Thomas F W Horn

Summary

Affiliation: Otto-von-Guericke University
Country: Germany

Publications

  1. ncbi request reprint In vivo microdialysis for nonapeptides in rat brain--a practical guide
    T F Horn
    Institute for Medical Neurobiology, OttovonGuericke University, Magdeburg, D 39120, Germany
    Methods 23:41-53. 2001
  2. ncbi request reprint Nitric oxide promotes intracellular calcium release from mitochondria in striatal neurons
    Thomas F W Horn
    Institute for Medical Neurobiology, University of Magdeburg, Germany
    FASEB J 16:1611-22. 2002
  3. ncbi request reprint Nitric oxide applications prior and simultaneous to potentially excitotoxic NMDA-evoked calcium transients: cell death or survival
    Aileen Schröter
    Institute for Medical Neurobiology, Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
    Brain Res 1060:1-15. 2005
  4. ncbi request reprint Blood-brain barrier permeability to the neuroprotectant oxyresveratrol
    Christian Breuer
    Institute for Medical Neurobiology, Otto von Guericke University, Leipziger Strasse 44, Magdeburg D 39120, Germany
    Neurosci Lett 393:113-8. 2006
  5. ncbi request reprint Oxyresveratrol (trans-2,3',4,5'-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia
    Shaida A Andrabi
    Institute for Medical Neurobiology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, Haus 36, D 39120, Magdeburg, Germany
    Brain Res 1017:98-107. 2004
  6. ncbi request reprint Cytosolic and mitochondrial glutathione in microglial cells are differentially affected by oxidative/nitrosative stress
    Sanjoy Roychowdhury
    Institute for Medical Neurobiology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Nitric Oxide 8:39-47. 2003
  7. ncbi request reprint Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: effect on nitrosative and oxidative stress derived from microglial cells
    Peter Lorenz
    Institute for Medical Neurobiology, Otto von Guericke University, Leipziger Strasse 44, D 39120, Magdeburg, Germany
    Nitric Oxide 9:64-76. 2003
  8. ncbi request reprint Natural and newly synthesized hydroxy-1-aryl-isochromans: a class of potential antioxidants and radical scavengers
    Peter Lorenz
    Institute for Medical Neurobiology, Otto von Guericke University, Leipziger Strasse 44, D 39120, Magdeburg, Germany
    Free Radic Res 39:535-45. 2005
  9. ncbi request reprint Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin
    Shaida A Andrabi
    Institute for Medical Neurobiology, Otto von Guericke University, Magdeburg, Germany
    FASEB J 18:869-71. 2004
  10. ncbi request reprint Nitric oxide produced in rat liver mitochondria causes oxidative stress and impairment of respiration after transient hypoxia
    Lorenz Schild
    Institute of Clinical Chemistry and Pathological Biochemistry, Department of Pathological Biochemistry, Otto von Guericke University, Magdeburg, Germany
    FASEB J 17:2194-201. 2003

Collaborators

Detail Information

Publications20

  1. ncbi request reprint In vivo microdialysis for nonapeptides in rat brain--a practical guide
    T F Horn
    Institute for Medical Neurobiology, OttovonGuericke University, Magdeburg, D 39120, Germany
    Methods 23:41-53. 2001
    ....
  2. ncbi request reprint Nitric oxide promotes intracellular calcium release from mitochondria in striatal neurons
    Thomas F W Horn
    Institute for Medical Neurobiology, University of Magdeburg, Germany
    FASEB J 16:1611-22. 2002
    ..An NO-activated mitochondrial permeability transition pore may lead to cell death after overstimulation of NMDA receptors...
  3. ncbi request reprint Nitric oxide applications prior and simultaneous to potentially excitotoxic NMDA-evoked calcium transients: cell death or survival
    Aileen Schröter
    Institute for Medical Neurobiology, Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
    Brain Res 1060:1-15. 2005
    ..They provide a possible explanation for the ambivalence of NO in neurodegenerative processes where glutamate receptor stimulation and mitochondrial [Ca2+]i sequestration are causally involved...
  4. ncbi request reprint Blood-brain barrier permeability to the neuroprotectant oxyresveratrol
    Christian Breuer
    Institute for Medical Neurobiology, Otto von Guericke University, Leipziger Strasse 44, Magdeburg D 39120, Germany
    Neurosci Lett 393:113-8. 2006
    ....
  5. ncbi request reprint Oxyresveratrol (trans-2,3',4,5'-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia
    Shaida A Andrabi
    Institute for Medical Neurobiology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, Haus 36, D 39120, Magdeburg, Germany
    Brain Res 1017:98-107. 2004
    ..This dose-dependent neuroprotective effect of oxyresveratrol in an in vivo stroke model demonstrates that this drug may prove to be beneficial for a therapeutic strategy to limit brain injury in acute brain ischemia...
  6. ncbi request reprint Cytosolic and mitochondrial glutathione in microglial cells are differentially affected by oxidative/nitrosative stress
    Sanjoy Roychowdhury
    Institute for Medical Neurobiology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Nitric Oxide 8:39-47. 2003
    ..We conclude that endogenous NO production in microglial cells does not compromise the mt-GSH pool which, in turn, might explain the ability of these cells to combat high-output NO production...
  7. ncbi request reprint Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: effect on nitrosative and oxidative stress derived from microglial cells
    Peter Lorenz
    Institute for Medical Neurobiology, Otto von Guericke University, Leipziger Strasse 44, D 39120, Magdeburg, Germany
    Nitric Oxide 9:64-76. 2003
    ..The radical and ROS scavenging properties, as well as the lower cytotoxicity towards microglia and the known good water solubility suggest OXY as a potential protectant against ROS/RNS...
  8. ncbi request reprint Natural and newly synthesized hydroxy-1-aryl-isochromans: a class of potential antioxidants and radical scavengers
    Peter Lorenz
    Institute for Medical Neurobiology, Otto von Guericke University, Leipziger Strasse 44, D 39120, Magdeburg, Germany
    Free Radic Res 39:535-45. 2005
    ....
  9. ncbi request reprint Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin
    Shaida A Andrabi
    Institute for Medical Neurobiology, Otto von Guericke University, Magdeburg, Germany
    FASEB J 18:869-71. 2004
    ..Our findings suggest that the direct inhibition of the mtPTP by melatonin may essentially contribute to its anti-apoptotic effects in transient brain ischemia...
  10. ncbi request reprint Nitric oxide produced in rat liver mitochondria causes oxidative stress and impairment of respiration after transient hypoxia
    Lorenz Schild
    Institute of Clinical Chemistry and Pathological Biochemistry, Department of Pathological Biochemistry, Otto von Guericke University, Magdeburg, Germany
    FASEB J 17:2194-201. 2003
    ..Such increased NO levels, in turn, inhibit mitochondrial respiration and may cause oxidative stress that leads to irreversible impairment of mitochondria...
  11. ncbi request reprint Oxidative stress in glial cultures: detection by DAF-2 fluorescence used as a tool to measure peroxynitrite rather than nitric oxide
    Sanjoy Roychowdhury
    Otto von Guericke University, Institute for Medical Neurobiology, Magdeburg, Germany
    Glia 38:103-14. 2002
    ..Nevertheless, our results also indicate that measurement of DCF fluorescence is a better tool for monitoring intracellular changes in the levels of NO and/or peroxynitrite than DAF-2...
  12. ncbi request reprint Combined modulation of the mitochondrial ATP-dependent potassium channel and the permeability transition pore causes prolongation of the biphasic calcium dynamics
    Yuliya A Dahlem
    Institute of Medical Neurobiology, Otto von Guericke University Magdeburg, Leipzigerstr 44, D 39120 Magdeburg, Germany
    Cell Calcium 39:387-400. 2006
    ..Hence, we propose that modulation of one of these channels leads to functional changes of the other channel by means of Delta[Ca(2+)](i) and Deltapsi(m)...
  13. ncbi request reprint Release patterns of excitatory and inhibitory amino acids within the hypothalamic supraoptic nucleus in response to direct nitric oxide administration during forced swimming in rats
    Mario Engelmann
    Otto von Guericke Universitat Magdeburg, Institut für Medizinische Neurobiologie, Leipziger Str 44, D 39120 Magdeburg, Germany
    Neurosci Lett 324:252-4. 2002
    ....
  14. ncbi request reprint Colocalization of urocortin and neuronal nitric oxide synthase in the hypothalamus and Edinger-Westphal nucleus of the rat
    Mariarosa G Spina
    Institute of Medical Neurobiology, Otto von Guericke University, Magdeburg D 39120, Germany
    J Comp Neurol 479:271-86. 2004
    ..These findings suggest an interaction between Ucn and NO signaling within the SON, rather than the PVN, that may modulate the regulation of feeding, reproduction, and anxiety-related behaviors...
  15. ncbi request reprint The human mitochondrial KATP channel is modulated by calcium and nitric oxide: a patch-clamp approach
    Yuliya A Dahlem
    Institute of Medical Neurobiology, Otto von Guericke University of Magdeburg, D 39120 Magdeburg, Germany
    Biochim Biophys Acta 1656:46-56. 2004
    ....
  16. ncbi request reprint GABA selectively controls the secretory activity of oxytocin neurons in the rat supraoptic nucleus
    Mario Engelmann
    Otto von Guericke Universitat Magdeburg, Institut für Medizinische Neurobiologie, Leipziger Str 44, D 39120 Magdeburg, Germany
    Eur J Neurosci 19:601-8. 2004
    ..Taken together, our data demonstrate that GABA is released within the SON during emotional stress to act as a selective inhibitor of both central and peripheral OXT secretion...
  17. ncbi request reprint Minocycline, a possible neuroprotective agent in Leber's hereditary optic neuropathy (LHON): studies of cybrid cells bearing 11,778 mutation
    Mohammad Fahad Haroon
    Institute of Medical Neurobiology, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Neurobiol Dis 28:237-50. 2007
    ..In relation with its high safety profile, these results would suggest minocycline as a promising neuroprotective agent in LHON...
  18. ncbi request reprint Lack of mitochondrial nitric oxide production in the mouse brain
    Zsombor Lacza
    Department of Physiology Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Neurochem 90:942-51. 2004
    ..We conclude that mouse brain mitochondria do not contain NOS isoforms, nor do they produce NO through a NOS-dependent mechanism...
  19. ncbi request reprint AMPA receptor-induced intracellular calcium response in the paraventricular nucleus is modulated by nitric oxide: calcium imaging in a hypothalamic organotypic cell culture model
    Sanjoy Roychowdhury
    Institute of Medical Neurobiology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Nitric Oxide 14:290-9. 2006
    ..Taken together, these data suggest that AMPA mediates the glutamate-induced [Ca(2+)](i) rises within the PVN, where endogenous NO is able to modulate such glutamate signaling in OCC...
  20. ncbi request reprint Mitochondria produce reactive nitrogen species via an arginine-independent pathway
    Zsombor Lacza
    Department of Physiology Pharmacology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Free Radic Res 40:369-78. 2006
    ..We conclude that mitochondria from brain, heart and liver are capable of significant RNS production via the respiratory chain rather than through an arginine-dependent mtNOS...