Stefan Schulz

Summary

Affiliation: Otto-von-Guericke University
Country: Germany

Publications

  1. ncbi request reprint Neuronal types expressing mu- and delta-opioid receptor mRNA in the rat hippocampal formation
    Ralf K Stumm
    Department of Pharmacology and Toxicology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Comp Neurol 469:107-18. 2004
  2. pmc Morphine induces terminal micro-opioid receptor desensitization by sustained phosphorylation of serine-375
    Stefan Schulz
    Institut fur Pharmakologie und Toxikologie, Otto von Guericke Universitat, Magdeburg, Germany
    EMBO J 23:3282-9. 2004
  3. ncbi request reprint Immunocytochemical identification of VPAC1, VPAC2, and PAC1 receptors in normal and neoplastic human tissues with subtype-specific antibodies
    Solveig Schulz
    Department of Obstetrics and Gynecology, Otto von Guericke University, Magdeburg, Germany
    Clin Cancer Res 10:8235-42. 2004
  4. ncbi request reprint Immunohistochemical localization of CCK1 cholecystokinin receptors in normal and neoplastic human tissues
    Stefan Schulz
    Department of Pharmacology and Toxicology, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Clin Endocrinol Metab 90:6149-55. 2005
  5. ncbi request reprint Immunolocalization of full-length NK1 tachykinin receptors in human tumors
    Stefan Schulz
    Department of Pharmacology and Toxicology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Histochem Cytochem 54:1015-20. 2006
  6. ncbi request reprint Immunofluorescent identification of neuropeptide B-containing nerve fibers and terminals in the rat hypothalamus
    Stefan Schulz
    Department of Pharmacology and Toxicology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Neurosci Lett 411:67-71. 2007
  7. ncbi request reprint Somatostatin receptor 2 is activated in cortical neurons and contributes to neurodegeneration after focal ischemia
    Ralf K Stumm
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Neurosci 24:11404-15. 2004
  8. doi request reprint Pasireotide and octreotide stimulate distinct patterns of sst2A somatostatin receptor phosphorylation
    Florian Pöll
    Department of Pharmacology and Toxicology, Friedrich Schiller University, Drackendorfer Strasse 1, D 07747 Jena, Germany
    Mol Endocrinol 24:436-46. 2010
  9. ncbi request reprint Heterodimerization of substance P and mu-opioid receptors regulates receptor trafficking and resensitization
    Manuela Pfeiffer
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    J Biol Chem 278:51630-7. 2003
  10. ncbi request reprint Membrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recycling
    Dai Fei Wu
    Department of Pharmacology and Toxicology, Otto von Guericke University, Magdeburg, Germany
    J Biol Chem 282:22239-47. 2007

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Neuronal types expressing mu- and delta-opioid receptor mRNA in the rat hippocampal formation
    Ralf K Stumm
    Department of Pharmacology and Toxicology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Comp Neurol 469:107-18. 2004
    ....
  2. pmc Morphine induces terminal micro-opioid receptor desensitization by sustained phosphorylation of serine-375
    Stefan Schulz
    Institut fur Pharmakologie und Toxikologie, Otto von Guericke Universitat, Magdeburg, Germany
    EMBO J 23:3282-9. 2004
    ..Thus, morphine promotes terminal MOR desensitization by inducing a persistent modification of Ser(375)...
  3. ncbi request reprint Immunocytochemical identification of VPAC1, VPAC2, and PAC1 receptors in normal and neoplastic human tissues with subtype-specific antibodies
    Solveig Schulz
    Department of Obstetrics and Gynecology, Otto von Guericke University, Magdeburg, Germany
    Clin Cancer Res 10:8235-42. 2004
    ..VIP/PACAP receptor visualization with this simple and rapid immunohistochemical method will facilitate identification of tumors with a sufficient receptor overexpression for diagnostic or therapeutic intervention...
  4. ncbi request reprint Immunohistochemical localization of CCK1 cholecystokinin receptors in normal and neoplastic human tissues
    Stefan Schulz
    Department of Pharmacology and Toxicology, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Clin Endocrinol Metab 90:6149-55. 2005
    ..Although it is well established that CCK receptors are widely distributed throughout the normal gastrointestinal tract, little is known about their cellular and subcellular localization in human normal and neoplastic tissues...
  5. ncbi request reprint Immunolocalization of full-length NK1 tachykinin receptors in human tumors
    Stefan Schulz
    Department of Pharmacology and Toxicology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Histochem Cytochem 54:1015-20. 2006
    ..NK1 receptor visualization with this simple and rapid immunohistochemical method will facilitate identification of tumors with a sufficient receptor overexpression for diagnostic or therapeutic intervention using SP analogs...
  6. ncbi request reprint Immunofluorescent identification of neuropeptide B-containing nerve fibers and terminals in the rat hypothalamus
    Stefan Schulz
    Department of Pharmacology and Toxicology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Neurosci Lett 411:67-71. 2007
    ..Together, NPB and its receptor GPR7 exist in close proximity in the rat hypothalamus and are, hence, ideally positioned to modulate neuroendocrine functions...
  7. ncbi request reprint Somatostatin receptor 2 is activated in cortical neurons and contributes to neurodegeneration after focal ischemia
    Ralf K Stumm
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Neurosci 24:11404-15. 2004
    ..In summary, we provide direct evidence for activation of SSTR2 by an endogenous ligand after focal ischemia. Activation of functional SSTR2 receptors contributes to increased SSTR2 gene expression and postischemic neurodegeneration...
  8. doi request reprint Pasireotide and octreotide stimulate distinct patterns of sst2A somatostatin receptor phosphorylation
    Florian Pöll
    Department of Pharmacology and Toxicology, Friedrich Schiller University, Drackendorfer Strasse 1, D 07747 Jena, Germany
    Mol Endocrinol 24:436-46. 2010
    ..Yet, we find that they promote strikingly different patterns of sst(2A) receptor phosphorylation and, hence, stimulate functionally distinct pools of beta-arrestin...
  9. ncbi request reprint Heterodimerization of substance P and mu-opioid receptors regulates receptor trafficking and resensitization
    Manuela Pfeiffer
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    J Biol Chem 278:51630-7. 2003
    ..Together, our findings indicate that MOR1 by virtue of its physical interaction with NK1 is sequestered via an endocytotic pathway with delayed recycling and resensitization kinetics...
  10. ncbi request reprint Membrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recycling
    Dai Fei Wu
    Department of Pharmacology and Toxicology, Otto von Guericke University, Magdeburg, Germany
    J Biol Chem 282:22239-47. 2007
    ..Taken together, these data provide evidence that M6a may act as a scaffolding molecule in the regulation of GPCR endocytosis and intracellular trafficking...
  11. doi request reprint Regional and cellular localization of the CXCl12/SDF-1 chemokine receptor CXCR7 in the developing and adult rat brain
    Bastian Schönemeier
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Comp Neurol 510:207-20. 2008
    ..Thus, CXCR4 and CXCR7 may cooperate or act independently in SDF-1-dependent neuronal development. In mature neurons and blood vessels CXCR7 appears to be the preponderant SDF-1-receptor...
  12. doi request reprint Phosphorylation of threonine 333 regulates trafficking of the human sst5 somatostatin receptor
    Aline Petrich
    Department of Pharmacology and Toxicology, Jena University Hospital Friedrich Schiller University Jena, Drackendorfer Strasse 1, D 07749 Jena, Germany
    Mol Endocrinol 27:671-82. 2013
    ..In addition, we identify G protein-coupled receptor kinase 2-mediated phosphorylation and protein phosphatase 1γ-mediated dephosphorylation of T333 as key regulators of rapid internalization and recycling of the human sst5 receptor...
  13. ncbi request reprint Expression of the mu-opioid receptor is induced in dentate gyrus granule cells after focal cerebrocortical ischaemia and stimulation of entorhinal afferents
    Ralf Stumm
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    Eur J Neurosci 22:1032-44. 2005
    ..In activated, MOR-expressing granule cells, inhibitory opioids may counter-regulate glutamatergic excitation by the perforant path...
  14. doi request reprint Structural determinants of agonist-selective signaling at the sst(2A) somatostatin receptor
    Falko Nagel
    Department of Pharmacology and Toxicology, University Hospital Jena, Friedrich Schiller University, Drackendorfer Strasse 1, D 07747 Jena, Germany
    Mol Endocrinol 25:859-66. 2011
    ..Together, these findings suggest that pasireotide activates the sst(2A) receptor via a molecular switch that is structurally and functionally distinct from that turned on during octreotide-driven sst(2A) activation...
  15. doi request reprint Tonic activation of CXC chemokine receptor 4 in immature granule cells supports neurogenesis in the adult dentate gyrus
    Angela Kolodziej
    Institut fur Pharmakologie und Toxikologie, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Neurosci 28:4488-500. 2008
    ..Therefore, our findings suggest that tonic activation of CXCR4 in newly formed granule cells by endogenous SDF-1 is essential for neurogenesis-dependent long-term memory in the adult hippocampus...
  16. ncbi request reprint Receptor endocytosis counteracts the development of opioid tolerance
    Thomas Koch
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Leipziger Strasse 44, Germany
    Mol Pharmacol 67:280-7. 2005
    ..Our findings suggest that opioids with high endocytotic efficacies might cause reduced opioid tolerance but can facilitate compensatory mechanisms, resulting in an enhanced opioid dependence...
  17. ncbi request reprint Phospholipase D2 modulates agonist-induced mu-opioid receptor desensitization and resensitization
    Thomas Koch
    Department of Pharmacology and Toxicology, Otto von Guericke University, Magdeburg, Germany
    J Neurochem 88:680-8. 2004
    ..In summary, our data strongly suggest that PLD2 is a modulator of agonist-induced endocytosis, desensitization and resensitization of the mu-opioid receptor...
  18. ncbi request reprint ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis
    Thomas Koch
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    J Biol Chem 278:9979-85. 2003
    ..Together, these data suggest that PLD2 play a key role in the regulation of agonist-induced endocytosis of the mu-opioid receptor...
  19. ncbi request reprint Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor
    Andrea Beyer
    Department of Pharmacology and Toxicology, Otto von Guericke University, Magdeburg, Germany
    J Neurochem 89:553-60. 2004
    ..After prolonged treatment with morphine, morphine-6-glucuronide or beta-endorphin both receptors showed similiar desensitization time courses. In addition, the receptor resensitization rates were nearly identical for both receptor types...
  20. doi request reprint UMB-3, a novel rabbit monoclonal antibody, for assessing μ-opioid receptor expression in mouse, rat and human formalin-fixed and paraffin-embedded tissues
    Amelie Lupp
    Department of Pharmacology and Toxicology, University Hospital, Friedrich Schiller University, D 07747 Jena, Germany
    Regul Pept 167:9-13. 2011
    ..Moreover, previous immunohistochemical investigations were restricted to frozen sections from perfusion-fixed rodent brain, largely due to the limited availability of MOR antibodies that effectively stain paraffin-embedded tissues...
  21. ncbi request reprint Patterns of SDF-1alpha and SDF-1gamma mRNAs, migration pathways, and phenotypes of CXCR4-expressing neurons in the developing rat telencephalon
    Ralf Stumm
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Comp Neurol 502:382-99. 2007
    ..We propose that regulated expression of SDF-1 in the intermediate/subventricular zone influences lateromedial tangential migration of CXCR4-expressing GABAergic neurons...
  22. doi request reprint Reassessment of sst3 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-5
    Amelie Lupp
    Department of Pharmacology and Toxicology, University Hospital, Friedrich Schiller University Jena, Jena, Germany
    Neuroendocrinology 96:301-10. 2012
    ..Apart from this, very little is known about the clinical relevance of the sst(3) receptor, which may in part be due to the lack of specific monoclonal sst(3) antibodies...
  23. doi request reprint Reassessment of sst(5) somatostatin receptor expression in normal and neoplastic human tissues using the novel rabbit monoclonal antibody UMB-4
    Amelie Lupp
    Department of Pharmacology and Toxicology, University Hospital, Friedrich Schiller University, Jena, Germany
    Neuroendocrinology 94:255-64. 2011
    ..However, so far highly specific rabbit monoclonal antibodies have been developed for the sst(2) receptor only (clone UMB-1)...
  24. doi request reprint Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1
    Thomas Fischer
    Department of Pharmacology and Toxicology, Friedrich Schiller University, Nonnenplan 4, 07743 Jena, Germany
    J Clin Endocrinol Metab 93:4519-24. 2008
    ..However, due to the lack of monoclonal and limited availability of specific polyclonal anti-sst2A antibodies, only very few patients can currently benefit from in vitro sst2 evaluation...
  25. ncbi request reprint Expression and function of somatostatin receptors in peripheral nerve sheath tumors
    Christian Mawrin
    Department of Neuropathology, Otto von Guericke University, Magdeburg, Germany
    J Neuropathol Exp Neurol 64:1080-8. 2005
    ..Furthermore, our findings suggest a potential clinical role for somatostatin receptor agonists in tumor imaging and/or treatment of schwannomas and MPNSTs...
  26. doi request reprint Differential effects of octreotide and pasireotide on somatostatin receptor internalization and trafficking in vitro
    Sarah Lesche
    Department of Pharmacology and Toxicology, Otto von Guericke University, Magdeburg, Germany
    J Clin Endocrinol Metab 94:654-61. 2009
    ..However, the effects of SOM230 on internalization and postendosomal sorting of individual human somatostatin receptor subtypes have not been determined so far...
  27. ncbi request reprint Immunocytochemical localisation of plasma membrane GHRH receptors in human tumours using a novel anti-peptide antibody
    Solveig Schulz
    Department of Obstetrics and Gynecology, Otto von Guericke University, 39120 Magdeburg, Germany
    Eur J Cancer 42:2390-6. 2006
    ..The GHRH receptor visualisation could be of value for a rapid immunohistochemical identification of those tumours which could be a target for diagnostic or therapeutic intervention using GHRH analogues...
  28. doi request reprint Analgesic tolerance to high-efficacy agonists but not to morphine is diminished in phosphorylation-deficient S375A μ-opioid receptor knock-in mice
    Gisela Grecksch
    Institute of Pharmacology and Toxicology, Faculty of Medicine, Otto von Guericke University, D 39120 Magdeburg, Germany
    J Neurosci 31:13890-6. 2011
    ..Whereas tolerance induced by DAMGO or etonitazene requires agonist-driven phosphorylation of S375, the development and maintenance of antinociceptive tolerance to morphine occurs independent of S375 phosphorylation...
  29. ncbi request reprint Differential beta-arrestin trafficking and endosomal sorting of somatostatin receptor subtypes
    Giovanni Tulipano
    Institut fur Pharmakologie und Toxikologie, Otto von Guericke Universitat, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Biol Chem 279:21374-82. 2004
    ..Together, these findings may provide important clues about the regulation of receptor responsiveness during long-term administration of somatostatin analogs...
  30. doi request reprint Enhanced expression of the CXCl12/SDF-1 chemokine receptor CXCR7 after cerebral ischemia in the rat brain
    Bastian Schönemeier
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Neuroimmunol 198:39-45. 2008
    ..These patterns suggest that SDF-1 may influence vascular, astroglial, and neuronal functions via CXCR7 and mediate cell recruitment to ischemic brain areas via CXCR4...
  31. ncbi request reprint CXCR4 regulates interneuron migration in the developing neocortex
    Ralf K Stumm
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    J Neurosci 23:5123-30. 2003
    ..Thus, our findings suggest that SDF-1, which is highly expressed in the embryonic leptomeninx, selectively regulates migration and layer-specific integration of CXCR4-expressing interneurons during neocortical development...
  32. ncbi request reprint Immunohistochemical detection of bombesin receptor subtypes GRP-R and BRS-3 in human tumors using novel antipeptide antibodies
    Solveig Schulz
    Department of Obstetrics and Gynecology, Otto von Guericke University, 39120, Magdeburg, Germany
    Virchows Arch 449:421-7. 2006
    ..The development of these novel antipeptide antibodies will facilitate the identification of those tumors, which may be targets for diagnostic or radiotherapeutic application of subtype-selective BN analogs...
  33. ncbi request reprint Mechanisms of somatostatin-evoked responses in neurons of the rat lateral amygdala
    Susanne Meis
    Institut fur Physiologie, Medizinische Fakultat, Otto von Guericke Universitat, Leipziger Str 44, D 39120 Magdeburg, Germany
    Eur J Neurosci 21:755-62. 2005
    ..It is suggested that these cellular mechanisms contribute to the role of somatostatin in decreasing anxiety behaviour as well as to anticonvulsant and antiepileptogenic actions of somatostatin or somatostatin agonists in the amygdala...
  34. ncbi request reprint Intracellular trafficking of somatostatin receptors
    Stefan Jacobs
    Institut fur Pharmakologie und Toxikologie, Universitat Wurzburg, Wurzburg, Germany
    Mol Cell Endocrinol 286:58-62. 2008
    ..This review will focus on the molecular mechanisms of the differential intracellular trafficking of sst(2), sst(3) and sst(5), and discusses our current knowledge on somatostatin receptor interacting proteins...
  35. ncbi request reprint Immunocytochemical identification of low-affinity NTS2 neurotensin receptors in parietal cells of human gastric mucosa
    Stefan Schulz
    Department of Pharmacology and Toxicology, Otto von Guericke University, Magdeburg, Germany
    J Endocrinol 191:121-8. 2006
    ..v. administration of neurotensin...
  36. ncbi request reprint Somatostatin receptor subtypes in human pheochromocytoma: subcellular expression pattern and functional relevance for octreotide scintigraphy
    Jochen Mundschenk
    Department of Endocrinology and Metabolism, Otto von Guericke University, D 39120 Magdeburg, Germany
    J Clin Endocrinol Metab 88:5150-7. 2003
    ..These tumors may represent a potential target treatment with somatostatin receptor agonists with improved sst(3) activity...
  37. pmc A transplantable phosphorylation probe for direct assessment of G protein-coupled receptor activation
    Andrea Kliewer
    Department of Pharmacology and Toxicology, Jena University Hospital Friedrich Schiller University Jena, Jena, Germany
    PLoS ONE 7:e39458. 2012
    ..Together, we propose the application of a phosphorylation probe for direct assessment of G protein-coupled receptor activation and demonstrate its utility in the pharmacological characterization of novel somatostatin analogs...
  38. ncbi request reprint Heterodimerization of somatostatin and opioid receptors cross-modulates phosphorylation, internalization, and desensitization
    Manuela Pfeiffer
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    J Biol Chem 277:19762-72. 2002
    ..Heterodimerization may thus represent a novel regulatory mechanism that could either restrict or enhance phosphorylation and desensitization of G protein-coupled receptors...
  39. ncbi request reprint Differential expression of sst1, sst2A, and sst3 somatostatin receptor proteins in low-grade and high-grade astrocytomas
    Christian Mawrin
    Department of Neuropathology, Otto von Guericke University, Magdeburg, Germany
    J Neuropathol Exp Neurol 63:13-9. 2004
    ..Furthermore, the presence or absence of the 5 somatostatin receptor subtypes did not significantly influence survival time in 14 GBM patients...
  40. doi request reprint Immunohistochemical identification of the PTHR1 parathyroid hormone receptor in normal and neoplastic human tissues
    Amelie Lupp
    Department of Pharmacology and Toxicology, Friedrich Schiller University, Jena, Germany
    Eur J Endocrinol 162:979-86. 2010
    ..Although it is well known that PTH acts primarily on kidney and bone, the precise cellular and subcellular sites of PTH action have not been visualised in human tissues...
  41. ncbi request reprint A dual role for the SDF-1/CXCR4 chemokine receptor system in adult brain: isoform-selective regulation of SDF-1 expression modulates CXCR4-dependent neuronal plasticity and cerebral leukocyte recruitment after focal ischemia
    Ralf K Stumm
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Neurosci 22:5865-78. 2002
    ..Thus, the isoform-specific regulation of SDF-1 expression modulates neurotransmission and cerebral infiltration via distinct CXCR4-dependent pathways...
  42. doi request reprint Differential regulation of somatostatin receptor dephosphorylation by β-arrestin1 and β-arrestin2
    Andrea Kliewer
    Department of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University Jena, Drackendorfer Strasse 1, 07747, Jena, Germany
    Naunyn Schmiedebergs Arch Pharmacol 387:263-9. 2014
    ..By contrast, β-arrestin2 is not essential for rapid sst2 receptor dephosphorylation. Together, these findings reveal a novel scaffolding function of β-arrestin1 that facilitates efficient targeting of PP1β to phosphorylated GPCRs. ..
  43. ncbi request reprint Expression changes of somatostatin receptor subtypes sst2A, sst2B, sst3 and sst4 after a cortical contusion trauma in rats
    Holger Braun
    Institut fur Pharmakologie und Toxikologie, Otto von Guericke Universitat Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Brain Res 930:191-9. 2002
    ..Taken together, after trauma we found deterioration of sst positive neurons and an additional activation of sst4 and sst2A expressing cells the final fate of which has to be elucidated further...
  44. doi request reprint New pansomatostatin ligands and their chelated versions: affinity profile, agonist activity, internalization, and tumor targeting
    Mihaela Ginj
    Division of Radiological Chemistry, University Hospital Basel, Basel, Switzerland
    Clin Cancer Res 14:2019-27. 2008
    ..Currently used targeting peptides mainly have sst2 affinity. We aimed at developing (radio)peptides that bind with high affinity to all receptor subtypes...
  45. ncbi request reprint Internalization of sst2, sst3, and sst5 receptors: effects of somatostatin agonists and antagonists
    Renzo Cescato
    Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Berne, Berne, Switzerland
    J Nucl Med 47:502-11. 2006
    ....
  46. ncbi request reprint Design, synthesis, and biological evaluation of somatostatin-based radiopeptides
    Mihaela Ginj
    Division of Radiological Chemistry, Department of Radiology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Chem Biol 13:1081-90. 2006
    ..Two of the derivatives thus obtained showed an improved binding affinity profile, enhanced internalization into cells expressing sst2 and sst3, respectively, and better tumor:kidney ratios in animals...
  47. pmc CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells
    Elena Vasyutina
    Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
    Genes Dev 19:2187-98. 2005
    ..Our analysis reveals a role of SDF1/CXCR4 signaling in the development of migrating muscle progenitors and shows that a threshold number of progenitor cells is required to generate muscle of appropriate size...
  48. ncbi request reprint Pain control by CXCR2 ligands through Ca2+-regulated release of opioid peptides from polymorphonuclear cells
    Heike L Rittner
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    FASEB J 20:2627-9. 2006
    ..These findings demonstrate that, beyond cell recruitment, CXCR2 ligands induce Ca2+-regulated opioid release from PMN and thereby inhibit inflammatory pain in vivo...
  49. ncbi request reprint Novel insights in somatostatin receptor physiology
    Giovanni Tulipano
    Division of Experimental Pharmacology and Toxicology, Department of Biomedical Sciences and Biotechnologies, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    Eur J Endocrinol 156:S3-11. 2007
    ..Different somatostatin analogs may induce distinct conformations of the receptor/ligand complex, preferentially coupled to either receptor signaling or receptor endocytosis...
  50. ncbi request reprint Inhibitory role of the somatostatin receptor SST2 on the intracrine-regulated cell proliferation induced by the 210-amino acid fibroblast growth factor-2 isoform: implication of JAK2
    Marylis Hortala
    INSERM U 531, Institut Louis Bugnard, CHU Rangueil, Toulouse, Cedex 4, France
    J Biol Chem 278:20574-81. 2003
    ..In summary, these data provide the following evidence: 1) the intracrine-induced proliferation can be reversed by extracellular acting polypeptides; 2) SST2 inhibitory signaling may involve the JAK2/SHP-1 pathway...
  51. ncbi request reprint Identification of cells expressing somatostatin receptor 2 in the gastrointestinal tract of Sstr2 knockout/lacZ knockin mice
    Jeremy P Allen
    Department of Neurobiology, The Babraham Institute, Babraham, Cambridge, CB2 4AT, United Kingdom
    J Comp Neurol 454:329-40. 2002
    ..Previous studies have shown that NOS neurons are descending interneurons and anally projecting, inhibitory motor neurons. Thus, somatostatin acting at SSTR2 receptors on NOS neurons might modulate descending relaxation...
  52. doi request reprint Indium-111-pentetreotide scintigraphy and somatostatin receptor subtype 2 expression: new prognostic factors for malignant well-differentiated endocrine tumors
    Amani Asnacios
    Department of Medical Oncology, Claudius Regaud Institute, Toulouse Purpan, France
    J Clin Oncol 26:963-70. 2008
    ..The aim of the present study was to evaluate the correlation between (111)In-pentetreotide scintigraphy, sst receptor expression, and prognosis...
  53. doi request reprint Substantial migration of SVZ cells to the cortex results in the generation of new neurons in the excitotoxically damaged immature rat brain
    Maryam Faiz
    Medical Histology, Department of Cell Biology, Physiology and Immunology, Neuroscience Institute, Autonomous University of Barcelona, Spain
    Mol Cell Neurosci 38:170-82. 2008
    ..But, there is little integration of these neurons into the existing circuitry, as seen by Fluorogold retrograde tracing from the internal capsule...
  54. ncbi request reprint Trifunctional somatostatin-based derivatives designed for targeted radiotherapy using auger electron emitters
    Mihaela Ginj
    Division of Radiological Chemistry, Department of Radiology, University Hospital Basel, Basel, Switzerland
    J Nucl Med 46:2097-103. 2005
    ....
  55. ncbi request reprint Novel iso-branched ether lipids as specific markers of developmental sporulation in the myxobacterium Myxococcus xanthus
    Michael W Ring
    Institut für Pharmazeutische Biotechnologie, Universitat des Saarlandes, 66041 Saarbrucken, Germany
    J Biol Chem 281:36691-700. 2006
    ..Finally, addition of TG-1 to mutants blocked in the biosynthesis of isovaleryl-CoA could restore aggregation and sporulation emphasizing the important role of iso-branched lipids for myxobacterial development...
  56. ncbi request reprint Interaction of brain somatostatin receptors with the PDZ domains of PSD-95
    Marcus Christenn
    Institut fur Zellbiochemie und klinische Neurobiologie, Martinistrasse 52, 20246 Hamburg, Germany
    FEBS Lett 581:5173-7. 2007
    ..As functional parameters of the receptor, such as coupling to potassium channels, are not affected by the interaction with PSD-95, the association may serve to localize the receptor to postsynaptic sites...
  57. pmc Autoinducer-2-regulated genes in Streptococcus mutans UA159 and global metabolic effect of the luxS mutation
    Helena Sztajer
    Helmholtz Center for Infection Research, Division of Cell Biology, Inhoffenstr 7, D 38124 Braunschweig, Germany
    J Bacteriol 190:401-15. 2008
    ..The data show that many phenotypes related to the luxS mutation cannot be ascribed to quorum sensing and have identified for the first time regulatory proteins potentially mediating AI-2-based signaling in gram-positive bacteria...
  58. doi request reprint Selective loss of somatostatin receptor 2 in octreotide-resistant growth hormone-secreting adenomas
    Ursula Plockinger
    Interdisziplinäres Stoffwechsel Centrum, Endokrinologie, Diabetes, und Stoffwechsel, Med Klinik m S Hepatologie und Gastroenterologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, D 13353 Berlin, Germany
    J Clin Endocrinol Metab 93:1203-10. 2008
    ..Hence, we investigated the immunocytochemical expression of sst in a large group of somatotroph tumors...
  59. ncbi request reprint Gene Regulation Ontology (GRO): design principles and use cases
    Elena Beisswanger
    Jena University Language and Information Engineering JULIE Lab, Jena, Germany
    Stud Health Technol Inform 136:9-14. 2008
    ..The GRO has just been submitted to the OBO library and is currently under review. It is available at http://www.ebi.ac.uk/Rebholz-srv/GRO/GRO.html...