A Schmitt

Summary

Country: Germany

Publications

  1. ncbi request reprint The brain-specific protein MLC1 implicated in megalencephalic leukoencephalopathy with subcortical cysts is expressed in glial cells in the murine brain
    Angelika Schmitt
    Department of Psychiatry and Psychotherapy, Section of Molecular Psychobiology, University of Wurzburg, Wurzburg, Germany
    Glia 44:283-95. 2003
  2. ncbi request reprint Adult neurogenesis in serotonin transporter deficient mice
    A Schmitt
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Neural Transm (Vienna) 114:1107-19. 2007
  3. ncbi request reprint Organic cation transporter capable of transporting serotonin is up-regulated in serotonin transporter-deficient mice
    A Schmitt
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Neurosci Res 71:701-9. 2003
  4. ncbi request reprint Modulation of serotonin transporter function by interleukin-4
    R Mossner
    Department of Psychiatry, University of Wurzburg, Germany
    Life Sci 68:873-80. 2001
  5. ncbi request reprint Quantitation of 5HT3 receptors in forebrain of serotonin transporter deficient mice
    R Mossner
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Germany
    J Neural Transm (Vienna) 111:27-35. 2004
  6. ncbi request reprint Neural stem cell proliferation is decreased in schizophrenia, but not in depression
    A Reif
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Wurzburg, Germany
    Mol Psychiatry 11:514-22. 2006
  7. ncbi request reprint Glutamate transporter EAAC1 is expressed in neurons and glial cells in the rat nervous system
    P Kugler
    Institute of Anatomy, University of Wurzburg, Wurzburg, Germany
    Glia 27:129-42. 1999
  8. ncbi request reprint Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice
    Michael Karl Boettger
    Department of Neurology, Julius Maximilians University, Josef Schneider Str 11, 97080, Wurzburg, Germany
    Eur J Pain 11:810-8. 2007
  9. doi request reprint Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life
    Claudia Kriegebaum
    Molecular Psychiatry, Department of Psychiatry, Psychosomatics and Psychotherapy, Julius Maximilians University of Wurzburg, Wurzburg, Germany
    Neurochem Int 57:512-7. 2010
  10. doi request reprint Sex-dependent metabolic alterations of rat liver after 12-week exposition to haloperidol or clozapine
    M von Wilmsdorff
    Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
    Horm Metab Res 46:782-8. 2014

Collaborators

Detail Information

Publications39

  1. ncbi request reprint The brain-specific protein MLC1 implicated in megalencephalic leukoencephalopathy with subcortical cysts is expressed in glial cells in the murine brain
    Angelika Schmitt
    Department of Psychiatry and Psychotherapy, Section of Molecular Psychobiology, University of Wurzburg, Wurzburg, Germany
    Glia 44:283-95. 2003
    ..Detailed information on Mlc1 expression in brain is likely to lead to a better understanding of Mlc1 involvement in the pathogenesis of both MLC and catatonic schizophrenia...
  2. ncbi request reprint Adult neurogenesis in serotonin transporter deficient mice
    A Schmitt
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Neural Transm (Vienna) 114:1107-19. 2007
    ....
  3. ncbi request reprint Organic cation transporter capable of transporting serotonin is up-regulated in serotonin transporter-deficient mice
    A Schmitt
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Neurosci Res 71:701-9. 2003
    ....
  4. ncbi request reprint Modulation of serotonin transporter function by interleukin-4
    R Mossner
    Department of Psychiatry, University of Wurzburg, Germany
    Life Sci 68:873-80. 2001
    ....
  5. ncbi request reprint Quantitation of 5HT3 receptors in forebrain of serotonin transporter deficient mice
    R Mossner
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Germany
    J Neural Transm (Vienna) 111:27-35. 2004
    ..The adaptive changes of 5HT3 receptor expression constitute a part of the complex regulatory pattern of 5HT receptors in 5HTT knockout mice...
  6. ncbi request reprint Neural stem cell proliferation is decreased in schizophrenia, but not in depression
    A Reif
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Wurzburg, Germany
    Mol Psychiatry 11:514-22. 2006
    ....
  7. ncbi request reprint Glutamate transporter EAAC1 is expressed in neurons and glial cells in the rat nervous system
    P Kugler
    Institute of Anatomy, University of Wurzburg, Wurzburg, Germany
    Glia 27:129-42. 1999
    ..We conclude that the glutamate transporter EAAC1 is not restricted to neurons but may also play an important role in glial cells, particularly in oligodendrocytes...
  8. ncbi request reprint Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice
    Michael Karl Boettger
    Department of Neurology, Julius Maximilians University, Josef Schneider Str 11, 97080, Wurzburg, Germany
    Eur J Pain 11:810-8. 2007
    ..These results support the proposed role of nNOS in sensitization of DRG neurones, and might indicate that CGRP is involved in this process...
  9. doi request reprint Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life
    Claudia Kriegebaum
    Molecular Psychiatry, Department of Psychiatry, Psychosomatics and Psychotherapy, Julius Maximilians University of Wurzburg, Wurzburg, Germany
    Neurochem Int 57:512-7. 2010
    ..The formation of the serotonergic system thus seems to be a preserved expressional pattern due to intrinsic cellular programs which occurs also in the absence of its key molecule, namely 5-HT...
  10. doi request reprint Sex-dependent metabolic alterations of rat liver after 12-week exposition to haloperidol or clozapine
    M von Wilmsdorff
    Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
    Horm Metab Res 46:782-8. 2014
    ..Chronic clozapine intake exerts sex-dependent effects on hepatic metabolism. Although haloperidol has been shown to change fewer metabolic parameters, it causes oxidative stress and neutral fat deposits in liver tissue in both sexes. ..
  11. ncbi request reprint The genomic organization of the murine Mlc1 (Wkl1, KIAA0027) gene
    V Steinke
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Germany
    J Neural Transm (Vienna) 110:333-43. 2003
    ..The characterization of the genomic structure of the murine gene will facilitate studies of gene function and physiological properties of the encoded protein in transgenic mouse models...
  12. doi request reprint Lack of the serotonin transporter in mice reduces locomotor activity and leads to gender-dependent late onset obesity
    N Uceyler
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Int J Obes (Lond) 34:701-11. 2010
    ....
  13. ncbi request reprint When cells become depressed: focus on neural stem cells in novel treatment strategies against depression
    J Benninghoff
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Federal Republic of Germany
    J Neural Transm (Vienna) 109:947-62. 2002
    ..In this review, the new area of neural stem cell research and the avenues of ongoing and future research sustaining the development of novel treatments for depression will be explored...
  14. ncbi request reprint A functional serotonin transporter gene polymorphism is associated with migraine with aura
    M Marziniak
    Department of Neurology, University of Wurzburg, Germany
    Neurology 64:157-9. 2005
    ..001). This indicates that the 5-HTT may be involved in the polygenic etiology of migraine with aura...
  15. pmc TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones
    Tina Dobler
    Institute of Physiology, University of Wurzburg, Röntgenring 9, 97070 Wurzburg, Germany
    J Physiol 585:867-79. 2007
    ..Most strikingly, cellular excitability of DRG neurones from functional KO mice was significantly augmented as revealed by reduced rheobase current to elicit action potentials...
  16. pmc Serotonergic innervation and serotonin receptor expression of NPY-producing neurons in the rat lateral and basolateral amygdaloid nuclei
    M Bonn
    Institute of Anatomy and Cell Biology, University of Wuerzburg, Koellikerstr 6, 97070, Wurzburg, Germany
    Brain Struct Funct 218:421-35. 2013
    ....
  17. ncbi request reprint Cellular and regional distribution of the glutamate transporter GLAST in the CNS of rats: nonradioactive in situ hybridization and comparative immunocytochemistry
    A Schmitt
    Institute of Anatomy, University of Wurzburg, D 97070 Wurzburg, Germany
    J Neurosci 17:1-10. 1997
    ..The latter observation suggests that the GLAST glutamate transporter participates in the regulation of extracellular glutamate concentrations, especially in brain areas receiving an intense glutamatergic innervation...
  18. ncbi request reprint The corticotropin-releasing factor (CRF)-system and monoaminergic afferents in the central amygdala: investigations in different mouse strains and comparison with the rat
    E Asan
    Department of Anatomy and Cell Biology, University of Wuerzburg, Koellikerstr 6, 97070 Wuerzburg, Germany
    Neuroscience 131:953-67. 2005
    ..The observed interspecies and interstrain differences in CRF input and CRF/monoaminergic interactions may influence the interpretation of findings concerning Ce functions in stress and fear in mouse models...
  19. ncbi request reprint Allelic variation of serotonin transporter expression is associated with depression in Parkinson's disease
    R Mossner
    Department of Psychiatry, University of Wurzburg, Wurzburg, Germany
    Mol Psychiatry 6:350-2. 2001
    ..Thus, the 5HTTLPR but not the MAOA gene promoter-associated polymorphism may be a risk factor for depression in PD patients, while neither polymorphism increases the risk for development of Parkinson's disease itself...
  20. ncbi request reprint A missense mutation in a novel gene encoding a putative cation channel is associated with catatonic schizophrenia in a large pedigree
    J Meyer
    Department of Psychiatry and Psychotherapy, University of Wurzburg, D 97080 Wurzburg, Germany
    Mol Psychiatry 6:302-6. 2001
    ....
  21. doi request reprint Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice
    Lise Gutknecht
    Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
    Eur Neuropsychopharmacol 19:266-82. 2009
    ..In conclusion, our findings indicate that brain 5-HT synthesis across the lifespan is exclusively maintained by TPH2...
  22. doi request reprint Decreased anxiety in mice lacking the organic cation transporter 3
    Thomas Wultsch
    Section of Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    J Neural Transm (Vienna) 116:689-97. 2009
    ....
  23. doi request reprint Excitability of pontine startle processing neurones is regulated by the two-pore-domain K+ channel TASK-3 coupled to 5-HT2C receptors
    Maruschka Weber
    Institute of Physiology II, Roentgenring 9, 97070 Wuerzburg, Germany
    Eur J Neurosci 28:931-40. 2008
    ..Thus, neuronal excitability of PnC giant neurones in vivo is most likely increased by serotonergic projections via the K(2)P channel TASK-3...
  24. doi request reprint Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice
    Lise Gutknecht
    Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080, Wuerzburg, Germany
    J Neural Transm (Vienna) 115:1127-32. 2008
    ..The findings confirm the exclusive specificity of Tph2 in brain 5-HT synthesis and suggest that Tph2-synthesized 5-HT is not required for serotonergic neuron formation...
  25. pmc Nitric oxide synthase modulates CFA-induced thermal hyperalgesia through cytokine regulation in mice
    Yong Chen
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Mol Pain 6:13. 2010
    ..Here we asked whether cytokines, which have well-described roles in inflammatory pain, are downstream targets of NO in inflammatory pain and which of the isoforms of NOS are involved in this process...
  26. ncbi request reprint Complementary neuronal and glial expression of two high-affinity glutamate transporter GLT1/EAAT2 forms in rat cerebral cortex
    Peter Kugler
    Institute of Anatomy and Cell Biology, University of Wurzburg, Koellikerstrasse 6, 97070, Wurzburg, Germany
    Histochem Cell Biol 119:425-35. 2003
    ..It is concluded that the cellular expression of the two GLT1 forms is complementary. The cytoplasmic vesicular distribution of GLT1v may represent an endogenous protective mechanism to limit glutamate-induced excitotoxicity...
  27. doi request reprint Should early improvement be re-defined to better predict the maintenance of response in first-episode schizophrenia patients?
    R Schennach
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich Department of Psychiatry and Psychotherapy, University of Gottingen, Germany
    Acta Psychiatr Scand 127:474-81. 2013
    ..To evaluate the predictive validity of early response in first-episode schizophrenia within a 1-year follow-up trial and to compare the resulting cutoff to the currently proposed early response definition (20% improvement by week 2)...
  28. ncbi request reprint Antidepressants and gene expression profiling: how to SNARE novel drug targets
    K P Lesch
    Department of Psychiatry and Psychotherapy, Section of Molecular Psychobiology, University of Wurzburg, Wurzburg, Germany
    Pharmacogenomics J 2:346-8. 2002
  29. ncbi request reprint Differential effect of endothelial nitric oxide synthase (NOS-III) on the regulation of adult neurogenesis and behaviour
    Andreas Reif
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Eur J Neurosci 20:885-95. 2004
    ..In conclusion, our results indicated that NOS-III is involved in the proliferation of neuronal progenitor cells, although behavioural analysis does not provide evidence for a pro-depressive effect of reduced neuroneogenesis...
  30. ncbi request reprint MLC1 polymorphisms are specifically associated with periodic catatonia, a subgroup of chronic schizophrenia
    Sandra Selch
    Department of Psychiatry and Psychotherapy Molecular and Clinical Psychobiology, University of Wurzburg, Wurzburg, Germany
    Biol Psychiatry 61:1211-4. 2007
    ....
  31. doi request reprint Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia
    S Kittel-Schneider
    Psychiatric Neurobiology and Bipolar Disorder Program, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080, Wurzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 265:127-36. 2015
    ..There was a significant association of the DGKH risk haplotype with increased amygdala volume in BD, but not in schizophrenia or healthy controls. These findings add to the notion of a role of DGKH in the pathogenesis of BD. ..
  32. doi request reprint The sex-dependent impact of chronic clozapine and haloperidol treatment on characteristics of the metabolic syndrome in a rat model
    M von Wilmsdorff
    Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
    Pharmacopsychiatry 46:1-9. 2013
    ..An increased risk for metabolic syndrome has been described for patients with psychotic disorders. Antipsychotic drugs possibly contribute to metabolic changes...
  33. ncbi request reprint A neuronal nitric oxide synthase (NOS-I) haplotype associated with schizophrenia modifies prefrontal cortex function
    A Reif
    Department of Psychiatry and Psychotherapy Section for Clinical and Molecular Psychobiology and Laboratory for Psychophysiology and Functional Imaging, Julius Maximilians University Würzburg, Wurzburg, Germany
    Mol Psychiatry 11:286-300. 2006
    ..Collectively these findings suggest that regulatory polymorphisms of NOS1 contribute to the genetic risk for SCZ, and modulate prefrontal brain functioning...
  34. ncbi request reprint Increased hippocampal DNA oxidation in serotonin transporter deficient mice
    R Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Federal Republic of Germany
    J Neural Transm (Vienna) 109:557-65. 2002
    ..Given the importance of the hippocampus in learning and memory, this may be the most important neurochemical consequence of the absence of the 5HTT...
  35. pmc pH measurement as quality control on human post mortem brain tissue: a study of the BrainNet Europe consortium
    C M Monoranu
    Department of Neuropathology, Institute of Pathology, University of Wurzburg, Germany
    Neuropathol Appl Neurobiol 35:329-37. 2009
    ..Here we examine the influence of several premortem and post mortem factors on pH, and discuss the role of pH as a biochemical marker for brain tissue quality...
  36. ncbi request reprint Neurogenesis and schizophrenia: dividing neurons in a divided mind?
    Andreas Reif
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 257:290-9. 2007
    ..In conclusion, several lines of evidence suggest that reduced AN may contribute to the etiopathogenesis of schizophrenic disorders, whereas it does not seem to be a critical risk factor for affective disorders...
  37. ncbi request reprint Neuronal nitric oxide synthase (NOS-I) knockout increases the survival rate of neural cells in the hippocampus independently of BDNF
    Sabrina Fritzen
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy Josef Schneider Str 11, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Mol Cell Neurosci 35:261-71. 2007
    ..Together, these results emphasize the important role of the different NOS isoforms with respect to adult neurogenesis...
  38. pmc Calcium-dependent assembly of centrin-G-protein complex in photoreceptor cells
    Alexander Pulvermüller
    Institut fur Medizinische Physik und Biophysik, Humboldt Universitat zu Berlin, Germany
    Mol Cell Biol 22:2194-203. 2002
    ..The Ca(2+)-dependent assembly of a G protein with centrin is a novel aspect of the supply of signaling proteins in sensory cells and a potential link between molecular translocations and signal transduction in general...
  39. ncbi request reprint ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3
    Doreen Wendholt
    Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany
    J Biol Chem 281:13805-16. 2006
    ..Thus, ProSAPiP1 and PSD-Zip70 are founders of a novel family of scaffolding proteins, the "Fezzins," which adds further complexity to the organization of the PSD protein network...