Bernd Lepenies

Summary

Affiliation: Max Planck Institute of Colloids and Interfaces
Country: Germany

Publications

  1. doi request reprint Targeting C-type lectin receptors with multivalent carbohydrate ligands
    Bernd Lepenies
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany Department of Biology, Chemistry, and Pharmacy, Freie Universitat Berlin, Germany Electronic address
    Adv Drug Deliv Rev 65:1271-81. 2013
  2. doi request reprint The promise of glycomics, glycan arrays and carbohydrate-based vaccines
    Bernd Lepenies
    Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Potsdam, Germany
    Immunopharmacol Immunotoxicol 32:196-207. 2010
  3. pmc Role of the C-type lectin receptors MCL and DCIR in experimental colitis
    Julia Hütter
    Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Potsdam, Germany Freie Universität Berlin, Institute of Chemistry and Biochemistry, Department of Biology, Chemistry and Pharmacy, Berlin, Germany
    PLoS ONE 9:e103281. 2014
  4. doi request reprint Hexameric supramolecular scaffold orients carbohydrates to sense bacteria
    Dan Grünstein
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany
    J Am Chem Soc 133:13957-66. 2011
  5. doi request reprint Biological evaluation of multivalent lewis X-MGL-1 interactions
    Magdalena Eriksson
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Muhlenberg 1, 14476 Potsdam Germany Institute for Chemistry and Biochemistry, Freie Universitat Berlin, Arnimallee 22, 14195 Berlin Germany
    Chembiochem 15:844-51. 2014
  6. doi request reprint Toward animal cell culture-based influenza vaccine design: viral hemagglutinin N-glycosylation markedly impacts immunogenicity
    Julia Hütter
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany
    J Immunol 190:220-30. 2013
  7. doi request reprint A platform to screen for C-type lectin receptor-binding carbohydrates and their potential for cell-specific targeting and immune modulation
    Maha Maglinao
    Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Am Muhlenberg 1, 14476 Potsdam, Germany Freie Universität Berlin, Institute of Chemistry and Biochemistry, Department of Biology, Chemistry and Pharmacy, Arnimallee 22, 14195 Berlin, Germany
    J Control Release 175:36-42. 2014
  8. doi request reprint Design, synthesis and biological evaluation of carbohydrate-functionalized cyclodextrins and liposomes for hepatocyte-specific targeting
    Gonçalo J L Bernardes
    Max Planck Institute of Colloids and Interfaces, Research Campus Golm, 14476 Potsdam, Germany
    Org Biomol Chem 8:4987-96. 2010
  9. doi request reprint Tailored Presentation of Carbohydrates on a Coiled Coil-Based Scaffold for Asialoglycoprotein Receptor Targeting
    Elsa Zacco
    Institute of Chemistry and Biochemistry, Freie Universitat Berlin, Takustrasse 3, 14195 Berlin, Germany
    ACS Chem Biol 10:2065-72. 2015
  10. doi request reprint Analysis of Carbohydrate-Carbohydrate Interactions Using Sugar-Functionalized Silicon Nanoparticles for Cell Imaging
    Chian Hui Lai
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany
    Nano Lett 16:807-11. 2016

Collaborators

  • Robert Klopfleisch
  • Erdmann Rapp
  • Daniel Kolarich
  • Niels Christian Reichardt
  • Peter H Seeberger
  • Julia Hütter
  • Maha Maglinao
  • Magdalena Eriksson
  • Timo Johannssen
  • Mark K Schlegel
  • Stephanie Zimmermann
  • Chian Hui Lai
  • Elsa Zacco
  • Dan Grünstein
  • Raghavendra Kikkeri
  • Mayeul Collot
  • Gonçalo J L Bernardes
  • Hidenori Tanaka
  • Luisa De Cola
  • Silvia Varela-Aramburu
  • Chien Wei Hsu
  • Jason L Heier
  • Jérémie Mortier
  • Beate Koksch
  • Achim D Gruber
  • Sonia Serna
  • Sebastian Götze
  • Dorthe von Smolinski
  • Dirk Höper
  • Udo Reichl
  • Jana V Rödig
  • Faustin Kamena
  • Konstantin Barylyuk
  • Renato Zenobi
  • Paola Laurino
  • Sung You Hong

Detail Information

Publications18

  1. doi request reprint Targeting C-type lectin receptors with multivalent carbohydrate ligands
    Bernd Lepenies
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany Department of Biology, Chemistry, and Pharmacy, Freie Universitat Berlin, Germany Electronic address
    Adv Drug Deliv Rev 65:1271-81. 2013
    ..Major emphasis is directed towards targeting of CLRs expressed by antigen-presenting cells to modulate immune responses...
  2. doi request reprint The promise of glycomics, glycan arrays and carbohydrate-based vaccines
    Bernd Lepenies
    Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Potsdam, Germany
    Immunopharmacol Immunotoxicol 32:196-207. 2010
    ..Furthermore, this review focuses on how immunological research can benefit from these novel tools provided by glycochemistry...
  3. pmc Role of the C-type lectin receptors MCL and DCIR in experimental colitis
    Julia Hütter
    Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Potsdam, Germany Freie Universität Berlin, Institute of Chemistry and Biochemistry, Department of Biology, Chemistry and Pharmacy, Berlin, Germany
    PLoS ONE 9:e103281. 2014
    ..MCL-/- as well as DCIR-/- mice exhibited only a slightly increased severity of disease compared to wild-type mice indicating a limited role for MCL and DCIR in the regulation of intestinal immunity. ..
  4. doi request reprint Hexameric supramolecular scaffold orients carbohydrates to sense bacteria
    Dan Grünstein
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany
    J Am Chem Soc 133:13957-66. 2011
    ..Simple visualization of binding between a fluorescent, multivalent mannose complex and the Escherichia coli strain ORN178 that possesses mannose-specific receptor sites illustrates the potential for these complexes as biosensors...
  5. doi request reprint Biological evaluation of multivalent lewis X-MGL-1 interactions
    Magdalena Eriksson
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Muhlenberg 1, 14476 Potsdam Germany Institute for Chemistry and Biochemistry, Freie Universitat Berlin, Arnimallee 22, 14195 Berlin Germany
    Chembiochem 15:844-51. 2014
    ..This study provides insights into how multivalent carbohydrate-lectin interactions can be exploited to modulate immune responses. ..
  6. doi request reprint Toward animal cell culture-based influenza vaccine design: viral hemagglutinin N-glycosylation markedly impacts immunogenicity
    Julia Hütter
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany
    J Immunol 190:220-30. 2013
    ..In conclusion, this study indicates a crucial importance of HA N-glycosylation for immunogenicity. Our findings have implications for cell line-based influenza vaccine design...
  7. doi request reprint A platform to screen for C-type lectin receptor-binding carbohydrates and their potential for cell-specific targeting and immune modulation
    Maha Maglinao
    Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Am Muhlenberg 1, 14476 Potsdam, Germany Freie Universität Berlin, Institute of Chemistry and Biochemistry, Department of Biology, Chemistry and Pharmacy, Arnimallee 22, 14195 Berlin, Germany
    J Control Release 175:36-42. 2014
    ..The platform described here allows for the identification of CLR ligands, as well as the evaluation of each ligand's cell-specific targeting and immune modulatory properties. ..
  8. doi request reprint Design, synthesis and biological evaluation of carbohydrate-functionalized cyclodextrins and liposomes for hepatocyte-specific targeting
    Gonçalo J L Bernardes
    Max Planck Institute of Colloids and Interfaces, Research Campus Golm, 14476 Potsdam, Germany
    Org Biomol Chem 8:4987-96. 2010
    ..The d-Gal/d-GalNAc-functionalized βCDs and liposomes presented here enable hepatocyte-specific targeting. Gal-functionalized βCDs are efficient molecular carriers to deliver doxorubicin in vitro into hepatocytes and induce apoptosis...
  9. doi request reprint Tailored Presentation of Carbohydrates on a Coiled Coil-Based Scaffold for Asialoglycoprotein Receptor Targeting
    Elsa Zacco
    Institute of Chemistry and Biochemistry, Freie Universitat Berlin, Takustrasse 3, 14195 Berlin, Germany
    ACS Chem Biol 10:2065-72. 2015
    ..Thus, this study demonstrates that the coiled-coil motif can be used as reliable scaffold for the rational presentation of ligands. ..
  10. doi request reprint Analysis of Carbohydrate-Carbohydrate Interactions Using Sugar-Functionalized Silicon Nanoparticles for Cell Imaging
    Chian Hui Lai
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany
    Nano Lett 16:807-11. 2016
    ..Cell binding studies, to investigate the biological relevance of these carbohydrate-carbohydrate interactions, also benefit from these fluorescent sugar-capped nanoparticles. ..
  11. doi request reprint Defined presentation of carbohydrates on a duplex DNA scaffold
    Mark K Schlegel
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Muhlenberg 1, 14476 Potsdam, Germany
    Chembiochem 12:2791-800. 2011
    ..Surface plasmon resonance and cellular uptake studies with bone-marrow-derived dendritic cells were used to assess the capability of these carbohydrate-modified duplexes to bind to mMGL receptors...
  12. doi request reprint Applications of synthetic carbohydrates to chemical biology
    Bernd Lepenies
    Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Research Campus Potsdam Golm, 14476 Potsdam, Germany
    Curr Opin Chem Biol 14:404-11. 2010
    ..This review focuses on how diverse carbohydrate structures can be synthetically derived and highlights the benefit of synthetic carbohydrates for glycobiology...
  13. doi request reprint The C-type lectin receptor DCIR is crucial for the development of experimental cerebral malaria
    Maha Maglinao
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany
    J Immunol 191:2551-9. 2013
    ..This study indicates that DCIR is critically involved in CM induction, thus highlighting the importance of this CLR in innate immunity during malaria infection. ..
  14. doi request reprint Carbohydrate-Based Vaccines: An Overview
    Julia Hütter
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Muhlenberg 1, 14476, Potsdam, Germany
    Methods Mol Biol 1331:1-10. 2015
    ..Current research also focuses on the development of carbohydrate-based vaccines against other pathogens such as viruses, fungi, protozoan parasites, or helminths...
  15. doi request reprint Glycans as Vaccine Antigens and Adjuvants: Immunological Considerations
    Stephanie Zimmermann
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Muhlenberg 1, 14476, Potsdam, Germany
    Methods Mol Biol 1331:11-26. 2015
    ..The second part of the chapter discusses the immunological mechanisms of carbohydrate-based adjuvants to increase the immunogenicity of vaccines. ..
  16. doi request reprint Identification and Characterization of Carbohydrate-Based Adjuvants
    Timo Johannssen
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Muhlenberg 1, 14476, Potsdam, Germany
    Methods Mol Biol 1331:173-87. 2015
    ..The resulting glycoconjugates are subsequently used to evaluate T cell activation in vitro and immunomodulation in vivo. ..
  17. doi request reprint Glycomics, glycoproteomics and the immune system
    Daniel Kolarich
    Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Am Muhlenberg 1, 14476 Potsdam, Germany
    Curr Opin Chem Biol 16:214-20. 2012
    ..In this review, we focus on different glycomics and glycoproteomics approaches and their application for studying protein glycosylation in the immune system...