Alexander Sturzu

Summary

Country: Germany

Publications

  1. ncbi request reprint Novel gastrin receptor-directed contrast agents - potential in brain tumor magnetic resonance imaging
    Alexander Sturzu
    Department of Neuroradiology, University of Tubingen, Germany
    Med Chem 8:133-7. 2012
  2. doi request reprint Rhodamine-marked bombesin: a novel means for prostate cancer fluorescence imaging
    Alexander Sturzu
    Department of Neuroradiology, University of Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    Invest New Drugs 32:37-46. 2014
  3. doi request reprint The gastrin/cholecystokinin-B receptor on prostate cells--a novel target for bifunctional prostate cancer imaging
    Alexander Sturzu
    Department of Neuroradiology, University of Tubingen, Germany Peptide Synthesis Laboratory, Interfaculty Institute of Biochemistry, University of Tubingen, Germany Electronic address
    Eur J Pharm Sci 52:69-76. 2014
  4. doi request reprint Novel bourgeonal fragrance conjugates for the detection of prostate cancer
    Alexander Sturzu
    Department of Neuroradiology, University of Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    Invest New Drugs 31:1151-7. 2013
  5. doi request reprint Using the neurotransmitter serotonin to target imaging agents to glioblastoma cells
    Alexander Sturzu
    Department of Neuroradiology, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Invest New Drugs 30:2141-7. 2012
  6. doi request reprint Potential of the gastric motility drug lorglumide in prostate cancer imaging
    Alexander Sturzu
    Department of Neuroradiology, University of Tubingen, Germany
    Eur J Pharm Sci 45:575-80. 2012
  7. ncbi request reprint A novel lily-of-the-valley fragrance contrast agent for magnetic resonance and fluorescence imaging of prostate cancer cells
    Alexander Sturzu
    Department of Neuroradiology, Molecular Imaging Laboratory, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Curr Pharm Biotechnol 13:373-7. 2012
  8. doi request reprint Magnetic resonance imaging of human glioma cells by means of an interleukin-6 receptor-targeted contrast agent
    Alexander Sturzu
    Department of Neuroradiology, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Chem Biol Drug Des 75:369-74. 2010
  9. doi request reprint Cellular uptake of cationic gadolinium-DOTA peptide conjugates with and without N-terminal myristoylation
    A Sturzu
    Peptide Synthesis Laboratory, Interfaculty Institute of Biochemistry, University of Tubingen, Hoppe Seyler Str 4, 72076 Tubingen, Germany
    Amino Acids 37:249-55. 2009
  10. doi request reprint Imaging of human glioma cells by means of a Syndecan-4 directed DOTA-conjugate
    Alexander Sturzu
    Peptide Synthesis Laboratory, Interfaculty Institute of Biochemistry, University of Tubingen, Hoppe Seyler Str 4, 72076, Tubingen, Germany
    Amino Acids 38:1415-21. 2010

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Novel gastrin receptor-directed contrast agents - potential in brain tumor magnetic resonance imaging
    Alexander Sturzu
    Department of Neuroradiology, University of Tubingen, Germany
    Med Chem 8:133-7. 2012
    ..The cytoplasm specificity of the conjugates also makes it a potential building block for the design of future cytoplasmdirected imaging and therapeutic conjugates...
  2. doi request reprint Rhodamine-marked bombesin: a novel means for prostate cancer fluorescence imaging
    Alexander Sturzu
    Department of Neuroradiology, University of Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    Invest New Drugs 32:37-46. 2014
    ..A rhodamine bombesin conjugate can be used as marker to differentiate between healthy cells and malignant cells such as prostate hyperplasia and prostate carcinoma in the early detection of cancer. ..
  3. doi request reprint The gastrin/cholecystokinin-B receptor on prostate cells--a novel target for bifunctional prostate cancer imaging
    Alexander Sturzu
    Department of Neuroradiology, University of Tubingen, Germany Peptide Synthesis Laboratory, Interfaculty Institute of Biochemistry, University of Tubingen, Germany Electronic address
    Eur J Pharm Sci 52:69-76. 2014
    ..The investigations show that the gastrin receptor is a promising tumor cell surface target for future prostate-cancer-specific imaging applications. ..
  4. doi request reprint Novel bourgeonal fragrance conjugates for the detection of prostate cancer
    Alexander Sturzu
    Department of Neuroradiology, University of Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    Invest New Drugs 31:1151-7. 2013
    ..The conjugates represent a platform for the development of future prostate-specific imaging applications, e.g. detection of metastasized lymph nodes during surgery by intraoperative laser examination. ..
  5. doi request reprint Using the neurotransmitter serotonin to target imaging agents to glioblastoma cells
    Alexander Sturzu
    Department of Neuroradiology, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Invest New Drugs 30:2141-7. 2012
    ..In conclusion the neurotransmitter serotonin could be successfully used to target imaging agents into human glioblastoma cells. This makes it of interest for future glioblastoma imaging methods...
  6. doi request reprint Potential of the gastric motility drug lorglumide in prostate cancer imaging
    Alexander Sturzu
    Department of Neuroradiology, University of Tubingen, Germany
    Eur J Pharm Sci 45:575-80. 2012
    ..Considering these results, CCKRA ligands like lorglumide could play a role in the future design of prostate-cancer-specific markers...
  7. ncbi request reprint A novel lily-of-the-valley fragrance contrast agent for magnetic resonance and fluorescence imaging of prostate cancer cells
    Alexander Sturzu
    Department of Neuroradiology, Molecular Imaging Laboratory, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Curr Pharm Biotechnol 13:373-7. 2012
    ..The examined conjugate showed high prostate-cell-specificity. This property makes it of potential value in the diagnosis of prostate cancer lymph node metastases...
  8. doi request reprint Magnetic resonance imaging of human glioma cells by means of an interleukin-6 receptor-targeted contrast agent
    Alexander Sturzu
    Department of Neuroradiology, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Chem Biol Drug Des 75:369-74. 2010
    ..The cytoplasm specificity of the conjugate also makes it a potential building block for the design of future cytoplasm-directed imaging and therapeutic conjugates...
  9. doi request reprint Cellular uptake of cationic gadolinium-DOTA peptide conjugates with and without N-terminal myristoylation
    A Sturzu
    Peptide Synthesis Laboratory, Interfaculty Institute of Biochemistry, University of Tubingen, Hoppe Seyler Str 4, 72076 Tubingen, Germany
    Amino Acids 37:249-55. 2009
    ..Up to 70% of cells showed cellular and nuclear uptake of the N-myristoylated HIV-1 Tat conjugate. Conjugate cytotoxicity appears to correlate with cellular uptake...
  10. doi request reprint Imaging of human glioma cells by means of a Syndecan-4 directed DOTA-conjugate
    Alexander Sturzu
    Peptide Synthesis Laboratory, Interfaculty Institute of Biochemistry, University of Tubingen, Hoppe Seyler Str 4, 72076, Tubingen, Germany
    Amino Acids 38:1415-21. 2010
    ..Competition experiments indicate that this uptake was receptor-mediated. This conjugate might be used for future MRI studies of brain tumors after systemic or intraoperative local application...
  11. doi request reprint The lily-of-the-valley fragrance receptor--potential in prostate cancer imaging
    Alexander Sturzu
    Peptide Synthesis Laboratory, Interfaculty Institute of Biochemistry, University of Tubingen, Tubingen, Germany
    Prostate 69:1599-602. 2009
    ..If conjugated to a dye, olfactory receptor ligands would represent candidates for markers of not only olfactory cells but also prostate tissue. Such a conjugate would be of great value for the detection of prostate cancer metastases...
  12. doi request reprint The fluorinated and chlorinated nuclear localization sequence of the SV 40 T antigen
    Alexander Sturzu
    Department of Neuroradiology, University of Tubingen, Germany
    Chem Biol Drug Des 73:127-31. 2009
    ..Such small non-radioactive fluorinated and chlorinated nuclear localization sequences may be used as important components for future antiglioma drug development...
  13. doi request reprint Value of apoptin's 40-amino-acid C-terminal fragment for the differentiation between human tumor and non-tumor cells
    Stefan Heckl
    Department of Neuroradiololgy, University of Tubingen, Medical School, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    Apoptosis 13:495-508. 2008
    ..Cellular and nuclear uptake of the FITC-labelled Apoptin(81-121) peptide was almost completely abolished after altering the NLS2 (replacement of five arginines with serines)...
  14. doi request reprint The influence of 2,4,6-tribromophenyl isocyanate on the cellular and nuclear uptake of the SV 40 T antigen nuclear localization sequence
    Stefan Heckl
    Department of Neuroradiology, University of Tubingen, Germany
    Eur J Pharmacol 583:32-6. 2008
    ..These cells stayed alive. TBPI, when bound to small peptides, may be an important component for future drugs against gliomas...
  15. ncbi request reprint Evaluating the diagnostic and chemotherapeutic potential of vancomycin-derived imaging conjugates
    Sumbla Sheikh
    Department of Neuroradiology, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Med Chem 8:1163-70. 2012
    ..The intracellular uptake of the vancomycin conjugates and the increased uptake into some of the malignant cell lines were interesting findings which should be further pursued...
  16. ncbi request reprint Ramoplanin imaging conjugates--synthesis and evaluation
    Sumbla Sheikh
    Department of Neuroradiology, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Med Chem 10:18-26. 2014
    ..Compared to the vancomycin conjugates the ramoplanin conjugates showed much weaker and slower uptake. Additionally, uptake of the ramoplanin conjugates led to strong membrane disruption and cell death...
  17. doi request reprint The differential influence of non-iodinated and mono- or diiodinated benzoic acids on cellular and nuclear uptake of the nuclear localization sequence of the SV 40 T antigen
    Stefan Heckl
    Department of Neuroradiology, University of Tubingen, Germany
    Int J Pharm 355:131-40. 2008
    ..Such mono- or diiodobenzoic acid conjugates may therefore have potential in the development of new non-radioactive drugs against malignant glioma cells...
  18. ncbi request reprint Fluorescence imaging of human cells with a novel conjugate of the antifungal nystatin
    Sumbla Sheikh
    Department of Neuroradiology, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Med Chem 10:348-54. 2014
    ..The results indicate that this conjugate shows potential for future imaging studies on certain human cancer cells. ..