Rainald Mossner

Summary

Country: Germany

Publications

  1. ncbi request reprint Increased hippocampal DNA oxidation in serotonin transporter deficient mice
    R Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Federal Republic of Germany
    J Neural Transm 109:557-65. 2002
  2. ncbi request reprint Unaltered susceptibility to scrapie in serotonin transporter deficient mice
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Neurochem Int 49:454-8. 2006
  3. ncbi request reprint Quantitation of 5HT3 receptors in forebrain of serotonin transporter deficient mice
    R Mossner
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Germany
    J Neural Transm 111:27-35. 2004
  4. ncbi request reprint Aberrant accumulation of serotonin in dopaminergic neurons
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Neurosci Lett 401:49-54. 2006
  5. ncbi request reprint The novel brain-specific tryptophan hydroxylase-2 gene in panic disorder
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Psychopharmacol 20:547-52. 2006
  6. ncbi request reprint Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder
    Rainald Mossner
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Int J Neuropsychopharmacol 9:437-42. 2006
  7. ncbi request reprint The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) is associated with schizophrenia and modulates verbal memory and the acoustic startle response
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 15:1205-15. 2012
  8. doi request reprint Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    J Psychiatr Res 46:1073-80. 2012
  9. doi request reprint Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Pharmacogenet Genomics 19:843-51. 2009
  10. pmc DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 260:209-15. 2010

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Increased hippocampal DNA oxidation in serotonin transporter deficient mice
    R Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Federal Republic of Germany
    J Neural Transm 109:557-65. 2002
    ..Given the importance of the hippocampus in learning and memory, this may be the most important neurochemical consequence of the absence of the 5HTT...
  2. ncbi request reprint Unaltered susceptibility to scrapie in serotonin transporter deficient mice
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Neurochem Int 49:454-8. 2006
    ..These findings argue against a major role of the 5-HTT in the pathogenesis of prion diseases in mice...
  3. ncbi request reprint Quantitation of 5HT3 receptors in forebrain of serotonin transporter deficient mice
    R Mossner
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Germany
    J Neural Transm 111:27-35. 2004
    ..The adaptive changes of 5HT3 receptor expression constitute a part of the complex regulatory pattern of 5HT receptors in 5HTT knockout mice...
  4. ncbi request reprint Aberrant accumulation of serotonin in dopaminergic neurons
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Neurosci Lett 401:49-54. 2006
    ..This provides a molecular rationale for improving antidepressant efficacy by additional pharmacological inhibition of the DAT...
  5. ncbi request reprint The novel brain-specific tryptophan hydroxylase-2 gene in panic disorder
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Psychopharmacol 20:547-52. 2006
    ..The results of this first study of TPH2 in panic disorder argue against an importance of allelic variation of TPH2 in the pathogenesis of panic disorder with or without agoraphobia...
  6. ncbi request reprint Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder
    Rainald Mossner
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Int J Neuropsychopharmacol 9:437-42. 2006
    ..58 (95% CI 0.98-6.82). In conclusion, the results link TPH2 variations to the pathogenesis of early-onset OCD and further support the aetiological relevance of 5-HT signalling in OCD...
  7. ncbi request reprint The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) is associated with schizophrenia and modulates verbal memory and the acoustic startle response
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 15:1205-15. 2012
    ..Based on these findings, we consider NPS as a promising target for antipsychotic drug development...
  8. doi request reprint Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    J Psychiatr Res 46:1073-80. 2012
    ..We also investigated the association of the SNPs to treatment response, but did not get significant results. In sum, our results argue for only a minor role of TPH2 in schizophrenia...
  9. doi request reprint Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Pharmacogenet Genomics 19:843-51. 2009
    ..Moreover, many antipsychotic drugs are antagonists at 5-HT3 receptors. However, the role of 5-HT3 receptor variants on response to antipsychotic drugs in schizophrenic patients is still unclear...
  10. pmc DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 260:209-15. 2010
    ..This is one of the first studies to identify a specific genetic factor for the progression of prodromal syndromes to schizophrenia, and further underscores the importance of the DAOA/G72 gene for schizophrenia...
  11. doi request reprint Novel schizophrenia risk gene TCF4 influences verbal learning and memory functioning in schizophrenia patients
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Neuropsychobiology 63:131-6. 2011
    ..Thus, we hypothesized that the disease-associated C allele of the rs9960767 polymorphism of the TCF4 gene led to impaired VDM functioning in schizophrenia patients...
  12. ncbi request reprint Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation
    Lise Gutknecht
    Molecular and Clinical Psychobiology, Department for Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Int J Neuropsychopharmacol 10:309-20. 2007
    ..These findings implicate alterations of 5-HT synthesis in emotion regulation and confirm TPH2 as a susceptibility and/or modifier gene of affective spectrum disorders...
  13. doi request reprint A variant of the neuronal amino acid transporter SLC6A15 is associated with ACTH and cortisol responses and cognitive performance in unipolar depression
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Int J Neuropsychopharmacol 16:83-90. 2013
    ..Our findings argue for a role of the SLC6A15 gene in ACTH and cortisol secretion during the Dex/CRH test and furthermore in the occurrence of cognitive impairments in unipolar depression...
  14. doi request reprint A promoter variant of SHANK1 affects auditory working memory in schizophrenia patients and in subjects clinically at risk for psychosis
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strase 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:117-24. 2012
    ..Our findings suggest a role of SHANK1 in working memory deficits in schizophrenia, which may arise from neurodevelopmental changes to prefrontal cortical areas...
  15. doi request reprint The schizophrenia risk gene ZNF804A influences the antipsychotic response of positive schizophrenia symptoms
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:193-7. 2012
    ..41 ± 0.71, P = 0.022). This provides further evidence that ZNF804A is of functional relevance to schizophrenia and indicates that ZNF804A may be a novel target for pharmacological interventions...
  16. doi request reprint Impact of TCF4 on the genetics of schizophrenia
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 261:S161-5. 2011
    ..This indicates that TCF4 influences key mechanisms of information processing, which may contribute to the pathogenesis of schizophrenia...
  17. ncbi request reprint Further evidence for a functional role of the glutamate receptor gene GRM3 in schizophrenia
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, Germany
    Eur Neuropsychopharmacol 18:768-72. 2008
    ..008). Our results provide further evidence for the potential importance of the glutamate receptor GRM3 in schizophrenia, and indicate that the novel antipsychotic LY2140023 may actually be targeting a pathogenic pathway of schizophrenia...
  18. doi request reprint A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patients
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Eur Neuropsychopharmacol 20:414-20. 2010
    ..This study provides additional evidence for a role of the serotonergic system and the 5-HT3 receptor in schizophrenia...
  19. ncbi request reprint Nicotine enhances antisaccade performance in schizophrenia patients and healthy controls
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Int J Neuropsychopharmacol 16:1473-81. 2013
    ..Instead, the findings likely represent genuine nicotine-induced enhancement of cognitive performance. ..
  20. doi request reprint Reduced thermal hyperalgesia and enhanced peripheral nerve injury after hind paw inflammation in mice lacking the serotonin-transporter
    Florian Palm
    Department of Neurology, University of Wurzburg, Neurologische Klinik der Universität, D 97080 Wurzburg, Germany
    Eur J Pain 12:790-7. 2008
    ..Human variants of the 5-HTT genotypes might be part of the factors determining the extent of nerve injury and hyperalgesia in inflammation...
  21. doi request reprint Association of amygdala volumes with cortisol secretion in unipolar depressed patients
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Psychiatry Res 202:96-103. 2012
    ....
  22. doi request reprint The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) influences age at onset of obsessive-compulsive disorder
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 16:1951-8. 2013
    ..In agreement with preclinical research, we suggest that NPS may be a promising pharmacological candidate with anti-obsessional properties...
  23. doi request reprint The effect of nicotine on sensorimotor gating is modulated by a CHRNA3 polymorphism
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Psychopharmacology (Berl) 229:31-40. 2013
    ..Moreover, the TT genotype of the nicotinic acetylcholine receptor (nAChR) α3-subunit (CHRNA3) rs1051730 polymorphism has previously been associated with diminished PPI and nicotine dependence...
  24. ncbi request reprint Absence of thermal hyperalgesia in serotonin transporter-deficient mice
    Carola Vogel
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    J Neurosci 23:708-15. 2003
    ..In contrast, bilateral mechanical allodynia, a centrally mediated phenomenon, was associated with decreased spinal 5-HT concentrations in 5-HTT-/- mice and may possibly be caused by a lack of spinal inhibition...
  25. ncbi request reprint Rare variants of the gene encoding the potassium chloride co-transporter 3 are associated with bipolar disorder
    Jobst Meyer
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Germany
    Int J Neuropsychopharmacol 8:495-504. 2005
    ..Our data strongly suggest that rare variants of SLC12A6 may represent risk factors for bipolar disorder...
  26. ncbi request reprint Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity
    Christian P Jacob
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Neuropsychopharmacology 30:1711-8. 2005
    ..Our findings further support the notion that allelic variation of MAOA activity contributes modestly to the balance of hyper- (impulsive-aggressive) and hyporeactive (anxious-depressive) traits...
  27. doi request reprint PCLO rs2522833 modulates HPA system response to antidepressant treatment in major depressive disorder
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Int J Neuropsychopharmacol 14:237-45. 2011
    ..Our results point to a moderating role of PCLO SNP rs2522833 on HPA regulation during antidepressant treatment, which may represent a neurobiological feature of stability of clinical response...
  28. ncbi request reprint A highly polymorphic poly-glutamine stretch in the potassium channel KCNN3 in migraine
    Rainald Mossner
    Department of Psychiatry, University of Wurzburg, Germany
    Headache 45:132-6. 2005
    ..Objective: The present study is designed to further elucidate the molecular genetic basis of migraine with and without aura...
  29. doi request reprint Nicotine differentially modulates antisaccade performance in healthy male non-smoking volunteers stratified for low and high accuracy
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Psychopharmacology (Berl) 221:27-38. 2012
    ..The response to acute nicotine is heterogeneous across subjects and samples; however, only a few reliable predictors of response have been identified...
  30. doi request reprint Investigation of the functional brain-derived neurotrophic factor gene variant Val66MET in migraine
    Martin Marziniak
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Neural Transm 115:1321-5. 2008
    ..Our data argue against a role of this well characterized BDNF gene variant as a risk factor in migraine...
  31. pmc Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Neuropsychopharmacology 35:1429-39. 2010
    ..These results suggest that sensorimotor gating is influenced by variations of the CHRNA3 gene, which might also have an impact on the course and severity of schizophrenia...
  32. ncbi request reprint A NOS-III haplotype that includes functional polymorphisms is associated with bipolar disorder
    Andreas Reif
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Int J Neuropsychopharmacol 9:13-20. 2006
    ..Our results thus suggest that the NOS-III genotype may convey a modest genetic risk to develop bipolar disorder. This finding should be further clarified by the use of within-family designs and in samples of other ethnicity...
  33. ncbi request reprint Differential effect of endothelial nitric oxide synthase (NOS-III) on the regulation of adult neurogenesis and behaviour
    Andreas Reif
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Eur J Neurosci 20:885-95. 2004
    ..In conclusion, our results indicated that NOS-III is involved in the proliferation of neuronal progenitor cells, although behavioural analysis does not provide evidence for a pro-depressive effect of reduced neuroneogenesis...
  34. ncbi request reprint Mutational analysis of the connexin 36 gene (CX36) and exclusion of the coding sequence as a candidate region for catatonic schizophrenia in a large pedigree
    Jobst Meyer
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, D 97080 Wurzburg, Germany
    Schizophr Res 58:87-91. 2002
    ..No variant exclusively cosegregates with the disease in a large pedigree that mainly supports the chromosome 15q14 locus, providing evidence that CX36 is not causative for the pathogenesis of catatonic schizophrenia in this family...
  35. ncbi request reprint Structural and functional characterization of the human PAX7 5'-flanking regulatory region
    Yana V Syagailo
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080, Wurzburg, Germany
    Gene 294:259-68. 2002
    ....
  36. ncbi request reprint Transmission disequilibrium analysis of the functional 5-HT3A receptor variant C178T in early-onset obsessive compulsive-disorder
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Psychopharmacol 21:833-6. 2007
    ..51 (95% CI 0.36-0.65). This argues against an involvement of the 5-HT(3A) receptor in the polygenic aetiology of early-onset OCD...
  37. ncbi request reprint The brain-specific protein MLC1 implicated in megalencephalic leukoencephalopathy with subcortical cysts is expressed in glial cells in the murine brain
    Angelika Schmitt
    Department of Psychiatry and Psychotherapy, Section of Molecular Psychobiology, University of Wurzburg, Wurzburg, Germany
    Glia 44:283-95. 2003
    ..Detailed information on Mlc1 expression in brain is likely to lead to a better understanding of Mlc1 involvement in the pathogenesis of both MLC and catatonic schizophrenia...
  38. ncbi request reprint Toxicity and metabolism of the chloral-derived mammalian alkaloid 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) in PC12 cells
    Gerhard Bringmann
    Institut fur Organische Chemie, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Z Naturforsch C 61:601-10. 2006
    ....
  39. ncbi request reprint Consensus paper of the WFSBP Task Force on Biological Markers: biological markers in depression
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    World J Biol Psychiatry 8:141-74. 2007
    ....
  40. doi request reprint Functional serotonin 1A receptor variant influences treatment response to atypical antipsychotics in schizophrenia
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Pharmacogenet Genomics 19:91-4. 2009
    ..003). The functional variant of the 5-HT1A receptor thus influences the response of schizophrenia patients to atypical antipsychotics and may be useful in the future to predict the pharmacogenetics of negative symptoms...
  41. ncbi request reprint Encephalopathy and myoclonus triggered by valproic acid
    Andreas Reif
    Department of Psychiatry, Julius Maximilians University of Wurzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 28:1061-3. 2004
    ..On VPA discontinuation, all symptoms vanished and EEG normalized. We thus suggest that direct VPA-induced encephalopathy in the absence of ammonemia does exist, in this case probably facilitated by psychotropic polypharmacy...