Jens Martens-Lobenhoffer

Summary

Affiliation: Otto-von-Guericke University
Country: Germany

Publications

  1. doi request reprint Quantification of meropenem in human plasma by HILIC - tandem mass spectrometry
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, Magdeburg, Germany Electronic address
    J Chromatogr B Analyt Technol Biomed Life Sci 1046:13-17. 2017
  2. doi request reprint First detection and quantification of N(δ)-monomethylarginine, a structural isomer of N(G)-monomethylarginine, in humans using MS(3)
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, 39120 Magdeburg, Germany Electronic address
    Anal Biochem 493:14-20. 2016
  3. doi request reprint A validated method for the quantification of fosfomycin in human plasma by liquid chromatography-tandem mass spectrometry
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, Magdeburg, Germany Electronic address
    J Chromatogr B Analyt Technol Biomed Life Sci 990:164-8. 2015
  4. doi request reprint Amino acid N-acetylation: metabolic elimination of symmetric dimethylarginine as symmetric N(α)-acetyldimethylarginine, determined in human plasma and urine by LC-MS/MS
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany Electronic address
    J Chromatogr B Analyt Technol Biomed Life Sci 975:59-64. 2015
  5. doi request reprint Mass spectrometric quantification of L-arginine and its pathway related substances in biofluids: the road to maturity
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, Magdeburg, Germany Electronic address
    J Chromatogr B Analyt Technol Biomed Life Sci 964:89-102. 2014
  6. doi request reprint Determination of asymmetric Nα-acetyldimethylarginine in humans: a phase II metabolite of asymmetric dimethylarginine
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, 39120 Magdeburg, Germany Electronic address
    Anal Biochem 452:25-30. 2014
  7. doi request reprint Probing AGXT2 enzyme activity in mouse tissue by applying stable isotope-labeled asymmetric dimethyl arginine as substrate
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, Leipziger Str 44, 39120, Magdeburg, Germany
    J Mass Spectrom 47:1594-600. 2012
  8. doi request reprint Quantification of L-arginine, asymmetric dimethylarginine and symmetric dimethylarginine in human plasma: a step improvement in precision by stable isotope dilution mass spectrometry
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, Magdeburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 904:140-3. 2012
  9. doi request reprint Detection and quantification of α-keto-δ-(N(G),N(G)-dimethylguanidino)valeric acid: a metabolite of asymmetric dimethylarginine
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, 39120 Magdeburg, Germany
    Anal Biochem 419:234-40. 2011
  10. doi request reprint Improved method for the determination of cyclic guanosine monophosphate (cGMP) in human plasma by LC-MS/MS
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, Magdeburg 39120, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 878:487-91. 2010

Collaborators

Detail Information

Publications42

  1. doi request reprint Quantification of meropenem in human plasma by HILIC - tandem mass spectrometry
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, Magdeburg, Germany Electronic address
    J Chromatogr B Analyt Technol Biomed Life Sci 1046:13-17. 2017
    ..A cross-validation with a validated and established HPLC-UV method confirmed the accuracy of the HILIC-MS/MS method in real patient samples...
  2. doi request reprint First detection and quantification of N(δ)-monomethylarginine, a structural isomer of N(G)-monomethylarginine, in humans using MS(3)
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, 39120 Magdeburg, Germany Electronic address
    Anal Biochem 493:14-20. 2016
    ..In a pilot study enrolling 10 healthy volunteers, mean concentrations of 48.0 ± 7.4 nmol/L for LNMMA and 27.4 ± 7.7 nmol/L for δ-MMA were found...
  3. doi request reprint A validated method for the quantification of fosfomycin in human plasma by liquid chromatography-tandem mass spectrometry
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, Magdeburg, Germany Electronic address
    J Chromatogr B Analyt Technol Biomed Life Sci 990:164-8. 2015
    ..Fosfomycin was stable in human plasma under all storing conditions relevant for clinical samples. First experiences with this method in clinical routine use confirmed the applicability and ruggedness of the analytical procedure. ..
  4. doi request reprint Amino acid N-acetylation: metabolic elimination of symmetric dimethylarginine as symmetric N(α)-acetyldimethylarginine, determined in human plasma and urine by LC-MS/MS
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany Electronic address
    J Chromatogr B Analyt Technol Biomed Life Sci 975:59-64. 2015
    ..Concentration found in human plasma and urine was 3.51 nM and 558 nM, respectively, with marked inter-individual differences...
  5. doi request reprint Mass spectrometric quantification of L-arginine and its pathway related substances in biofluids: the road to maturity
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, Magdeburg, Germany Electronic address
    J Chromatogr B Analyt Technol Biomed Life Sci 964:89-102. 2014
    ..The use of stable isotope labeled internal standards enables high precision and accuracy in mass spectrometry-based quantitative analysis. ..
  6. doi request reprint Determination of asymmetric Nα-acetyldimethylarginine in humans: a phase II metabolite of asymmetric dimethylarginine
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, 39120 Magdeburg, Germany Electronic address
    Anal Biochem 452:25-30. 2014
    ..643±0.454 nmol/L and urine levels of 152.7±76.7 nmol/L or 13.0±8.9 nmol/mmol creatinine. The method is a suitable tool for investigating this currently mostly neglected ADMA elimination pathway...
  7. doi request reprint Probing AGXT2 enzyme activity in mouse tissue by applying stable isotope-labeled asymmetric dimethyl arginine as substrate
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, Leipziger Str 44, 39120, Magdeburg, Germany
    J Mass Spectrom 47:1594-600. 2012
    ..21 pmol/min/mg total protein in kidney tissue, with coefficients of variation of 6.31% and 11.25%, respectively. This method can be applied as a tool for the characterization of the ADMA elimination by the AGXT2 pathway...
  8. doi request reprint Quantification of L-arginine, asymmetric dimethylarginine and symmetric dimethylarginine in human plasma: a step improvement in precision by stable isotope dilution mass spectrometry
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, Magdeburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 904:140-3. 2012
    ..82% for L-arginine, 2.12% for ADMA and 2.83% for SDMA, were achieved at basal plasma concentrations. The respective inter-day precision values were 4.01% for l-arginine, 3.77% for ADMA and 3.86% for SDMA...
  9. doi request reprint Detection and quantification of α-keto-δ-(N(G),N(G)-dimethylguanidino)valeric acid: a metabolite of asymmetric dimethylarginine
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, 39120 Magdeburg, Germany
    Anal Biochem 419:234-40. 2011
    ..1 and 77.5 nmol/L. In urine samples, concentrations between 0.0114 and 1.03 μmol/mmol creatinine were found. This method can be used as a tool for the scientific investigation of the ADMA conversion to DMGV via the enzyme AGXT2...
  10. doi request reprint Improved method for the determination of cyclic guanosine monophosphate (cGMP) in human plasma by LC-MS/MS
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, Magdeburg 39120, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 878:487-91. 2010
    ..The accuracy was always better than 4%. Plasma concentrations in healthy human subjects determined with this method were 3.92+/-1.17 nM (n=20). The method was, due to its isotope labeled I.S., matrix independent...
  11. doi request reprint Determination of micafungin and anidulafungin in human plasma: UV- or mass spectrometric quantification?
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, Magdeburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 879:2051-6. 2011
    ..Therefore, the mass spectrometric chromatograms served only as identity confirmation of the observed UV-peaks...
  12. doi request reprint Identification and quantification of the atypical metabolite ornithine-lactam in human plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS)
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, 39120 Magdeburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2284-9. 2009
    ..In EDTA-plasma samples from 30 volunteers ornithine-lactam concentrations ranging from 0.136 to 0.653 microM were determined. These concentrations correlated significantly (p<0.001, R(2)=0.784) to those of ornithine in EDTA-plasma...
  13. doi request reprint Validated high performance liquid chromatography-UV detection method for the determination of daptomycin in human plasma
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, Leipziger Str 44, Magdeburg 39120, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 875:546-50. 2008
    ..The accuracy was always better than 7%. Daptomycin was stable in aqueous solutions for 2 months frozen at-20 degrees C. However, in plasma frozen at -20 degrees C a loss of 25% in 1 month was observed...
  14. ncbi request reprint Enantioselective quantification of omeprazole and its main metabolites in human serum by chiral HPLC-atmospheric pressure photoionization tandem mass spectrometry
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 857:301-7. 2007
    ..5-375 ng/ml for the 5-hydroxyomeprazole enantiomers, respectively. Intra- and inter-day relative standard deviations are <7% for omeprazole and 5-hydroxyomeprazole enantiomers, and <9% for omeprazole-sulfon, respectively...
  15. ncbi request reprint Asymmetric dimethylarginine (ADMA) accelerates cell senescence
    Stefanie M Bode-Boger
    Institute of Clinical Pharmacology, University Hospital Otto von Guericke University, Magdeburg, Germany
    Vasc Med 10:S65-71. 2005
    ..This study provides evidence that modest changes of intracellular ADMA levels are associated with significant effects on slowing down endothelial senescence...
  16. doi request reprint Effect of telmisartan on nitric oxide--asymmetrical dimethylarginine system: role of angiotensin II type 1 receptor gamma and peroxisome proliferator activated receptor gamma signaling during endothelial aging
    Fortunato Scalera
    Institute of Clinical Pharmacology, University Hospital Otto von Guericke University, Magdeburg, Germany
    Hypertension 51:696-703. 2008
    ..We therefore propose that telmisartan translationally and posttranslationally upregulated DDAH expression via activation of PPARgamma signaling, causing ADMA to diminish and increase NO synthesis sufficient to delay senescence...
  17. ncbi request reprint Erythropoietin increases asymmetric dimethylarginine in endothelial cells: role of dimethylarginine dimethylaminohydrolase
    Fortunato Scalera
    Institute of Clinical Pharmacology, University Hospital, Otto von Guericke University, Leipziger Strasse, 44 D 39120, Magdeburg, Germany
    J Am Soc Nephrol 16:892-8. 2005
    ..EPO and NESP posttranslationally impair DDAH activity via increased oxidative stress, causing ADMA as an important cardiovascular risk factor to accumulate and inhibit NO synthesis...
  18. doi request reprint Red wine decreases asymmetric dimethylarginine via SIRT1 induction in human endothelial cells
    Fortunato Scalera
    Faculty of Medicine, Institute of Clinical Pharmacology, Otto von Guericke University, Magdeburg, Germany
    Biochem Biophys Res Commun 390:703-9. 2009
    ..These data are the first demonstration that RW by activating SIRT1 impairs synthesis and increases metabolism of ADMA. This effect of RW is accentuated in senescent cells probably due to enhanced DDAH activity...
  19. ncbi request reprint Aspirin reduces endothelial cell senescence
    Stefanie M Bode-Boger
    Institute of Clinical Pharmacology, University Hospital, Otto von Guericke University, Germany
    Biochem Biophys Res Commun 334:1226-32. 2005
    ..These findings demonstrate that aspirin delays the onset of endothelial senescence by preventing a decrease in NO formation/generation. This might provide a therapeutic strategy aimed at blocking aging-induced NO inhibition...
  20. doi request reprint Paradoxical effect of L-arginine: acceleration of endothelial cell senescence
    Fortunato Scalera
    Institute of Clinical Pharmacology, Medical Faculty, Otto von Guericke University, Magdeburg, Germany
    Biochem Biophys Res Commun 386:650-5. 2009
    ..The most possible explanation for the paradoxical acceleration of senescence by L-arginine so far may be the translational and posttranslational activation of arginase II...
  21. ncbi request reprint Symmetrical dimethylarginine: a new combined parameter for renal function and extent of coronary artery disease
    Stefanie M Bode-Boger
    Institute of Clinical Pharmacology, University Hospital, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    J Am Soc Nephrol 17:1128-34. 2006
    ..It is concluded that SDMA might be a useful parameter for detecting patients in very early stages of chronic kidney disease and for determining their risk for developing cardiovascular disease...
  22. ncbi request reprint Effect of L-arginine on asymmetric dimethylarginine (ADMA) or homocysteine-accelerated endothelial cell aging
    Fortunato Scalera
    Institute of Clinical Pharmacology, University Hospital Otto von Guericke University, Magdeburg, Germany
    Biochem Biophys Res Commun 345:1075-82. 2006
    ..This might provide a new strategy to delay ADMA or homocysteine-accelerated aging...
  23. doi request reprint The impact of rapid atrial pacing on ADMA and endothelial NOS
    Andreas Goette
    Department of Internal Medicine, Division of Cardiology, Otto von Guericke University, Magdeburg, Germany
    Int J Cardiol 154:141-6. 2012
    ..The aim of the present study was to determine the impact of rapid atrial pacing (RAP) on ADMA levels and eNOS expression...
  24. doi request reprint Pharmacokinetics and dose recommendations of Niaspan® in chronic kidney disease and dialysis patients
    Ines Reiche
    Institute of Clinical Pharmacology, Otto von Guericke University Magdeburg, Leipziger Str 44, Magdeburg, Germany
    Nephrol Dial Transplant 26:276-82. 2011
    ..The present study was performed to analyse the pharmacokinetics of prolonged-release nicotinic acid in CKD and in dialysis patients to derive dose recommendations...
  25. ncbi request reprint Determination of ornithine in human plasma by hydrophilic interaction chromatography-tandem mass spectrometry
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, Magdeburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 855:271-5. 2007
    ..However, arginine to ornithine ratios kept constant during the complete observation time...
  26. ncbi request reprint Determination of cerebrospinal fluid concentrations of arginine and dimethylarginines in patients with subarachnoid haemorrhage
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Neurosci Methods 164:155-60. 2007
    ..The decrease of the L-arginine to ADMA ratio points to a progressive impairment of the NO production rate in the brain after SAH which is confirmed by a simultaneous decrease in nitrate and nitrite concentrations in CSF...
  27. ncbi request reprint Fenofibrate increases the L-arginine:ADMA ratio by increase of L-arginine concentration but has no effect on ADMA concentration
    Jutta Dierkes
    Institute of Clinical Chemistry and Biochemistry, University Hospital, Leipziger Str 44, D 39120 Magdeburg, Germany
    Atherosclerosis 173:239-44. 2004
    ..The results do not support the view that in vivo ADMA metabolism itself is directly influenced by cholesterol or homocysteine...
  28. doi request reprint Decreased meropenem levels in Intensive Care Unit patients with augmented renal clearance: benefit of therapeutic drug monitoring
    Uwe Tröger
    Institute of Clinical Pharmacology, Otto von Guericke University Magdeburg, Universitatsklinikum, Leipziger Straße 44, D 39120 Magdeburg, Germany
    Int J Antimicrob Agents 40:370-2. 2012
    ..In the meantime, daily measurement of creatinine clearance as well as TDM can be used to identify patients who manifest ARC, thereby allowing drug therapy to achieve the therapeutic range...
  29. doi request reprint Asymmetric dimethylarginine predicts appropriate implantable cardioverter-defibrillator intervention in patients with left ventricular dysfunction
    H Immo Lehmann
    Division of Cardiology, Department of Internal Medicine, Otto von Guericke University, Magdeburg, Germany
    Europace 13:1428-35. 2011
    ..We sought to investigate whether biomarkers of nitric oxide metabolism can predict the occurrence of ventricular tachyarrhythmias and might be used as risk markers in these pts...
  30. doi request reprint Omeprazole-induced cough in a patient with gastroesophageal reflux disease
    Ines Reiche
    Institute of Clinical Pharmacology, Otto von Guericke University, Magdeburg, Germany
    Eur J Gastroenterol Hepatol 22:880-2. 2010
    ..Therefore, physicians should be aware of the onset or an exacerbation of cough during omeprazole therapy...
  31. doi request reprint Intravenous colistin in a patient with serious burns and borderline syndrome: the benefits of therapeutic drug monitoring
    Stefanie M Bode-Boger
    Institute of Clinical Pharmacology, Otto von Guericke University Magdeburg, Leipziger Straße 44, 39120 Magdeburg, Germany Electronic address
    Int J Antimicrob Agents 42:357-60. 2013
    ..The pharmacokinetics of colistin are currently poorly understood. TDM of colistin methanesulfonate and colistin may represent an invaluable approach to optimise colistin drug exposure in ICU patients with fluctuating renal clearance...
  32. ncbi request reprint Simultaneous detection of arginine, asymmetric dimethylarginine, symmetric dimethylarginine and citrulline in human plasma and urine applying liquid chromatography-mass spectrometry with very straightforward sample preparation
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, University Hospital, Otto von Guericke University, Leipziger Strasse 44, D39120 Magdeburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 798:231-9. 2003
    ..S.D. is 5.7%. In urine, these values for ADMA are 3.8 and 6.4%, respectively. All other analytes in plasma as well as in urine exhibit intra-day R.S.D. below 8%. The corresponding inter-day R.S.D. are all below 13%...
  33. ncbi request reprint Fast and efficient determination of arginine, symmetric dimethylarginine, and asymmetric dimethylarginine in biological fluids by hydrophilic-interaction liquid chromatography-electrospray tandem mass spectrometry
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University Magdeburg, University Hospital, Magdeburg, Germany
    Clin Chem 52:488-93. 2006
    ..Research in this field requires the measurement of Arg and of ADMA and its closely related substance, symmetric dimethylarginine (SDMA)...
  34. ncbi request reprint Determination of asymmetric dimethylarginine: liquid chromatography-mass spectrometry or ELISA?
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, University Hospital, Otto von Guericke University, Magdeburg, Germany
    Clin Chem 51:2188-9. 2005
  35. ncbi request reprint Determination of arginine and asymmetric dimethylarginine (ADMA) in human plasma by liquid chromatography/mass spectrometry with the isotope dilution technique
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University Magdeburg, University Hospital, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    J Mass Spectrom 39:1287-94. 2004
    ..355 +/- 0.066 microM, with a normal range for ADMA from 0.225 to 0.485 microM. The corresponding values for end-stage chronic renal failure patients are ARG = 48.1 +/- 18.5 microM, p < 0.01 and ADMA = 0.673 +/- 0.134 M, p < 0.001...
  36. doi request reprint The effects of G-CSF-induced mobilization of progenitor cells are limited by ADMA
    Andreas Goette
    Division of Cardiology, University Hospital Magdeburg, Germany
    Int J Cardiol 143:264-70. 2010
    ..However, mobilization of progenitor cells by application of G-CSF gives inconsistent clinical effects. The aim of the present study was to assess pathophysiologic effects of progenitor cell mobilization...
  37. ncbi request reprint Chromatographic-mass spectrometric methods for the quantification of L-arginine and its methylated metabolites in biological fluids
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, University Hospital Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 851:30-41. 2007
    ..A consensus emerges that the concentration values in plasma of young healthy volunteers are about 65 microM for Arg, 0.4 microM for ADMA and 0.5 microM for SDMA...
  38. ncbi request reprint Determination of levetiracetam in human plasma with minimal sample pretreatment
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, University Hospital, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 819:197-200. 2005
    ..The respective inter-day values are: R.S.D. < 4% and accuracies better than 2%. Frequently co-administered antiepileptic drugs do not interfere with the assay. The method has been successfully applied to patient samples...
  39. doi request reprint Birth by cesarean section is associated with elevated neonatal plasma levels of dimethylarginines
    Gabriella Vida
    Department of Obstetrics and Gynecology, Faculty of Medicine Institute of Health Promotion and Family Care, University of Pecs, Pecs, Hungary
    Pediatr Int 54:476-9. 2012
    ....
  40. ncbi request reprint Natural and newly synthesized hydroxy-1-aryl-isochromans: a class of potential antioxidants and radical scavengers
    Peter Lorenz
    Institute for Medical Neurobiology, Otto von Guericke University, Leipziger Strasse 44, D 39120, Magdeburg, Germany
    Free Radic Res 39:535-45. 2005
    ....
  41. ncbi request reprint Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L-arginine accelerates endothelial cell senescence
    Fortunato Scalera
    Institute of Clinical Pharmacology, University Hospital, Otto von Guericke University, Magdeburg, Germany
    Arterioscler Thromb Vasc Biol 24:1816-22. 2004
    ..Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), and its accumulation has been associated with cardiovascular disease. We aimed to investigate the role of ADMA in endothelial cell senescence...
  42. ncbi request reprint Clinical pharmacokinetics of dorzolamide
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, Magdeburg, Germany
    Clin Pharmacokinet 41:197-205. 2002
    ..This review summarises the pharmacokinetic and pharmacodynamic properties of dorzolamide and its metabolite in eye tissues and in the systemic circulation...