- Research needs in allergy: an EAACI position paper, in collaboration with EFANikolaos G Papadopoulos
Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
Clin Transl Allergy 2:21. 2012..Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein...
- EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapyMoises A Calderon
Section of Allergy and Clinical Immunology, Imperial College, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
Clin Transl Allergy 2:20. 2012....
- Efficacy and safety of specific immunotherapy with a high-dose sublingual grass pollen preparation: a double-blind, placebo-controlled trialOliver Pfaar
Rhinology and Allergology Center, Wiesbaden, Germany
Ann Allergy Asthma Immunol 100:256-63. 2008..Sublingual immunotherapy (SLIT) is increasingly being used for the treatment of allergic rhinitis, but there are conflicting study results demonstrating clinically relevant efficacy...
- [Specific immunotherapy for allergic rhinitis. Current methods and innovative developments]O Pfaar
Zentrum für Rhinologie und Allergologie der HNO Universitätsklinik Mannheim, An den Quellen 10, 65183 Wiesbaden
HNO 56:764-75. 2008....
- Pathophysiology of itching and sneezing in allergic rhinitisOliver Pfaar
Center for Allergy and Rhinology, Wiesbaden, Germany
Swiss Med Wkly 139:35-40. 2009..Further, the role of neuropeptides and neurotrophins with regard to neuronal and immune cell activation which might play a key role in the future treatment of allergic rhinitis are discussed...
- Safety of two cluster schedules for subcutaneous immunotherapy in allergic rhinitis or asthma patients sensitized to inhalant allergensO Pfaar
Center for Rhinology and Allergology Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, An den Quellen 10, Wiesbaden DE 65189, Germany
Int Arch Allergy Immunol 150:102-8. 2009..Subcutaneous immunotherapy (SCIT) usually requires a long titration phase, which can be associated with various adverse events (AEs)...
- Clinical outcome measures of specific immunotherapyOliver Pfaar
Center for Rhinology and Allergology, Wiesbaden, Germany
Curr Opin Allergy Clin Immunol 9:208-13. 2009..In particular, it focuses on primary and secondary outcome measurements and reviews the advantages and disadvantages of each method...
- [Cluster immunotherapy of persistent allergic rhinoconjunctivitis. Safety aspects of induction therapy with mite depot allergen preparations]O Pfaar
HNO Universitätsklinik, Mannheim
HNO 57:1099-105. 2009..In cluster SIT, 2-3 injections per treatment day are applied resulting in an accelerated achievement of the maintenance dose...
- Safety of a depigmented, polymerized vaccine for the treatment of allergic rhinoconjunctivitis and allergic asthmaOliver Pfaar
Center for Rhinology and Allergology, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, An den Quellen 10, Wiesbaden, Germany
Am J Rhinol Allergy 24:220-5. 2010..Clinical efficacy of specific immunotherapy (SIT) with depigmented, polymerized allergen extracts is well documented in placebo-controlled trials, and safety data are encouraging although further data are required...
- [Application of humanized Anti-IgE antibodies (omalizumab). A new principle in the treatment of allergic diseases in ENT medicine]O Pfaar
Zentrum für Rhinologie und Allergologie Wiesbaden der HNO Universitätsklinik Mannheim, An den Quellen 10, 65183 Wiesbaden
HNO 55:981-90; quiz 991-2. 2007..Further areas of applications in ENT medicine could be anticipated in other IgE-related illnesses, such as allergic rhinitis, food allergies, laryngitis and chronic allergy-related rhinosinusitis...
- Treatment of hypertrophic palatine tonsils using bipolar radiofrequency-induced thermotherapy (RFITT.)O Pfaar
Department of Otorhinolaryngology Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
Acta Otolaryngol 127:1176-81. 2007..Radiofrequency volume reduction of palatine tonsils is a gentle and safe treatment method in selected patients, which should carefully be considered as an alternative to tonsillectomy or tonsillotomy...
- [The value and possibilities of immunotherapy in the treatment of allergic rhinitis]O Pfaar
Zentrum für Allergologie und Rhinologie Wiesbaden
MMW Fortschr Med 148:28-32. 2006..For sublingual therapy, too, questions about the impact on asthma development, new sensitizations and long-term outcomes have not yet been fully clarified...
- Aspirin desensitization in aspirin intolerance: update on current standards and recent improvementsOliver Pfaar
Center for Allergy and Rhinology, Wiesbaden, Germany
Curr Opin Allergy Clin Immunol 6:161-6. 2006..In particular, it focuses on current standards and recent improvements in aspirin desensitization. Recent publications on various desensitization protocols and routes of administration are discussed...
- [Olfactory testing: diagnostic methods for investigating the sense of smell]O Pfaar
Zentrum für Rhinologie und Allergologie, Wiesbaden
MMW Fortschr Med 148:34-6. 2006..For testing smell in the demented, comatose or simulating patient, the measurement of chemosensory evoked potentials (CSEP) is an established method...
- [Cluster immunotherapy in allergic rhinoconjunctivitis: review of a new therapeutic approach]O Pfaar
Zentrum für Rhinologie und Allergologie, An den Quellen 10, 65183, Wiesbaden, Germany
Hautarzt 57:875-80. 2006..As far as safety goes, cluster immunotherapy is an interesting alternative for the dose-increase period. In addition, recent studies reveal that clinical benefits appear sooner with cluster immunotherapy...
- [Bronchial asthma--what is of importance for the ENT-specialist?]O Pfaar
Zentrum für Rhinologie und Allergologie, Wiesbaden
Laryngorhinootologie 85:834-44; quiz 845-6. 2006..This article gives a detailed overview on these topics and the current guidelines...
- Eicosanoids, aspirin-intolerance and the upper airways--current standards and recent improvements of the desensitization therapyO Pfaar
Center for Rhinology and Allergy, Wiesbaden, Germany
J Physiol Pharmacol 57:5-13. 2006..Recently, the intravenous route for the inititial increment desensitization has been described which might offer new therapeutical possibilities in the treatment of ASA-intolerant patients...
- [Diagnosis and treatment of insect venom allergy. An important allergic issue for the ear, nose and throat specialist]O Pfaar
Zentrum für Rhinologie und Allergologie Wiesbaden
HNO 53:1099-115. 2005..The important dose-increase phase can be performed using conventional, cluster, rush or ultra-rush schedules. Specific immunotherapy is successful in nearly 90% to 100% of patients after 3-5 years of treatment...
- Immunologic effect and tolerability of intra-seasonal subcutaneous immunotherapy with an 8-day up-dosing schedule to 10,000 standardized quality-units: a double-blind, randomized, placebo-controlled trialOliver Pfaar
Center for Rhinology and Allergology, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Wiesbaden, Germany
Clin Ther 34:2072-81. 2012..However, because subjects often present to physicians with allergy symptoms during the pollen season, "within-season" initiation of specific immunotherapy is of special interest...
- Accelerated up-dosing of subcutaneous immunotherapy with a registered allergoid grass pollen preparationOliver Pfaar
Center for Rhinology and Allergology Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Dusseldorf, Germany
Int Arch Allergy Immunol 160:420-4. 2013..In addition, for patients with multiple pollen allergies, patients coming near the beginning of pollen season, and patients who wish to up-dose faster, an accelerated induction regimen would be helpful...
- Safety aspects of Cluster immunotherapy with semi-depot allergen extracts in seasonal allergic rhinoconjunctivitisOliver Pfaar
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany
Eur Arch Otorhinolaryngol 267:245-50. 2010..With respect to safety aspects, this accelerated dosage schedule could turn into an interesting alternative for dosage increase during subcutaneous immunotherapy (SCIT)...
- Aspirin desensitization: useful treatment for chronic rhinosinusitis with nasal polyps (CRSwNP) in aspirin-exacerbated respiratory disease (AERD)?Ludger Klimek
Center for Rhinology and Allergology, An den Quellen 10, 65183, Wiesbaden, Germany
Curr Allergy Asthma Rep 14:441. 2014..For application, the nasal, bronchial, oral and intravenous routes have been described. Aspirin desensitization has been proven to be efficacious and safe and was able to reduce the need for other medications in AERD patients. ..
- Cluster protocols in SCIT: enough evidence for practical use?Oliver Pfaar
Centre for Rhinology and Allergology Wiesbaden of the Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, D 65183 Wiesbaden, Germany
Curr Opin Allergy Clin Immunol 10:188-93. 2010..The review provides a comprehensive evaluation of Cluster schedules in subcutaneous-specific immunotherapy (SCIT) in terms of the safety profile and onset of clinical and immunological effects...
- Sublingual allergen-specific immunotherapy adjuvanted with monophosphoryl lipid A: a phase I/IIa studyOliver Pfaar
Department of Otorhinolaryngology, University Hospital Mannheim, Center for Rhinology and Allergology, Wiesbaden, Germany
Int Arch Allergy Immunol 154:336-44. 2011..This is the first reported study of adjuvanted SLIT...
- Aspirin intolerance: does desensitization alter the course of the disease?L Klimek
Center for Rhinology and Allergy, An den Quellen 10, D 65183 Wiesbaden, Germany
Immunol Allergy Clin North Am 29:669-75. 2009..Apart from surgical or pharmacologic therapy, ASA-desensitization therapy is the treatment of choice. Various desensitization protocols and routes of administration are discussed...
- A comparison of immunotherapy delivery methods for allergen immunotherapyLudger Klimek
Allergy Center, An den Quellen 10, D 65183 Wiesbaden, Germany
Expert Rev Clin Immunol 9:465-74; quiz 475. 2013..Allergic diseases are among the most common diseases in humans. Besides allergen avoidance, allergen-specific immunotherapy is the only causative treatment option. During recent years, many innovations of this therapy have emerged...
- Mechanical obstruction of the olfactory cleft reveals differences between orthonasal and retronasal olfactory functionsOliver Pfaar
Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, D 01307 Dresden, Germany
Chem Senses 31:27-31. 2006..This might become a valuable model of hyposmia for future investigations...
- New opportunities for allergen immunotherapy using synthetic peptide immuno-regulatory epitopes (SPIREs)Ludger Klimek
a Center for Rhinology and Allergology, Wiesbaden, Germany
Expert Rev Clin Immunol 12:1123-35. 2016..Synthetic peptide immuno-regulatory epitopes, a new class of AIT, are allergen peptides with a shorter, more convenient treatment regimen that could potentially have benefits on adherence and outcomes...
- Clinically relevant outcome measures for new pharmacotherapy, allergen avoidance and immunotherapy trials in allergic rhinoconjunctivitisOliver Pfaar
aCenter for Rhinology and Allergology, Wiesbaden bDepartment of Otorhinolaryngology, Head and Neck Surgery, Universitatsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany cSection of Allergology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
Curr Opin Allergy Clin Immunol 15:197-203. 2015....
- Sublingual Immunotherapy with a Five-Grass Pollen Tablet in Adult Patients with Allergic Rhinitis: An Open, Prospective, Noninterventional, Multicenter StudyOliver Pfaar
Center for Rhinology and Allergology, 65183 Wiesbaden, Germany Department of Otorhinolaryngology, Head and Neck Surgery, Universitatsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany
Biomed Res Int 2015:584291. 2015..Although the safety and efficacy of sublingual immunotherapy (SLIT) with a five-grass pollen tablet have been demonstrated in randomized clinical trials (RCTs), these outcomes must always be evaluated in real-life medical practice...
- Safety and effect on reported symptoms of depigmented polymerized allergen immunotherapy: a retrospective study of 2927 paediatric patientsOliver Pfaar
Center for Rhinology and Allergology, Wiesbaden, Germany Department of Otorhinolaryngology, Head and Neck Surgery, Universitatsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Pediatr Allergy Immunol 26:280-6. 2015..To date, there is little information on their safety and clinical effects for children and adolescents with allergic disease...
- Patient-reported outcomes and quality-of-life questionnaires in the assessment of rhinoconjunctivitis in childhoodDésirée Larenas-Linnemann
aHospital Médica Sur, Mexico DF, Mexico bDepartment of Otorhinolaryngology, Head and Neck Surgery, Center for Rhinology and Allergology, University Hospital Mannheim, Wiesbaden, Germany
Curr Opin Allergy Clin Immunol 14:192-9. 2014..Clinical trials using allergen immunotherapy (AIT), the sole causal treatment of allergies, are being conducted, but discussions on optimal patient-related outcomes (PROs) are still ongoing...
- Adjuvants for immunotherapyOliver Pfaar
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany
Curr Opin Allergy Clin Immunol 12:648-57. 2012..This article gives an overview about the current state of preclinical and clinical studies using different kinds of adjuvants and their effect on allergen-specific immunotherapy (SIT)...
- [Specific immunotherapy with depigmented allergoids]L Klimek
Zentrum für Rhinologie und Allergologie, An den Quellen 10, 65183, Wiesbaden, Deutschland
HNO 58:51-6. 2010..Recent data suggest that the modified polymerized allergoids allow a safe rush titration in a few days or even in 1 day (ultra-rush titration)...
- Assessment of olfactory function after septoplasty: a longitudinal studyO Pfaar
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, 01307 Dresden, Germany
Rhinology 42:195-9. 2004..Aim of the study was to evaluate septoplasty-related changes of lateralised olfactory function during both early and late postoperative periods in comparison to the preoperative situation...
- Allergological approach to drug hypersensitivity reactionsBernhard Przybilla
Klinik und Poliklinik fur Dermatologie und Allergologie, Ludwig Maximilians Universität Frauenlobstr 9 1180337 Munich, Germany
J Dtsch Dermatol Ges 6:240-3. 2008