R Paus

Summary

Country: Germany

Publications

  1. pmc New roles for glial cell line-derived neurotrophic factor and neurturin: involvement in hair cycle control
    N V Botchkareva
    Department of Dermatology, Charite, Humboldt University, Berlin, Germany
    Am J Pathol 156:1041-53. 2000
  2. ncbi request reprint Topical calcitriol enhances normal hair regrowth but does not prevent chemotherapy-induced alopecia in mice
    R Paus
    Department of Dermatology, Virchow Hospital, Humboldt Universitat zu Berlin, Germany
    Cancer Res 56:4438-43. 1996
  3. ncbi request reprint Neural mechanisms of hair growth control
    R Paus
    Department of Dermatology, Charite, Humboldt Universitat zu Berlin, Germany
    J Investig Dermatol Symp Proc 2:61-8. 1997
  4. ncbi request reprint Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 act as "epitheliotrophins" in murine skin
    V A Botchkarev
    Department of Dermatology, Charite, Humboldt Universitat zu Berlin, Germany
    Lab Invest 79:557-72. 1999
  5. ncbi request reprint A role for p75 neurotrophin receptor in the control of apoptosis-driven hair follicle regression
    V A Botchkarev
    Department of Dermatology, Charite, Humboldt University, Berlin, Germany
    FASEB J 14:1931-42. 2000
  6. ncbi request reprint Distinct roles for nerve growth factor and brain-derived neurotrophic factor in controlling the rate of hair follicle morphogenesis
    N V Botchkareva
    Department of Dermatology, Charite, Humboldt University, Berlin, Germany
    J Invest Dermatol 114:314-20. 2000
  7. pmc A new role for neurotrophin-3: involvement in the regulation of hair follicle regression (catagen)
    V A Botchkarev
    Department of Dermatology, Charite Hospital, Humboldt University, Berlin, Germany
    Am J Pathol 153:785-99. 1998
  8. ncbi request reprint A role for p75 neurotrophin receptor in the control of hair follicle morphogenesis
    N V Botchkareva
    Department of Dermatology, Charite, Humboldt University Berlin, Berlin, Germany
    Dev Biol 216:135-53. 1999
  9. pmc Abundant production of brain-derived neurotrophic factor by adult visceral epithelia. Implications for paracrine and target-derived Neurotrophic functions
    M Lommatzsch
    Department of Laboratory Medicine, Charite, Humboldt University, Berlin, Germany
    Am J Pathol 155:1183-93. 1999
  10. ncbi request reprint A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis
    R Paus
    Department of Dermatology, Charite, Humboldt University, Berlin, Germany
    J Invest Dermatol 113:523-32. 1999

Collaborators

Detail Information

Publications46

  1. pmc New roles for glial cell line-derived neurotrophic factor and neurturin: involvement in hair cycle control
    N V Botchkareva
    Department of Dermatology, Charite, Humboldt University, Berlin, Germany
    Am J Pathol 156:1041-53. 2000
    ....
  2. ncbi request reprint Topical calcitriol enhances normal hair regrowth but does not prevent chemotherapy-induced alopecia in mice
    R Paus
    Department of Dermatology, Virchow Hospital, Humboldt Universitat zu Berlin, Germany
    Cancer Res 56:4438-43. 1996
    ..Thus, it may be unrealistic to expect that topical calcitriol can prevent human CIA, but topical calcitriols may well enhance the regrowth of a normal hair coat...
  3. ncbi request reprint Neural mechanisms of hair growth control
    R Paus
    Department of Dermatology, Charite, Humboldt Universitat zu Berlin, Germany
    J Investig Dermatol Symp Proc 2:61-8. 1997
    ..We delineate a hypothetical working model of piloneural interactions and propose that targeted manipulations deserve systematic exploration as a novel strategy for managing hair growth disorders...
  4. ncbi request reprint Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 act as "epitheliotrophins" in murine skin
    V A Botchkarev
    Department of Dermatology, Charite, Humboldt Universitat zu Berlin, Germany
    Lab Invest 79:557-72. 1999
    ..Therefore, BDNF, NT-3, and NT-4 can also act as "epitheliotrophins" and may thus be intimately involved in the control of epidermal homeostasis...
  5. ncbi request reprint A role for p75 neurotrophin receptor in the control of apoptosis-driven hair follicle regression
    V A Botchkarev
    Department of Dermatology, Charite, Humboldt University, Berlin, Germany
    FASEB J 14:1931-42. 2000
    ....
  6. ncbi request reprint Distinct roles for nerve growth factor and brain-derived neurotrophic factor in controlling the rate of hair follicle morphogenesis
    N V Botchkareva
    Department of Dermatology, Charite, Humboldt University, Berlin, Germany
    J Invest Dermatol 114:314-20. 2000
    ..These data further strengthen the concept that neurotrophin signaling is an important element in controlling the rate of hair follicle morphogenesis, yet also highlight the complexity of this signaling system...
  7. pmc A new role for neurotrophin-3: involvement in the regulation of hair follicle regression (catagen)
    V A Botchkarev
    Department of Dermatology, Charite Hospital, Humboldt University, Berlin, Germany
    Am J Pathol 153:785-99. 1998
    ..Therefore, tyrosine kinase C agonists and antagonists deserve systematic exploration for the management of hair growth disorders that are related to premature (alopecia/effluvium) or retarded catagen (hirsutism/hypertrichosis)...
  8. ncbi request reprint A role for p75 neurotrophin receptor in the control of hair follicle morphogenesis
    N V Botchkareva
    Department of Dermatology, Charite, Humboldt University Berlin, Berlin, Germany
    Dev Biol 216:135-53. 1999
    ....
  9. pmc Abundant production of brain-derived neurotrophic factor by adult visceral epithelia. Implications for paracrine and target-derived Neurotrophic functions
    M Lommatzsch
    Department of Laboratory Medicine, Charite, Humboldt University, Berlin, Germany
    Am J Pathol 155:1183-93. 1999
    ..The abundance of BDNF protein in certain internal organs suggests that this neurotrophin may regulate the function of adult visceral sensory and motor neurons...
  10. ncbi request reprint A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis
    R Paus
    Department of Dermatology, Charite, Humboldt University, Berlin, Germany
    J Invest Dermatol 113:523-32. 1999
    ....
  11. ncbi request reprint BDNF overexpression induces differential increases among subsets of sympathetic innervation in murine back skin
    V A Botchkarev
    Department of Dermatology, Charite, Humboldt University Berlin, Germany
    Eur J Neurosci 10:3276-83. 1998
    ....
  12. ncbi request reprint Involvement of hepatocyte growth factor/scatter factor and met receptor signaling in hair follicle morphogenesis and cycling
    G Lindner
    Department of Dermatology, Charite, Humboldt University, Berlin, Germany
    FASEB J 14:319-32. 2000
    ..Lindner, G., Menrad, A., Gherardi, E., Merlino, G., Welker, P., Handjiski, B., Roloff, B., Paus, R. Involvement of hepatocyte growth factor/scatter factor and Met receptor signaling in hair follicle morphogenesis and cycling...
  13. ncbi request reprint Indications for a 'brain-hair follicle axis (BHA)': inhibition of keratinocyte proliferation and up-regulation of keratinocyte apoptosis in telogen hair follicles by stress and substance P
    P C Arck
    Department of Internal Medicine, Charite, Humboldt University, Berlin, Germany
    FASEB J 15:2536-8. 2001
    ..We conclude that stress can indeed inhibit hair growth in vivo, probably via a substance P-dependent activation of macrophages and/or mast cells in the context of a brain-hair follicle axis...
  14. ncbi request reprint Noggin is a mesenchymally derived stimulator of hair-follicle induction
    V A Botchkarev
    Department of Dermatology, Charite, Humboldt University Berlin, Germany
    Nat Cell Biol 1:158-64. 1999
    ....
  15. ncbi request reprint Distinct patterns of NCAM expression are associated with defined stages of murine hair follicle morphogenesis and regression
    S Müller-Röver
    Department of Dermatology, Charite, Humboldt Universitat zu Berlin, Berlin, Germany
    J Histochem Cytochem 46:1401-10. 1998
    ..These highly restricted and developmentally controlled expression patterns suggest an important role for NCAM in hair follicle topobiology during morphogenesis and cyclic remodeling of this miniorgan...
  16. ncbi request reprint Hair-cycle-associated remodeling of the peptidergic innervation of murine skin, and hair growth modulation by neuropeptides
    E M Peters
    Department of Dermatology, University Hospital Eppendorf, University of Hamburg, Martinstr. 52, D-20246 Hamburg, Germany
    J Invest Dermatol 116:236-45. 2001
    ....
  17. pmc The role of the hairless (hr) gene in the regulation of hair follicle catagen transformation
    A A Panteleyev
    Department of Dermatology, Charite, Humboldt University, Berlin, Germany University Hospital Eppendorf, University of Hamburg, Hamburg, Germany
    Am J Pathol 155:159-71. 1999
    ..This provides new insights into the pathobiology of the hr mutation, and suggests that the normal hr gene product is a crucial element of catagen control...
  18. ncbi request reprint E- and P-cadherin expression during murine hair follicle morphogenesis and cycling
    S Müller-Röver
    Dept of Dermatology, Charite, Humboldt Universitat zu Berlin, Germany
    Exp Dermatol 8:237-46. 1999
    ....
  19. ncbi request reprint Patterns of proliferation and apoptosis during murine hair follicle morphogenesis
    M Magerl
    Department of Dermatology, , Humboldt-University, Berlin, Germany
    J Invest Dermatol 116:947-55. 2001
    ....
  20. ncbi request reprint The skin POMC system (SPS). Leads and lessons from the hair follicle
    R Paus
    Department of Dermatology, Charite, Humboldt University, Berlin, Germany
    Ann N Y Acad Sci 885:350-63. 1999
    ..This may be an integral component of cutaneous stress response-systems, and may most instructively be studied using the murine hair cycle as a model...
  21. ncbi request reprint Towards optimization of an organotypic assay system that imitates human hair follicle-like epithelial-mesenchymal interactions
    B Havlickova
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, D 20246 Hamburg, Germany
    Br J Dermatol 151:753-65. 2004
    ..However, simplified organotypic systems are needed for dissecting the underlying epithelial-mesenchymal interactions and as screening tools for candidate hair growth-modulatory agents...
  22. ncbi request reprint Functional role of beta 1 integrin-mediated signalling in the human hair follicle
    J E Kloepper
    Department of Dermatology, Allergology and Venerology, University Hospital of Schleswig Holstein, University of Lubeck, Lubeck, Germany
    Exp Cell Res 314:498-508. 2008
    ..The physiologically relevant organ culture assay employed here is a potential research tool for exploring whether targeted stimulation of beta1 integrin-mediated signalling is a suitable candidate for human hair loss management...
  23. doi request reprint Is thyrotropin-releasing hormone a novel neuroendocrine modulator of keratin expression in human skin?
    Y Ramot
    Department of Dermatology, University of Lubeck, D 23538 Lubeck, Germany
    Br J Dermatol 169:146-51. 2013
    ..Preliminary evidence had suggested that thyrotropin-releasing hormone (TRH) may regulate keratin gene transcription...
  24. ncbi request reprint The nude mouse skin phenotype: the role of Foxn1 in hair follicle development and cycling
    L Mecklenburg
    Department of Dermatology, University Hospital Eppendorf, Hamburg, Germany
    Exp Mol Pathol 71:171-8. 2001
    ..More recently, the most obvious clinical feature of this mutant mouse, lack of hair, has been capitalized on to define the role of Foxn1 in normal and pathological skin and hair follicle physiology...
  25. doi request reprint Human hair follicle epithelium has an antimicrobial defence system that includes the inducible antimicrobial peptide psoriasin (S100A7) and RNase 7
    K Reithmayer
    Department of Dermatology, Venereology and Allergology, University Hospital of Schleswig Holstein, Campus Lubeck, Lübeck D 23538, Germany
    Br J Dermatol 161:78-89. 2009
    ..However, they rarely show clinical signs of infection. This suggests the presence of local, efficient, antimicrobial defence systems, which may include antimicrobial peptides (AMPs)...
  26. doi request reprint Endocrine controls of primary adult human stem cell biology: thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro
    S Tiede
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    Eur J Cell Biol 89:769-77. 2010
    ....
  27. ncbi request reprint Cutaneous immunomodulation and coordination of skin stress responses by alpha-melanocyte-stimulating hormone
    T A Luger
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Germany
    Ann N Y Acad Sci 840:381-94. 1998
    ..These findings indicate that, in addition to the cytokine network, neurohormones within the cutaneous microenvironment are a crucial element for the induction, elicitation, and regulation of cutaneous immune and inflammatory responses...
  28. ncbi request reprint Immunology of the hair follicle: a short journey into terra incognita
    R Paus
    Department of Dermatology, Charite, Humboldt University Berlin, Germany
    J Investig Dermatol Symp Proc 4:226-34. 1999
    ..The paper closes by sketching immunobiologic, clinical, and pharmacologic perspectives in trichoimmunology that deserve the attention of immunologists, dermatologists, and hair biologists alike...
  29. ncbi request reprint Intact hair follicle innervation is not essential for anagen induction and development
    M Maurer
    Department of Dermatology, Charite, Humboldt Universitat zu Berlin, Germany
    Arch Dermatol Res 290:574-8. 1998
    ..Thus, even though cutaneous nerves may exert a minor modulatory role in depilation-induced hair growth, they are not essential for normal murine anagen development...
  30. ncbi request reprint A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages
    S Müller-Röver
    Department of Dermatology, University Hospital Eppendorf, University of Hamburg, Hamburg, Germany
    J Invest Dermatol 117:3-15. 2001
    ....
  31. doi request reprint Immunohistological pointers to a possible role for excessive cathelicidin (LL-37) expression by apocrine sweat glands in the pathogenesis of hidradenitis suppurativa/acne inversa
    V U Emelianov
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    Br J Dermatol 166:1023-34. 2012
    ..The cause of follicular occlusion, a key early event in the pathogenesis of hidradenitis suppurativa (HS), also known as acne inversa, remains unknown...
  32. ncbi request reprint Hair cycle-dependent plasticity of skin and hair follicle innervation in normal murine skin
    V A Botchkarev
    Department of Dermatology, Charite, Humboldt Universitat zu Berlin, Germany
    J Comp Neurol 386:379-95. 1997
    ....
  33. doi request reprint The alpha-melanocyte stimulating hormone-related tripeptide K(D)PT stimulates human hair follicle pigmentation in situ under proinflammatory conditions
    K C Meyer
    Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Br J Dermatol 160:433-7. 2009
    ....
  34. doi request reprint Evidence that the bulge region is a site of relative immune privilege in human hair follicles
    K C Meyer
    Department of Dermatology, Allergology and Venereology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Br J Dermatol 159:1077-85. 2008
    ..Recent gene profiling data suggest that, besides the anagen hair bulb, the epithelial stem cell region in the outer root sheath of hair follicles (HFs), termed the bulge, may also represent an area of relative immune privilege (IP)...
  35. ncbi request reprint Neurotrophin-3 involvement in the regulation of hair follicle morphogenesis
    V A Botchkarev
    Department of Dermatology, Charite, Humboldt University, Berlin, Germany
    J Invest Dermatol 111:279-85. 1998
    ..These observations suggest that NT-3 is an important growth modulator during morphogenesis and remodeling of neuroectodermal-mesenchymal interaction systems like the hair follicle...
  36. ncbi request reprint Chronobiology of the hair follicle: hunting the " hair cycle clock"
    R Paus
    Department of Dermatology, University Hospital Eppendorf, University of Hamburg, Germany
    J Investig Dermatol Symp Proc 4:338-45. 1999
    ..Hopefully, this provocative hypothesis will encourage the proposition of novel, comprehensive HCC theories...
  37. ncbi request reprint Interferon-gamma is a potent inducer of catagen-like changes in cultured human anagen hair follicles
    T Ito
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Br J Dermatol 152:623-31. 2005
    ..Interferon (IFN)-gamma appears to be an important hair cycle modulator in mice. It is unclear whether it has similar hair growth modulatory functions in human hair follicles...
  38. ncbi request reprint Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: annotated tables
    M Nakamura
    Department of Dermatology, University Hospital Eppendorf, University of Hamburg, Martinistrasse 52, D-20246, Hamburg, Germany
    Exp Dermatol 10:369-90. 2001
    ....
  39. ncbi request reprint Towards defining the pathogenesis of the hairless phenotype
    A A Panteleyev
    Department of Dermatology, Charite, Humboldt University, Berlin, Germany
    J Invest Dermatol 110:902-7. 1998
    ..Thus, hairless mice offer a unique model for dissecting the as yet obscure functional properties of the hr gene product in maintaining follicle integrity during normal catagen...
  40. ncbi request reprint Elements of the interleukin-1 signaling system show hair cycle-dependent gene expression in murine skin
    R Hoffmann
    Department of Dermatology, Philipp University, Deutschhausstrasse 9, D 35033, Marburg, Germany
    Eur J Dermatol 8:475-7. 1998
    ..Therefore, our findings are consistent with the concept that IL-1alpha, IL-1beta, IL-1-RI and IL-1-RII are involved in the control of catagen development...
  41. ncbi request reprint Expression of galectin-1 and -3 and of accessible binding sites during murine hair cycle
    U Wollina
    Department of Dermatology, Friedrich Schiller University of Jena, Germany
    Histol Histopathol 15:85-94. 2000
    ..The present study provides the first evidence for a cycle-related expression of both galectin-1 and -3 and their binding sites during murine hair cycle...
  42. doi request reprint Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor-β2/insulin-like growth factor-1-mediated regulation of the hair cycle in male and female human hair follicle
    T W Fischer
    Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Br J Dermatol 171:1031-43. 2014
    ..Caffeine reportedly counteracts the suppression of hair shaft production by testosterone in organ-cultured male human hair follicles (HFs)...
  43. doi request reprint α-Melanocyte-stimulating hormone: a protective peptide against chemotherapy-induced hair follicle damage?
    M Bohm
    Department of Dermatology, University of Munster, Von Esmarch Street 58, D 48149, Munster, Germany
    Br J Dermatol 170:956-60. 2014
    ..Because α-melanocyte-stimulating hormone (α-MSH) exerts a number of cytoprotective effects and is well tolerated, we hypothesized that it may be a candidate CIA-protective agent...
  44. doi request reprint The 'melanocyte-keratin' mystery revisited: neither normal human epidermal nor hair follicle melanocytes express keratin 16 or keratin 6 in situ
    Y Ramot
    Department of Dermatology, University of Lubeck, Lübeck D 23538, Germany
    Br J Dermatol 161:933-8. 2009
    ..However, several studies have challenged this paradigm by reporting, for example, that melanoma cells can express keratins and that normal human epidermal melanocytes, which derive from the neural crest, express keratin 16 (K16) in situ...
  45. pmc Is alopecia areata an autoimmune-response against melanogenesis-related proteins, exposed by abnormal MHC class I expression in the anagen hair bulb?
    R Paus
    Department of Dermatology, University Hospital Rudolf Virchow Freie Universität Berlin, Germany
    Yale J Biol Med 66:541-54. 1993
    ..The suppression of MHC I--expression and synthesis of MRP in the hair bulb, and the "tolerization" of MRP-DP autoreactive CD8+ T cells may be promising strategies for treating AA...
  46. ncbi request reprint The 'follicular trochanter': an epithelial compartment of the human hair follicle bulge region in need of further characterization
    S Tiede
    Department of Dermatology, University Hospital Schleswig Holstein, University of Lubeck, 23538 Lubeck, Germany
    Br J Dermatol 157:1013-6. 2007
    ..The morphology and immunoreactivity patterns of this structure, the 'follicular trochanter', are described herein...