Norbert Schaschke

Summary

Country: Germany

Publications

  1. ncbi request reprint Bivalent inhibition of beta-tryptase: distance scan of neighboring subunits by dibasic inhibitors
    Norbert Schaschke
    Max Planck Institut fur Biochemie, D 82152, Martinsried, Germany
    Bioorg Med Chem Lett 12:985-8. 2002
  2. ncbi request reprint Miraziridine A: natures blueprint towards protease class-spanning inhibitors
    Norbert Schaschke
    Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    Bioorg Med Chem Lett 14:855-7. 2004
  3. ncbi request reprint Inhibition of human mu-calpain by conformationally constrained calpastatin peptides
    José Pfizer
    Max Planck Institut fur Biochemie, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Biol Chem 389:83-90. 2008
  4. ncbi request reprint Affinity chromatography of tryptases: design, synthesis and characterization of a novel matrix-bound bivalent inhibitor
    Norbert Schaschke
    Max Planck Institut fur Biochemie, Am Klopferspitz 18a, 82152 Martinsried, Germany
    Chembiochem 6:95-103. 2005
  5. ncbi request reprint Epoxysuccinyl peptide-derived cathepsin B inhibitors: modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin
    Norbert Schaschke
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Biol Chem 383:849-52. 2002
  6. pmc Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft
    Igor Stern
    Department of Biochemistry and Molecular Biology, Josef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Biochem J 381:511-7. 2004
  7. pmc Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation
    Kithiganahalli N Balaji
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, Bethesda, MD 20892, USA
    J Exp Med 196:493-503. 2002
  8. doi request reprint Inhibition of cathepsin L by epoxysuccinyl peptides simultaneously addressing active-site and remote-site regions
    Norbert Schaschke
    Fakultat fur Chemie, Universitat Bielefeld, Universitatsstrasse 25, 33615 Bielefeld, Germany
    Chembiochem 9:1721-4. 2008
  9. ncbi request reprint Conformational and molecular modeling studies of beta-cyclodextrin-heptagastrin and the third extracellular loop of the cholecystokinin 2 receptor
    Craig Giragossian
    Department of Chemistry, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    Biochemistry 43:2724-31. 2004
  10. ncbi request reprint Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: enhancing cell permeability by conjugation with penetratin
    Shirley Gil-Parrado
    Abteilung für Klinische Chemie und Klinische Biochemie, Chirurgische Klinik Innenstadt, Klinikum der Ludwig Maximilians Universität, Nussbaumstr 20, D 80336 MUnchen, Germany
    Biol Chem 384:395-402. 2003

Collaborators

  • Dusan Turk
  • Klaudia Brix
  • Heiko Büth
  • Werner Machleidt
  • Luis Moroder
  • José Pfizer
  • Irmgard Assfalg-Machleidt
  • Petra Boukamp
  • Craig Giragossian
  • Igor Stern
  • Shirley Gil-Parrado
  • Kithiganahalli N Balaji
  • Raluca Ostafe
  • Pier Luigi Buttigieg
  • Stefanie R Dannenmann
  • Maren Rehders
  • Hans Jürgen Stark
  • Christian P Sommerhoff
  • Dale F Mierke
  • Henrike Veith
  • Maren Hansen
  • Benedikt Hartwig
  • Norbert E Fusenig
  • Roland Meier-Bornheim
  • Brit Wolters
  • Ferdinando Fiorino
  • Dominga Deluca
  • Dietmar Pfeiler
  • Pierre A Henkart
  • Marta Catalfamo

Detail Information

Publications13

  1. ncbi request reprint Bivalent inhibition of beta-tryptase: distance scan of neighboring subunits by dibasic inhibitors
    Norbert Schaschke
    Max Planck Institut fur Biochemie, D 82152, Martinsried, Germany
    Bioorg Med Chem Lett 12:985-8. 2002
    ..These experimental data are in full agreement with predictions derived from a novel modeling program that allows the docking of bivalent ligands...
  2. ncbi request reprint Miraziridine A: natures blueprint towards protease class-spanning inhibitors
    Norbert Schaschke
    Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    Bioorg Med Chem Lett 14:855-7. 2004
    ..Therefore, this unique compound represents a blueprint for the design of protease class-spanning inhibitors...
  3. ncbi request reprint Inhibition of human mu-calpain by conformationally constrained calpastatin peptides
    José Pfizer
    Max Planck Institut fur Biochemie, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Biol Chem 389:83-90. 2008
    ....
  4. ncbi request reprint Affinity chromatography of tryptases: design, synthesis and characterization of a novel matrix-bound bivalent inhibitor
    Norbert Schaschke
    Max Planck Institut fur Biochemie, Am Klopferspitz 18a, 82152 Martinsried, Germany
    Chembiochem 6:95-103. 2005
    ..This matrix selectively recognizes and binds beta-tryptase from crude protein mixtures and thus is useful as a geometry-driven means of isolating and purifying human mast cell tryptases...
  5. ncbi request reprint Epoxysuccinyl peptide-derived cathepsin B inhibitors: modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin
    Norbert Schaschke
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Biol Chem 383:849-52. 2002
    ....
  6. pmc Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft
    Igor Stern
    Department of Biochemistry and Molecular Biology, Josef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Biochem J 381:511-7. 2004
    ....
  7. pmc Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation
    Kithiganahalli N Balaji
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, Bethesda, MD 20892, USA
    J Exp Med 196:493-503. 2002
    ..These experiments support a model in which granule-derived surface cathepsin B provides self-protection for degranulating cytotoxic lymphocytes...
  8. doi request reprint Inhibition of cathepsin L by epoxysuccinyl peptides simultaneously addressing active-site and remote-site regions
    Norbert Schaschke
    Fakultat fur Chemie, Universitat Bielefeld, Universitatsstrasse 25, 33615 Bielefeld, Germany
    Chembiochem 9:1721-4. 2008
  9. ncbi request reprint Conformational and molecular modeling studies of beta-cyclodextrin-heptagastrin and the third extracellular loop of the cholecystokinin 2 receptor
    Craig Giragossian
    Department of Chemistry, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    Biochemistry 43:2724-31. 2004
    ....
  10. ncbi request reprint Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: enhancing cell permeability by conjugation with penetratin
    Shirley Gil-Parrado
    Abteilung für Klinische Chemie und Klinische Biochemie, Chirurgische Klinik Innenstadt, Klinikum der Ludwig Maximilians Universität, Nussbaumstr 20, D 80336 MUnchen, Germany
    Biol Chem 384:395-402. 2003
    ..g. calpain inhibitor 1) which inhibit the lysosomal cathepsins and partially the proteasome as well or even better than the calpains...
  11. ncbi request reprint HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration
    Heiko Büth
    School of Engineering and Science, International University Bremen, Bremen, Germany
    Eur J Cell Biol 83:781-95. 2004
    ..Thus, our results strongly suggest that cell surface-associated cathepsin B is a protease that contributes to the remodelling of the extracellular matrix and thereby promotes keratinocyte migration during wound healing...
  12. ncbi request reprint (2S,3S)-Oxirane-2,3-dicarboxylic acid: a privileged platform for probing human cysteine cathepsins
    Norbert Schaschke
    Fakultat fur Chemie, Universitat Bielefeld, Universitatsstrasse 25, D 33615 Bielefeld, Germany
    J Biotechnol 129:308-15. 2007
    ..Depending on the complexity of the attached recognition elements, either the activity of the entire group of human cysteine cathepsins or individual members can be detected...
  13. ncbi request reprint Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes
    Heiko Büth
    School of Engineering and Science, Jacobs University Bremen formerly International University Bremen, Campus Ring 6, Research II 107, D 28759 Bremen, Germany
    Eur J Cell Biol 86:747-61. 2007
    ....