M B Ranke

Summary

Country: Germany

Publications

  1. ncbi request reprint Turner's syndrome
    M B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, D 72076, Tuebingen, Germany
    Lancet 358:309-14. 2001
  2. doi request reprint Muscle function improves during growth hormone therapy in short children born small for gestational age: results of a peripheral quantitative computed tomography study on body composition
    Roland Schweizer
    Pediatric Endocrinology Section, University Hospital for Children and Adolescents, Hoppe Seyler Strasse 1, D 72076 Tuebingen, Germany
    J Clin Endocrinol Metab 93:2978-83. 2008
  3. ncbi request reprint Significance of basal IGF-I, IGFBP-3 and IGFBP-2 measurements in the diagnostics of short stature in children
    M B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 54:60-8. 2000
  4. ncbi request reprint Pilot study of elevated levels of insulin-like growth factor-binding protein-2 as indicators of hepatocellular carcinoma
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 60:174-80. 2003
  5. ncbi request reprint Relevance of IGF-I, IGFBP-3, and IGFBP-2 measurements during GH treatment of GH-deficient and non-GH-deficient children and adolescents
    M B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tubingen, Germany
    Horm Res 55:115-24. 2001
  6. ncbi request reprint Adult height after GH therapy in 188 Ullrich-Turner syndrome patients: results of the German IGLU Follow-up Study 2001
    M B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Eur J Endocrinol 147:625-33. 2002
  7. ncbi request reprint Decreased expression of IGF-II and its binding protein, IGF-binding protein-2, in genital skin fibroblasts of patients with complete androgen insensitivity syndrome compared with normally virilized males
    M W Elmlinger
    Pediatric Endocrinology, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 86:4741-6. 2001
  8. ncbi request reprint Secretion of noncomplexed 'Big' (10-18 kD) forms of insulin-like growth factor-II by 12 soft tissue sarcoma cell lines
    M W Elmlinger
    Paediatric Endocrinology, University Children s Hospital, Tubingen, Germany
    Horm Res 52:178-85. 1999
  9. doi request reprint Variants of the FTO gene in obese children and their impact on body composition and metabolism before and after lifestyle intervention
    J Schum
    Pediatric Endocrinology and Diabetes, University Children s Hospital, Tuebingen, Germany
    Exp Clin Endocrinol Diabetes 120:128-31. 2012
  10. doi request reprint Short children with low birth weight born either small for gestational age or average for gestational age show similar growth response and changes in insulin-like growth factor-1 to growth hormone treatment during the first prepubertal year
    M B Ranke
    University Children s Hospital, Tubingen, Germany
    Horm Res Paediatr 76:104-12. 2011

Collaborators

Detail Information

Publications104 found, 100 shown here

  1. ncbi request reprint Turner's syndrome
    M B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, D 72076, Tuebingen, Germany
    Lancet 358:309-14. 2001
    ..New developments in research allow patients with Turner's syndrome to have multidisciplinary care...
  2. doi request reprint Muscle function improves during growth hormone therapy in short children born small for gestational age: results of a peripheral quantitative computed tomography study on body composition
    Roland Schweizer
    Pediatric Endocrinology Section, University Hospital for Children and Adolescents, Hoppe Seyler Strasse 1, D 72076 Tuebingen, Germany
    J Clin Endocrinol Metab 93:2978-83. 2008
    ..They also face a high risk of the metabolic syndrome developing after childhood. It is not known whether low muscle mass influences muscle function...
  3. ncbi request reprint Significance of basal IGF-I, IGFBP-3 and IGFBP-2 measurements in the diagnostics of short stature in children
    M B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 54:60-8. 2000
    ..We conclude that the determination of basal IGF parameters is, together with anthropometry and imaging techniques, an indispensable tool for differentiating between GHD and ISS; and that IGFBP-2 plays an additional role in this process...
  4. ncbi request reprint Pilot study of elevated levels of insulin-like growth factor-binding protein-2 as indicators of hepatocellular carcinoma
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 60:174-80. 2003
    ..Our aim was to evaluate the role of IGFBP-2 levels together with insulin-like growth factor (IGF)-I, IGF-II and IGFBP-3 in the diagnostic work-up of patients with hepatocellular carcinoma (HCC)...
  5. ncbi request reprint Relevance of IGF-I, IGFBP-3, and IGFBP-2 measurements during GH treatment of GH-deficient and non-GH-deficient children and adolescents
    M B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tubingen, Germany
    Horm Res 55:115-24. 2001
    ..In adults, high IGF-I levels were found to be associated with side effects and long-term risks...
  6. ncbi request reprint Adult height after GH therapy in 188 Ullrich-Turner syndrome patients: results of the German IGLU Follow-up Study 2001
    M B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Eur J Endocrinol 147:625-33. 2002
    ..We aimed to evaluate the factors influencing true adult height (HT) after long-term (from 1987 to 2000) GH treatment in Ullrich-Turner syndrome (UTS) based on modalities conceived in the 1980s...
  7. ncbi request reprint Decreased expression of IGF-II and its binding protein, IGF-binding protein-2, in genital skin fibroblasts of patients with complete androgen insensitivity syndrome compared with normally virilized males
    M W Elmlinger
    Pediatric Endocrinology, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 86:4741-6. 2001
    ....
  8. ncbi request reprint Secretion of noncomplexed 'Big' (10-18 kD) forms of insulin-like growth factor-II by 12 soft tissue sarcoma cell lines
    M W Elmlinger
    Paediatric Endocrinology, University Children s Hospital, Tubingen, Germany
    Horm Res 52:178-85. 1999
    ..Due to these characteristics, the big-IGF-II forms probably have an altered biological effect on the tumour cells when compared to IGF-II...
  9. doi request reprint Variants of the FTO gene in obese children and their impact on body composition and metabolism before and after lifestyle intervention
    J Schum
    Pediatric Endocrinology and Diabetes, University Children s Hospital, Tuebingen, Germany
    Exp Clin Endocrinol Diabetes 120:128-31. 2012
    ..To investigate the impact of variants of the FTO gene (rs1421085, rs17817449, rs9939609) in obese children before and after lifestyle intervention...
  10. doi request reprint Short children with low birth weight born either small for gestational age or average for gestational age show similar growth response and changes in insulin-like growth factor-1 to growth hormone treatment during the first prepubertal year
    M B Ranke
    University Children s Hospital, Tubingen, Germany
    Horm Res Paediatr 76:104-12. 2011
    ..The aim of this analysis was to compare the growth response to GH in children with low birth weight born SGA or appropriate for gestational age (AGA)...
  11. ncbi request reprint Predicting the response to recombinant human growth hormone in Turner syndrome: KIGS models. KIGS International Board. Kabi International Growth Study
    M B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Acta Paediatr Suppl 88:122-5. 1999
    ....
  12. ncbi request reprint IGF-II serum levels are normal in children with Silver-Russell syndrome who frequently carry epimutations at the IGF2 locus
    G Binder
    Pediatric Endocrinology Section, University Children s Hospital, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 91:4709-12. 2006
    ..It has been speculated that these mutations characterized by demethylation of ICR1 cause diminished IGF2 expression...
  13. doi request reprint Functional and total IGFBP3 for the assessment of disorders of the GH/IGF1 axis in children with chronic kidney disease, GH deficiency, or short stature after SGA status at birth
    A K Büscher
    Department of Pediatrics II, Pediatric Nephrology, Endocrinology and Diabetology, Gastroenterology and Transplant Medicine, University Children s Hospital, University of Duisburg Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Eur J Endocrinol 166:923-31. 2012
    ..A new assay for functional (f-)IGFBP3 exclusively detects IGFBP3 capable of IGF binding. The aim of the study was to evaluate the significance of f-IGFBP3 measurements for the assessment of uremic abnormalities of the GH/IGF1 axis...
  14. ncbi request reprint Catch-up growth in autosomal dominant isolated growth hormone deficiency (IGHD type II)
    G Binder
    University Children s Hospital, Pediatric Endocrinology Section, Hoppe Seyler Str 1, 72076 Tuebingen, Germany
    Growth Horm IGF Res 17:242-8. 2007
    ..Data on the GH-induced catch-up growth of severely GH-deficient children affected by monogenetic defects are missing...
  15. ncbi request reprint Genital skin fibroblasts (GF) of patients with androgen insensitivity syndrome express higher insulin-like growth factor binding protein (IGFBP)-2, -3 and -5 than GF of normally virilized males
    D Diesing
    Pediatric Endocrinology, University Children s Hospital, Tubingen, Germany
    Horm Res 60:73-8. 2003
    ....
  16. doi request reprint Metacarpal thickness, width, length and medullary diameter in children--reference curves from the First Zürich Longitudinal Study
    D D Martin
    Pediatric Endocrinology and Diabetology, University Children s Hospital, Hoppe Seyler Strasse 1, 72076 Tubingen, Germany
    Osteoporos Int 22:1525-36. 2011
    ..Reference data for the four metacarpal measures are presented...
  17. doi request reprint Prevalence and incidence of endocrine disorders in children: results of a survey in Baden-Wuerttemberg and Bavaria (EndoPrIn BB) 2000-2001
    R Schweizer
    University Children s Hospital, Pediatric Endocrinology and Diabetology, Hoppe Seyler Strasse 1, Tubingen, Germany
    Klin Padiatr 222:67-72. 2010
    ..Sparse data is available on the incidence of endocrine disorders among children in Germany...
  18. doi request reprint The functional muscle-bone unit in obese children - altered bone structure leads to normal strength strain index
    S Ehehalt
    Pediatric Endocrinology and Diabetology, University Children s Hospital, Tuebingen, Germany
    Exp Clin Endocrinol Diabetes 119:321-6. 2011
    ..Obese children have a twofold increased risk of fracture of the forearm compared to non-obese children...
  19. ncbi request reprint The d3-growth hormone (GH) receptor polymorphism is associated with increased responsiveness to GH in Turner syndrome and short small-for-gestational-age children
    G Binder
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 91:659-64. 2006
    ....
  20. ncbi request reprint Radiological signs of Leri-Weill dyschondrosteosis in Turner syndrome
    G Binder
    University Children s Hospital and Growth Research Center, Tubingen, Germany
    Horm Res 55:71-6. 2001
    ..The aim of this study was to systematically examine left-hand radiographs from Turner girls for the presence of signs of LWD...
  21. ncbi request reprint Reference values for height and weight in Prader-Willi syndrome based on 315 patients
    H A Wollmann
    University Children s Hospital, Growth Research Center, Tubingen, Germany
    Eur J Pediatr 157:634-42. 1998
    ..The extent of pubertal growth was reduced for the group. Mean adult height was 161.6+/-8.1 cm (23 males) and 150.2+/-5.5 cm (21 females). Head circumference for age was normal for boys and girls...
  22. doi request reprint Human growth hormone measurement by means of a sensitive ELISA of whole blood spots on filter paper
    M Langkamp
    Paediatric Endocrinology Section, University Hospital for Children and Adolescents, Tubingen, Germany
    Growth Horm IGF Res 18:526-32. 2008
    ..Our study is the first to investigate the reliability of a very sensitive assay for the quantification of GH in dried blood spots on filter paper...
  23. ncbi request reprint Measuring IGF-I, IGFBP-2 and IGFBP-3 from dried blood spots on filter paper is not only practical but also reliable
    B S Schütt
    Paediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tubingen, Germany
    Growth Horm IGF Res 13:75-80. 2003
    ..The aim of this study is to adapt measurements of IGF-I, IGFBP-2 and IGFBP-3 to dried blood filter disk assays...
  24. ncbi request reprint Cortical bone density is normal in prepubertal children with growth hormone (GH) deficiency, but initially decreases during GH replacement due to early bone remodeling
    R Schweizer
    Pediatric Endocrinology Section, University Children s Hospital, University of Tuebingen D 72076, Germany
    J Clin Endocrinol Metab 88:5266-72. 2003
    ..Thus, the manifestation of GH deficiency is evidently similar in children and adults, and pQCT provides important information in addition to DEXA measurements, as DEXA does not take bone structure into account...
  25. ncbi request reprint X-linked congenital adrenal hypoplasia: new mutations and long-term follow-up in three patients
    G Binder
    Paediatric Endocrinology Section, Children s Hospital, University of Tuebingen, Tuebingen, Germany
    Clin Endocrinol (Oxf) 53:249-55. 2000
    ..The diagnostic procedure in male children and adolescents presenting with adrenal crisis should include ACTH stimulation tests and mutational analysis of DAX-1 in the absence of another proven aetiology...
  26. ncbi request reprint PTPN11 mutations are associated with mild growth hormone resistance in individuals with Noonan syndrome
    G Binder
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 90:5377-81. 2005
    ....
  27. ncbi request reprint New paradigms for growth hormone treatment in the 21st century: prediction models
    M B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    J Pediatr Endocrinol Metab 13:1365-9. 2000
    ..Growth prediction models will facilitate realistic expectations and will permit stepwise goals to be set and monitored...
  28. ncbi request reprint The course of neonatal cholestasis in congenital combined pituitary hormone deficiency
    G Binder
    University Children s Hospital, Tuebingen, Germany
    J Pediatr Endocrinol Metab 20:695-702. 2007
    ..Neonatal cholestatic hepatitis is frequently associated with congenital combined pituitary hormone deficiency (CCPHD). Data on the course of this hepatopathy are scarce...
  29. ncbi request reprint Transactivation of the IGFBP-2 promoter in human tumor cell lines
    M W Elminger
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse, 72076, Tuebingen, Germany
    Mol Cell Endocrinol 175:211-8. 2001
    ..Since increased biological activity had also been demonstrated for natural pro-IGF forms often produced by tumors, pro-IGFs may be involved in the mechanism leading to elevated IGFBP-2 expression of tumors in vivo...
  30. ncbi request reprint Mutant and misfolded human growth hormone is rapidly degraded through the proteasomal degradation pathway in a cellular model for isolated growth hormone deficiency type II
    K Kannenberg
    Pediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    J Neuroendocrinol 19:882-90. 2007
    ..The results of the present study indicate that, in IGHD II, somatotrophs continuously have to remove misfolded del(32-71)-hGH via the proteasomal degradation pathway, suggesting a mechanism that may result in chronic cellular stress...
  31. ncbi request reprint Dominant transmission of prepubertal gynecomastia due to serum estrone excess: hormonal, biochemical, and genetic analysis in a large kindred
    G Binder
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Str 1, 72076 Tuebingen, Germany
    J Clin Endocrinol Metab 90:484-92. 2005
    ..In women, this mode of aromatase excess may remain clinically inapparent...
  32. ncbi request reprint Reference intervals from birth to adulthood for serum thyroxine (T4), triiodothyronine (T3), free T3, free T4, thyroxine binding globulin (TBG) and thyrotropin (TSH)
    M W Elmlinger
    University Children s Hospital, Paediatric Endocrinology Section, Tuebingen, Germany
    Clin Chem Lab Med 39:973-9. 2001
    ..Our findings complement these of earlier studies. The developed reference intervals can be used to assess the thyroid status of patients, particularly if the measurements are done on the Immulite/Immulite 2000 system...
  33. ncbi request reprint Acromegaly and end-stage renal disease: a diagnostic challenge
    K Müssig
    Division of Endocrinology, Metabolism, and Pathobiochemistry, Department of Internal Medicine, University Hospital of Tubingen, Tubingen, Germany
    J Endocrinol Invest 29:745-9. 2006
    ..This suggested that the disturbances of the GH/IGF-I axis in our patient were due to chronic renal disease, rather than acromegaly. In the work-up for acromegaly, clinicians should be alerted to GH resistance in chronic renal failure...
  34. ncbi request reprint Incidence of IDDM in German children aged 0-14 years. A 6-year population-based study (1987-1993)
    A Neu
    Children s Hospital, University of Tuebingen, Germany
    Diabetes Care 20:530-3. 1997
    ..To register the total number of newly diagnosed cases in Baden-Wuerttemberg (a federal state in southwest Germany), data on 1,160 children were retrospectively collected for the years 1987-1993...
  35. ncbi request reprint Long-term treatment of growth hormone insensitivity syndrome with IGF-I. Results of the European Multicentre Study. The Working Group on Growth Hormone Insensitivity Syndromes
    M B Ranke
    University Children s Hospitals of Tübingen, Germany
    Horm Res 51:128-34. 1999
    ..If treatment is started at an early age, there is considerable potential for achieving height normalisation. The treatment modalities need to be optimized with respect to the growth-promoting and metabolic effects of IFG-I...
  36. ncbi request reprint Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin
    M W Elmlinger
    Pediatric Endocrinology, Children s Hospital, University of Tubingen, Germany
    Regul Pept 84:37-42. 1999
    ..The tight coupling of their mRNA expression suggests a functional association of both receptors in the tumor cells...
  37. ncbi request reprint Pegvisomant treatment in gigantism caused by a growth hormone-secreting giant pituitary adenoma
    K Müssig
    Department of Endocrinology, Metabolism and Pathobiochemistry, University Hospital of Internal Medicine, University of Tubingen, Germany
    Exp Clin Endocrinol Diabetes 115:198-202. 2007
    ..Treatment options for GH-secreting pituitary adenomas have been widened with the availability of long-acting dopamine agonists, depot preparations of somatostatin analogues, and recently the GH receptor antagonist pegvisomant...
  38. doi request reprint [Considerations of growth hormone treatment during the transition from adolescence to adulthood]
    M B Ranke
    Universitätsklinik für Kinder und Jugendmedizin, Pädiatrische Endokrinologie und Diabetologie, Universitat Tubingen
    Dtsch Med Wochenschr 134:1117-20. 2009
    ..0 SDS). GH treatment during the transition phase should be monitored by an endocrinologist with expertise in dealing with adolescent and adult patients, as well as having experience in structuring treatment and documentation...
  39. ncbi request reprint In vivo expression of insulin-like growth factor-binding protein-2 in human gliomas increases with the tumor grade
    M W Elmlinger
    Pediatric Endocrinology, Children s Hospital, University of Tuebingen, D 72076 Tuebingen, Germany
    Endocrinology 142:1652-8. 2001
    ..The results suggest cell type-specific accumulation of IGFBP-1, -2, and -3 in human glial tumors of the brain. The increase in IGFBP-2 expression with this malignancy suggests a role of IGFBP-2 in the biology of human gliomas...
  40. ncbi request reprint Late effects after stem cell transplantation (SCT) in children--growth and hormones
    M B Ranke
    Haematology Oncology and Endocrinology, Department of Paediatrics, University of Tubingen, Tubingen, Germany
    Bone Marrow Transplant 35:S77-81. 2005
    ..Patients and their families need to be made familiar with this concept early and physicians need to understand that such a system must be implemented as part of a comprehensive care...
  41. ncbi request reprint Integrin-mediated action of insulin-like growth factor binding protein-2 in tumor cells
    B S Schütt
    Pediatric Endocrinology Section, University Children s Hospital, 72076 Tuebingen, Germany
    J Mol Endocrinol 32:859-68. 2004
    ..01). Since one of the cell lines used does not express a functional IGF-I receptor, these data demonstrate that IGFBP-2 can act in an IGF-independent manner, at least in part by an interaction with alpha5beta1-integrin...
  42. ncbi request reprint Sensitivity to IGF-I in short children born small for gestational age
    M B Ranke
    Section Pediatric Endocrinology, Children s Hospital, Tuebingen, Germany
    J Endocrinol Invest 29:21-6. 2006
    ..Adequate additional therapies could in future result in positive effects on co-morbidities associated with IGF-I insensitivity in SGA children in addition to height gain...
  43. doi request reprint Effects of dehydroepiandrosterone therapy on pubic hair growth and psychological well-being in adolescent girls and young women with central adrenal insufficiency: a double-blind, randomized, placebo-controlled phase III trial
    G Binder
    Pediatric Endocrinology, University Children s Hospital, Tuebingen, Germany
    J Clin Endocrinol Metab 94:1182-90. 2009
    ..The efficacy of oral dehydroepiandrosterone (DHEA) in the treatment of atrichia pubis and psychological distress in young females with central adrenal insufficiency is unknown. Our study aimed to evaluate this therapy...
  44. doi request reprint Continuous rise in incidence of childhood Type 1 diabetes in Germany
    S Ehehalt
    University Children s Hospital, Eberhard Karls University, Tubingen, Germany
    Diabet Med 25:755-7. 2008
    ..To assess the incidence and the trend in incidence of Type 1 diabetes (T1DM) in children and adolescents < 15 years of age in Baden-Württemberg (BW), Germany...
  45. ncbi request reprint The potential of prediction models based on data from KIGS as tools to measure responsiveness to growth hormone. Pharmacia International Growth Database
    M B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 55:44-8. 2001
    ..This will improve the efficacy and safety of GH treatment as well as reducing the costs involved...
  46. ncbi request reprint Isolated GH deficiency (IGHD) type II: imaging of the pituitary gland by magnetic resonance reveals characteristic differences in comparison with severe IGHD of unknown origin
    G Binder
    University Children s Hospital, Hoppe Seyler Strasse 1, 72076 Tubingen, Germany
    Eur J Endocrinol 147:755-60. 2002
    ..To determine the specific morphology of the pituitary gland in children with severe isolated GH deficiency due to GH-1 gene mutations (IGHD type II)...
  47. ncbi request reprint Varying clinical presentations at onset of type 1 diabetes mellitus in children--epidemiological evidence for different subtypes of the disease?
    A Neu
    University of Tuebingen, University Children s Hospital, Tuebingen, Germany
    Pediatr Diabetes 2:147-53. 2001
    ..Our objective is to analyze whether clinical presentation follows a uniform pattern or whether there is evidence for different subtypes...
  48. ncbi request reprint Mixed gonadal dysgenesis and precocious puberty
    D I Iliev
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 58:30-3. 2002
    ..The karyotype was 46,XY/45,X. These findings confirmed the diagnosis of mixed gonadal dysgenesis with testosterone-producing gonadoblastoma...
  49. ncbi request reprint Screening for growth hormone (GH) gene splice-site mutations in sporadic cases with severe isolated GH deficiency using ectopic transcript analysis
    G Binder
    University Children s Hospital, Tubingen, Germany
    J Clin Endocrinol Metab 80:1247-52. 1995
    ..abstract truncated at 400 words)..
  50. ncbi request reprint Growth during the first two years predicts pre-school height in children born with very low birth weight (VLBW): results of a study of 1,320 children in Germany
    Branko Trebar
    Paediatric Endocrinology Section, University Children s Hospital, D 72076 Tuebingen, Germany
    Pediatr Res 62:209-14. 2007
    ..65 SDS): 1st yr Ht SDS; change (2nd yr) in Ht and weight SDS; MPH SDS; 1st yr weight SDS; birth weight SDS. Thus, some AGA and SGA children born VLBW remain short and preventive strategies need to be developed for those at risk...
  51. ncbi request reprint Insulin-like growth factors and binding proteins in early milk from mothers of preterm and term infants
    Martin W Elmlinger
    Pediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 68:124-31. 2007
    ..The results provide further evidence that IGFBP-2 and IGF-II in breast milk are relevant factors for the early development of preterm infants...
  52. ncbi request reprint Growth hormone binding protein levels in children are associated with birth weight, postnatal weight gain, and insulin secretion
    Ken K Ong
    Medical Research Council Epidemiology Unit, Cambridge CB2 0QQ, UK
    Metabolism 56:1412-7. 2007
    ..Increased GH sensitivity in such children could contribute to links between rapid infancy weight gain and subsequent faster rates of childhood growth and maturation...
  53. ncbi request reprint Growth hormone treatment and adverse events in Prader-Willi syndrome: data from KIGS (the Pfizer International Growth Database)
    Maria E Craig
    Institute of Endocrinology and Diabetes, Children s Hospital at Westmead, Westmead, NSW, Australia
    Clin Endocrinol (Oxf) 65:178-85. 2006
    ..To evaluate the response to recombinant GH treatment and adverse events in children with Prader-Willi syndrome (PWS) from KIGS, the Pfizer International Growth Database...
  54. ncbi request reprint Prevalence of autoantibodies associated with thyroid and celiac disease in Ullrich-Turner syndrome in relation to adult height after growth hormone treatment
    Markus Bettendorf
    University Children s Hospital, Heidelberg, Germany
    J Pediatr Endocrinol Metab 19:149-54. 2006
    ..Therefore, medical care for patients with UTS should routinely include screening for these autoimmune disorders in order to assure early detection and appropriate treatment...
  55. ncbi request reprint Major determinants of height development in Turner syndrome (TS) patients treated with GH: analysis of 987 patients from KIGS
    Michael B Ranke
    Paediatric Endocrinology Section, Children s Hospital, University of Tuebingen, D 72076 Tuebingen, Germany
    Pediatr Res 61:105-10. 2007
    ..Evidently, height at GH start (the taller, the better), age at GH start (the younger, the better), the responsiveness to GH (the higher, the better) and age at puberty (the later, the better) determine NAH...
  56. ncbi request reprint Age at growth hormone therapy start and first-year responsiveness to growth hormone are major determinants of height outcome in idiopathic short stature
    Michael B Ranke
    Paediatric Endocrinology Section, Children s Hospital, University of Tubingen, Tubingen, Germany
    Horm Res 68:53-62. 2007
    ..To develop methods to identify factors associated with a favorable outcome in GH-treated children with idiopathic short stature (ISS)...
  57. pmc Insulin-like growth factor-binding proteins 2 and 3 are independent predictors of a poor prognosis in patients with dilated cardiomyopathy
    Sabine Hassfeld
    Heart 93:359-60. 2007
  58. ncbi request reprint Similar effects of long-term exogenous growth hormone (GH) on bone and muscle parameters: a pQCT study of GH-deficient and small-for-gestational-age (SGA) children
    Roland Schweizer
    Paediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076, Tubingen, Germany
    Bone 41:875-81. 2007
    ..Treatment with GH in short children has focused on height development. Little is known about the concomitant changes in muscle mass, bone structure and bone strength...
  59. ncbi request reprint In vitro analysis of hGH secretion in the presence of mutations of amino acids involved in zinc binding
    Daniel I Iliev
    Pediatric Endocrinology Section, University Children s Hospital, Tuebingen, Germany
    J Mol Endocrinol 39:163-7. 2007
    ..Our in vitro data do not support the hypothesis of disturbed Zn(2+) binding as a major pathogenetic mechanism in dominantly transmitted GH deficiency...
  60. ncbi request reprint Central laboratory reassessment of IGF-I, IGF-binding protein-3, and GH serum concentrations measured at local treatment centers in growth-impaired children: implications for the agreement between outpatient screening and the results of somatotropic axis
    Berthold P Hauffa
    Division of Pediatric Endocrinology and Diabetology, University Children s Hospital, Heidelberg, Germany
    Eur J Endocrinol 157:597-603. 2007
    ....
  61. ncbi request reprint Growth and development are similar in VLBW children born appropriate and small for gestational age: an interim report on 97 preschool children
    Michael B Ranke
    Paediatric Endocrinology Section, University Hospital for Children and Adolescents, Tuebingen, Germany
    J Pediatr Endocrinol Metab 20:1017-26. 2007
    ..To investigate growth and development in a cohort of children born with very low birth weight (VLBW) treated at a single tertiary neonatal unit...
  62. doi request reprint The endocrine phenotype in silver-russell syndrome is defined by the underlying epigenetic alteration
    Gerhard Binder
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Str 1, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 93:1402-7. 2008
    ..Around 50% of children with Silver-Russell syndrome (SRS) carry a hypomethylation of the imprinting control region 1 at the IGF2/H19 locus on 11p15, the functional significance of which is unknown...
  63. doi request reprint Search for subtelomeric imbalances by multiplex ligation-dependent probe amplification in Silver-Russell syndrome
    Katja Eggermann
    Institute of Human Genetics, RWTH Aachen, Aachen, Germany
    Genet Test 12:111-3. 2008
    ..It can therefore be concluded that this type of chromosomal aberration does not belong to the genetic causes of SRS and it is not necessary to include this test in the diagnostic algorithm of the disease...
  64. doi request reprint Normal values of circulating insulin-like growth factor-I bioactivity in the healthy population: comparison with five widely used IGF-I immunoassays
    Michael P Brugts
    Department of Internal Medicine, Erasmus MC, Dr Molewaterplein 50, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 93:2539-45. 2008
    ..Recently an IGF-I-specific kinase receptor activation assay (KIRA) has been developed as an alternative method. However, no normative values have been established for the IGF-I KIRA...
  65. ncbi request reprint Effect of growth hormone (GH) treatment on the near-final height of 1258 patients with idiopathic GH deficiency: analysis of a large international database
    Edward O Reiter
    Baystate Medical Center Children s Hospital, Tufts University School of Medicine, Springfield, Massachusetts 01199, USA
    J Clin Endocrinol Metab 91:2047-54. 2006
    ..Although successful in increasing height velocity, such treatment often falls short of helping patients achieve full genetic height potential...
  66. ncbi request reprint Defining insulin-like growth factor-I deficiency
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, University of Tuebingen, Tuebingen, Germany
    Horm Res 65:9-14. 2006
  67. ncbi request reprint Children with acute Perthes' disease have asymmetrical lower leg growth and abnormal collagen turnover
    Patricia M Crofton
    Department of Paediatric Biochemistry, Royal Hospital for Sick Children, Edinburgh, UK
    Acta Orthop 76:841-7. 2005
    ..Our aim was to establish whether the acute phase of Perthes' disease is associated with abnormalities of growth, of bone or of collagen turnover...
  68. ncbi request reprint The early dehydroepiandrosterone sulfate rise of adrenarche and the delay of pubarche indicate primary ovarian failure in Turner syndrome
    David D Martin
    University Children s Hospital, D 72076 Tuebingen, Germany
    J Clin Endocrinol Metab 89:1164-8. 2004
    ..These data demonstrate that normal timing of adrenarche is dependent on gonadal function and suggest that normal pubarche is the clinical manifestation of the ovarian conversion of DHEAS to active androgens...
  69. ncbi request reprint Ketoacidosis at onset of type 1 diabetes mellitus in children--frequency and clinical presentation
    Andreas Neu
    University of Tuebingen, University Children s Hospital, Hoppe Seyler Str 1, 72076, Tubingen, Germany
    Pediatr Diabetes 4:77-81. 2003
    ..Since 1987, patients with newly diagnosed diabetes mellitus type 1 under 15 yr of age have been registered in Baden-Wuerttemberg (BW), Germany...
  70. ncbi request reprint Characterization of genomic variants in CSH1 and GH2, two candidate genes for Silver-Russell syndrome in 17q24-q25
    Sebastian Prager
    Institute of Human Genetics, RWTH Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Genet Test 7:259-63. 2003
    ..Investigation of CSH1 deletions in further SRS and growth retarded patients will enable us to establish under which circumstances haploinsufficiency of CSH1 is likely to result in clinical changes...
  71. ncbi request reprint Bone Turnover and Growth during and after Chemotherapy in Children with Solid Tumors
    Louise F Bath
    Section of Child Life and Health, Department of Reproductive and Developmental Sciences, 20 Sylvan Place, Edinburgh EH9 IUW, Scotland
    Pediatr Res 55:224-30. 2004
    ..BALP remained suppressed throughout treatment (p < 0.001). Intense courses of treatment for solid tumors have a direct suppressive effect on bone turnover, with an imbalance between collagen synthesis and degradation...
  72. ncbi request reprint Auxology is a valuable instrument for the clinical diagnosis of SHOX haploinsufficiency in school-age children with unexplained short stature
    Gerhard Binder
    University Children s Hospital, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 88:4891-6. 2003
    ..Our observations suggest that it is rational to limit SHOX mutation screening to children with an extremities-trunk ratio less than 1.95 + 1/2 height (m) and to add a critical judgment of the hand radiography...
  73. ncbi request reprint The mathematical model for total pubertal growth in idiopathic growth hormone (GH) deficiency suggests a moderate role of GH dose
    Michael B Ranke
    Pediatric Endocrinology Section, University Children s Hospital, Tubingen D 72076 Germany
    J Clin Endocrinol Metab 88:4748-53. 2003
    ..The use of a higher GH dosage at the onset of puberty should thus depend on the individual's height development. The TPG model aids in the planning of individually optimized and cost-effective GH treatment...
  74. ncbi request reprint The KIGS experience with the addition of gonadotropin-releasing hormone agonists to growth hormone (GH) treatment of children with idiopathic GH deficiency
    Edward O Reiter
    Baystate Medical Center Children s Hospital, Tufts University School of Medicine Springfield, MA 01199, USA
    Horm Res 60:68-73. 2003
    ..These data suggest that the attainment of a substantial height SDS by manipulating the tempo of puberty is limited, but that optimizing growth during the pre-pubertal phase is a more important factor...
  75. ncbi request reprint Prediction model of total pubertal growth in idiopathic growth hormone deficiency: analysis of data from KIGS
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 60:58-9. 2003
  76. ncbi request reprint Early-onset idiopathic growth hormone deficiency within KIGS
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 60:18-21. 2003
    ..Thus, it is suggested that early diagnosis and initiation of treatment in GH-deficient patients is strongly needed to achieve the maximum effects from therapy...
  77. ncbi request reprint Serum insulin-like growth factor I reference values for an automated chemiluminescence immunoassay system: results from a multicenter study
    Georg Brabant
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule, Hannover, Germany
    Horm Res 60:53-60. 2003
    ..The objective of the present study was to develop cross-sectional reference values for S-IGF-I measured by an automated chemiluminescence immunoassay (Nichols Advantage)...
  78. ncbi request reprint Reference ranges for serum concentrations of lutropin (LH), follitropin (FSH), estradiol (E2), prolactin, progesterone, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), cortisol and ferritin in neonates, children and young adul
    Martin W Elmlinger
    University Children s Hospital, Paediatric Endocrinology Section, Tuebingen, Germany
    Clin Chem Lab Med 40:1151-60. 2002
    ..Our findings agree with earlier studies. The calculated reference intervals can be used to assess the development of children, particularly for measurements performed by the Immulite and Immulite 2000 chemiluminescence assay systems...
  79. ncbi request reprint Prediction of response to growth hormone treatment in short children born small for gestational age: analysis of data from KIGS (Pharmacia International Growth Database)
    Michael B Ranke
    Sektion Pädiatrische Endokrinologie, Universitatsklinikum Tubingen, Eberhard Karls Universitat, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 88:125-31. 2003
    ..Furthermore, this model can be used to provide patients with a realistic expectation of treatment and may help to identify compliance problems or other underlying causes of treatment failure...
  80. ncbi request reprint A growth prediction model for short children born small for gestational age
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    J Pediatr Endocrinol Metab 15:1273. 2002
  81. ncbi request reprint Catch-up growth: new lessons for the clinician
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    J Pediatr Endocrinol Metab 15:1257-66. 2002
    ....
  82. ncbi request reprint Age-dependency of insulin-like growth factors, insulin-like growth factor-binding proteins, and acid labile subunit in plasma and wounds of surgical patients
    Corinna Wicke
    Department of Surgery, Pediatric Endocrinology Section of the Children s Hospital, and BG Trauma Center, University of Tubingen, Tubingen, Germany
    Wound Repair Regen 10:360-5. 2002
    ..The current data adds to accumulating evidence that a decline in the IGF system in aged patients contributes to the healing deficits observed in the elderly...
  83. ncbi request reprint Central reassessment of GH concentrations measured at local treatment centers in children with impaired growth: consequences for patient management
    Berthold P Hauffa
    Department of Pediatric Hematology Oncology and Endocrinology, University Children s Hospital, Essen, Germany
    Eur J Endocrinol 150:291-7. 2004
    ....
  84. ncbi request reprint Musculoskeletal abnormalities of the forearm in patients with juvenile idiopathic arthritis relate mainly to bone geometry
    Johannes Roth
    University Children s Hospital, Tuebingen, Germany
    Arthritis Rheum 50:1277-85. 2004
    ..This study was undertaken to obtain a more detailed understanding of the musculoskeletal system in JIA by analyzing bone density, bone geometry, and muscle force as the most important factor in bone development...
  85. ncbi request reprint IGFs, IGFBPs, IGF-binding sites and biochemical markers of bone metabolism during differentiation in human pulp fibroblasts
    Katharina M Reichenmiller
    Department of Conservative Dentistry, School of Dental Medicine at the University of Tübingen, Germany
    Horm Res 62:33-9. 2004
    ..To investigate the role of the insulin-like growth factors (IGF) system during the differentiation of human pulp-derived fibroblasts (HPF)...
  86. ncbi request reprint Diagnostic proceeding in Silver-Russell syndrome
    Thomas Eggermann
    Institute of Human Genetics, Aachen, Germany
    Mol Diagn 9:205-9. 2005
    ..Here, we report on our experiences of UPD testing in patients referred to our laboratory with the clinical diagnosis of SRS. A diagnostic algorithm for SRS is suggested...
  87. ncbi request reprint IGF-I and IGF binding protein-3 levels during initial GH dosage step-up are indicators of GH sensitivity in GH-deficient children and short children born small for gestational age
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 64:68-76. 2005
    ..A stepwise increment of the GH dose is an approach aimed at avoiding adverse events. We investigated GH sensitivity by studying IGF-I and IGFBP-3 concentrations during the initial phase of GH treatment...
  88. ncbi request reprint Final height in children with medulloblastoma treated with growth hormone
    Michael B Ranke
    Paediatric Endocrinology Section, Children s Hospital, University of Tubingen, Tubingen, Germany
    Horm Res 64:28-34. 2005
    ..Height in general is severely compromised in survivors. The present study is an extension of the investigation by the author's group of the effect of exogenous growth hormone (GH) among medulloblastoma patients...
  89. ncbi request reprint Insulin-like growth factor-I treatment of growth disorders, diabetes mellitus and insulin resistance
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tubingen, Germany
    Trends Endocrinol Metab 16:190-7. 2005
    ..Further studies on IGF-I metabolic effects and growing understanding of the IGF-I-IGF-binding protein system could open new therapeutic avenues...
  90. ncbi request reprint Insulin-like growth factors as diagnostic tools in growth hormone deficiency during childhood and adolescence: the KIGS experience
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 62:17-25. 2004
    ....
  91. ncbi request reprint Total pubertal growth and markers of puberty onset in adolescents with GHD: comparison between mathematical growth analysis and pubertal staging methods
    David D Martin
    Paediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, DE 72076 Tübingen, Germany
    Horm Res 63:95-101. 2005
    ..Two methods of determining puberty onset (Preece- Baines model 1 (PB1) and Tanner staging) were used to calculate total pubertal growth (TPG) in adolescents with growth hormone deficiency (GHD)...
  92. ncbi request reprint Uterine size in women with Turner syndrome after induction of puberty with estrogens and long-term growth hormone therapy: results of the German IGLU Follow-up Study 2001
    Helmuth G Doerr
    University Hospital for Children and Adolescents, Erlangen, Germany
    Hum Reprod 20:1418-21. 2005
    ..To evaluate the factors influencing uterine size in young adult women with Turner syndrome (TS) after long-term growth hormone (GH) treatment...
  93. ncbi request reprint Increased response, but lower responsiveness, to growth hormone (GH) in very young children (aged 0-3 years) with idiopathic GH Deficiency: analysis of data from KIGS
    Michael B Ranke
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tuebingen, Germany
    J Clin Endocrinol Metab 90:1966-71. 2005
    ..The early detection and GH treatment of congenital GHD is advantageous as a cost-effective strategy for achieving greater improvement of absolute height and growth velocity...
  94. ncbi request reprint Insulin tolerance test causes hypokalaemia and can provoke cardiac arrhythmias
    Gerhard Binder
    University Children s Hospital, Tubingen, Germany
    Horm Res 62:84-7. 2004
    ..In addition, in the case of a comatose child during ITT the determination of the glucose and potassium level as well as adequate treatment are necessary...
  95. ncbi request reprint Reference ranges for two automated chemiluminescent assays for serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3)
    Martin W Elmlinger
    Pediatric Endocrinology, University Children s Hospital, Tuebingen, Germany
    Clin Chem Lab Med 42:654-64. 2004
    ..5th centile. In conclusion, the automated IMMULITE IGF-I and IGFBP-3 assays are reliable tools in the diagnosis of pathologies of the GH/IGF axis and in the follow-up of their therapies...
  96. ncbi request reprint SHOX haploinsufficiency and Leri-Weill dyschondrosteosis: prevalence and growth failure in relation to mutation, sex, and degree of wrist deformity
    Gerhard Binder
    Section of Pediatric Endocrinology, University Children s Hospital, Hoppe Seyler Strasse 1, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 89:4403-8. 2004
    ..No statistically significant effects of type of mutation, age of menarche, or sex on height were observed. The effect of GH therapy varied between individuals and needs to be examined in controlled studies...
  97. ncbi request reprint Screening for insulin-like growth factor-I receptor mutations in patients with Silver-Russell syndrome
    Gerhard Binder
    University Children s Hospital and Growth Research Center, Tubingen, Germany
    J Pediatr Endocrinol Metab 15:1167-71. 2002
    ..Our data do not support the suggestion that the IGF-I receptor is frequently involved in the pathogenesis of SRS...
  98. ncbi request reprint Structural analysis of human growth hormone with respect to the dominant expression of growth hormone (GH) mutations in isolated GH deficiency type II
    Daniel I Iliev
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tuebingen Germany
    Endocrinology 146:1411-7. 2005
    ..The inhibitory effect of GH mutants on heterologously expressed, non-GH proteins suggests that the dominant negative effect is not limited to GH or to proteins of the regulated secretory pathway, but may depend on expression levels...
  99. ncbi request reprint Bone age progression during the first year of growth hormone therapy in pre-pubertal children with idiopathic growth hormone deficiency, Turner syndrome or idiopathic short stature, and in short children born small for gestational age: analysis of data fr
    Feyza Darendeliler
    Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Horm Res 63:40-7. 2005
    ....
  100. ncbi request reprint MR imaging and spectroscopy of a tuber cinereum hamartoma in a patient with growth hormone deficiency and hypogonadotropic hypogonadism
    David D Martin
    Section for Pediatric Endocrinology, University of Tubingen, 72076 Tubingen, Germany
    AJNR Am J Neuroradiol 24:1177-80. 2003
    ..This report stresses the advantages of short-TE spectroscopy and demonstrates that regional variations in spectra should be considered when reference structures are used...
  101. ncbi request reprint Recurrence of brain tumours in patients treated with growth hormone: analysis of KIGS (Pfizer International Growth Database)
    Feyza Darendeliler
    Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Acta Paediatr 95:1284-90. 2006
    ..Growth hormone (GH) has been used successfully in the treatment of short stature secondary to GH deficiency in survivors of childhood brain tumours. There has been concern that GH might increase the risk of recurrence...