
    Zhiyong Fan
    Osteoarticular and Arthritis Research Group, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr, 8 10, 91054 Erlangen, Germany
    Rheumatol Int 26:900-3. 2006
    ..Our data suggest that ERK and NFkB pathways are particularly important for IL-1beta regulating collagen type II and MMP-1 and -13 expression and that p38, but not JNK is additionally involved in MMP-1 and -13 induction...
  76. ncbi request reprint Expression of cartilage-specific markers in calcified and non-calcified atherosclerotic lesions
    Thomas Aigner
    Institute of Pathology, University of Leipzig, Liebigstr 26, D 04103 Leipzig, Germany
    Atherosclerosis 196:37-41. 2008
    ..Occasionally, however, chondrocytic differentiation markers occur within atherosclerotic lesions. This most likely represents a metaplastic event associated, but not causative for atherosclerotic vessel degeneration and calcification...
  77. ncbi request reprint [Allergy-associated colitis. Characterization of an entity and its differential diagnoses]
    Susanna Müller
    Pathologisches Institut, Universitat Erlangen Nurnberg, Erlangen
    Pathologe 24:28-35. 2003
    ..Despite characteristic histologic changes in colonic biopsy specimens, a final diagnosis depends on careful clinical examination and exclusion of several differential diagnoses...
  78. ncbi request reprint Growth plate cartilage as developmental model in osteoarthritis research--potentials and limitations
    T Aigner
    Institute of Pathology, University of Leipzig, Liebigstr 26, 0341 Leipzig, FRG
    Curr Drug Targets 8:377-85. 2007
    ....
  79. ncbi request reprint Aging theories of primary osteoarthritis: from epidemiology to molecular biology
    T Aigner
    Osteoarticular and Arthritis Research Group, Department of Pathology, University of Erlangen Nurnberg, Germany
    Rejuvenation Res 7:134-45. 2004
    ....
  80. ncbi request reprint Osteoarthritis: pathobiology-targets and ways for therapeutic intervention
    T Aigner
    Institute of Pathology, University of Leipzig, Liebigstrasse 26, 04103 Leipzig, Germany
    Adv Drug Deliv Rev 58:128-49. 2006
    ..All the named tissues offer different directions and ways for therapeutic intervention...
  81. ncbi request reprint Extraskeletal myxoid chondrosarcomas do not show a chondrocytic phenotype
    Thomas Aigner
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Mod Pathol 17:214-21. 2004
    ..Chondrocytic differentiation is an unusual facet in the spectrum of differentiation patterns exhibited by these lesions...
  82. ncbi request reprint Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells
    Kolja Gelse
    University of Erlangen Nuernberg, Erlangen, Germany
    Arthritis Rheum 48:430-41. 2003
    ..To investigate the repair of partial-thickness lesions in rat articular cartilage by combining cell transplantation with transfer of growth factor complementary DNA (cDNA)...
  83. ncbi request reprint Identification of calponin 3 as a novel Smad-binding modulator of BMP signaling expressed in cartilage
    Jochen Haag
    Cartilage Research, Department of Pathology, University of Leipzig, Liebigstrasse 26, 04103, Leipzig, Germany
    Exp Cell Res 313:3386-94. 2007
    ..Furthermore, our data provide a possible explanation for the effect of the related protein calponin 1 on bone and cartilage development...
  84. pmc Activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilage
    Zhiyong Fan
    Department of Pathology, University of Erlangen, Erlangen, Germany
    Am J Pathol 171:938-46. 2007
    ..Second, IL-1 seems to be involved in normal cartilage tissue homeostasis as shown by identification of baseline expression patterns and signaling cascade activation...
  85. ncbi request reprint Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling
    Beate B Böhm
    Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 52:1100-9. 2005
    ..In addition, a human chondrocyte cell line overexpressing ADAM15 was used to investigate the role of ADAM15 in an in vitro model of chondrocyte-matrix interactions...
  86. ncbi request reprint Bone morphogenetic protein-mediating receptor-associated Smads as well as common Smad are expressed in human articular chondrocytes but not up-regulated or down-regulated in osteoarthritic cartilage
    Brigitte Bau
    Cartilage Research, Department of Pathology, University of Erlangen Nürnberg Erlangen, Germany
    J Bone Miner Res 17:2141-50. 2002
    ....
  87. ncbi request reprint Type II collagen as specific marker for mesenchymal chondrosarcomas compared to other small cell sarcomas of the skeleton
    Susanna Müller
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Mod Pathol 18:1088-94. 2005
    ..Thus, the presence of type II collagen in the extracellular tumor matrix significantly facilitates the diagnosis of mesenchymal chondrosarcomas in the absence of histologically visible chondroid matrix formation...
  88. ncbi request reprint Hgs physically interacts with Smad5 and attenuates BMP signaling
    Jochen Haag
    Osteoarticular and Arthritis Research, Department of Pathology, Friedrich Alexander University of Erlangen Nuremberg, Krankenhausstr 8 10, D 91054 Erlangen, Germany
    Exp Cell Res 312:1153-63. 2006
    ..Thus, it is tempting to speculate that both might be related to each other given the suppressive effect of BMP signaling on Hgs shown in this study...
  89. ncbi request reprint IL-1beta induction of IL-6 and LIF in normal articular human chondrocytes involves the ERK, p38 and NFkappaB signaling pathways
    Zhiyong Fan
    Osteoarticular and Arthritis Research Group, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, D 91054 Erlangen, Germany
    Cytokine 28:17-24. 2004
    ..However, the ERK-pathway appeared to be particularly important and might be, therefore, of particular potential if one intends to block induction of these molecules by IL-1 in arthritic joint disease...
  90. ncbi request reprint Subtyping of osteoarthritic synoviopathy
    S Oehler
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, FRG
    Clin Exp Rheumatol 20:633-40. 2002
    ..In this study, we present a systematic analysis of the synovial reaction pattern in early and late stages of the osteoarthritic disease process...
  91. pmc Eosinophil infiltration and degranulation in oesophageal mucosa from adult patients with eosinophilic oesophagitis: a retrospective and comparative study on pathological biopsy
    S Mueller
    Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany
    J Clin Pathol 59:1175-80. 2006
    ..To examine eosinophil infiltration and degranulation in 50 oesophageal biopsy specimens from 30 patients (21 men, 9 women; mean 39 years) with eosinophilic oesophagitis, by haematoxylin and eosin staining and immunohistochemistry...
  92. ncbi request reprint Localised massive tumourous xanthomatosis of the small intestine
    N Melling
    Department of Surgery, University of Erlangen Nuremberg, Krankenhausstr 12, 91054, Erlangen, Germany
    Int J Colorectal Dis 22:1401-4. 2007
    ....
  93. ncbi request reprint Primary intraosseous meningioma of the mandible: CT and MR imaging features
    M Lell
    Department of Radiology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    AJNR Am J Neuroradiol 28:129-31. 2007
    ..The CT and MR imaging features of mandibular meningioma are reviewed with reference to prior published descriptions of this unusual entity...
  94. ncbi request reprint Prognostic relevance of cell biologic and biochemical features in conventional chondrosarcomas
    Thomas Aigner
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Cancer 94:2273-81. 2002
    ..Currently, tumor grade is the only parameter of prognostic significance besides stage and, possibly, resection margins. Additional independent prognostic markers therefore would be highly valuable for patient management...
  95. doi request reprint Matrix biochemistry and cell biology of dedifferentiated chondrosarcomas
    Kerstin Dornauer
    Institute of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Pathol Int 60:365-72. 2010
    ..There was no difference in the clinical outcome of patients with differing high-grade tumor types, emphasizing that grade is a more important predictor of biological behavior than the direction of tumor differentiation...
  96. ncbi request reprint Analysis of protein distribution in cartilage using immunofluorescence and laser confocal scanning microscopy
    Stephan Soeder
    Department of Pathology, University of Erlangen Nurnberg, Germany
    Methods Mol Med 101:107-25. 2004
    ..However, as with many methodologies, technical knowledge and experience is important to avoid and/or interpret either false-positive or false-negative results...
  97. ncbi request reprint Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions
    Ina Knerr
    University Hospital for Children and Adolescents, University of Erlangen Nuremberg, Germany
    FEBS Lett 579:3991-8. 2005
    ..We propose that GCMa-driven syncytin expression is the key mechanism for syncytiotrophoblast formation...
  98. ncbi request reprint Comparative effects of TGF-beta 1 and TGF-beta 2 on extracellular matrix production, proliferation, migration, and collagen contraction of human Tenon's capsule fibroblasts in pseudoexfoliation and primary open-angle glaucoma
    Ulrike B Kottler
    Department of Ophthalmology, University Erlangen Nurnberg, Erlangen, Germany
    Exp Eye Res 80:121-34. 2005
    ....
  99. ncbi request reprint Antisense inhibition of osteogenic protein 1 disturbs human articular cartilage integrity
    Stephan Soder
    Rush University Medical Center, Chicago, Illinois 60612, USA
    Arthritis Rheum 52:468-78. 2005
    ..To delineate the role of endogenous osteogenic protein 1 (OP-1) in human articular cartilage homeostasis via the inhibition of OP-1 gene expression by antisense oligonucleotides...
  100. ncbi request reprint Jun activation domain-binding protein 1 binds Smad5 and inhibits bone morphogenetic protein signaling
    Jochen Haag
    University of Leipzig, Leipzig, Germany
    Arthritis Rheum 54:3878-84. 2006
    ..The present study was undertaken to identify binding partners of the Smad proteins, the intracellular mediators of BMP activity, which might actively modify BMP signaling in chondrocytes...
  101. ncbi request reprint The human chondrosarcoma HCS-2/8 cell line is responsive to BMP-7, but not to IL-1beta
    Joachim Saas
    Department of Thrombosis and Angiogenesis, Sanofi Aventis, Frankfurt, Germany
    Front Biosci 10:2027-35. 2005
    ..In this respect, HCS-2/8 cells are a validated tool for studying BMP-effects on chondrocytes, but not e.g. effects of interleukin-1...