Alexander Rebl

Summary

Affiliation: Research Institute for the Biology of Farm Animals
Country: Germany

Publications

  1. doi request reprint Characterization of dehydrodolichyl diphosphate synthase gene in rainbow trout (Oncorhynchus mykiss)
    Alexander Rebl
    Research Institute for the Biology of Farm Animals FBN, Molecular Biology Research Unit, Wilhelm Stahl Allee 2, Dummerstorf, Germany
    Comp Biochem Physiol B Biochem Mol Biol 152:260-5. 2009
  2. doi request reprint Peptidylarginine deiminase gene is differentially expressed in freshwater and brackish water rainbow trout
    Alexander Rebl
    Forschungsinstitut fur die Biologie landwirtschaftlicher Nutztiere FBN, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Mol Biol Rep 37:2333-9. 2010
  3. ncbi request reprint Cloning and tissue-specific expression of a delta-COP homologue in a freshwater and a brackish water-adapted strain of rainbow trout (Oncorhynchus mykiss)
    Alexander Rebl
    Forschungsinstitut fur die Biologie landwirtschaftlicher Nutztiere FBN, Molecular Biology Research Unit, Dummerstorf, Germany
    Genes Genet Syst 84:239-43. 2009
  4. doi request reprint Comparative molecular characterization of the regucalcin (RGN) gene in rainbow trout (Oncorhynchus mykiss) and maraena whitefish (Coregonus marena)
    Marieke Verleih
    Leibniz Institut für Nutztierbiologie FBN, Fachbereich Molekularbiologie, Wilhelm Stahl Allee 2, 18196, Dummerstorf, Germany
    Mol Biol Rep 39:4291-300. 2012
  5. doi request reprint Iron-sulfur cluster scaffold (ISCU) gene is duplicated in salmonid fish and tissue and temperature dependent expressed in rainbow trout
    Marieke Verleih
    Leibniz Institut für Nutztierbiologie FBN, Fachbereich Molekularbiologie, Dummerstorf, Germany
    Gene 512:251-8. 2013
  6. doi request reprint MARCH5 gene is duplicated in rainbow trout, but only fish-specific gene copy is up-regulated after VHSV infection
    Alexander Rebl
    Leibniz Institut für Nutztierbiologie FBN, Fachbereich Molekularbiologie, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Fish Shellfish Immunol 31:1041-50. 2011
  7. doi request reprint Characterization of the interleukin 1 receptor-associated kinase 4 (IRAK4)-encoding gene in salmonid fish: the functional copy is rearranged in Oncorhynchus mykiss and that factor can impair TLR signaling in mammalian cells
    Andreas Brietzke
    Leibniz Institute for Farm Animal Biology, Institute for Genome Biology, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Fish Shellfish Immunol 36:206-14. 2014
  8. doi request reprint Transcriptome profiling of gill tissue in regionally bred and globally farmed rainbow trout strains reveals different strategies for coping with thermal stress
    Alexander Rebl
    Institut für Genombiologie, Leibniz Institut für Nutztierbiologie FBN, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Mar Biotechnol (NY) 15:445-60. 2013
  9. doi request reprint Identification of differentially expressed protective genes in liver of two rainbow trout strains
    Alexander Rebl
    Leibniz Institut für Nutztierbiologie FBN, Fachbereich Molekularbiologie, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Vet Immunol Immunopathol 145:305-15. 2012
  10. doi request reprint Tollip, a negative regulator of TLR-signalling, is encoded by twin genes in salmonid fish
    Alexander Rebl
    Research Institute for the Biology of Farm Animals FBN, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Fish Shellfish Immunol 25:153-62. 2008

Collaborators

Detail Information

Publications30

  1. doi request reprint Characterization of dehydrodolichyl diphosphate synthase gene in rainbow trout (Oncorhynchus mykiss)
    Alexander Rebl
    Research Institute for the Biology of Farm Animals FBN, Molecular Biology Research Unit, Wilhelm Stahl Allee 2, Dummerstorf, Germany
    Comp Biochem Physiol B Biochem Mol Biol 152:260-5. 2009
    ..This is the first report of a prenyltransferase homologue from a teleostean species...
  2. doi request reprint Peptidylarginine deiminase gene is differentially expressed in freshwater and brackish water rainbow trout
    Alexander Rebl
    Forschungsinstitut fur die Biologie landwirtschaftlicher Nutztiere FBN, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Mol Biol Rep 37:2333-9. 2010
    ..Quantitative Real-Time RT-PCR revealed that PADI gene is differentially expressed in liver, trunk kidney, and spleen of two trout strains, the freshwater-cultured STEELHEAD trout and the brackish water strain BORN...
  3. ncbi request reprint Cloning and tissue-specific expression of a delta-COP homologue in a freshwater and a brackish water-adapted strain of rainbow trout (Oncorhynchus mykiss)
    Alexander Rebl
    Forschungsinstitut fur die Biologie landwirtschaftlicher Nutztiere FBN, Molecular Biology Research Unit, Dummerstorf, Germany
    Genes Genet Syst 84:239-43. 2009
    ..Quantitative Real-Time RT-PCR revealed that delta-COP is differentially expressed in liver and gill tissue of two rainbow trout strains, the freshwater strain STEELHEAD and the brackish water-adapted strain BORN...
  4. doi request reprint Comparative molecular characterization of the regucalcin (RGN) gene in rainbow trout (Oncorhynchus mykiss) and maraena whitefish (Coregonus marena)
    Marieke Verleih
    Leibniz Institut für Nutztierbiologie FBN, Fachbereich Molekularbiologie, Wilhelm Stahl Allee 2, 18196, Dummerstorf, Germany
    Mol Biol Rep 39:4291-300. 2012
    ..The differences in gene expression support our assumption that RGN might play a role in recovery of rainbow trout after environmental stress...
  5. doi request reprint Iron-sulfur cluster scaffold (ISCU) gene is duplicated in salmonid fish and tissue and temperature dependent expressed in rainbow trout
    Marieke Verleih
    Leibniz Institut für Nutztierbiologie FBN, Fachbereich Molekularbiologie, Dummerstorf, Germany
    Gene 512:251-8. 2013
    ..Although results partially reflect the expected strain- and tissue-specific ISCUA and ISCUB regulation in rainbow trout, the data do not support the assumed association of ISCU with the trait robustness...
  6. doi request reprint MARCH5 gene is duplicated in rainbow trout, but only fish-specific gene copy is up-regulated after VHSV infection
    Alexander Rebl
    Leibniz Institut für Nutztierbiologie FBN, Fachbereich Molekularbiologie, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Fish Shellfish Immunol 31:1041-50. 2011
    ..7-fold elevated copy number of the respective gene in gills four days after infection, whereas MARCH5B transcript level did not increase...
  7. doi request reprint Characterization of the interleukin 1 receptor-associated kinase 4 (IRAK4)-encoding gene in salmonid fish: the functional copy is rearranged in Oncorhynchus mykiss and that factor can impair TLR signaling in mammalian cells
    Andreas Brietzke
    Leibniz Institute for Farm Animal Biology, Institute for Genome Biology, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Fish Shellfish Immunol 36:206-14. 2014
    ..Our data unexpectedly imply that IRAK4 is involved in establishing threshold levels of active NF-κB in resting cells. ..
  8. doi request reprint Transcriptome profiling of gill tissue in regionally bred and globally farmed rainbow trout strains reveals different strategies for coping with thermal stress
    Alexander Rebl
    Institut für Genombiologie, Leibniz Institut für Nutztierbiologie FBN, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Mar Biotechnol (NY) 15:445-60. 2013
    ..This manuscript provides an overview of the genes of the multifunctional gills in rainbow trout that are mandated after temperature change, suggesting links between the different temperature-dependent pathways and gene networks. ..
  9. doi request reprint Identification of differentially expressed protective genes in liver of two rainbow trout strains
    Alexander Rebl
    Leibniz Institut für Nutztierbiologie FBN, Fachbereich Molekularbiologie, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Vet Immunol Immunopathol 145:305-15. 2012
    ..This data indicate that the examined genes contribute to an improved first barrier against invading pathogens in BORN trout...
  10. doi request reprint Tollip, a negative regulator of TLR-signalling, is encoded by twin genes in salmonid fish
    Alexander Rebl
    Research Institute for the Biology of Farm Animals FBN, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Fish Shellfish Immunol 25:153-62. 2008
    ..Moreover, pathways dampening the activity of the TLR-cascade may have been conserved from lower vertebrates to mammals since Tollip, as a respective key factor has been highly conserved from fish to human...
  11. doi request reprint Comparison of splenic transcriptome activity of two rainbow trout strains differing in robustness under regional aquaculture conditions
    Judith M Köbis
    Leibniz Institut für Nutztierbiologie FBN, Fachbereich Molekularbiologie, Wilhelm Stahl Allee 2, 18196, Dummerstorf, Germany
    Mol Biol Rep 40:1955-66. 2013
    ..In concert with the data interpretation of the achieved comparative transcriptome analysis for the involved rainbow trout strains, we provide the full mRNA sequence of trout MARCH3 and its hypothetical protein structure...
  12. doi request reprint Duplicated NELL2 genes show different expression patterns in two rainbow trout strains after temperature and pathogen challenge
    Alexander Rebl
    Leibniz Institut für Nutztierbiologie FBN, Fachbereich Molekularbiologie, Dummerstorf, Germany
    Comp Biochem Physiol B Biochem Mol Biol 163:65-73. 2012
    ....
  13. doi request reprint Molecular characterization of PRR13 and its tissue-specific expression in rainbow trout (Oncorhynchus mykiss)
    Marieke Verleih
    Fachbereich Molekularbiologie, Leibniz Institut für Nutztierbiologie FBN, Wilhelm Stahl Allee 2, 18196, Dummerstorf, Germany
    Fish Physiol Biochem 36:1271-6. 2010
    ....
  14. doi request reprint Salmonid Tollip and MyD88 factors can functionally replace their mammalian orthologues in TLR-mediated trout SAA promoter activation
    Alexander Rebl
    Leibniz Institute for Farm Animal Biology FBN, Molecular Biology Research Unit, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Dev Comp Immunol 35:81-7. 2011
    ..We provide for the first time evidence that also the Tollip-mediated negative loop of TLR signaling may be conserved in non-mammalian organisms...
  15. doi request reprint Characterization of two key molecules of teleost innate immunity from rainbow trout (Oncorhynchus mykiss): MyD88 and SAA
    Alexander Rebl
    Research Institute for the Biology of Farm Animals FBN, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Vet Immunol Immunopathol 131:122-6. 2009
    ..Both factors share a remarkable high degree of structural conservation with their mammalian orthologs suggesting that innate immune defense mechanisms may also functionally be conserved between fish and mammals...
  16. doi request reprint Transcriptome sequencing of maraena whitefish (Coregonus maraena)
    Andreas Brietzke
    Leibniz Institute for Farm Animal Biology, Institute for Genome Biology, Fish Genetics Unit, Wilhelm Stahl Allee 2, 18196, Dummerstorf, Germany
    Mar Genomics 29:27-29. 2016
    ..Functional annotation obtained a transcript composition predominantly comprising enzyme-coding genes...
  17. doi request reprint Toll-like receptors in maraena whitefish: Evolutionary relationship among salmonid fishes and patterns of response to Aeromonas salmonicida
    Simone Altmann
    Leibniz Institute for Farm Animal Biology FBN, Institute for Genome Biology, Fish Genetics Unit, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Fish Shellfish Immunol 54:391-401. 2016
    ..salmonicida inflammation in whitefish. The present results contribute to improved understanding of the host-pathogen interaction in salmonid fish. ..
  18. doi request reprint Impact of Thermal Stress on Kidney-Specific Gene Expression in Farmed Regional and Imported Rainbow Trout
    Marieke Verleih
    Institute for Genome Biology, Leibniz Institute for Farm Animal Biology FBN, Wilhelm Stahl Allee 2, 18196, Dummerstorf, Germany
    Mar Biotechnol (NY) 17:576-92. 2015
    ..Our analyses suggest SERPINH1 and CIRBP as general marker genes for heat stress and cold stress in trout, respectively...
  19. pmc Aeromonas salmonicida Infection Only Moderately Regulates Expression of Factors Contributing to Toll-Like Receptor Signaling but Massively Activates the Cellular and Humoral Branches of Innate Immunity in Rainbow Trout (Oncorhynchus mykiss)
    Andreas Brietzke
    Leibniz Institute for Farm Animal Biology FBN, Institute of Genome Biology, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    J Immunol Res 2015:901015. 2015
    ..salmonicida. The recruitment of cellular factors of innate immunity rather than induced expression of pathogen receptors is hence of key importance for mounting a first immune defense against invading A. salmonicida. ..
  20. doi request reprint Structurally diverse genes encode Tlr2 in rainbow trout: The conserved receptor cannot be stimulated by classical ligands to activate NF-κB in vitro
    Andreas Brietzke
    Leibniz Institute for Farm Animal Biology FBN, Institute of Genome Biology, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Dev Comp Immunol 54:75-88. 2016
    ..We discuss impaired heterodimerization with a necessary Tlr partner as one from among several alternatives to explain the dysfunction of Tlr2a in the interspecies reconstitution system of TLR signaling...
  21. doi request reprint Comprehensive and comparative transcription analyses of the complement pathway in rainbow trout
    Judith M Köbis
    Leibniz Institut für Nutztierbiologie FBN, Institut für Genombiologie, Dummerstorf, Germany
    Fish Shellfish Immunol 42:98-107. 2015
    ..However, a significantly lower expression of numerous genes especially in spleen seems characteristic for the BORN strain. This suggests a strain-specific complement pathway regulation under the selected rearing conditions. ..
  22. doi request reprint ST2 from rainbow trout quenches TLR signalling, localises at the nuclear membrane and allows the nuclear translocation of MYD88
    Alexander Rebl
    Leibniz Institute for Farm Animal Biology FBN, Institute for Genome Biology, Wilhelm Stahl Allee 2, 18196, Dummerstorf, Germany
    Dev Comp Immunol 67:139-152. 2017
    ..Hence, we validated that trout ST2 is a dampener of TLR signalling and interacts with MYD88. The spatial distribution of these factors raises questions about how this repressive mechanism functions...
  23. doi request reprint The proximal promoter of a novel interleukin-8-encoding gene in rainbow trout (Oncorhynchus mykiss) is strongly induced by CEBPA, but not NF-κB p65
    Alexander Rebl
    Leibniz Institute for Farm Animal Biology FBN, Institute for Genome Biology, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Dev Comp Immunol 46:155-64. 2014
    ..Similar promoter induction potential and intracellular localization of the mammalian and teleostean CEBPA and -B factors suggests their functional conservation throughout evolution. ..
  24. doi request reprint Toll-like receptor signaling in bony fish
    Alexander Rebl
    Research Institute for the Biology of Farm Animals FBN, Dummerstorf, Germany
    Vet Immunol Immunopathol 134:139-50. 2010
    ..This review summarizes studies characterizing TLRs from several teleost species and discusses features of piscine TLR signaling on the background of the respective mammalian knowledge...
  25. ncbi request reprint Characterization of twin toll-like receptors from rainbow trout (Oncorhynchus mykiss): evolutionary relationship and induced expression by Aeromonas salmonicida salmonicida
    Alexander Rebl
    Research Institute for the Biology of Farm Animals FBN, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Dev Comp Immunol 31:499-510. 2007
    ..Our sequence information will be useful to establish expression constructs for these factors necessary to analyse the pathogen specific signal transduction activating the innate immune defence in fish...
  26. doi request reprint Multiple gene and transcript variants encoding trout C-polysaccharide binding proteins are differentially but strongly induced after infection with Aeromonas salmonicida
    Judith M Köbis
    Leibniz Institute for Farm Animal Biology FBN, Institute for Genome Biology, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Fish Shellfish Immunol 60:509-519. 2017
    ..Overexpression of TCBP1 increased the level of active NF-κB factors and induced cell death, indicating its involvement in proapoptotic NF-κB-dependent signalling routes...
  27. doi request reprint GRP94 is encoded by two differentially expressed genes during development of rainbow trout (Oncorhynchus mykiss)
    Alexander Rebl
    Leibniz Institute for Farm Animal Biology FBN, Institute of Genome Biology, Wilhelm Stahl Allee 2, 18196, Dummerstorf, Germany
    Fish Physiol Biochem 40:1917-26. 2014
    ..The concentration of the GRP94b-encoding mRNA was only ~0.1% compared to the GRP94a mRNA level. These structural and gene expression data together suggest that the two GRP94 gene products fulfill different physiological roles...
  28. doi request reprint Cytogenetic anchoring of radiation hybrid and virtual maps of sheep chromosome X and comparison of X chromosomes in sheep, cattle, and human
    Tom Goldammer
    Forschungsbereich Molekularbiologie, Forschungsinstitut für die Biologie landwirtschaftlicher Nutztiere, Dummerstorf, Germany
    Chromosome Res 17:497-506. 2009
    ....
  29. doi request reprint Cloning and characterization of the proximal promoter region of rainbow trout (Oncorhynchus mykiss) interleukin-6 gene
    Merle D Zante
    Leibniz Institute for Farm Animal Biology FBN, Institute of Genome Biology, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Fish Shellfish Immunol 43:249-56. 2015
    ..Truncation of this fragment caused a significant decrease in IL6 promoter activation. This characterization of the proximal promoter of the IL6-encoding gene provides basic knowledge about the IL6 gene expression in rainbow trout. ..
  30. doi request reprint Identification and de novo sequencing of housekeeping genes appropriate for gene expression analyses in farmed maraena whitefish (Coregonus maraena) during crowding stress
    Simone Altmann
    Fish Genetics Unit, Institute for Genome Biology, Leibniz Institute for Farm Animal Biology FBN, Wilhelm Stahl Allee 2, 18196, Dummerstorf, Germany
    Fish Physiol Biochem 41:397-412. 2015
    ..This is the first study that provides a subset of seven de novo sequenced housekeeping genes usable as reference genes in studies of stress response in maraena whitefish. ..