Michael Schrader

Summary

Affiliation: Philipps University
Country: Germany

Publications

  1. ncbi request reprint Growth and division of peroxisomes
    Michael Schrader
    Department of Cell Biology and Cell Pathology, University of Marburg, 35037 Marburg, Germany
    Int Rev Cytol 255:237-90. 2006
  2. doi request reprint 6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells
    Maria Gomez-Lazaro
    Grupo de Neurofarmacologia, Department Ciencias Médicas, Facultad de Medicina, Universidad de Castilla La Mancha Centro Regional de Investigaciones Biomédicas, Albacete, Spain
    Free Radic Biol Med 44:1960-9. 2008
  3. ncbi request reprint Peroxisomes and oxidative stress
    Michael Schrader
    Department of Cell Biology and Cell Pathology, University of Marburg, Robert Koch Str 6, 35037 Marburg, Germany
    Biochim Biophys Acta 1763:1755-66. 2006
  4. ncbi request reprint Shared components of mitochondrial and peroxisomal division
    Michael Schrader
    Department of Cell Biology and Cell Pathology, University of Marburg, Robert Koch Str 6, 35037 Marburg, Germany
    Biochim Biophys Acta 1763:531-41. 2006
  5. ncbi request reprint Peroxisomal motility and interaction with microtubules
    Michael Schrader
    Department of Cell Biology and Cell Pathology, Philipps University, 35037 Marburg, Germany
    Microsc Res Tech 61:171-8. 2003
  6. ncbi request reprint Real time imaging reveals a peroxisomal reticulum in living cells
    M Schrader
    Department of Biology, The Johns Hopkins University, Baltimore, MD, USA
    J Cell Sci 113:3663-71. 2000
  7. ncbi request reprint Tubulo-reticular clusters of peroxisomes in living COS-7 cells: dynamic behavior and association with lipid droplets
    M Schrader
    Department of Cell Biology and Cell Pathology, Philipps University, Marburg, Germany
    J Histochem Cytochem 49:1421-29. 2001
  8. ncbi request reprint Peroxisome elongation and constriction but not fission can occur independently of dynamin-like protein 1
    Annett Koch
    Department of Cell Biology and Cell Pathology, Robert Koch Strasse 6, University of Marburg, Marburg, 35037, Germany
    J Cell Sci 117:3995-4006. 2004
  9. pmc A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells
    Annett Koch
    Department of Cell Biology and Cell Pathology, University of Marburg, 35037 Marburg, Germany
    Mol Biol Cell 16:5077-86. 2005
  10. ncbi request reprint Elongation of peroxisomes as an indicator for efficient dynamin-like protein 1 knock down in mammalian cells
    Antje Boll
    Department of Cell Biology and Cell Pathology, University of Marburg, Marburg, Germany
    J Histochem Cytochem 53:1037-40. 2005

Collaborators

  • Yisang Yoon
  • Francisco Amado
  • Rui Vitorino
  • Werner J Kovacs
  • Stephen Gould
  • Annett Koch
  • Maria Gomez-Lazaro
  • Heike Borta
  • Floriane Faust
  • Nina A Bonekamp
  • Markus Grabenbauer
  • Jan Philipp Bach
  • Antje Boll
  • Mark A McNiven
  • Miguel Aroso
  • Cornelia Rinn
  • Dagmar Zeuschner
  • Joaquin Jordan
  • Maria F Galindo
  • Brigitte Agricola
  • Oliver Borchers
  • Waltraud Ackermann
  • Georg H Lüers
  • Gabriele Schneider
  • Meinolf Thiemann

Detail Information

Publications20

  1. ncbi request reprint Growth and division of peroxisomes
    Michael Schrader
    Department of Cell Biology and Cell Pathology, University of Marburg, 35037 Marburg, Germany
    Int Rev Cytol 255:237-90. 2006
    ..Special emphasis is on the function of dynamin-related proteins (DRPs), on Fis1, a putative adaptor for DRPs, on the role of the Pex11 family of peroxisomal membrane proteins, and the cytoskeleton...
  2. doi request reprint 6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells
    Maria Gomez-Lazaro
    Grupo de Neurofarmacologia, Department Ciencias Médicas, Facultad de Medicina, Universidad de Castilla La Mancha Centro Regional de Investigaciones Biomédicas, Albacete, Spain
    Free Radic Biol Med 44:1960-9. 2008
    ..Our data demonstrate for the first time an involvement of mitochondrial fragmentation and Drp1 function in 6-OHDA-induced apoptosis...
  3. ncbi request reprint Peroxisomes and oxidative stress
    Michael Schrader
    Department of Cell Biology and Cell Pathology, University of Marburg, Robert Koch Str 6, 35037 Marburg, Germany
    Biochim Biophys Acta 1763:1755-66. 2006
    ..In this respect the role of PPARalpha, which is highly activated in those mice, in prevention of oxidative stress deserves further investigation...
  4. ncbi request reprint Shared components of mitochondrial and peroxisomal division
    Michael Schrader
    Department of Cell Biology and Cell Pathology, University of Marburg, Robert Koch Str 6, 35037 Marburg, Germany
    Biochim Biophys Acta 1763:531-41. 2006
    ..This review addresses the current state of knowledge concerning the dynamics and fission of peroxisomes, especially in relation to mitochondrial morphology and division in mammalian cells...
  5. ncbi request reprint Peroxisomal motility and interaction with microtubules
    Michael Schrader
    Department of Cell Biology and Cell Pathology, Philipps University, 35037 Marburg, Germany
    Microsc Res Tech 61:171-8. 2003
    ..The characterisation of the underlying molecular components of this machinery is providing insight into the mechanisms regulating peroxisomal morphology and intracellular distribution...
  6. ncbi request reprint Real time imaging reveals a peroxisomal reticulum in living cells
    M Schrader
    Department of Biology, The Johns Hopkins University, Baltimore, MD, USA
    J Cell Sci 113:3663-71. 2000
    ..Our data reveal that peroxisomal behavior in vivo is significantly more dynamic and interactive than previously thought and suggest a role for the dynein/dynactin motor in peroxisome motility...
  7. ncbi request reprint Tubulo-reticular clusters of peroxisomes in living COS-7 cells: dynamic behavior and association with lipid droplets
    M Schrader
    Department of Cell Biology and Cell Pathology, Philipps University, Marburg, Germany
    J Histochem Cytochem 49:1421-29. 2001
    ..These data provide further evidence for the dynamic nature of the peroxisomal compartment and indicate that peroxisomal clusters have a function in lipid metabolism...
  8. ncbi request reprint Peroxisome elongation and constriction but not fission can occur independently of dynamin-like protein 1
    Annett Koch
    Department of Cell Biology and Cell Pathology, Robert Koch Strasse 6, University of Marburg, Marburg, 35037, Germany
    J Cell Sci 117:3995-4006. 2004
    ..They further indicate that peroxisomal elongation, constriction and fission require distinct sets of proteins, and that the dynamin-like protein DLP1 functions primarily in the latter process...
  9. pmc A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells
    Annett Koch
    Department of Cell Biology and Cell Pathology, University of Marburg, 35037 Marburg, Germany
    Mol Biol Cell 16:5077-86. 2005
    ..These findings provide the first evidence for a role of Fis1 in peroxisomal fission and suggest that the fission machinery of mitochondria and peroxisomes shares common components...
  10. ncbi request reprint Elongation of peroxisomes as an indicator for efficient dynamin-like protein 1 knock down in mammalian cells
    Antje Boll
    Department of Cell Biology and Cell Pathology, University of Marburg, Marburg, Germany
    J Histochem Cytochem 53:1037-40. 2005
    ..We present a fast, easy, and convenient protocol for efficient gene silencing in a large number of cells, which can be used for quantitative and biochemical studies...
  11. doi request reprint Analysis of low abundance membrane-associated proteins from rat pancreatic zymogen granules
    Heike Borta
    Department of Cell Biology and Cell Pathology, Philipps University of Marburg, Robert Koch Strasse 6, Marburg, Germany
    J Proteome Res 9:4927-39. 2010
    ..Interestingly, for both proteins, proteoglycan-binding properties have been reported. The importance of our findings for sorting and packaging during ZG formation is discussed...
  12. doi request reprint Rab8 is involved in zymogen granule formation in pancreatic acinar AR42J cells
    Floriane Faust
    Department of Cell Biology and Cell Pathology, University of Marburg, Robert Koch Str 6, 35037 Marburg, Germany
    Traffic 9:964-79. 2008
    ..These data provide first evidence for a role of Rab8 early on in ZG formation at the Golgi complex and thus, apical trafficking of digestive enzymes in acinar cells of the pancreas...
  13. ncbi request reprint Mammalian peroxisomes and reactive oxygen species
    Michael Schrader
    Department of Cell Biology and Cell Pathology, University of Marburg, Robert Koch Strasse 6, 35037, Marburg, Germany
    Histochem Cell Biol 122:383-93. 2004
    ....
  14. ncbi request reprint Assay and functional analysis of dynamin-like protein 1 in peroxisome division
    Michael Schrader
    Department of Cell Biology and Cell Pathology, University of Marburg, Germany
    Methods Enzymol 404:586-97. 2005
    ..Here, we present methods that have been used for studying the role of DLP1 in peroxisome biogenesis and division...
  15. ncbi request reprint Dynamin-like protein 1 is involved in peroxisomal fission
    Annett Koch
    Department of Cell Biology and Cell Pathology, University of Marburg, Robert Koch Str 5, Germany
    J Biol Chem 278:8597-605. 2003
    ..These findings were confirmed by silencing of DLP1 using siRNA. We propose a direct role for the dynamin-like protein DLP1 in peroxisomal fission and in the maintenance of peroxisomal morphology in mammalian cells...
  16. ncbi request reprint The secretory granule protein syncollin localizes to HL-60 cells and neutrophils
    Jan Philipp Bach
    Department of Cell Biology and Cell Pathology, University of Marburg, Robert Koch Str 6, D 35037 Marburg, Germany
    J Histochem Cytochem 54:877-88. 2006
    ..Treatment with a phorbol ester triggered the release of syncollin indicating that in HL-60 cells it is a secretory protein that can be mobilized upon stimulation. A putative role for syncollin in host defense is discussed...
  17. ncbi request reprint Mitochondria and peroxisomes: are the 'big brother' and the 'little sister' closer than assumed?
    Michael Schrader
    Centre for Cell Biology, Department of Biology, University of Aveiro, Aveiro, Portugal
    Bioessays 29:1105-14. 2007
    ..This review addresses the dynamics and division of mitochondria and peroxisomes as well as their functional similarities to provide insight as to why these organelles share the fission machinery in evolutionary aspects...
  18. pmc The peroxisome: still a mysterious organelle
    Michael Schrader
    Centre for Cell Biology and Department of Biology, University of Aveiro, 3810 193 Aveiro, Portugal
    Histochem Cell Biol 129:421-40. 2008
    ..Furthermore, recent advances on the role of peroxisomes in medicine and in the identification of novel peroxisomal proteins are discussed...
  19. ncbi request reprint The hypolipidemic compound cetaben induces changes in Golgi morphology and vesicle movement
    Werner J Kovacs
    Institute of Medical Chemistry, University of Vienna, Waehringerstrasse 10, 1090 Vienna, Austria
    Histochem Cell Biol 122:95-109. 2004
    ..Thus, cetaben-induced changes such as fragmentation of the Golgi apparatus and the dispersion of lysosomes away from their juxtanuclear location were reversible...