Gaspar Jekely

Summary

Affiliation: Max Planck Institute for Biological Cybernetics
Country: Germany

Publications

  1. pmc An option space for early neural evolution
    Gaspar Jekely
    Max Planck Institute for Developmental Biology, Spemannstrasse 35, Tubingen 72076, Germany
    Philos Trans R Soc Lond B Biol Sci 370:. 2015
  2. pmc Wnt6 is required for maxillary palp formation in Drosophila
    Nikolaos Doumpas
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Biol 11:104. 2013
  3. pmc Global view of the evolution and diversity of metazoan neuropeptide signaling
    Gaspar Jekely
    Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 110:8702-7. 2013
  4. pmc Whole-body gene expression pattern registration in Platynereis larvae
    Albina Asadulina
    Max Planck Institute for Developmental Biology, Spemannstrasse 35, Tubingen, 72076, Germany
    Evodevo 3:27. 2012
  5. pmc Antibodies against conserved amidated neuropeptide epitopes enrich the comparative neurobiology toolbox
    Markus Conzelmann
    Max Planck Institute for Developmental Biology, Spemannstrasse 35, Tubingen 72076, Germany
    Evodevo 3:23. 2012
  6. pmc Origin and early evolution of neural circuits for the control of ciliary locomotion
    Gaspar Jekely
    Max Planck Institute for Developmental Biology, Tubingen, Germany
    Proc Biol Sci 278:914-22. 2011
  7. pmc Evolution of phototaxis
    Gaspar Jekely
    Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076 Tubingen, Germany
    Philos Trans R Soc Lond B Biol Sci 364:2795-808. 2009
  8. doi request reprint Mechanism of phototaxis in marine zooplankton
    Gaspar Jekely
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany
    Nature 456:395-9. 2008
  9. pmc Origin of the nucleus and Ran-dependent transport to safeguard ribosome biogenesis in a chimeric cell
    Gaspar Jekely
    Max Planck Institute for Developmental Biology, Spemannstrasse 35 72076 Tübingen, Germany
    Biol Direct 3:31. 2008
  10. ncbi request reprint Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration
    Gaspar Jekely
    Developmental Biology Program, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Dev Cell 9:197-207. 2005

Collaborators

Detail Information

Publications30

  1. pmc An option space for early neural evolution
    Gaspar Jekely
    Max Planck Institute for Developmental Biology, Spemannstrasse 35, Tubingen 72076, Germany
    Philos Trans R Soc Lond B Biol Sci 370:. 2015
    ..This broad mapping of the option space enables an overview of the many influences and constraints that may have played a role in the evolution of the first nervous systems. ..
  2. pmc Wnt6 is required for maxillary palp formation in Drosophila
    Nikolaos Doumpas
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Biol 11:104. 2013
    ..To test whether Wnt6 also contributes towards wing size regulation, we generated Wnt6 knockout flies...
  3. pmc Global view of the evolution and diversity of metazoan neuropeptide signaling
    Gaspar Jekely
    Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 110:8702-7. 2013
    ..The reconstruction of the neuropeptide-signaling repertoire at deep nodes of the animal phylogeny allowed the formulation of a testable scenario of the evolution of animal neuroendocrine systems...
  4. pmc Whole-body gene expression pattern registration in Platynereis larvae
    Albina Asadulina
    Max Planck Institute for Developmental Biology, Spemannstrasse 35, Tubingen, 72076, Germany
    Evodevo 3:27. 2012
    ..Recently a reference template with registered gene expression patterns has been generated for the anterior part (episphere) of the Platynereis trochophore larva and used for the detailed study of neuronal development...
  5. pmc Antibodies against conserved amidated neuropeptide epitopes enrich the comparative neurobiology toolbox
    Markus Conzelmann
    Max Planck Institute for Developmental Biology, Spemannstrasse 35, Tubingen 72076, Germany
    Evodevo 3:23. 2012
    ..These antibodies label respective neuron-populations and their axons and dendrites in a large number of species across various animal phyla...
  6. pmc Origin and early evolution of neural circuits for the control of ciliary locomotion
    Gaspar Jekely
    Max Planck Institute for Developmental Biology, Tubingen, Germany
    Proc Biol Sci 278:914-22. 2011
    ..The sensory-motor nervous systems of cnidarians and ciliated larvae of diverse phyla show that brains, like all biological structures, are not irreducibly complex...
  7. pmc Evolution of phototaxis
    Gaspar Jekely
    Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076 Tubingen, Germany
    Philos Trans R Soc Lond B Biol Sci 364:2795-808. 2009
    ..We can conclude that it is relatively easy to evolve phototaxis once cell polarity, ciliary swimming and a stable cell shape are present...
  8. doi request reprint Mechanism of phototaxis in marine zooplankton
    Gaspar Jekely
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany
    Nature 456:395-9. 2008
    ..We propose that the underlying direct coupling of light sensing and ciliary locomotor control was a principal feature of the proto-eye and an important landmark in the evolution of animal eyes...
  9. pmc Origin of the nucleus and Ran-dependent transport to safeguard ribosome biogenesis in a chimeric cell
    Gaspar Jekely
    Max Planck Institute for Developmental Biology, Spemannstrasse 35 72076 Tübingen, Germany
    Biol Direct 3:31. 2008
    ..Such an autogenous scenario is cell biologically feasible, but it is not clear what were the selective or neutral mechanisms that had led to the origin of the nuclear compartment...
  10. ncbi request reprint Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration
    Gaspar Jekely
    Developmental Biology Program, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Dev Cell 9:197-207. 2005
    ..Cbl and Sprint both regulate early steps of RTK endocytosis. Thus, a physiological role of RTK endocytosis is to ensure localized intracellular response to guidance cues by stimulating spatial restriction of signaling...
  11. pmc Neuropeptides regulate swimming depth of Platynereis larvae
    Markus Conzelmann
    Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 108:E1174-83. 2011
    ..We propose that the simple circuitry found in these ciliated larvae represents an ancestral state in nervous system evolution...
  12. pmc Conserved MIP receptor-ligand pair regulates Platynereis larval settlement
    Markus Conzelmann
    Max Planck Institute for Developmental Biology, 72076 Tuebingen, Germany
    Proc Natl Acad Sci U S A 110:8224-9. 2013
    ..We demonstrate by morpholino-mediated knockdown that MIP signals via this receptor to trigger settlement. These results reveal a role for a conserved MIP receptor-ligand pair in regulating marine annelid settlement...
  13. pmc The evolution of nervous system centralization
    Detlev Arendt
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany
    Philos Trans R Soc Lond B Biol Sci 363:1523-8. 2008
    ..This way, different aspects of the molecular architecture of the urbilaterian nervous system are reconstructed and yield insight into the degree of centralization that was in place in the bilaterian ancestors...
  14. pmc A serial multiplex immunogold labeling method for identifying peptidergic neurons in connectomes
    Reza Shahidi
    Max Planck Institute for Developmental Biology, Tubingen, Germany
    elife 4:. 2015
    ..Our approach enables the direct overlaying of chemical neuromodulatory maps onto synaptic connectomic maps in the study of nervous systems. ..
  15. pmc The neuropeptide complement of the marine annelid Platynereis dumerilii
    Markus Conzelmann
    Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076, Tubingen, Germany
    BMC Genomics 14:906. 2013
    ..Despite these advances, comprehensive peptidome resources have yet to be reported...
  16. pmc Expression dynamics and protein localization of rhabdomeric opsins in Platynereis larvae
    Nadine Randel
    Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076 Tuebingen, Germany
    Integr Comp Biol 53:7-16. 2013
    ....
  17. ncbi request reprint Origin of eukaryotic endomembranes: a critical evaluation of different model scenarios
    Gaspar Jekely
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Adv Exp Med Biol 607:38-51. 2007
    ..I argue that such models can best satisfy the major constraints of membrane topology, membrane heredity and straightforwardly account for selection pressures while being consistent with genomic findings...
  18. pmc Inter-individual stereotypy of the Platynereis larval visual connectome
    Nadine Randel
    Max Planck Institute for Developmental Biology, Tubingen, Germany
    elife 4:e08069. 2015
    ..Our work shows the extent to which the eye circuitry in Platynereis larvae is hard-wired. ..
  19. pmc Object-based representation and analysis of light and electron microscopic volume data using Blender
    Albina Asadulina
    Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076, Tubingen, Germany
    BMC Bioinformatics 16:229. 2015
    ..Complex electron microscopic reconstructions from large tissue volumes are also challenging to visualize and analyze...
  20. doi request reprint Spectral Tuning of Phototaxis by a Go-Opsin in the Rhabdomeric Eyes of Platynereis
    Martin Gühmann
    Max Planck Institute for Developmental Biology, Spemannstraße 35, 72076 Tubingen, Germany
    Curr Biol 25:2265-71. 2015
    ..Our results highlight spectral tuning of phototaxis as a potential mechanism contributing to opsin diversity...
  21. ncbi request reprint Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium
    Gaspar Jekely
    European Molecular Biology Laboratory, Heidelberg, Germany
    Bioessays 28:191-8. 2006
    ..We propose a scenario for how the initial membrane patch gradually protruded to enhance exposure to the environment, then started to move, and finally compartmentalised to render receptor signalling and ciliary beating more efficient...
  22. ncbi request reprint Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in bilateria
    Alexandru S Denes
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, 69117, Germany
    Cell 129:277-88. 2007
    ..Our data indicate that this mediolateral architecture was present in the last common bilaterian ancestor and thus support a common origin of nervous system centralization in Bilateria...
  23. ncbi request reprint Cellular resolution expression profiling using confocal detection of NBT/BCIP precipitate by reflection microscopy
    Gaspar Jekely
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    Biotechniques 42:751-5. 2007
    ..Whole-mount reflection CLSM will thus greatly facilitate large-scale cellular resolution expression profiling in vertebrate and invertebrate model organisms...
  24. pmc Deep transcriptome-sequencing and proteome analysis of the hydrothermal vent annelid Alvinella pompejana identifies the CvP-bias as a robust measure of eukaryotic thermostability
    Thomas Holder
    Max Planck Institute for Developmental Biology, Spemannstr, 35, Tubingen, D 72076, Germany
    Biol Direct 8:2. 2013
    ..A. pompejana is one of the most thermotolerant metazoans, making this animal a subject of great interest for studies of eukaryotic thermoadaptation...
  25. pmc Evolution in a nutshell. EMBL PhD student symposium on evolution
    Gaspar Jekely
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    EMBO Rep 3:307-11. 2002
  26. pmc Hrs mediates downregulation of multiple signalling receptors in Drosophila
    Gaspar Jekely
    European Molecular Biology Laboratory, Developmental Biology Program, Heidelberg, Germany
    EMBO Rep 4:1163-8. 2003
    ..Finally, most hrs-dependent receptor turnover appears to be ligand independent. Thus, both active and inactive signalling receptors are targeted for degradation in vivo and Hrs is required for their removal...
  27. doi request reprint Towards a systems-level understanding of development in the marine annelid Platynereis dumerilii
    Elizabeth A Williams
    Max Planck Institute for Developmental Biology, Spemannstraße 35, Tubingen D 72076, Germany
    Curr Opin Genet Dev 39:175-181. 2016
    ....
  28. pmc Think small
    Luis A Bezares-Calderón
    Max Planck Institute for Developmental Biology, Tubingen, Germany
    elife 5:. 2016
    ..The tadpole larva of a sea squirt is only the second animal to have its entire nervous system mapped out, and the results confirm that there is still much to learn from the smallest brains...
  29. pmc Phototaxis and the origin of visual eyes
    Nadine Randel
    Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076 Tubingen, Germany
    Philos Trans R Soc Lond B Biol Sci 371:20150042. 2016
    ..We propose that non-visual systems may have preceded visual phototactic systems in evolution that in turn may have repeatedly served as intermediates during the evolution of image-forming eyes. ..
  30. ncbi request reprint Small GTPases and the evolution of the eukaryotic cell
    Gaspar Jekely
    European Molecular Biology Laboratory, Developmental Biology, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Bioessays 25:1129-38. 2003
    ..Based on the reconstruction of putative roles for ancestral small GTPases, a hypothetical scenario on the origins of the first endomembranes, the nucleus, and phagocytosis is presented...