Burkert Pieske

Summary

Country: Germany

Publications

  1. ncbi request reprint Rate dependence of [Na+]i and contractility in nonfailing and failing human myocardium
    Burkert Pieske
    Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen, Germany
    Circulation 106:447-53. 2002
  2. pmc Natriuretic peptide vs. clinical information for diagnosis of left ventricular systolic dysfunction in primary care
    Janka Koschack
    Department of General Practice, Georg August University Gottingen, Germany
    BMC Fam Pract 9:14. 2008
  3. ncbi request reprint [Na+]i handling in the failing human heart
    Burkert Pieske
    Abt Kardiologie und Pneumologie, Zentrum Innere Medizin, Klinik der Georg August Universität, Robert Koch Strasse 40, 37075, Gottingen, Germany
    Cardiovasc Res 57:874-86. 2003
  4. ncbi request reprint Sarcoplasmic reticulum Ca2+ load in human heart failure
    Burkert Pieske
    Labor für Molekulare Kardiologie und Herzmuskelphysiologie, Abteilung Kardiologie und Angiologie, Georg August Universitat Gottingen, Robert Koch Str 40, 37085 Göttingen, Germany
    Basic Res Cardiol 97:I63-71. 2002
  5. ncbi request reprint [Pathophysiological basis of heart failure]
    B Pieske
    Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen
    Ther Umsch 57:284-92. 2000
  6. ncbi request reprint Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits: evaluation of mechanisms
    Wolfgang Schillinger
    Herzzentrum, Kardiologie und Pneumologie, Georg August Universitaet Goettingen, Robert Koch Strasse 40, 37099 Goettingen, Germany
    Circulation 116:57-66. 2007
  7. ncbi request reprint Stretch-dependent modulation of [Na+]i, [Ca2+]i, and pHi in rabbit myocardium--a mechanism for the slow force response
    Claus Luers
    Department of Cardiology and Pneumology, University of Goettingen, Robert Koch Strasse 40, 37075 Goettingen, Germany
    Cardiovasc Res 68:454-63. 2005
  8. ncbi request reprint Increased SR Ca2+ cycling contributes to improved contractile performance in SERCA2a-overexpressing transgenic rats
    Lars S Maier
    Abt Kardiologie and Pneumologie Herzzentrum, Georg August Universitat Gottingen, Germany
    Cardiovasc Res 67:636-46. 2005
  9. ncbi request reprint Stretch-dependent slow force response in isolated rabbit myocardium is Na+ dependent
    Dirk von Lewinski
    Department of Cardiology and Pneumology, Georg August University, Robert Koch Str 40, 37075, Gottingen, Germany
    Cardiovasc Res 57:1052-61. 2003
  10. ncbi request reprint Functional relevance of the stretch-dependent slow force response in failing human myocardium
    Dirk von Lewinski
    Department of Cardiology and Pneumology, Georg August University, Gottingen, Germany
    Circ Res 94:1392-8. 2004

Detail Information

Publications66

  1. ncbi request reprint Rate dependence of [Na+]i and contractility in nonfailing and failing human myocardium
    Burkert Pieske
    Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen, Germany
    Circulation 106:447-53. 2002
    ..Because Ca2+ and Na+ homeostasis are intimately linked through the Na+/Ca2+ exchanger, we compared the regulation of [Na+]i in nonfailing (NF) and failing human myocardium...
  2. pmc Natriuretic peptide vs. clinical information for diagnosis of left ventricular systolic dysfunction in primary care
    Janka Koschack
    Department of General Practice, Georg August University Gottingen, Germany
    BMC Fam Pract 9:14. 2008
    ..Whether or not natriuretic peptide testing is a useful and cost-effective diagnostic instrument in primary care settings, however, is still a matter of debate...
  3. ncbi request reprint [Na+]i handling in the failing human heart
    Burkert Pieske
    Abt Kardiologie und Pneumologie, Zentrum Innere Medizin, Klinik der Georg August Universität, Robert Koch Strasse 40, 37075, Gottingen, Germany
    Cardiovasc Res 57:874-86. 2003
    ....
  4. ncbi request reprint Sarcoplasmic reticulum Ca2+ load in human heart failure
    Burkert Pieske
    Labor für Molekulare Kardiologie und Herzmuskelphysiologie, Abteilung Kardiologie und Angiologie, Georg August Universitat Gottingen, Robert Koch Str 40, 37085 Göttingen, Germany
    Basic Res Cardiol 97:I63-71. 2002
    ..Reduced SR Ca2+ release is due to diminished SR Ca2+ content directly related to a depressed expression of SERCA2a protein. Enhancing SERCA function or expression may improve SR Ca2+ handling in failing human myocardium...
  5. ncbi request reprint [Pathophysiological basis of heart failure]
    B Pieske
    Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen
    Ther Umsch 57:284-92. 2000
    ..Endothelin and angiotensin may contribute to the regulation of myocardial contractility in the human heart, but their functional relevance in the regulation of myocardial contractility under clinical conditions remains to be evaluated...
  6. ncbi request reprint Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits: evaluation of mechanisms
    Wolfgang Schillinger
    Herzzentrum, Kardiologie und Pneumologie, Georg August Universitaet Goettingen, Robert Koch Strasse 40, 37099 Goettingen, Germany
    Circulation 116:57-66. 2007
    ..Proton pump inhibitors are used extensively for acid-related gastrointestinal diseases. Their effect on cardiac contractility has not been assessed directly...
  7. ncbi request reprint Stretch-dependent modulation of [Na+]i, [Ca2+]i, and pHi in rabbit myocardium--a mechanism for the slow force response
    Claus Luers
    Department of Cardiology and Pneumology, University of Goettingen, Robert Koch Strasse 40, 37075 Goettingen, Germany
    Cardiovasc Res 68:454-63. 2005
    ..We tested whether stretch-dependent stimulation of Na(+)/H(+) exchange (NHE1) and consecutive changes in pH(i) and/or [Na(+)](i) may underlie the SFR...
  8. ncbi request reprint Increased SR Ca2+ cycling contributes to improved contractile performance in SERCA2a-overexpressing transgenic rats
    Lars S Maier
    Abt Kardiologie and Pneumologie Herzzentrum, Georg August Universitat Gottingen, Germany
    Cardiovasc Res 67:636-46. 2005
    ..We reported that SERCA2a-overexpression in transgenic rat hearts (TG) results in improved contractility. However, it was not clear whether TG have improved contractility due to frequency-dependent improved SR Ca2+ handling...
  9. ncbi request reprint Stretch-dependent slow force response in isolated rabbit myocardium is Na+ dependent
    Dirk von Lewinski
    Department of Cardiology and Pneumology, Georg August University, Robert Koch Str 40, 37075, Gottingen, Germany
    Cardiovasc Res 57:1052-61. 2003
    ..Stretch induces functional and trophic effects in mammalian myocardium via various signal transduction pathways. We tested stretch signal transduction on immediate and slow force response (SFR) in rabbit myocardium...
  10. ncbi request reprint Functional relevance of the stretch-dependent slow force response in failing human myocardium
    Dirk von Lewinski
    Department of Cardiology and Pneumology, Georg August University, Gottingen, Germany
    Circ Res 94:1392-8. 2004
    ..The data demonstrate the existence of a functionally relevant, SR-Ca2+-dependent SFR in failing human myocardium, which partly depends on NHE1 and reverse-mode NCX activation...
  11. ncbi request reprint Mechanistic insight into the functional and toxic effects of Strophanthidin in the failing human myocardium
    Dirk von Lewinski
    Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    Eur J Heart Fail 9:1086-94. 2007
    ..Data on cardiac glycosides in isolated failing human myocardium are scarce and the frequency-dependent actions and toxicity of Strophanthidin have not yet been characterized...
  12. ncbi request reprint Insulin-like growth factor-1 exerts Ca2+-dependent positive inotropic effects in failing human myocardium
    Dirk von Lewinski
    Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen, Germany
    Circ Res 92:169-76. 2003
    ..The increased [Ca2+]i with IGF-1 originates from both enhanced L-type Ca2+ currents and enhanced Na+-H+ exchange-dependent reverse-mode Na+-Ca2+ exchange. These nongenomic functional effects of IGF-1 may be of clinical relevance...
  13. ncbi request reprint Insulin causes [Ca2+]i-dependent and [Ca2+]i-independent positive inotropic effects in failing human myocardium
    Dirk von Lewinski
    Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen, Gottingen, Germany
    Circulation 111:2588-95. 2005
    ..We examined inotropic responses and signal transduction mechanisms of insulin in human myocardium...
  14. ncbi request reprint Na(+)-Ca(2+) exchanger overexpression predisposes to reactive oxygen species-induced injury
    Stefan Wagner
    Department of Cardiology and Pneumology, , Robert Koch Str 40, , Germany
    Cardiovasc Res 60:404-12. 2003
    ..It was shown that failing cardiac myocytes are more susceptible to ROS-induced damage, possibly due to increased expression of the sarcolemmal Na-Ca exchanger (NCX)...
  15. ncbi request reprint Impact of diabetes on left ventricular diastolic function in patients with arterial hypertension
    Rolf Wachter
    Department of Cardiology and Pneumology, University of Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    Eur J Heart Fail 9:469-76. 2007
    ..To analyse the effect of diabetes (DM) on diastolic function in hypertensive patients...
  16. doi request reprint Overexpression of CaMKIIδc in RyR2R4496C+/- knock-in mice leads to altered intracellular Ca2+ handling and increased mortality
    Nataliya Dybkova
    Department of Cardiology and Pneumology, Georg August University Gottingen, Gottingen, Germany
    J Am Coll Cardiol 57:469-79. 2011
    ..We investigated whether increased Ca(2+)/calmodulin-dependent kinase II (CaMKII) activity aggravates defective excitation-contraction coupling and proarrhythmic activity in mice expressing R4496C mutated cardiac ryanodine receptors (RyR2)...
  17. doi request reprint Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial
    Frank Edelmann
    Department of Cardiology and Pneumology, Heart Center, University of Gottingen, Gottingen, Germany
    JAMA 309:781-91. 2013
    ..Diastolic heart failure (ie, heart failure with preserved ejection fraction) is a common condition without established therapy, and aldosterone stimulation may contribute to its progression...
  18. doi request reprint Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot study
    Frank Edelmann
    Department of Cardiology, University of Gottingen, Gottingen, Germany
    J Am Coll Cardiol 58:1780-91. 2011
    ..We sought to determine whether structured exercise training (ET) improves maximal exercise capacity, left ventricular diastolic function, and quality of life (QoL) in patients with heart failure with preserved ejection fraction (HFpEF)...
  19. ncbi request reprint Improved systolic and diastolic myocardial function with intracoronary pyruvate in patients with congestive heart failure
    Hans Peter Hermann
    Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen, Robert Koch Str 40, Göttingen D 37075, Germany
    Eur J Heart Fail 6:213-8. 2004
    ..Pyruvate increases myocardial performance in isolated myocardium and improves hemodynamics in patients with congestive heart failure...
  20. ncbi request reprint Atrial myocardium is the predominant inotropic target of adrenomedullin in the human heart
    Egbert Bisping
    Department of Cardiology, University of Gottingen, Gottingen, Germany
    Am J Physiol Heart Circ Physiol 293:H3001-7. 2007
    ..The inotropic effects are related to increased cAMP levels and stimulation of PKA. In heart failure, the responsiveness to ADM is reduced in atria and ventricles...
  21. doi request reprint Impact of obstructive sleep apnoea on diastolic function
    Rolf Wachter
    Dept of Cardiology and Pneumology, University of Gottingen, Gottingen, Germany
    Eur Respir J 41:376-83. 2013
    ..Moderate-to-severe OSA is independently associated with diastolic dysfunction in patients with classical risk factors for diastolic dysfunction...
  22. ncbi request reprint Influence of pyruvate on contractile performance and Ca(2+) cycling in isolated failing human myocardium
    Gerd Hasenfuss
    Abteilung Kardiologie und Pneumologie, Zentrum Innere Medizin, Georg August Universitat Gottingen, Germany
    Circulation 105:194-9. 2002
    ..We assessed the influence of pyruvate on systolic and diastolic myocardial function and its subcellular mode of action in isolated myocardium from end-stage failing human hearts...
  23. ncbi request reprint The role of SR Ca(2+)-content in blunted inotropic responsiveness of failing human myocardium
    Lars S Maier
    Abteilung Kardiologie und Pneumologie, Zentrum Innere Medizin, Georg August Universitat Gottingen, Gottingen, Germany
    J Mol Cell Cardiol 34:455-67. 2002
    ..In contrast, the maintained inotropic response to pyruvate despite reduced SR Ca(2+)-loading points to additional subcellular effects such as enhanced myofilament Ca(2+)-responsiveness...
  24. doi request reprint Rationale and design of the 'aldosterone receptor blockade in diastolic heart failure' trial: a double-blind, randomized, placebo-controlled, parallel group study to determine the effects of spironolactone on exercise capacity and diastolic function in pa
    Frank Edelmann
    Department of Cardiology and Pneumology, University of Gottingen, Robert Koch Str 40, D 37075 Gottingen, Germany
    Eur J Heart Fail 12:874-82. 2010
    ..Aldo-DHF will test the hypothesis that aldosterone receptor blockade by spironolactone will improve exercise capacity and diastolic function in patients with DHF...
  25. doi request reprint Plasma mid-regional pro-adrenomedullin levels are inversely associated with anxiety but unrelated to depression: Results from the observational DIAST-CHF study in patients with cardiovascular risk factors
    Thomas Meyer
    Department of Psychosomatic Medicine and Psychotherapy, University of Gottingen, Gottingen, Germany German Centre for Cardiovascular Research, Germany
    Psychoneuroendocrinology 62:227-32. 2015
    ....
  26. pmc Elevated Plasma C-Terminal Endothelin-1 Precursor Fragment Concentrations Are Associated with Less Anxiety in Patients with Cardiovascular Risk Factors. Results from the Observational DIAST-CHF Study
    Thomas Meyer
    Department of Psychosomatic Medicine and Psychotherapy, University of Gottingen, Gottingen, Germany German Centre for Cardiovascular Research, partner site Göttingen, Gottingen, Germany
    PLoS ONE 10:e0136739. 2015
    ..The role of endothelin-1 (ET-1) in the neurobiology of anxiety is unknown, therefore, we assessed in the observational multicenter DIAST-CHF study whether the C-terminal ET-1 precursor fragment (CT-proET-1) is linked to anxiety...
  27. doi request reprint Effects of exercise training on different quality of life dimensions in heart failure with preserved ejection fraction: the Ex-DHF-P trial
    Kathleen Nolte
    Department of Cardiology, University of Gottingen, Gottingen, Germany
    Eur J Prev Cardiol 22:582-93. 2015
    ..Exercise training (ET) improves physical QoL in HFpEF, but the effects on other aspects of QoL are unknown...
  28. ncbi request reprint Calcium cycling in congestive heart failure
    Gerd Hasenfuss
    Department of Cardiology and Pneumology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    J Mol Cell Cardiol 34:951-69. 2002
  29. pmc Blunted frequency-dependent upregulation of cardiac output is related to impaired relaxation in diastolic heart failure
    Rolf Wachter
    Department of Cardiology and Pneumology, University of Gottingen, Gottingen, Germany
    Eur Heart J 30:3027-36. 2009
    ..We tested the hypothesis that, in heart failure with normal ejection fraction (HFNEF), diastolic dysfunction is accentuated at increasing heart rates, and this contributes to impaired frequency-dependent augmentation of cardiac output...
  30. pmc Heart failure therapy in diabetic patients-comparison with the recent ESC/EASD guideline
    Frank Edelmann
    Department of Cardiology and Pneumology, University of Gottingen, Gottingen, Germany
    Cardiovasc Diabetol 10:15. 2011
    ..To assess heart failure therapies in diabetic patients with preserved as compared to impaired systolic ventricular function...
  31. doi request reprint Higher plasma levels of MR-pro-atrial natriuretic peptide are linked to less anxiety: results from the observational DIAST-CHF study
    Thomas Meyer
    Department of Psychosomatic Medicine and Psychotherapy, German Centre for Cardiovascular Research, University of Gottingen, Gottingen, Germany
    Clin Res Cardiol 104:574-81. 2015
    ..In the present study, we investigated whether in patients with cardiovascular risk factors higher plasma levels of natriuretic peptides are linked to reduced anxiety...
  32. ncbi request reprint [Dyspnea and normal systolic function]
    Gerd Hasenfuss
    Abteilung Kardiologie und Pneumologie, Universitat Gottingen, Gottingen
    Herz 29:602-8. 2004
    ..The results of ongoing trials (e. g., I-Preserve) may offer new therapeutic options, and evidence-based guidelines for the so far often unsatisfactory treatment of diastolic dysfunction/heart failure are awaited...
  33. ncbi request reprint Method-related effects of adenovirus-mediated LacZ and SERCA1 gene transfer on contractile behavior of cultured failing human cardiomyocytes
    J Weisser-Thomas
    Georg August Universitat Gottingen, Abteilung Kardiologie und Pneumologie, Zentrum Innere Medizin, Robert Koch Str 40, 37075 Gottingen, Germany
    J Pharmacol Toxicol Methods 51:91-103. 2005
    ..However, the functional consequences of cell isolation, cell culture per se and adenovirus-mediated transfer of the LacZ or SERCA1 gene in failing human cardiomyocytes warrant further investigation...
  34. ncbi request reprint Relationship between Na+-Ca2+-exchanger protein levels and diastolic function of failing human myocardium
    G Hasenfuss
    Zentrum Innere Medizin, Abteilung Kardiologie und Pneumologie, Universitat Gottingen, Germany
    Circulation 99:641-8. 1999
    ..In the failing human heart, sarcoplasmic reticulum (SR) calcium handling is impaired, and therefore, calcium elimination and diastolic function may depend on the expression of sarcolemmal Na+-Ca2+ exchanger...
  35. ncbi request reprint Influence of cyclosporine A on contractile function, calcium handling, and energetics in isolated human and rabbit myocardium
    P M Janssen
    Abt Kardiologie und Pneumologie, Universitat Gottingen, Gottingen, Germany
    Cardiovasc Res 47:99-107. 2000
    ..We investigated the direct effects of CsA on myocardial function, because these are largely unknown...
  36. ncbi request reprint The functional effect of adenoviral Na+/Ca2+ exchanger overexpression in rabbit myocytes depends on the activity of the Na+/K+-ATPase
    W Schillinger
    Herzzentrum Göttingen, Kardiologie und Pneumologie, Georg August Universitat Gottingen, Robert Koch Strasse 40, 37075, Gottingen, Germany
    Cardiovasc Res 57:996-1003. 2003
    ..The functional consequences of Na+/Ca2+ exchanger (NCX) overexpression in heart failure have been controversially discussed. NCX function strongly depends on intracellular sodium which has been shown to be increased in heart failure...
  37. ncbi request reprint Influence of the novel inotropic agent levosimendan on isometric tension and calcium cycling in failing human myocardium
    G Hasenfuss
    Zentrum Innere Medizin, Abteilung für Kardiologie und Pneumologie, Universitat Gottingen, Germany
    Circulation 98:2141-7. 1998
    ..Levosimendan was shown to increase calcium sensitivity by a novel mechanism and to inhibit phosphodiesterase III activity in animal myocardium...
  38. ncbi request reprint High plasma levels of N-terminal pro-atrial natriuretic peptide associated with low anxiety in severe heart failure
    Christoph Herrmann-Lingen
    Department of Psychosomatics and Psychotherapy, University of Gottingen, Gottingen, Germany
    Psychosom Med 65:517-22. 2003
    ..We therefore assessed associations of the Atrial Natriuretic Pro-Peptide (pro-ANP) with anxiety in patients with CHF and controls...
  39. doi request reprint Tolerability and Feasibility of Beta-Blocker Titration in HFpEF Versus HFrEF: Insights From the CIBIS-ELD Trial
    Frank Edelmann
    Department of Cardiology, Charite Universitatsmedizin, Campus Virchow Klinkum, Berlin, Germany Department of Cardiology and Pneumology, Göttingen University Medical Center, Gottingen, Germany DZHK Partner Site Berlin, Berlin, Germany DZHK Partner Site Göttingen, Gottingen, Germany
    JACC Heart Fail 4:140-9. 2016
    ..This study evaluated the tolerability and feasibility of titration of 2 distinctly acting beta-blockers (BB) in elderly heart failure patients with preserved (HFpEF) and reduced (HFrEF) left ventricular ejection fraction...
  40. ncbi request reprint [Restrictive cardiomyopathy]
    Rolf Wachter
    Abteilung Kardiologie und Pneumologie, Universitat, Gottingen
    Herz 30:558-64. 2005
    ..Diagnosis of the underlying disease is mandatory for therapy of RKMP, as there are specific therapeutic options for symptom relief. Heart transplantation may be an option in end-stage heart failure...
  41. doi request reprint Peripartum cardiomyopathy--a new treatment option by inhibition of prolactin secretion
    Boriana G Jahns
    Department of Gynecology and Obstetrics, Georg August University, Gottingen, Germany
    Am J Obstet Gynecol 199:e5-6. 2008
    ..Recent experimental data implicate a causal role of prolactin. We report a patient with PPCM who responded well to treatment with Bromocriptine in addition to standard therapy of heart failure...
  42. ncbi request reprint Improvement of impaired renal function in heart transplant recipients treated with mycophenolate mofetil and low-dose cyclosporine
    I Aleksic
    Department of Thoracic and Cardiovascular Surgery, Georg August University, Gottingen, Germany
    Transplantation 69:1586-90. 2000
    ..We have studied the impact of CsA dose reduction in association with mycophenolate mofetil (MMF) treatment on renal function in heart transplant recipients with suspected CsA nephrotoxicity (serum creatinine level >2 mg/dl)...
  43. ncbi request reprint Renal function and safety of heart transplant recipients switched to mycophenolate mofetil and low-dose cyclosporine
    M Baryalei
    Department of Thoracic and Cardiovascular Surgery, Georg August University, Gottingen, Germany
    Transplant Proc 35:1539-42. 2003
    ..We evaluated cyclosporine (CSA) dose reduction and mycophenolate mofetil (MMF) treatment versus maintained CSA dosage and azathioprine (AZA) in HTX regarding renal function and safety from CSA nephrotoxicity (creatinine > 1.7 mg/dL)...
  44. ncbi request reprint Influence of mild hypothermia on myocardial contractility and circulatory function
    J Weisser
    Abteilung Kardiologie und Pneumologie, Zentrum Innere Medizin, , Germany
    Basic Res Cardiol 96:198-205. 2001
    ..These effects translate into improved hemodynamic parameters of left ventricular function...
  45. pmc Association of glucose metabolism with diastolic function along the diabetic continuum
    R Stahrenberg
    Department of Cardiology and Pneumology, University of Goettingen, 37075, Goettingen, Germany
    Diabetologia 53:1331-40. 2010
    ..Hyperglycaemia and insulin resistance have been linked to diastolic dysfunction experimentally. We investigated the association between glucose metabolism and diastolic function along the whole spectrum of glucose metabolism states...
  46. ncbi request reprint Frequency-dependence of the slow force response
    Dirk von Lewinski
    Department of Cardiology, Medical University Graz, Austria
    Front Biosci 13:7202-9. 2008
    ..Subcellular mechanisms underlying the SFR are not fundamentally affected by stimulation rate. The SFR may have more pronounced physiological effects at lower heart rates...
  47. pmc Angiotensin II and myosin light-chain phosphorylation contribute to the stretch-induced slow force response in human atrial myocardium
    Jens Kockskamper
    Division of Cardiology, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    Cardiovasc Res 79:642-51. 2008
    ..The functional effects of stretch on human atrium, however, are poorly understood. Thus, we characterized the stretch-induced force response in human atrium and evaluated the underlying cellular mechanisms...
  48. ncbi request reprint Alternans goes subcellular: a "disease" of the ryanodine receptor?
    Burkert Pieske
    Circ Res 91:553-5. 2002
  49. ncbi request reprint Sodium and the heart: a hidden key factor in cardiac regulation
    Burkert Pieske
    Cardiovasc Res 57:871-2. 2003
  50. ncbi request reprint Phosphorylation of the cardiac ryanodine receptor by Ca2+/calmodulin-dependent protein kinase II: the dominating twin of protein kinase A?
    Jens Kockskamper
    Circ Res 99:333-5. 2006
  51. pmc Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes
    Beate Fiedler
    Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany
    Proc Natl Acad Sci U S A 99:11363-8. 2002
    ..Inhibition of calcineurin-NFAT signaling by PKG I provides a framework for understanding how NO inhibits cardiac myocyte hypertrophy...
  52. ncbi request reprint The seasonal peculiarities of force-frequency relationships in active ground squirrel Spermophilus undulatus ventricle
    Olga V Nakipova
    Institute of Cell Biophysics, Russian Academy of Sciences, Institutskaya Street 3, 142290 Pushchino Moscow region, Russia
    Cryobiology 55:173-81. 2007
    ..Also, how myocardium during the hibernation period copes functionally with acute decreases in temperature was investigated...
  53. ncbi request reprint Urocortin II enhances contractility in rabbit ventricular myocytes via CRF(2) receptor-mediated stimulation of protein kinase A
    Li Zhen Yang
    Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    Cardiovasc Res 69:402-11. 2006
    ..Direct effects of UcnII on adult cardiomyocytes have not been evaluated before. Our aim was to characterize functional effects of UcnII on cardiomyocytes and to elucidate the underlying signaling pathway(s) and cellular mechanisms...
  54. ncbi request reprint Endothelin-1 enhances nuclear Ca2+ transients in atrial myocytes through Ins(1,4,5)P3-dependent Ca2+ release from perinuclear Ca2+ stores
    Jens Kockskamper
    Department of Cardiology and Pneumology, University Medicine Gottingen, Germany
    J Cell Sci 121:186-95. 2008
    ..This effect is mediated by the coupling of endothelin receptor A to PLC-Ins(1,4,5)P3 signalling and might contribute to excitation-transcription coupling...
  55. pmc The slow force response to stretch in atrial and ventricular myocardium from human heart: functional relevance and subcellular mechanisms
    Jens Kockskamper
    Department of Cardiology, Medical University of Graz, Auenbruggerplatz 15, Graz, Austria
    Prog Biophys Mol Biol 97:250-67. 2008
    ..Increased myofilament Ca2+ sensitivity through MLCK-induced phosphorylation of MLC2 is a novel mechanism contributing to the SFR in both atrium and ventricle...
  56. ncbi request reprint Expression of ten RGS proteins in human myocardium: functional characterization of an upregulation of RGS4 in heart failure
    Clemens Mittmann
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Abteilung für Pharmakologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Cardiovasc Res 55:778-86. 2002
    ..We investigated the expression of RGS proteins in the human heart and whether they take part in the pathophysiological changes of heart failure...
  57. ncbi request reprint Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A
    Christoph Boehmer
    Department of Physiology I, University of Tubingen, Gmelinstrasse 5, D 72076, Tubingen, Germany
    Cardiovasc Res 57:1079-84. 2003
    ....
  58. ncbi request reprint How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology
    Walter J Paulus
    Laboratory of Physiology, VU University Medical Center, Van der Boechorststraat, 7, 1081 BT, Amsterdam, The Netherlands
    Eur Heart J 28:2539-50. 2007
    ..The updated strategies for the diagnosis and exclusion of HFNEF are useful not only for individual patient management but also for patient recruitment in future clinical trials exploring therapies for HFNEF...
  59. ncbi request reprint Selective upregulation of beta1-adrenergic receptors and dephosphorylation of troponin I in end-stage heart failure patients supported by ventricular assist devices
    Hendrik Milting
    Ruhr Universität Bochum Herz and Diabeteszentrum NRW, Erich and Hanna Klessmann Institut für Kardiovaskuläre Forschung and Entwicklung 32545 Bad Oeynhausen, Germany
    J Mol Cell Cardiol 41:441-50. 2006
    ..25 percentile of donor hearts. VAD-support is associated with partial normalization of the betaAR-signal transduction pathways. This beneficial effect is related to a posttranscriptional increase in beta1AR-density...
  60. pmc Interferon-gamma induces chronic active myocarditis and cardiomyopathy in transgenic mice
    Kurt Reifenberg
    Central Laboratory Animal Facility, Johannes Gutenberg University, Mainz, Germany
    Am J Pathol 171:463-72. 2007
    ..Myotoxic IFN-gamma effects could not be detected in smooth or striated muscle tissue, suggesting cardiomyocellular specificity of the toxic IFN-gamma effect. The precise mechanism of IFN-gamma cardiotoxicity remains to be elucidated...
  61. ncbi request reprint Prevalence and natural history of heart failure in outpatient HIV-infected subjects: rationale and design of the HIV-HEART study
    Till Neumann
    Department of Cardiology, University of Duisburg Essen, Medical School, Hufelandstr 55, 45122 Essen, Germany
    Eur J Med Res 12:243-8. 2007
    ..The present study evaluates the frequency and clinical course of myocardial dysfunction and heart failure in a HIV-infected population...
  62. ncbi request reprint Arginase: a modulator of myocardial function
    Heiner Post
    Am J Physiol Heart Circ Physiol 290:H1747-8. 2006
  63. doi request reprint Randomized, double blind study of non-excitatory, cardiac contractility modulation electrical impulses for symptomatic heart failure
    Martin M Borggrefe
    I Medizinische Klinik, Klinikum Mannheim GmbH, Universitatsklinikum, Medizinische Fakultät Mannheim der Universität Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Eur Heart J 29:1019-28. 2008
    ..We performed a randomized, double blind, crossover study of cardiac contractility modulation (CCM) signals in heart failure patients...
  64. ncbi request reprint Levosimendan in regional myocardial ischemia
    Burkert Pieske
    Cardiovasc Drugs Ther 16:379-81. 2002
  65. pmc Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes
    Jens Kockskamper
    Division of Cardiology, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    J Mol Cell Cardiol 45:128-47. 2008
    ....
  66. doi request reprint Impact of diabetes and hypertension on the heart
    Burkert Pieske
    Department of Cardiology, Medical University of Graz, Graz, Austria
    Curr Opin Cardiol 23:340-9. 2008
    ....