Christoph Holscher

Summary

Affiliation: Research Center Borstel
Country: Germany

Publications

  1. pmc Altered mucosal immune response after acute lung injury in a murine model of Ataxia Telangiectasia
    Olaf Eickmeier
    Pediatric Pulmonology, Allergy and Cystic Fibrosis, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt D 60590, Germany
    BMC Pulm Med 14:93. 2014
  2. doi Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9
    Christoph Holscher
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    Eur J Immunol 38:680-94. 2008
  3. ncbi The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases
    Christoph Holscher
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Parkallee 22, 23845 Borstel, Germany
    Med Microbiol Immunol 193:1-17. 2004
  4. ncbi The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis
    Christoph Holscher
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    J Immunol 174:3534-44. 2005
  5. ncbi Targeting IL-23 in autoimmunity
    Christoph Holscher
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Curr Opin Investig Drugs 6:489-95. 2005
  6. pmc IL-22 is mainly produced by IFNγ-secreting cells but is dispensable for host protection against Mycobacterium tuberculosis infection
    Jochen Behrends
    Infection Immunology, Research Center Borstel RCB, Borstel, Germany
    PLoS ONE 8:e57379. 2013
  7. ncbi Selectin ligand-independent priming and maintenance of T cell immunity during airborne tuberculosis
    Tanja Schreiber
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Germany
    J Immunol 176:1131-40. 2006
  8. ncbi Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis
    Norbert Reiling
    Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    J Immunol 169:3480-4. 2002
  9. doi Fucosyltransferase IV and VII-directed selectin ligand function determines long-term survival in experimental tuberculosis
    Stefan Ehlers
    Molecular Inflammation Medicine, Christian Albrechts Universitat, Kiel, Germany Microbial Inflammation Research, Research Center Borstel, Parkallee 1, 23845 Borstel, Borstel, Germany
    Immunobiology 214:674-82. 2009
  10. doi MyDths and un-TOLLed truths: sensor, instructive and effector immunity to tuberculosis
    Norbert Reiling
    Microbial Interface Biology, Research Center Borstel, D 23845 Borstel, Germany
    Immunol Lett 116:15-23. 2008

Collaborators

Detail Information

Publications26

  1. pmc Altered mucosal immune response after acute lung injury in a murine model of Ataxia Telangiectasia
    Olaf Eickmeier
    Pediatric Pulmonology, Allergy and Cystic Fibrosis, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt D 60590, Germany
    BMC Pulm Med 14:93. 2014
    ..In A-T, disease of the respiratory system causes significant morbidity and is a frequent cause of death...
  2. doi Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9
    Christoph Holscher
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    Eur J Immunol 38:680-94. 2008
    ..Rather, MyD88, but not TLR2, TLR4 and TLR9, is critical for triggering macrophage effector mechanisms central to anti-mycobacterial defense...
  3. ncbi The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases
    Christoph Holscher
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Parkallee 22, 23845 Borstel, Germany
    Med Microbiol Immunol 193:1-17. 2004
    ..This review focuses on these IL-12-related cytokines contributing to fine tuning of T cell responses after infection with intracellular pathogens...
  4. ncbi The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis
    Christoph Holscher
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    J Immunol 174:3534-44. 2005
    ..In conclusion, IL-27 both prevents optimal antimycobacterial protection and limits the pathological sequelae of chronic inflammation...
  5. ncbi Targeting IL-23 in autoimmunity
    Christoph Holscher
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Curr Opin Investig Drugs 6:489-95. 2005
    ..This review summarizes recent findings regarding IL-23-mediated autoreactive inflammatory responses, and introduces possible therapeutic interventions that are aimed at mitigating autoimmune inflammation...
  6. pmc IL-22 is mainly produced by IFNγ-secreting cells but is dispensable for host protection against Mycobacterium tuberculosis infection
    Jochen Behrends
    Infection Immunology, Research Center Borstel RCB, Borstel, Germany
    PLoS ONE 8:e57379. 2013
    ..Therefore, targeting of IL-22 in inflammatory disease may represent a therapeutic approach that does not incur the danger of reactivation TB...
  7. ncbi Selectin ligand-independent priming and maintenance of T cell immunity during airborne tuberculosis
    Tanja Schreiber
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Germany
    J Immunol 176:1131-40. 2006
    ....
  8. ncbi Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis
    Norbert Reiling
    Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    J Immunol 169:3480-4. 2002
    ..tuberculosis in borderline situations, its function, and that of CD14 and TLR4, in initiating protective responses against naturally low-dose airborne infection is redundant...
  9. doi Fucosyltransferase IV and VII-directed selectin ligand function determines long-term survival in experimental tuberculosis
    Stefan Ehlers
    Molecular Inflammation Medicine, Christian Albrechts Universitat, Kiel, Germany Microbial Inflammation Research, Research Center Borstel, Parkallee 1, 23845 Borstel, Borstel, Germany
    Immunobiology 214:674-82. 2009
    ..These results suggest that targeting selectin ligand function during treatment of chronic inflammatory disorders may run the risk of accelerating TB disease progression...
  10. doi MyDths and un-TOLLed truths: sensor, instructive and effector immunity to tuberculosis
    Norbert Reiling
    Microbial Interface Biology, Research Center Borstel, D 23845 Borstel, Germany
    Immunol Lett 116:15-23. 2008
    ..Disrupted IL-1R and/or IFN-gamma signaling pathways likely play a much more prominent role in explaining the exquisite susceptibility of MyD88-deficient mice to TB than the function of MyD88 as a TLR adaptor...
  11. pmc Autocrine IL-10 induces hallmarks of alternative activation in macrophages and suppresses antituberculosis effector mechanisms without compromising T cell immunity
    Tanja Schreiber
    Infection Immunology Research, Research Center Borstel, Borstel, Germany
    J Immunol 183:1301-12. 2009
    ..Taken together, macrophage-derived IL-10 triggers aspects of alternative macrophage activation and promotes Mtb recrudescence independent of overt effects on anti-TB T cell immunity...
  12. ncbi The lymphotoxin beta receptor is critically involved in controlling infections with the intracellular pathogens Mycobacterium tuberculosis and Listeria monocytogenes
    Stefan Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    J Immunol 170:5210-8. 2003
    ..tuberculosis infection as wild-type mice, these data demonstrate that signaling of LT alpha(1)beta(2) heterotrimers via the LT beta R is an essential prerequisite for containment of intracellular pathogens...
  13. ncbi Interleukin-12p40 mediates transient protection against Mycobacterium avium infection in the absence of interleukin-12
    Stefan Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, Germany
    Immunobiology 210:217-27. 2005
    ..This phenotype probably reflects an IL-12p40-dependent effect on macrophage activation at the level of innate immunity...
  14. doi Mincle is not essential for controlling Mycobacterium tuberculosis infection
    Lisa Heitmann
    Infection Immunology, Research Center Borstel, Borstel, Germany
    Immunobiology 218:506-16. 2013
    ..From our results we conclude that absence of the innate receptor Mincle can be fully compensated for in vivo in terms of sensing Mtb and mounting a protective inflammatory immune response...
  15. ncbi Alternatively activated macrophages express the IL-27 receptor alpha chain WSX-1
    Dominik Rückerl
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Immunobiology 211:427-36. 2006
    ..We therefore conclude from our study that IL-10, IL-4 and IL-27 collaborate in modulating macrophage activation by successive upregulation of the IL-4Ralpha and WSX-1 on alternatively activated macrophages...
  16. ncbi Interleukin-15 mediates protection against experimental tuberculosis: a role for NKG2D-dependent effector mechanisms of CD8+ T cells
    Alexandra Rausch
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    Eur J Immunol 36:1156-67. 2006
    ..Hence, our results implicate IL-15 and NKG2D as promising targets for modulating CD8+ T cell-mediated protection against tuberculosis...
  17. doi DAP10 contributes to CD8(+) T cell-mediated cytotoxic effector mechanisms during Mycobacterium tuberculosis infection
    Manuela Hessmann
    Infection Immunology, Research Center Borstel, Borstel, Germany
    Immunobiology 216:639-47. 2011
    ..Together, our results suggest that during Mtb infection DAP10 is required for maximal cytolytic activity of CD8 T cells...
  18. pmc Epstein-Barr virus-induced gene 3 suppresses T helper type 1, type 17 and type 2 immune responses after Trypanosoma cruzi infection and inhibits parasite replication by interfering with alternative macrophage activation
    Julia Böhme
    Infection Immunology, Research Centre Borstel, Borstel, Germany
    Immunology 147:338-48. 2016
    ..Further studies are needed to dissect the underlying mechanisms and clarify whether EBI3 association with IL-27 or/and IL-35 accounts for its anti-inflammatory character in parasitic disease. ..
  19. pmc TGF-β-responsive myeloid cells suppress type 2 immunity and emphysematous pathology after hookworm infection
    Lisa Heitmann
    Infection Immunology, Research Center Borstel, Borstel, Germany
    Am J Pathol 181:897-906. 2012
    ..Thus, TGF-β effects on myeloid cells suppress helminth immunity as a consequence of restoring lung function after infection...
  20. doi gp130 on macrophages/granulocytes modulates inflammation during experimental tuberculosis
    Jan Sodenkamp
    Infection Immunology, Research Center Borstel, Borstel, Germany
    Eur J Cell Biol 90:505-14. 2011
    ..Our study revealed an immunoregulatory function of gp130 cytokines on macrophages/granulocytes, which is, however, not critical for modulating the outcome of TB...
  21. doi Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis
    Jan Sodenkamp
    Infection Immunology, Research Center Borstel, Borstel, Germany
    Immunobiology 217:996-1004. 2012
    ..Our finding that IL-6 trans-signaling plays no role for protective immune responses against Mtb supports the superior safety of therapeutic targeting of IL-6 trans-signaling compared to anti-TNF treatment...
  22. doi NALP3 is not necessary for early protection against experimental tuberculosis
    Kerstin Walter
    Division of Molecular Inflammation Medicine, Research Center Borstel, Borstel, Germany
    Immunobiology 215:804-11. 2010
    ..In conclusion, despite its involvement in cytokine processing, NALP3 is not essential for induction of protective immunity to Mtb...
  23. pmc During acute experimental infection with the reticulotropic Trypanosoma cruzi strain Tulahuen IL-22 is induced IL-23-dependently but is dispensable for protection
    Hanna Erdmann
    Division of Infection Immunology, Research Centre Borstel, Borstel, Germany
    Sci Rep 6:32927. 2016
    ..Taken together, although IL-22 is expressed, it seems to play a minor role in protection and pathology during the acute systemic infection with the reticulotropic Tulahuen strain of T. cruzi. ..
  24. pmc A Mutation in IL4RA Is Associated with the Degree of Pathology in Human TB Patients
    Christoph Holscher
    Infection Immunology, Research Center Borstel, Parkallee 22, 23845 Borstel, Germany German Center for Infection Research, Germany
    Mediators Inflamm 2016:4245028. 2016
    ..Together, our genetic association study in human TB patients further supports the assumption that IL-13/IL-4Rα-dependent mechanisms are involved in mediating tissue pathology of human TB. ..
  25. doi Poly(inosinic-cytidylic) acid-triggered exacerbation of experimental asthma depends on IL-17A produced by NK cells
    Lars P Lunding
    Division of Mouse Models of Asthma, Priority Area Asthma and Allergy, Research Center Borstel, Airway Research Center North, Member of the German Center for Lung Research, 23845 Borstel, Germany
    J Immunol 194:5615-25. 2015
    ..These experiments indicate a central role for IL-17 derived from NK cells but not from Th17 cells in the pathogenesis of virus-triggered exacerbation of experimental asthma...
  26. doi IL-17A promotes macrophage effector mechanisms against Trypanosoma cruzi by trapping parasites in the endolysosomal compartment
    Hanna Erdmann
    Infection Immunology, Research Center Borstel, 23845 Borstel, Germany
    Immunobiology 218:910-23. 2013
    ..This IL-17A-dependent mechanism represents a novel function of IL-17A trapping pathogens in endosomal/lysosomal compartments and enhancing exposure time to antimicrobial effectors of the macrophage...