Reinhold Tacke

Summary

Country: Germany

Publications

  1. ncbi request reprint Monocyclic zwitterionic lambda(5)Si-silicates with an SiO(2)FC(2) framework: syntheses and structural characterization in the solid state and in solution
    R Tacke
    Institut fur Anorganische Chemie, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Inorg Chem 40:2520-7. 2001
  2. ncbi request reprint Spirocyclic zwitterionic lambda5Si-silicates with two bidentate ligands derived from alpha-amino acids or alpha-hydroxycarboxylic acids: synthesis, structure, and stereodynamics
    Reinhold Tacke
    Institut fur Anorganische Chemie, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    J Am Chem Soc 126:14493-505. 2004
  3. doi request reprint Odorant design based on the carbon/silicon switch strategy
    Reinhold Tacke
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, D 97074 Wurzburg
    Chem Biodivers 5:920-41. 2008
  4. ncbi request reprint Sila-haloperidol, a silicon analogue of the dopamine (D2) receptor antagonist haloperidol: synthesis, pharmacological properties, and metabolic fate
    Reinhold Tacke
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074 Wurzburg, Germany
    ChemMedChem 3:152-64. 2008
  5. doi request reprint High-affinity, selective σ ligands of the 1,2,3,4-tetrahydro-1,4'-silaspiro[naphthalene-1,4'-piperidine] type: syntheses, structures, and pharmacological properties
    Reinhold Tacke
    Institut fur Anorganische Chemie, Universitat Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    ChemMedChem 7:523-32. 2012
  6. doi request reprint Disila-analogues of the synthetic retinoids EC23 and TTNN: synthesis, structure and biological evaluation
    Josef B G Gluyas
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, D 97074 Wurzburg, Germany
    Org Biomol Chem 10:6914-29. 2012
  7. doi request reprint Neutral penta- and hexacoordinate silicon(IV) complexes containing two bidentate ligands derived from the alpha-amino acids (S)-alanine, (S)-phenylalanine, and (S)-tert-leucine
    Smaranda Cota
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074 Wurzburg, Germany
    Chemistry 16:6582-9. 2010
  8. doi request reprint Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology
    W Peter Lippert
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074 Wurzburg, Germany
    ChemMedChem 4:1143-52. 2009
  9. doi request reprint Novel silicon-based patchouli odorants of the trialkyl(1-hydroxy-1-methylethyl)silane type: design, synthesis, and olfactory properties
    Astrid Sunderkötter
    Institut fur Anorganische Chemie, Universitat Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    Chemistry 16:7404-21. 2010
  10. doi request reprint Novel neutral hexacoordinate benzamidinatosilicon(IV) complexes with SiN3OF2, SiN3OCl2, SiN3OBr2, SiN5O and SiN3O3 skeletons
    Konstantin Junold
    Universitat Wurzburg, Institut fur Anorganische Chemie, Germany
    Dalton Trans 40:9844-57. 2011

Collaborators

  • F Matthias Bickelhaupt
  • Hinrich Gronemeyer
  • Bernhard Wünsch
  • Barbara Muller
  • Martin Kaupp
  • Natacha Rochel
  • Dino Moras
  • Hanns Hatt
  • Pierre Germain
  • David Tebbe
  • M U Kassack
  • John S Mills
  • William Bains
  • Graham A Showell
  • Christian Burschka
  • Johannes A Baus
  • Konstantin Junold
  • Felix M Mück
  • Marcel Geyer
  • Rüdiger Bertermann
  • Steffen Dörrich
  • Bastian Theis
  • Philip Kraft
  • Célia Fonseca Guerra
  • W Peter Lippert
  • Eric Wellner
  • Matthias W Büttner
  • Jennifer B Bauer
  • Marco Nutz
  • Christoph Mahler
  • Josef B G Gluyas
  • Claudia Kobelt
  • Sabine Lorenzen
  • Astrid Sunderkötter
  • Smaranda Cota
  • Kathrin Götz
  • Claudine Gaudon
  • Diana Ivanova
  • Leszek Doszczak
  • Xaver Kästele
  • Heidi Schneider
  • Ola Fjellström
  • Jordi Poater
  • Olle Karlsson
  • Sebastian Saloman
  • Linda Gustafsson
  • Duncan Armstrong
  • Ulrik Jurva
  • Claudia Küpper
  • Dorit Kloss
  • Katharina Sinner
  • Thomas Vent-Schmidt
  • Sarah Schweeberg
  • Sebastian Riedel
  • Dominic Auerhammer
  • Judith Vallet
  • Jörg Weiss
  • C Fonseca Guerra
  • Stefan A Przyborski
  • Todd B Marder
  • Victoria B Christie
  • Daniel M Tams
  • Andrew P Henderson
  • Bridgid A Murray
  • Matthias Beyer
  • Pierre Antony
  • Stefan Metz
  • Stefan Maisch
  • Yoshiteru Sato
  • Annika Triller
  • Jürgen O Daiss
  • Audrey Bindler
  • Carole Peluso-Iltis
  • Hans Peter Weber
  • Sabrina Kammerer
  • Peter Klüfers

Detail Information

Publications41

  1. ncbi request reprint Monocyclic zwitterionic lambda(5)Si-silicates with an SiO(2)FC(2) framework: syntheses and structural characterization in the solid state and in solution
    R Tacke
    Institut fur Anorganische Chemie, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Inorg Chem 40:2520-7. 2001
    ..VT (1)H NMR studies with 11b-14b in CH(3)CN in the temperature range 25-85 degrees C gave no indications for an enantiomerization process [(A)/(C)-enantiomerization] at the silicon atom...
  2. ncbi request reprint Spirocyclic zwitterionic lambda5Si-silicates with two bidentate ligands derived from alpha-amino acids or alpha-hydroxycarboxylic acids: synthesis, structure, and stereodynamics
    Reinhold Tacke
    Institut fur Anorganische Chemie, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    J Am Chem Soc 126:14493-505. 2004
    ....
  3. doi request reprint Odorant design based on the carbon/silicon switch strategy
    Reinhold Tacke
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, D 97074 Wurzburg
    Chem Biodivers 5:920-41. 2008
    ..Examples resulting from this strategy are sila-coranol, sila-dimetol, sila-linalool, sila-muguetalcohol, sila-majantol, sila-hydratropyl acetate, sila-bourgeonal, sila-lilial, disila-versalide, and disila-okoumal...
  4. ncbi request reprint Sila-haloperidol, a silicon analogue of the dopamine (D2) receptor antagonist haloperidol: synthesis, pharmacological properties, and metabolic fate
    Reinhold Tacke
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074 Wurzburg, Germany
    ChemMedChem 3:152-64. 2008
    ..Due to the special chemical properties of silicon, the metabolic fates of the C/Si analogues 1 a and 1 b are totally different...
  5. doi request reprint High-affinity, selective σ ligands of the 1,2,3,4-tetrahydro-1,4'-silaspiro[naphthalene-1,4'-piperidine] type: syntheses, structures, and pharmacological properties
    Reinhold Tacke
    Institut fur Anorganische Chemie, Universitat Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    ChemMedChem 7:523-32. 2012
    ....
  6. doi request reprint Disila-analogues of the synthetic retinoids EC23 and TTNN: synthesis, structure and biological evaluation
    Josef B G Gluyas
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, D 97074 Wurzburg, Germany
    Org Biomol Chem 10:6914-29. 2012
    ..Disila-TTNN (7b) can be regarded as a powerful RARβ,γ-selective retinoid...
  7. doi request reprint Neutral penta- and hexacoordinate silicon(IV) complexes containing two bidentate ligands derived from the alpha-amino acids (S)-alanine, (S)-phenylalanine, and (S)-tert-leucine
    Smaranda Cota
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074 Wurzburg, Germany
    Chemistry 16:6582-9. 2010
    ..The deprotonated amino acids act as monoanionic (6) or as mono- and dianionic ligands (7-11). The experimental investigations were complemented by computational studies of the stereoisomers of 6 and 7...
  8. doi request reprint Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology
    W Peter Lippert
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074 Wurzburg, Germany
    ChemMedChem 4:1143-52. 2009
    ..This is the first demonstration of an increase in binding affinity of a ligand to a nuclear receptor by C/Si replacement, thereby adding this C/Si switch strategy to the repertoire of nuclear receptor ligand design...
  9. doi request reprint Novel silicon-based patchouli odorants of the trialkyl(1-hydroxy-1-methylethyl)silane type: design, synthesis, and olfactory properties
    Astrid Sunderkötter
    Institut fur Anorganische Chemie, Universitat Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    Chemistry 16:7404-21. 2010
    ....
  10. doi request reprint Novel neutral hexacoordinate benzamidinatosilicon(IV) complexes with SiN3OF2, SiN3OCl2, SiN3OBr2, SiN5O and SiN3O3 skeletons
    Konstantin Junold
    Universitat Wurzburg, Institut fur Anorganische Chemie, Germany
    Dalton Trans 40:9844-57. 2011
    ..Compounds 3 and 4 contain the novel SiN(3)OBr(2) and SiN(3)OF(2) skeletons, while compounds 5-7 are the first neutral hexacoordinate silicon(IV) complexes with an SiN(5)O skeleton...
  11. doi request reprint Disila-galaxolide and derivatives: synthesis and olfactory characterization of silicon-containing derivatives of the musk odorant galaxolide
    Steffen Dörrich
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074 Wurzburg, Germany
    Chemistry 19:11396-408. 2013
    ....
  12. doi request reprint Optically active zwitterionic lambda(5)Si,lambda(5)Si'-disilicates: syntheses, crystal structures, and behavior in aqueous solution
    Bastian Theis
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, Wurzburg, Germany
    Chemistry 14:4618-30. 2008
    ..Although these lambda(5)Si,lambda(5)Si'-disilicates contain SiO(4)C skeletons, some of them display a remarkable stability in aqueous solution as shown by NMR spectroscopy and ESI mass spectrometry...
  13. doi request reprint Reactivity of the Donor-Stabilized Silylenes [iPrNC(Ph)NiPr]2 Si and [iPrNC(NiPr2 )NiPr]2 Si: Activation of CO2 and CS2
    Felix M Mück
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074 Würzburg Germany, Fax 49 931 31 84609
    Chemistry 21:16665-72. 2015
    ..Treatment of the dinuclear silicon(IV) complexes 5 and 6 with CO2 also affords the six-coordinate carbonatosilicon(IV) complexes 4 and 8, respectively. ..
  14. doi request reprint Bis[N,N'-diisopropylbenzamidinato(-)]silicon(II): Lewis acid/base reactions with triorganylboranes
    Konstantin Junold
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074 Würzburg Germany, Fax 49 931 31 84609
    Chemistry 20:12411-5. 2014
    ..Additionally, the bonding situation in 2 and 3 was analyzed by quantum chemical studies. ..
  15. doi request reprint Reactions of the Donor-Stabilized Silylene Bis[N,N'-diisopropyl-benzamidinato(-)]silicon(II) with Brønsted Acids
    Konstantin Junold
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074 Würzburg Germany, Fax 49 931 31 84609
    Chemistry 20:16462-6. 2014
    ..The formation of 2-4 can be formally described in terms of a Brønsted acid/base reaction, coupled with a redox process (Si(II) →Si(IV) , H(+) →H(-) ). ..
  16. doi request reprint Novel silicon-containing analogues of the retinoid agonist bexarotene: syntheses and biological effects on human pluripotent stem cells
    Jennifer B Bauer
    Institut fur Anorganische Chemie, Universitat Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    ChemMedChem 6:1509-17. 2011
    ..The biological data obtained indicate that bexarotene, contrary to the silicon-containing analogues disila-bexarotene, 8, and 9, may partially act to induce cell differentiation...
  17. doi request reprint Synthesis, structure and reactivity of a donor-stabilised silylene with a bulky bidentate benzamidinato ligand
    Reinhold Tacke
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, D 97074 Wurzburg, Germany
    Dalton Trans 44:14959-74. 2015
    ....
  18. doi request reprint Activation of sulfur dioxide by bis[N,N'-diisopropylbenzamidinato(-)]silicon(II): synthesis of neutral six-coordinate silicon(IV) complexes with chelating O,O'-Sulfito or O,O'-dithionito ligands
    Konstantin Junold
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074 Würzburg Germany
    Chemistry 20:12781-5. 2014
    ..Compounds 2 and 3 were structurally characterized by crystal structure analyses and multinuclear NMR spectroscopic studies in the solid state and in solution. ..
  19. doi request reprint The donor-stabilized silylene bis[N,N'-diisopropylbenzamidinato(-)]silicon(II): synthesis, electronic structure, and reactivity
    Konstantin Junold
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074 Würzburg Germany, Fax 49 931 31 84609
    Chemistry 20:9319-29. 2014
    ..These studies further supported the assumption that the silylene is four-coordinate in solution...
  20. doi request reprint Neutral six-coordinate and cationic five-coordinate silicon(IV) complexes with two bidentate monoanionic N,S-pyridine-2-thiolato(-) ligands
    Johannes A Baus
    Institut fur Anorganische Chemie, Universitat Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    Inorg Chem 52:10664-76. 2013
    ..These experimental investigations were complemented by computational studies, including bonding analyses based on relativistic density functional theory. ..
  21. ncbi request reprint Zwitterionic and anionic multinuclear pentacoordinate silicon(IV) complexes with bridging (R,R)-tartrato(4-) ligands and SiO5 skeletons: synthesis and reactivity in aqueous solution
    Bastian Theis
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074 Wurzburg, Germany
    Chemistry 18:2202-6. 2012
    ..Hydrolysis of 1 yields 2, which shows a remarkable kinetic stability in water. Upon dissolution of 1 and 2 in water, the nutrients choline and orthosilicic acid are formed by hydrolysis...
  22. ncbi request reprint Disila-okoumal: a silicon analogue of the ambergris odorant okoumal
    Matthias W Büttner
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074 Wurzburg, Germany
    Chembiochem 8:1447-54. 2007
    ..31 ng per L air was measured for the 2R-configured silicon compounds 6 a and 6 c...
  23. ncbi request reprint Silicon analogues of the retinoid agonists TTNPB and 3-methyl-TTNPB, disila-TTNPB and disila-3-methyl-TTNPB: chemistry and biology
    Matthias W Büttner
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074 Wurzburg, Germany
    Chembiochem 8:1688-99. 2007
    ....
  24. doi request reprint Cationic Five-Coordinate Bis(guanidinato)silicon(IV) Complexes with SiN4 El Skeletons (El=S, Se): "Heterolytic Activation" of S-S and Se-Se Bonds
    Felix M Mück
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074, Wurzburg, Germany
    Chemistry 22:5830-4. 2016
    ..Compounds 4 and 5 were characterized by crystal structure analyses and NMR spectroscopic studies in the solid state. ..
  25. doi request reprint Synthesis and Pharmacological Properties of Silicon-Containing GPR81 and GPR109A Agonists
    Marcel Geyer
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074, Wurzburg, Germany
    ChemMedChem 10:2063-70. 2015
    ..This work supports the value of including silicon chemistry into the toolbox of medicinal chemistry. ..
  26. doi request reprint Si- and C-Functional Organosilicon Building Blocks for Synthesis Based on 4-Silacyclohexan-1-ones Containing the Silicon Protecting Groups MOP (4-Methoxyphenyl), DMOP (2,6-Dimethoxyphenyl), or TMOP (2,4,6-Trimethoxyphenyl)
    Marcel Geyer
    Institut fur Anorganische Chemie, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    J Org Chem 80:5804-11. 2015
    ..Thus, the C- and Si-functional compounds 1a-1c, 2a-2c, 3a-3c, 4a-4c, 5a, and 5b represent versatile building blocks for synthesis. ..
  27. doi request reprint Synthesis and olfactory characterization of silicon-containing derivatives of the acyclic lily-of-the-valley odorant 5,7,7-trimethyl-4-methylideneoctanal
    Steffen Dörrich
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, D 97074 Wurzburg, phone 49 931 3185250 fax 49 931 3184609
    Chem Biodivers 11:1675-87. 2014
    ..To gain more information about the structureodor correlation in the family of lily-of-the-valley or 'muguet' odorants, C/Si analogs 1a/1b and derivatives 2-6 were evaluated for their olfactory properties. ..
  28. ncbi request reprint Prediction of perception: probing the hOR17-4 olfactory receptor model with silicon analogues of bourgeonal and lilial
    Leszek Doszczak
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074 Wurzburg, Germany
    Angew Chem Int Ed Engl 46:3367-71. 2007
  29. doi request reprint Five-coordinate silicon(II) compounds with Si-M bonds (M = Cr, Mo, W, Fe): Bis[N,N'-diisopropylbenzamidinato(-)]silicon(II) as a ligand in transition-metal complexes
    Konstantin Junold
    Institut fur Anorganische Chemie, Universitat Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    Inorg Chem 52:11593-9. 2013
    ..These experimental investigations were complemented by computational studies to gain insight into the bonding situation of 2-5. The nature of the Si-M bonds is best described as a single bond. ..
  30. ncbi request reprint Neutral pentacoordinate silicon(IV) complexes with silicon-chalcogen (S, Se, Te) bonds
    Bastian Theis
    , , Am Hubland, , Germany
    Chemistry 15:7329-38. 2009
    ..With the synthesis of compounds 1-3 and 6-10, it has been demonstrated that pentacoordinate silicon compounds with soft chalcogen ligand atoms (S, Se, Te) can be stable in the solid state and in solution...
  31. doi request reprint Stable five-coordinate silicon(IV) complexes with SiN4 X skeletons (X = S, Se, Te) and Si=X double bonds
    Konstantin Junold
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074 Wurzburg, Germany
    Chemistry 18:16288-91. 2012
    ....
  32. doi request reprint Iron(II), Cobalt(II), Nickel(II), and Zinc(II) Silylene Complexes: Reaction of the Silylene [iPrNC(NiPr2 )NiPr]2 Si with FeBr2 , CoBr2 , NiBr2 ⋅MeOCH2 CH2 OMe, ZnCl2 ,
    Johannes A Baus
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074, Wurzburg, Germany
    Chemistry . 2016
    ....
  33. doi request reprint Novel transition-metal (M=Cr, Mo, W, Fe) carbonyl complexes with bis(guanidinato)silicon(II) ligands
    Felix M Mück
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074 Würzburg Germany, Fax 49 931 31 84609
    Chemistry 20:9620-6. 2014
    ..Compounds 7-10 were characterized by elemental analyses (C, H, N), crystal structure analyses, and NMR spectroscopic studies in the solid state and in solution. ..
  34. ncbi request reprint Bis[N,N'-diisopropylbenzamidinato(-)]silicon(II): a silicon(II) compound with both a bidentate and a monodentate amidinato ligand
    Konstantin Junold
    Universitat Wurzburg, Institut fur Anorganische Chemie, Germany
    Angew Chem Int Ed Engl 51:7020-3. 2012
    ..Reaction of 2 with [W(CO)(6)] and with I(2) yields the λ(5)-silicon(II) complex 3 and the λ(6)-silicon(IV) complex 4, respectively...
  35. ncbi request reprint Synthesis and structural characterisation of neutral pentacoordinate silicon(IV) complexes with a tridentate dianionic N,N,S chelate ligand
    Claudia Kobelt
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, D 97074, Wurzburg, Germany
    Dalton Trans 41:2148-62. 2012
    ..These experimental investigations were complemented by computational studies...
  36. ncbi request reprint Novel neutral hexacoordinate silicon(IV) complexes with two bidentate monoanionic benzamidinato ligands
    Konstantin Junold
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, D 97074, Wurzburg, Germany
    Dalton Trans 39:9401-13. 2010
    ..Compounds 9 and 10 are the first hexacoordinate silicon(iv) complexes with Si-Se bonds...
  37. ncbi request reprint Neutral six-coordinate bis(dithiocarbamato)silicon(iv) complexes with an SiCl2S4 skeleton
    Johannes A Baus
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074 Wurzburg, Germany
    Dalton Trans . 2016
    ..In this study, dithiocarbamato ligands were implemented in silicon coordination chemistry for the first time. Compounds 3 and 4 represent the first six-coordinate silicon(iv) complexes with an SiCl2S4 skeleton...
  38. doi request reprint Can silicon make an excellent drug even better? An in vitro and in vivo head-to-head comparison between loperamide and its silicon analogue sila-loperamide
    Marcel Geyer
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074 Würzburg Germany
    ChemMedChem 10:911-24. 2015
    ..This study provides some of the most detailed insights into the effects of a carbon/silicon switch and how this carbon/silicon exchange affects overall drug properties. ..
  39. ncbi request reprint (R)-sila-venlafaxine: a selective noradrenaline reuptake inhibitor for the treatment of emesis
    Graham A Showell
    Paradigm Therapeutics Ltd, 162 Cambridge Science Park, Milton Road, Cambridge CB4 0GP, UK
    Bioorg Med Chem Lett 16:2555-8. 2006
    ..The (R)-sila-analogue of the antidepressant venlafaxine is devoid of the serotonin reuptake inhibition observed with the marketed drug, leading to a selective noradrenaline reuptake inhibitor displaying anti-emetic properties...
  40. ncbi request reprint Not unhydrolyzed at pH 8
    Xaver Kästele
    Department Chemie und Biochemie, Ludwig Maximilians Universitat, Butenandtstrasse 5 13, 81377 Munchen, Germany
    Angew Chem Int Ed Engl 45:3212-4. 2006
  41. ncbi request reprint Silicon chemistry as a novel source of chemical diversity in drug design
    William Bains
    Amedis Pharmaceuticals Ltd, 162 Cambridge Science Park, Milton Road, Cambridge, CB4 0GP, UK
    Curr Opin Drug Discov Devel 6:526-43. 2003
    ....