Christof Schaefer

Summary

Country: Germany

Publications

  1. ncbi request reprint Angiotensin II-receptor-antagonists: further evidence of fetotoxicity but not teratogenicity
    Christof Schaefer
    Fachbereich Embryonaltoxikologie Department of Embryotoxicology, Berliner Betrieb für Zentrale Gesundheitliche Aufgaben, Berlin, Germany
    Birth Defects Res A Clin Mol Teratol 67:591-4. 2003
  2. doi request reprint Drug safety in pregnancy: utopia or achievable prospect? Risk information, risk research and advocacy in Teratology Information Services
    Christof Schaefer
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie, Berlin Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Spandauer Damm 130, Berlin, Germany
    Congenit Anom (Kyoto) 51:6-11. 2011
  3. doi request reprint Isotretinoin exposure and pregnancy outcome: an observational study of the Berlin Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy
    Christof Schaefer
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie BBGes, Berlin Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Spandauer Damm 130, Haus 10, 14050, Berlin, Germany
    Arch Gynecol Obstet 281:221-7. 2010
  4. doi request reprint Fetal outcome after technetium scintigraphy in early pregnancy
    Christof Schaefer
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie BBGes, Berlin Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Spandauer Damm 130, Haus 10, Berlin 14050, Germany
    Reprod Toxicol 28:161-6. 2009
  5. doi request reprint [Drug therapy during pregnancy]
    C Schaefer
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie, Berliner Betrieb für Zentrale Gesundheitliche Aufgaben, Spandauer Damm 130, Berlin, Germany
    Internist (Berl) 50:455-65; quiz 466. 2009
  6. doi request reprint Using observational cohort data for studying drug effects on pregnancy outcome--methodological considerations
    Christof Schaefer
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie BBGes, Berlin Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Spandauer Damm 130, Haus 10, 14050 Berlin, Germany
    Reprod Toxicol 26:36-41. 2008
  7. ncbi request reprint Post-marketing surveillance system for drugs in pregnancy--15 years experience of ENTIS
    Christof Schaefer
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie, Berliner Betrieb für Zentrale Gesundheitliche Aufgaben, Spandauer Damm 130, Haus 10, 14050 Berlin, Germany
    Reprod Toxicol 20:331-43. 2005
  8. ncbi request reprint Vitamin K antagonists and pregnancy outcome. A multi-centre prospective study
    Christof Schaefer
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie, Berliner Betrieb für Zentrale Gesundheitliche Aufgaben, Spandauer Damm 130, Haus 10, 14050 Berlin, Germany
    Thromb Haemost 95:949-57. 2006
  9. doi request reprint The safety of calcium channel blockers during pregnancy: a prospective, multicenter, observational study
    Corinna Weber-Schoendorfer
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie, BBGes, Berlin Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Spandauer Damm 130, Haus 10, 14050 Berlin, Germany
    Reprod Toxicol 26:24-30. 2008
  10. doi request reprint Atypical antipsychotic drugs and pregnancy outcome: a prospective, cohort study
    Frank Habermann
    Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Clin Psychopharmacol 33:453-62. 2013

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Angiotensin II-receptor-antagonists: further evidence of fetotoxicity but not teratogenicity
    Christof Schaefer
    Fachbereich Embryonaltoxikologie Department of Embryotoxicology, Berliner Betrieb für Zentrale Gesundheitliche Aufgaben, Berlin, Germany
    Birth Defects Res A Clin Mol Teratol 67:591-4. 2003
    ..The other enrolls women prospectively according to exposure to particular drugs during pregnancy, with follow-up of pregnancy outcome...
  2. doi request reprint Drug safety in pregnancy: utopia or achievable prospect? Risk information, risk research and advocacy in Teratology Information Services
    Christof Schaefer
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie, Berlin Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Spandauer Damm 130, Berlin, Germany
    Congenit Anom (Kyoto) 51:6-11. 2011
    ....
  3. doi request reprint Isotretinoin exposure and pregnancy outcome: an observational study of the Berlin Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy
    Christof Schaefer
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie BBGes, Berlin Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Spandauer Damm 130, Haus 10, 14050, Berlin, Germany
    Arch Gynecol Obstet 281:221-7. 2010
    ..A detailed investigation of the incidence and outcome of these pregnancies would fill an important gap...
  4. doi request reprint Fetal outcome after technetium scintigraphy in early pregnancy
    Christof Schaefer
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie BBGes, Berlin Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Spandauer Damm 130, Haus 10, Berlin 14050, Germany
    Reprod Toxicol 28:161-6. 2009
    ..Therefore, clinical data was needed to assess the risk and safety of technetium scintigraphy with respect to prenatal development...
  5. doi request reprint [Drug therapy during pregnancy]
    C Schaefer
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie, Berliner Betrieb für Zentrale Gesundheitliche Aufgaben, Spandauer Damm 130, Berlin, Germany
    Internist (Berl) 50:455-65; quiz 466. 2009
    ....
  6. doi request reprint Using observational cohort data for studying drug effects on pregnancy outcome--methodological considerations
    Christof Schaefer
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie BBGes, Berlin Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Spandauer Damm 130, Haus 10, 14050 Berlin, Germany
    Reprod Toxicol 26:36-41. 2008
    ....
  7. ncbi request reprint Post-marketing surveillance system for drugs in pregnancy--15 years experience of ENTIS
    Christof Schaefer
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie, Berliner Betrieb für Zentrale Gesundheitliche Aufgaben, Spandauer Damm 130, Haus 10, 14050 Berlin, Germany
    Reprod Toxicol 20:331-43. 2005
    ..As a TIS is contacted mainly for insufficiently documented drugs or those suspected of acting as developmental toxicants there is even a selection for products needing research...
  8. ncbi request reprint Vitamin K antagonists and pregnancy outcome. A multi-centre prospective study
    Christof Schaefer
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie, Berliner Betrieb für Zentrale Gesundheitliche Aufgaben, Spandauer Damm 130, Haus 10, 14050 Berlin, Germany
    Thromb Haemost 95:949-57. 2006
    ..Close follow-up by the obstetrician including level II ultrasound should be recommended in any case of VKA exposure during pregnancy...
  9. doi request reprint The safety of calcium channel blockers during pregnancy: a prospective, multicenter, observational study
    Corinna Weber-Schoendorfer
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie, BBGes, Berlin Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Spandauer Damm 130, Haus 10, 14050 Berlin, Germany
    Reprod Toxicol 26:24-30. 2008
    ..To assess the safety of calcium channel blockers during the first trimester of pregnancy...
  10. doi request reprint Atypical antipsychotic drugs and pregnancy outcome: a prospective, cohort study
    Frank Habermann
    Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Clin Psychopharmacol 33:453-62. 2013
    ..Because neonates exposed to SGAs or FGAs in the last gestational week are at higher risk of postnatal disorders, delivery should be planned in clinics with neonatal intensive care units. ..
  11. doi request reprint Pregnancy outcome after methotrexate treatment for rheumatic disease prior to or during early pregnancy: a prospective multicenter cohort study
    Corinna Weber-Schoendorfer
    Charité Universitätsmedizin Berlin and Pharmakovigilanz und Beratungszentrum Embryonaltoxikologie, Berlin, Germany
    Arthritis Rheumatol 66:1101-10. 2014
    ..The aim of this study was to evaluate the risk of spontaneous abortion, major birth defects, elective termination of pregnancy, shortened gestational age at delivery, and reduced birth weight in women exposed to MTX...
  12. doi request reprint The safety of cetirizine during pregnancy. A prospective observational cohort study
    Corinna Weber-Schoendorfer
    Pharmakovigilanz und Beratungszentrum Embryonaltoxikologie Berlin, Berlin Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Spandauer Damm 130, Haus 10, 14050 Berlin, Germany
    Reprod Toxicol 26:19-23. 2008
    ..To assess the safety of cetirizine during pregnancy...
  13. pmc Pregnancy outcome after TNF-α inhibitor therapy during the first trimester: a prospective multicentre cohort study
    Corinna Weber-Schoendorfer
    Pharmakovigilanzzentrum Embryonaltoxikologie, Institut fur Klinische Pharmakologie und Toxikologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    Br J Clin Pharmacol 80:727-39. 2015
    ..The aim of this study was to evaluate the risk of major birth defects, spontaneous abortion, preterm birth and reduced birth weight after first trimester exposure to TNF-α inhibitors...
  14. pmc Observational cohort study of pregnancy outcome after first-trimester exposure to fluoroquinolones
    Stephanie Padberg
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Antimicrob Agents Chemother 58:4392-8. 2014
    ..These reassuring findings support the recommendation to allow fluoroquinolone use in early pregnancy in selected cases. After the use of moxifloxacin, a detailed fetal ultrasound examination should be considered...
  15. doi request reprint No evidence for an increased risk of adverse pregnancy outcome after paternal low-dose methotrexate: an observational cohort study
    Corinna Weber-Schoendorfer
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie, Charite Universitatsmedizin Berlin, Spandauer Damm 130, Haus 10, 14050 Berlin, Germany
    Rheumatology (Oxford) 53:757-63. 2014
    ..The aim of this study was to investigate whether paternal low-dose MTX therapy around conception has an unfavourable effect on pregnancy outcome...
  16. doi request reprint [Drug safety in pregnancy - the Embryotox project]
    Christof Schaefer
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie, Charite Universitatsmedizin Berlin, Berlin
    Z Evid Fortbild Qual Gesundhwes 106:723-8. 2012
    ..Individual consultations are available drawing on the results from the institute's own database and other working groups, and regularly updated information is also available via the open access database www.embryotox.de...
  17. doi request reprint Does the average drug exposure in pregnant women affect pregnancy outcome? A comparison of two approaches to estimate the baseline risks of adverse pregnancy outcome
    Evelin Wacker
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Pharmacoepidemiol Drug Saf 24:353-60. 2015
    ..The aim of this investigation was to compare two distinct definitions of maternal exposure status for comparison cohorts...
  18. pmc Angiotensin-II receptor 1 antagonist fetopathy--risk assessment, critical time period and vena cava thrombosis as a possible new feature
    Marc Oppermann
    Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Charite Universitatsmedizin Berlin, 14050 Berlin, Germany
    Br J Clin Pharmacol 75:822-30. 2013
    ..This study aimed to assess the risk of fetopathy, the sensitive time window, and possible new symptoms in prospective as well as retrospective cases with AT₁-antagonist treatment during the second or third trimester of pregnancy...
  19. doi request reprint Hip arthroplasty with high chromium and cobalt blood levels--Case report of a patient followed during pregnancy and lactation period
    Marc Oppermann
    Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Charite Universitatsmedizin, Berlin, Germany
    Reprod Toxicol 53:51-3. 2015
    ..An association between hypospadias and Cr/Co has to be considered speculative. The otherwise favorable outcome of this case may be reassuring for pregnant and breast-feeding patients with metal-on-metal hip replacements...
  20. pmc Case report: High chromium and cobalt levels in a pregnant patient with bilateral metal-on-metal hip arthroplasties
    Juliane Fritzsche
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Institut fur Klinische Pharmakologie und Toxikologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    Clin Orthop Relat Res 470:2325-31. 2012
    ..Metal-on-metal bearings frequently are used in young patients leading to the concern that disseminated metals such as chromium (Cr) and cobalt (Co) as the main constituents could affect pregnancies...
  21. ncbi request reprint Exposure to vitamin K antagonists during pregnancy
    Christof Schaefer
    The Research Institute for Risk and Safety, Information of Medicines in Pregnancy and Lactation, Berlin, Germany
    Clin Adv Hematol Oncol 4:509-10. 2006
  22. doi request reprint Congenital bladder exstrophy associated with Duogynon hormonal pregnancy tests-signal for teratogenicity or consumer report bias?
    Gregor Tümmler
    Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Charité University Clinic Berlin, Berlin, Germany
    Reprod Toxicol 45:14-9. 2014
    ..Bladder exstrophy may be a yet undetected teratogenic effect of Duogynon, but may also represent a reporting bias. The present study highlights the difficulties of evaluating consumer reports which may be influenced by public media. ..
  23. ncbi request reprint Pregnancy outcome after exposure to ranitidine and other H2-blockers. A collaborative study of the European Network of Teratology Information Services
    Hanneke Garbis
    Teratology Information Service, National Institute of Public Health and Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Reprod Toxicol 19:453-8. 2005
    ..Published data on pregnancy outcome after exposure to H2-blockers is scarce. The aim of the present study was to evaluate the data collected by the memberships of the European Network of Teratology Information Services (ENTIS)...
  24. ncbi request reprint Safety of haloperidol and penfluridol in pregnancy: a multicenter, prospective, controlled study
    Orna Diav-Citrin
    Israeli Teratogen Information Service, Jerusalem 91120, Israel
    J Clin Psychiatry 66:317-22. 2005
    ..To assess the safety of the butyrophenone neuroleptics haloperidol and penfluridol in pregnancy...
  25. doi request reprint Statistical methods for estimating the probability of spontaneous abortion in observational studies--analyzing pregnancies exposed to coumarin derivatives
    Reinhard Meister
    Department of, Mathematics, University of Applied Sciences, Technische Fachhochschule Berlin, Luxemburger Strasse 10, 13353 Berlin, Germany
    Reprod Toxicol 26:31-5. 2008
    ....
  26. ncbi request reprint Pregnancy outcome of women exposed to azathioprine during pregnancy
    Lee Hilary Goldstein
    Clinical Pharmacology Unit, Teratogen Information Service, Assaf Harofeh Medical Center, Sackler School of Medicine, Tel Aviv University, Israel
    Birth Defects Res A Clin Mol Teratol 79:696-701. 2007
    ..Our objective was too determine whether exposure to AZP during pregnancy increases the risk for major malformations and to determine the effect on pregnancy outcome...