Jurgen Floege

Summary

Affiliation: RWTH Aachen
Country: Germany

Publications

  1. ncbi request reprint beta2-microglobulin-derived amyloidosis: an update
    J Floege
    Division of Nephrology, University of Aachen, Aachen, Germany
    Kidney Int Suppl 78:S164-71. 2001
  2. ncbi request reprint Vascular calcification in patients with end-stage renal disease
    Jurgen Floege
    Medizinische Klinik II, Klinikum der RWTH, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Nephrol Dial Transplant 19:V59-66. 2004
  3. ncbi request reprint Evidence-based recommendations for immunosuppression in IgA nephropathy: handle with caution
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    Nephrol Dial Transplant 18:241-5. 2003
  4. ncbi request reprint Glomerular remodelling: novel therapeutic approaches derived from the apparently chaotic growth factor network
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, Germany
    Nephron 91:582-7. 2002
  5. doi request reprint Late angiotensin II receptor blockade in progressive rat mesangioproliferative glomerulonephritis: new insights into mechanisms
    Luigi Villa
    Division of Nephrology, RWTH Aachen University Hospital, Germany
    J Pathol 229:672-84. 2013
  6. ncbi request reprint Relation of circulating Matrix Gla-Protein and anticoagulation status in patients with aortic valve calcification
    Ralf Koos
    Department of Cardiology, Medical Faculty, RWTH Aachen University, Aachen, Germany
    Thromb Haemost 101:706-13. 2009
  7. pmc PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis
    Frank Eitner
    Division of Nephrology and Immunology, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    J Am Soc Nephrol 19:281-9. 2008
  8. doi request reprint Osteogenesis of heterotopically transplanted mesenchymal stromal cells in rat models of chronic kidney disease
    Rafael Kramann
    Division of Nephrology and Clinical Immunology, Medical Faculty Rheinisch Westfaelische Technische Hochschule RWTH Aachen University, Aachen, Germany Institute of Pathology, Medical Faculty Rheinisch Westfaelische Technische Hochschule RWTH Aachen University, Aachen, Germany
    J Bone Miner Res 28:2523-34. 2013
  9. ncbi request reprint Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes
    Uta Kunter
    Division of Nephrology, University Hospital RWTH Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    J Am Soc Nephrol 18:1754-64. 2007
  10. ncbi request reprint Extracellular actin impairs glomerular capillary repair in experimental mesangioproliferative glomerulonephritis
    Ulf Janssen
    Division of Nephrology, Universitie of Aachen, Germany
    Nephron Exp Nephrol 93:e158-67. 2003

Detail Information

Publications103 found, 100 shown here

  1. ncbi request reprint beta2-microglobulin-derived amyloidosis: an update
    J Floege
    Division of Nephrology, University of Aachen, Aachen, Germany
    Kidney Int Suppl 78:S164-71. 2001
    ..Such factors, which have changed over the last years as part of general improvements in dialysis care, may explain why the prevalence of the amyloidosis appears to decrease...
  2. ncbi request reprint Vascular calcification in patients with end-stage renal disease
    Jurgen Floege
    Medizinische Klinik II, Klinikum der RWTH, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Nephrol Dial Transplant 19:V59-66. 2004
    ..Yet, it remains unclear whether sevelamer HCl reduces vascular calcification by preventing episodes of hypercalcaemia and/or by reducing low-density lipoprotein (LDL)-cholesterol levels...
  3. ncbi request reprint Evidence-based recommendations for immunosuppression in IgA nephropathy: handle with caution
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    Nephrol Dial Transplant 18:241-5. 2003
  4. ncbi request reprint Glomerular remodelling: novel therapeutic approaches derived from the apparently chaotic growth factor network
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, Germany
    Nephron 91:582-7. 2002
    ....
  5. doi request reprint Late angiotensin II receptor blockade in progressive rat mesangioproliferative glomerulonephritis: new insights into mechanisms
    Luigi Villa
    Division of Nephrology, RWTH Aachen University Hospital, Germany
    J Pathol 229:672-84. 2013
    ..We identified down-regulation of platelet-derived growth factor receptors and CCR6 as potential mediators of telmisartan-related renoprotection. CCR6 may also regulate the renal outcome in human mesangioprolfierative glomerulonephritis...
  6. ncbi request reprint Relation of circulating Matrix Gla-Protein and anticoagulation status in patients with aortic valve calcification
    Ralf Koos
    Department of Cardiology, Medical Faculty, RWTH Aachen University, Aachen, Germany
    Thromb Haemost 101:706-13. 2009
    ..In addition, our data suggest that OAC treatment may decrease local expression of MGP, resulting in decreased circulating MGP levels and subsequently increased aortic valve calcifications as an adverse side effect...
  7. pmc PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis
    Frank Eitner
    Division of Nephrology and Immunology, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    J Am Soc Nephrol 19:281-9. 2008
  8. doi request reprint Osteogenesis of heterotopically transplanted mesenchymal stromal cells in rat models of chronic kidney disease
    Rafael Kramann
    Division of Nephrology and Clinical Immunology, Medical Faculty Rheinisch Westfaelische Technische Hochschule RWTH Aachen University, Aachen, Germany Institute of Pathology, Medical Faculty Rheinisch Westfaelische Technische Hochschule RWTH Aachen University, Aachen, Germany
    J Bone Miner Res 28:2523-34. 2013
    ....
  9. ncbi request reprint Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes
    Uta Kunter
    Division of Nephrology, University Hospital RWTH Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    J Am Soc Nephrol 18:1754-64. 2007
    ..These data suggest that MSC treatment can be a valuable therapeutic approach only if adipogenic maldifferentiation is prevented...
  10. ncbi request reprint Extracellular actin impairs glomerular capillary repair in experimental mesangioproliferative glomerulonephritis
    Ulf Janssen
    Division of Nephrology, Universitie of Aachen, Germany
    Nephron Exp Nephrol 93:e158-67. 2003
    ..Our combined in vivo and in vitro observations suggest that the release of intracellular actin during mesangiolysis is an endogenous pathway by which glomerular capillary damage is augmented...
  11. ncbi request reprint PDGF-D inhibition by CR002 ameliorates tubulointerstitial fibrosis following experimental glomerulonephritis
    Peter Boor
    Division of Nephrology, University Hospital Aachen, Pauwelsstr 30, D 52074 Aachen, Germany
    Nephrol Dial Transplant 22:1323-31. 2007
    ..Administration of the PDGF-D neutralizing fully human monoclonal antibody CR002 in the acute phase of progressive anti-Thy 1.1 glomerulonephritis reduced glomerular and secondary tubulointerstitial damage...
  12. doi request reprint Induction of progressive glomerulonephritis by podocyte-specific overexpression of platelet-derived growth factor-D
    Claudia R C van Roeyen
    Division of Nephrology, RWTH Aachen University Hospital, Aachen, Germany
    Kidney Int 80:1292-305. 2011
    ..Hence, podocyte-specific growth factor overexpression can induce paracrine mesangial cell proliferation upstream of the filtration flow...
  13. ncbi request reprint Fetuin-A (AHSG) prevents extraosseous calcification induced by uraemia and phosphate challenge in mice
    Ralf Westenfeld
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    Nephrol Dial Transplant 22:1537-46. 2007
    ..Chronic kidney disease (CKD) is associated with vascular and tissue calcification. The extent of vascular calcification has been identified as an independent risk factor of cardiovascular death in patients on haemodialysis...
  14. doi request reprint Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts
    Claudia Seikrit
    Division of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany
    Nephrol Dial Transplant 28:889-900. 2013
    ..Whereas PDGF-CC binds to both the PDGF receptors (PDGFRs)-αα- and -αβ, PDGF-AA binds more selectively to the αα-receptor, suggesting potential differences in the biological activities...
  15. pmc Proximal tubular cells contain a phenotypically distinct, scattered cell population involved in tubular regeneration
    Bart Smeets
    Division of Nephrology and Immunology, University Hospital of the Aachen University of Technology RWTH, Aachen, Germany
    J Pathol 229:645-59. 2013
    ..Our data indicate rather that these cells represent transiently dedifferentiated tubular cells involved in regeneration...
  16. doi request reprint Notch-3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury
    Sonja Djudjaj
    Department of Nephrology and Hypertension, Diabetes and Endocrinology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Pathol 228:286-99. 2012
    ..Thus, specific blockade of this receptor may be suitable as therapeutic option to delay progression of kidney disease...
  17. doi request reprint Uraemia disrupts the vascular niche in a 3D co-culture system of human mesenchymal stem cells and endothelial cells
    Rafael Kramann
    Division of Nephrology and Clinical Immunology, Medical Faculty, RWTH Aachen University, Aachen, Germany
    Nephrol Dial Transplant 27:2693-702. 2012
    ..The uraemic microenvironment predisposes to increased levels of reactive oxygen species, accelerated ageing of endothelial cells (EC) and vascular sclerosis...
  18. ncbi request reprint Complement C5 mediates experimental tubulointerstitial fibrosis
    Peter Boor
    Division of Nephrology, Rheinische Westfälische Technische Hochschule, University of Aachen, Aachen, Germany
    J Am Soc Nephrol 18:1508-15. 2007
    ..Using a combined genetic and pharmacologic approach, C5, in particular C5a, is identified as a novel profibrotic factor in renal disease and as a potential new therapeutic target...
  19. doi request reprint Analysis of calcifications in patients with coral reef aorta
    Georg Schlieper
    Department of Nephrology and Clinical Immunology, RWTH University Hospital, and Central Facility for Electron Microscopy, RWTH University, Aachen, Germany
    Ann Vasc Surg 24:408-14. 2010
    ..The aim of our study was to investigate calcification inhibitors and the ultrastructure of calcifications in patients with coral reef aorta...
  20. pmc Origin of parietal podocytes in atubular glomeruli mapped by lineage tracing
    Kevin Schulte
    Department of Nephrology and Immunology, RWTH University of Aachen, Aachen, NRW, Germany
    J Am Soc Nephrol 25:129-41. 2014
    ..These results suggest that induction of atubular glomeruli leads to ablation of PECs and subsequent migration of visceral podocytes onto Bowman's capsule, rather than transdifferentiation from PECs to parietal podocytes. ..
  21. doi request reprint Growth arrest-specific protein 1 is a novel endogenous inhibitor of glomerular cell activation and proliferation
    Claudia R C van Roeyen
    Division of Nephrology, RWTH University Hospital Aachen, Aachen, Germany
    Kidney Int 83:251-63. 2013
    ..Thus, GAS1 is a novel endogenous inhibitor of glomerular mesangial cell proliferation and may be a novel therapeutic target in mesangioproliferative glomerular diseases...
  22. pmc PDGF-C mediates glomerular capillary repair
    Peter Boor
    Division of Nephrology and Immunology, University Hospital Aachen, Pauwelsstr 30, D 52074 Aachen, Germany
    Am J Pathol 177:58-69. 2010
    ..These results identify PDGF-C as a novel, potent pro-angiogenic factor in the kidney that can accelerate capillary healing in experimental glomerulonephritis and thrombotic microangiopathy...
  23. ncbi request reprint R-roscovitine (CYC202) alleviates renal cell proliferation in nephritis without aggravating podocyte injury
    Maja Milovanceva-Popovska
    Division of Nephrology, University of Aachen, Aachen, Germany
    Kidney Int 67:1362-70. 2005
    ..Since podocytes express CDK2 in nephritis and since loss of podocytes contributes to glomerulosclerosis, the rationale of the present study was to test whether CDK2 inhibition is safe in instances of podocyte injury...
  24. ncbi request reprint The effects of platelet-derived growth factor antagonism in experimental glomerulonephritis are independent of the transforming growth factor-beta system
    Tammo Ostendorf
    Division of Nephrology and Immunology, University of Aachen, Aachen, Germany
    J Am Soc Nephrol 13:658-67. 2002
    ..These observations suggest that the effects of PDGF-B antagonism are independent of TGF-beta in mesangioproliferative glomerulonephritides...
  25. doi request reprint Platelet-derived growth factor (PDGF)-C neutralization reveals differential roles of PDGF receptors in liver and kidney fibrosis
    Ina V Martin
    Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany
    Am J Pathol 182:107-17. 2013
    ..PDGF-C antagonism, therefore, may not be effective to treat liver fibrosis...
  26. doi request reprint Extracellular YB-1 blockade in experimental nephritis upregulates Notch-3 receptor expression and signaling
    Ute Raffetseder
    Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany
    Nephron Exp Nephrol 118:e100-8. 2011
    ....
  27. doi request reprint Serological cardiovascular and mortality risk predictors in dialysis patients receiving sevelamer: a prospective study
    Vincent Matthias Brandenburg
    Department of Nephrology, University Hospital of the RWTH Aachen, Pauwelsstase 30, Aachen, Germany
    Nephrol Dial Transplant 25:2672-9. 2010
    ..We assessed how sevelamer hydrochloride influences the evolution of serum fetuin-A and other serological factors predicting cardiovascular outcome and survival in haemodialysis patients...
  28. doi request reprint Vascular access calcification predicts mortality in hemodialysis patients
    Georg Schlieper
    Department of Nephrology and Clinical Immunology, RWTH University Hospital Aachen, Aachen, Germany
    Kidney Int 74:1582-7. 2008
    ..Our study suggests that detection of vascular access calcification is a cost-effective method to identify patients at increased mortality risk...
  29. pmc Circulating nonphosphorylated carboxylated matrix gla protein predicts survival in ESRD
    Georg Schlieper
    Department of Nephrology and Clinical Immunology, Rheinisch Westfalische Technische Hochschule, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Am Soc Nephrol 22:387-95. 2011
    ..Lower levels of circulating dp-cMGP may serve as a predictor of mortality in dialysis patients. Whether vitamin K supplementation improves outcomes requires further study...
  30. pmc Fetuin-A protects against atherosclerotic calcification in CKD
    Ralf Westenfeld
    Department of Nephrology, Rheinisch Westfälische Technische Hochschule RWTH Aachen University Hospital, Aachen, Germany
    J Am Soc Nephrol 20:1264-74. 2009
    ..In conclusion, fetuin-A inhibits pathologic calcification in both the soft tissue and vasculature, even in the setting of atherosclerosis...
  31. doi request reprint Warfarin induces cardiovascular damage in mice
    Thilo Kruger
    From the Department of Nephrology, University Hospital of the Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany T K, S O, N K, P B, G S, V M B, J F Department of Biochemistry, Cardiovascular Research Institute CARIM, University of Maastricht, Maastricht, The Netherlands L J S Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Düsseldorf, Dusseldorf, Germany A M v d S, V V, R W Department of Pathology, University Hospital of the RWTH Aachen, Aachen, Germany P B Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia P B 2nd Department of Medicine, Military Hospital Budapest, Budapest, Hungary B C F Nephrology, Hospital Coburg, Coburg, Germany M K VitaK BV, Maastricht, The Netherlands C V Biointerface Laboratory, Hiroshima University Hospital
    Arterioscler Thromb Vasc Biol 33:2618-24. 2013
    ..Here, we investigated functional cardiovascular characteristics in a mouse model with warfarin-induced media calcification...
  32. ncbi request reprint Renal side effects of anti-VEGF therapy in man: a new test system
    Tammo Ostendorf
    Division of Nephrology, University Hospital Aachen, Pauwelsstr 30, D 52057 Aachen, Germany
    Nephrol Dial Transplant 22:2778-80. 2007
  33. doi request reprint Effects and mechanisms of angiotensin II receptor blockade with telmisartan in a normotensive model of mesangioproliferative nephritis
    Luigi Villa
    Division of Nephrology, University Hospital RWTH Aachen, Aachen, Germany
    Nephrol Dial Transplant 26:3131-43. 2011
    ..We examined the effect of low-dose telmisartan (LT) and high-dose telmisartan (HT) versus conventional antihypertensive therapy in the rat anti-Thy1.1 model of glomerulonephritis...
  34. doi request reprint Impact of sirolimus, tacrolimus and mycophenolate mofetil on osteoclastogenesis--implications for post-transplantation bone disease
    Ralf Westenfeld
    Department of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany
    Nephrol Dial Transplant 26:4115-23. 2011
    ..Glucocorticoid-induced osteoporosis on top of pre-existing renal osteodystrophy is considered the major pathogenic factor, while the role of non-glucocorticoid immunosuppressants is less well defined...
  35. doi request reprint A novel, dual role of CCN3 in experimental glomerulonephritis: pro-angiogenic and antimesangioproliferative effects
    Claudia R C van Roeyen
    Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany
    Am J Pathol 180:1979-90. 2012
    ..Manipulation of CCN3 may represent a novel approach to help repair glomerular endothelial damage and mesangioproliferative changes...
  36. doi request reprint Differential regulation of chemokine CCL5 expression in monocytes/macrophages and renal cells by Y-box protein-1
    Ute Raffetseder
    Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany
    Kidney Int 75:185-96. 2009
    ..We show that YB-1 is a cell-type specific regulator of CCL5 expression in infiltrating T-cells and monocytes/macrophages and acts as an adaptive controller of inflammation during kidney allograft rejection...
  37. ncbi request reprint Antagonism of PDGF-D by human antibody CR002 prevents renal scarring in experimental glomerulonephritis
    Tammo Ostendorf
    Division of Nephrology, University Hospital Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    J Am Soc Nephrol 17:1054-62. 2006
    ..In conclusion, these data provide evidence for a causal role of PDGF-D in the pathogenesis of renal scarring and point to a new therapeutic approach to progressive mesangioproliferative renal disease...
  38. doi request reprint Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Aachen, Germany
    Lab Invest 88:1090-100. 2008
    ....
  39. ncbi request reprint The map kinase ERK regulates renal activity of cyclin-dependent kinase 2 in experimental glomerulonephritis
    Dirk Bokemeyer
    Division of Nephrology, Augusta Hospital, Bochum, Germany
    Nephrol Dial Transplant 22:3431-41. 2007
    ..In vitro, the extracellular signal-regulated kinase (ERK) is an intracellular convergence point of multiple stimuli, which affect the cell cycle. However, the role of ERK in cell cycle regulation in vivo is unknown...
  40. ncbi request reprint Selective cyclooxygenase-2 inhibition impairs glomerular capillary healing in experimental glomerulonephritis
    Masashi Kitahara
    Division of Nephrology and Immunology, University of Aachen, Aachen, Germany
    J Am Soc Nephrol 13:1261-70. 2002
    ..1 glomerulonephritis. These data suggest that selective COX-2 inhibitors should be used with caution among patients with inflammatory endocapillary glomerular disorders...
  41. ncbi request reprint PDGF-C expression in the developing and normal adult human kidney and in glomerular diseases
    Frank Eitner
    Division of Nephrology and Immunology, Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Am Soc Nephrol 14:1145-53. 2003
    ..We conclude that PDGF-C is constitutively expressed in the human kidney and is upregulated in podocytes and interstitial cells after injury/activation of these cells...
  42. ncbi request reprint Ultrasonographic fata morgana
    Vincent M Brandenburg
    Department of Nephrology and Immunology, University Hospital, Rheinisch Westfalische Technische Hochschule, Aachen, Germany
    Nephrol Dial Transplant 18:845-6. 2003
  43. ncbi request reprint Calcification and the usual suspect phosphate: still guilty but there are other guys behind the scenes
    Markus Ketteler
    Division of Nephrology, RWTH University Hospital Aachen, Germany
    Nephrol Dial Transplant 21:33-5. 2006
  44. ncbi request reprint Mesangial cell expression of proto-oncogene Ets-1 during progression of mesangioproliferative glomerulonephritis
    Ute Raffetseder
    Department of Nephrology and Clinical Immunology, University Hospital of Aachen, Aachen, Germany
    Kidney Int 66:622-32. 2004
    ..The expression of Ets-1 mRNA and protein was analyzed in healthy rat kidney and in a model for mesangioproliferative disease without and with inhibition of platelet-derived growth factor-B (PDGF-B) activity...
  45. pmc Tracing the origin of glomerular extracapillary lesions from parietal epithelial cells
    Bart Smeets
    Department of Nephrology and Immunology, University Hospital of the Aachen University of Technology, Pauwelsstrasse 30, Aachen, Germany
    J Am Soc Nephrol 20:2604-15. 2009
    ..In conclusion, PECs constitute the majority of cells that compose early extracapillary proliferative lesions in both crescentic glomerulonephritis and collapsing glomerulopathy, suggesting similar pathomechanisms in both diseases...
  46. pmc The Montreal Cognitive Assessment (MoCA) - a sensitive screening instrument for detecting cognitive impairment in chronic hemodialysis patients
    Frances E Tiffin-Richards
    Department of Neurology, RWTH Aachen University Hospital, Aachen, Germany Jülich Aachen Research Alliance JARA Translational Brain Medicine, Aachen and Jülich, Germany
    PLoS ONE 9:e106700. 2014
    ....
  47. doi request reprint Prognostic impact of renal arterial resistance index upon renal allograft survival: the time point matters
    Rafael Kramann
    Department of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany
    Nephrol Dial Transplant 27:3958-63. 2012
    ..We performed a retrospective analysis of RI and its power to predict renal allograft failure or death with special emphasis on the time point of RI measurement...
  48. ncbi request reprint Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis
    Thilo Kruger
    Department of Nephrology and Clinical Immunology, University Clinic of Aachen, Aachen, Germany
    J Am Soc Nephrol 15:613-21. 2004
    ..These results are the first to identify and characterize renal CD11c(+) cells as DC and to demonstrate marked changes in experimental glomerulonephritis...
  49. ncbi request reprint Inducible nitric oxide synthase-derived nitric oxide promotes glomerular angiogenesis via upregulation of vascular endothelial growth factor receptors
    Tammo Ostendorf
    Division of Nephrology and Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    J Am Soc Nephrol 15:2307-19. 2004
    ..These data identify iNOS-derived NO production as the first in vivo regulator of the glomerular VEGF system and as an important mechanism promoting glomerular healing...
  50. ncbi request reprint Transplanted mesenchymal stem cells accelerate glomerular healing in experimental glomerulonephritis
    Uta Kunter
    Division of Nephrology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    J Am Soc Nephrol 17:2202-12. 2006
    ....
  51. doi request reprint Regardless of etiology, progressive renal disease causes ultrastructural and functional alterations of peritubular capillaries
    Janka Babickova
    Institute of Pathology, RWTH University of Aachen, Aachen, Germany Division of Nephrology, RWTH University of Aachen, Aachen, Germany Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia Institute for Clinical and Translational Research, Biomedical Research Center SAS, Bratislava, Slovakia
    Kidney Int . 2016
    ..Analyses of these alterations could provide read-outs for the evaluation of therapeutic approaches targeting the renal microvasculature...
  52. pmc IL-6 Trans-Signaling Drives Murine Crescentic GN
    Gerald S Braun
    Division of Nephrology and Immunology, Rheinisch Westfälische Technische Hochschule RWTH Aachen University, Aachen Germany Institute of Biochemistry and Molecular Biology, RWTH Aachen University, Aachen, Germany
    J Am Soc Nephrol 27:132-42. 2016
    ..Collectively, our data suggest a central role for IL-6 trans-signaling in crescentic nephritis and offer options for more effective and specific therapeutic interventions in the IL-6 system. ..
  53. doi request reprint Common histological patterns in glomerular epithelial cells in secondary focal segmental glomerulosclerosis
    Christoph Kuppe
    Department of Internal Medicine II, Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany
    Kidney Int 88:990-8. 2015
    ..Hence, our findings support the hypothesis that FSGS lesions follow a final cellular pathway to nephron loss that includes involvement of cells expressing PEC markers. ..
  54. pmc Long-term effects of the iron-based phosphate binder, sucroferric oxyhydroxide, in dialysis patients
    Jurgen Floege
    RWTH University Hospital Aachen, Aachen, Germany
    Nephrol Dial Transplant 30:1037-46. 2015
    ..Long-term efficacy and tolerability of the iron-based phosphate binder, sucroferric oxyhydroxide (previously known as PA21), was compared with that of sevelamer carbonate (sevelamer) in an open-label Phase III extension study...
  55. pmc Calcineurin-mediated YB-1 dephosphorylation regulates CCL5 expression during monocyte differentiation
    Christina Alidousty
    From the Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    J Biol Chem 289:21401-12. 2014
    ..Our findings point to a critical role of YB-1 in the resolution of inflammatory processes which may largely be due to CN-mediated dephosphorylation. ..
  56. ncbi request reprint The role of PDGF-D in mesangioproliferative glomerulonephritis
    Jurgen Floege
    Division of Nephrology and Immunology, RWTH University of Aachen, Aachen, Germany
    Contrib Nephrol 157:153-8. 2007
    ..In addition, first observations suggest that PDGF-D may also contribute to secondary renal changes that characterize progressive renal failure, i.e. tubulointerstitial fibrosis...
  57. doi request reprint Exposure to uremic serum induces a procalcific phenotype in human mesenchymal stem cells
    Rafael Kramann
    Department of Nephrology and Clinical Immunology, Medical Faculty RWTH, Aachen University, Aachen, Germany
    Arterioscler Thromb Vasc Biol 31:e45-54. 2011
    ..The current study is based on the hypothesis that mesenchymal stem cells (MSC) constitute critical cells for procalcific extracellular matrix remodeling in patients with chronic kidney disease...
  58. ncbi request reprint Therapeutic targets for prevention and regression of progressive fibrosing renal diseases
    Frank Eitner
    Division of Nephrology and Immunology, Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Curr Opin Investig Drugs 6:255-61. 2005
    ..This is likely by combining compounds that interfere with a variety of targets simultaneously...
  59. pmc Ultrastructural analysis of vascular calcifications in uremia
    Georg Schlieper
    Department of Nephrology and Clinical Immunology, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Am Soc Nephrol 21:689-96. 2010
    ..Furthermore, considering the core-shell structure of the calcifications, apoptotic bodies or matrix vesicles may serve as a calcification nidus...
  60. ncbi request reprint Pro-fibrogenic potential of PDGF-D in liver fibrosis
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, and Division of Nephrology, RWTH University Hospital Aachen, D 52074 Aachen, Germany
    J Hepatol 46:1064-74. 2007
    ..We analyzed the expression of platelet-derived growth factor D (PDGF-D) in an experimental bile duct-ligated (BDL) rat model and assessed its biological function in cultured hepatic stellate cells (HSC) and myofibroblasts (MFB)...
  61. ncbi request reprint A fully human monoclonal antibody (CR002) identifies PDGF-D as a novel mediator of mesangioproliferative glomerulonephritis
    Tammo Ostendorf
    Division Nephrology, University of Aachen, Germany
    J Am Soc Nephrol 14:2237-47. 2003
    ....
  62. doi request reprint Risk factors for cardiovascular calcifications in non-diabetic Caucasian haemodialysis patients
    Georg Schlieper
    Department of Nephrology, University Hospital Aachen, Aachen, Germany
    Kidney Blood Press Res 32:161-8. 2009
    ..Diabetes mellitus and ethnicity are known factors that affect the extent of cardiovascular calcifications. However, most studies have investigated mixed cohorts with diabetics and/or mixed ethnicity...
  63. ncbi request reprint Supportive Versus Immunosuppressive Therapy of Progressive IgA nephropathy (STOP) IgAN trial: rationale and study protocol
    Frank Eitner
    Division of Nephrology and Immunology, RWTH University of Aachen, Aachen, Germany
    J Nephrol 21:284-9. 2008
    ..The Supportive Versus Immunosuppressive Therapy of Progressive IgA Nephropathy (STOP IgAN) trial aims to answer if, in IgAN patients, an immunosuppressive treatment is more effective than a supportive treatment...
  64. doi request reprint The role of PDGF-D in healthy and fibrotic kidneys
    Eva M Buhl
    Division of Nephrology, RWTH University of Aachen, Aachen, Germany Institute of Pathology, RWTH University of Aachen, Aachen, Germany
    Kidney Int 89:848-61. 2016
    ..PDGF-D may be a suitable therapeutic target to combat kidney fibrosis. ..
  65. pmc Origin of regenerating tubular cells after acute kidney injury
    Katja Berger
    Departments of Internal Medicine II, Nephrology and Immunology, and Internal Medicine III, Gastroenterology and Endocrinology, Rheinisch Westfaelische Technische Hochschule RWTH Aachen University Hospital, D 52074 Aachen, Germany
    Proc Natl Acad Sci U S A 111:1533-8. 2014
    ..Understanding and modulating these phenotypic changes using the PEC-rtTA mouse may lead to more specific therapies in AKI. ..
  66. doi request reprint Sailing between Scylla and Charybdis: oral long-term anticoagulation in dialysis patients
    Thilo Kruger
    RWTH Aachen University Hospital, Aachen, Germany
    Nephrol Dial Transplant 28:534-41. 2013
    ..This review attempts to balance the potential risks and benefits of coumarin usage in ESRD patients and to give the best possible recommendations for everyday patient care...
  67. ncbi request reprint Bone pain with scintigraphy suggestive of widespread metastases--do not forget phosphate
    Vincent M Brandenburg
    Division of Nephrology, University Hospital, Medical School, Aachen, Germany
    Nephrol Dial Transplant 17:504-7. 2002
  68. ncbi request reprint Recurrent glomerulonephritis following renal transplantation: an update
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, Germany
    Nephrol Dial Transplant 18:1260-5. 2003
  69. ncbi request reprint Expression of A20 in the vessel wall of rat-kidney allografts correlates with protection from transplant arteriosclerosis
    Uta Kunter
    Division of Nephrology, Department of Medicine, Universitätsklinikum der RWTH Aachen, Aachen, Germany
    Transplantation 75:3-9. 2003
    ..Recent data suggests that grafts contribute to their own survival by way of up-regulation of "cytoprotective" genes...
  70. ncbi request reprint When man turns to stone: extraosseous calcification in uremic patients
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, Aachen, Germany
    Kidney Int 65:2447-62. 2004
  71. pmc Subtotal ablation of parietal epithelial cells induces crescent formation
    Eva Maria Sicking
    Division of Nephrology and Clinical Immunology, Medical Faculty, RWTH Aachen University, Aachen, Germany
    J Am Soc Nephrol 23:629-40. 2012
    ..In summary, subtotal ablation of PECs leads the remaining PECs to react with cellular activation and proliferation, which ultimately forms cellular crescents...
  72. doi request reprint Current therapy for IgA nephropathy
    Jurgen Floege
    Department of Nephrology and Clinical Immunology, RWTH University of Aachen, Aachen, Germany
    J Am Soc Nephrol 22:1785-94. 2011
    ..In other atypical patients with secondary IgAN, treatment should target the underlying primary disease. And fourth is the transplanted patient with recurrent IgAN where the mainstay of treatment is optimized supportive care...
  73. doi request reprint Association of fetuin-A levels with the progression of aortic valve calcification in non-dialyzed patients
    Ralf Koos
    Department for Cardiology, Pulmonology, and Vascular Medicine, University Hospital RTWH Aachen, RWTH University Aachen, Pauwelsstrasse 30, Aachen 52057, Germany
    Eur Heart J 30:2054-61. 2009
    ..We investigated the relationship between baseline fetuin-A serum levels and the rate of progression of aortic valve calcification (AVC) in non-dialyzed patients with aortic valve disease (AVD)...
  74. pmc The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification
    Cora Schafer
    Interdisciplinary Center for Clinical Research on Biochematerials, University Clinics, Aachen, Germany
    J Clin Invest 112:357-66. 2003
    ..Taken together, our data demonstrate a critical role of Ahsg as an inhibitor of unwanted mineralization and provide a novel therapeutic concept to prevent ectopic calcification accompanying various diseases...
  75. ncbi request reprint Mutant mice provide new insight into the role of (mis-)glycation in IgA nephropathy and other glomerular diseases
    Jurgen Floege
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    Nephrol Dial Transplant 22:1518-20. 2007
  76. ncbi request reprint Bone marrow transplantation rescues Alport mice
    Jurgen Floege
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    Nephrol Dial Transplant 21:2721-3. 2006
  77. doi request reprint Study design and subject baseline characteristics in the ADVANCE Study: effects of cinacalcet on vascular calcification in haemodialysis patients
    Jurgen Floege
    Division of Nephrology, RWTH University of Aachen, Aachen, Germany
    Nephrol Dial Transplant 25:1916-23. 2010
    ..We report the ADVANCE Study design and baseline subject characteristics...
  78. doi request reprint Sodium thiosulfate in the treatment of calcific uremic arteriolopathy
    Georg Schlieper
    Department of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany
    Nat Rev Nephrol 5:539-43. 2009
    ..Large clinical trials to evaluate the efficacy and long-term safety of sodium thiosulfate are clearly warranted...
  79. doi request reprint Risk factors for Pneumocystis jiroveci pneumonia (PcP) in renal transplant recipients
    Frank Eitner
    Division of Nephrology and Immunology, Rheinisch Westfälische Technische Hochschule Aachen, Germany
    Nephrol Dial Transplant 26:2013-7. 2011
    ..Individual risk factors for susceptibility to PcP are incompletely understood...
  80. ncbi request reprint Hypertension superimposed on type II diabetes in Goto Kakizaki rats induces progressive nephropathy
    Ulf Janssen
    Division of Nephrology, University of Aachen, Aachen, Germany
    Kidney Int 63:2162-70. 2003
    ..The aim of this study was to investigate the effect of superimposed hypertension on renal function and morphology under conditions of hyper- and normoglycemia...
  81. doi request reprint The PDGF family in renal fibrosis
    Tammo Ostendorf
    Department of Nephrology, RWTH University of Aachen, Pauwelsstr 30, 52074, Aachen, Germany
    Pediatr Nephrol 27:1041-50. 2012
    ..The recent identification of endogenous PDGF inhibitors offers additional novel therapeutic strategies...
  82. ncbi request reprint Lumbar bone mineral density in very long-term renal transplant recipients: impact of circulating sex hormones
    Vincent M Brandenburg
    Department of Nephrology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, 52057, Aachen, Germany
    Osteoporos Int 16:1611-20. 2005
    ..The lumbar BMD decreased by -0.6+/-1.9% per year. In postmenopausal long-term renal transplant recipients, low estradiol levels were associated with accelerated bone loss...
  83. pmc Macrophage activation syndrome in a patient with pulmonary inflammatory myofibroblastic tumour
    Christoph Kuppe
    Department of Nephrology and Clinical Immunology, University Hospital of the Aachen University of Technology RWTH, Aachen, Germany
    Allergy Asthma Clin Immunol 8:6. 2012
    ..Bone marrow aspiration, the main tool for a definite diagnosis, revealed macrophages phagocytosing haematopoietic cells. Immunosuppressive therapy with corticosteroids and cyclosporine was an effective treatment in this patient...
  84. ncbi request reprint In vivo identification of the mitogen-activated protein kinase cascade as a central pathogenic pathway in experimental mesangioproliferative glomerulonephritis
    Dirk Bokemeyer
    Medical Policlinic, Division of Nephrology, University of Bonn, Bonn, Germany
    J Am Soc Nephrol 13:1473-80. 2002
    ..These observations point to ERK as a putative intracellular mediator of the proliferative response in GN and suggest that pharmacologic treatments that interfere with the activation of ERK may be of potential therapeutic interest...
  85. ncbi request reprint Novel insights into renal fibrosis
    Frank Eitner
    Division of Nephrology and Immunology, Aachen University, Aachen, Germany
    Curr Opin Nephrol Hypertens 12:227-32. 2003
    ..Renal fibrosis characterizes a common endpoint of diverse renal diseases which leads to functional impairment ultimately resulting in terminal renal failure...
  86. ncbi request reprint Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study
    Markus Ketteler
    Department of Nephrology and Immunology, University Hospital Aachen, Aachen, Germany
    Lancet 361:827-33. 2003
    ..We aimed to investigate the hypothesis that AHSG deficiency is directly related to uraemic vascular calcification...
  87. ncbi request reprint "Missing" inhibitors of calcification: general aspects and implications in renal failure
    Markus Ketteler
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Pediatr Nephrol 20:383-8. 2005
    ....
  88. doi request reprint The pathogenesis of IgA nephropathy: what is new and how does it change therapeutic approaches?
    Jurgen Floege
    Division of Nephrology and Immunology, RWTH University of Aachen, Germany
    Am J Kidney Dis 58:992-1004. 2011
    ....
  89. doi request reprint Chronic kidney disease growth factors in renal fibrosis
    Peter Boor
    Department of Nephrology Institute of Pathology, RWTH University of Aachen, Aachen, Germany
    Clin Exp Pharmacol Physiol 38:441-50. 2011
    ..4. Animal studies suggest that manipulation of growth factors might be an effective treatment option for patients with renal fibrosis and CKD. So far, only inhibition of CTGF is being tested in patients with diabetic nephropathy...
  90. pmc Electrical forces determine glomerular permeability
    Ralf Hausmann
    Molecular Pharmacology, University Hospital of Rheinisch Westfälische Technische Hochschule RWTH Aachen University, Aachen, Germany
    J Am Soc Nephrol 21:2053-8. 2010
    ..It provides a unique approach to the microanatomy of the glomerulus, renal autoregulation, and the pathogenesis of proteinuria...
  91. pmc CCN3/NOV small interfering RNA enhances fibrogenic gene expression in primary hepatic stellate cells and cirrhotic fat storing cell line CFSC
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, 52074, Aachen, Germany
    J Cell Commun Signal 6:11-25. 2012
    ..These results indicate the complexity of CCN actions that are far beyond the classic Yin/Yang interplay...
  92. doi request reprint Henoch-Schönlein purpura complicated by cardiac involvement: case report and review of the literature
    Holger H Lutz
    Department of Hepatology and Gastroenterology, University Hospital RWTH Aachen, Aachen, Germany
    Am J Kidney Dis 54:e9-15. 2009
    ..The case presentation is followed by a review of the literature for manifestations, treatments, and outcomes in patients with HSP complicated by cardiac involvement...
  93. doi request reprint Immune modulating therapy for IgA nephropathy: rationale and evidence
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, RWTH Aachen, Germany
    Semin Nephrol 28:38-47. 2008
    ....
  94. ncbi request reprint A new look at platelet-derived growth factor in renal disease
    Jurgen Floege
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    J Am Soc Nephrol 19:12-23. 2008
    ..Accordingly, targeted intervention against the various PDGF isoforms offers a promising novel therapeutic approach to renal disease...
  95. doi request reprint No evidence for a role of cosmc-chaperone mutations in European IgA nephropathy patients
    Friederike Malycha
    Department of Human Genetics, Division of Nephrology and Immunology, Aachen, Germany
    Nephrol Dial Transplant 24:321-4. 2009
    ..Mosaic mutations of cosmc have been shown to result in autoimmune disease. We hypothesized that cosmc mutations might contribute to the altered IgA1 galactosylation in IgAN patients...
  96. ncbi request reprint Expression of a novel PDGF isoform, PDGF-C, in normal and diseased rat kidney
    Frank Eitner
    Division of Nephrology and Immunology, University of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Am Soc Nephrol 13:910-7. 2002
    ..PDGF-C may therefore be involved in the pathogenesis of renal scarring...
  97. doi request reprint Renal fibrosis: novel insights into mechanisms and therapeutic targets
    Peter Boor
    Department of Nephrology, RWTH University of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Nat Rev Nephrol 6:643-56. 2010
    ....
  98. doi request reprint Renal allograft failure in a hyperparathyroid patient following initiation of a calcimimetic
    Claudia Seikrit
    Division of Nephrology and Immunology, RWTH University of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Nat Rev Nephrol 7:237-41. 2011
    ..While on dialysis, he had developed secondary hyperparathyroidism, which persisted after transplantation despite treatment with cinacalcet...
  99. doi request reprint A novel bioimpedance technique to monitor fluid volume state during hemodialysis treatment
    Guillermo Medrano
    Philips Chair for Medical Information Technology MedIT, Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany
    ASAIO J 56:215-20. 2010
    ..The KK method, especially in combination with proper use of the introduced DeltaRe/UFV (%/L) normalization could possibly offer new options for comfortable online monitoring and the evaluation of fluid volume state during dialysis...
  100. ncbi request reprint Podocyte damage resulting in podocyturia: a potential diagnostic marker to assess glomerular disease activity
    Arndt Petermann
    Division of Nephrology, RWTH University of Aachen, Aachen, Germany
    Nephron Clin Pract 106:c61-6. 2007
    ..However, at present technical issues still prevent a broad clinical application of podocyturia detection in clinical practice...
  101. doi request reprint Littoral cell angioma of the spleen mimicking posttransplantation lymphoma in a 63-year-old renal transplant patient
    Anja Susanne Mühlfeld
    Division of Nephrology and Immunology, University Hospital of the RWTH Aachen, Aachen, Germany
    Am J Kidney Dis 52:e11-4. 2008
    ..More specific tools need to be developed to aid in the differential diagnosis of splenic masses to avoid splenectomy in patients with littoral cell angiomas...