Sandra Goebbels

Summary

Affiliation: Max Planck Institute for Experimental Medicine
Country: Germany

Publications

  1. doi request reprint Neuron-glia signaling and the protection of axon function by Schwann cells
    Susanne Quintes
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    J Peripher Nerv Syst 15:10-6. 2010
  2. doi request reprint Elevated phosphatidylinositol 3,4,5-trisphosphate in glia triggers cell-autonomous membrane wrapping and myelination
    Sandra Goebbels
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany or
    J Neurosci 30:8953-64. 2010
  3. pmc Genetic disruption of Pten in a novel mouse model of tomaculous neuropathy
    Sandra Goebbels
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    EMBO Mol Med 4:486-99. 2012
  4. ncbi request reprint Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre mice
    Sandra Goebbels
    Max Planck Institute of Experimental Medicine, Goettingen, Germany
    Genesis 44:611-21. 2006
  5. doi request reprint Neuronal basic helix-loop-helix proteins Neurod2/6 regulate cortical commissure formation before midline interactions
    Ingo Bormuth
    Max Planck Institute of Experimental Medicine, Department of Neurogenetics, D 37075 Gottingen, Germany
    J Neurosci 33:641-51. 2013
  6. pmc Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue
    Nicolas Snaidero
    Max Planck Institute of Experimental Medicine, Cellular Neuroscience, Hermann Rein Strasse, 3, 37075 Gottingen, Germany Department of Neurology, University of Gottingen, Robert Koch Strasse, 40, 37075 Gottingen, Germany
    Cell 156:277-90. 2014
  7. doi request reprint Neuroinflammation in white matter tracts of Cnp1 mutant mice amplified by a minor brain injury
    Georg L Wieser
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075, Gottingen, Germany
    Glia 61:869-80. 2013
  8. doi request reprint In vivo imaging and noninvasive ablation of pyramidal neurons in adult NEX-CreERT2 mice
    Amit Agarwal
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Goettingen, Germany
    Cereb Cortex 22:1473-86. 2012
  9. pmc Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system
    Bastian G Brinkmann
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen 37075, Germany
    Neuron 59:581-95. 2008
  10. pmc Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
    Ursula Funfschilling
    Max Planck Institute of Experimental Medicine, Department of Neurogenetics, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    Nature 485:517-21. 2012

Collaborators

Detail Information

Publications17

  1. doi request reprint Neuron-glia signaling and the protection of axon function by Schwann cells
    Susanne Quintes
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    J Peripher Nerv Syst 15:10-6. 2010
    ..Understanding the cross talk between neurons and Schwann cells will help to further define the role of glia in preserving axonal integrity and to develop therapeutic strategies for peripheral neuropathies such as CMT1A...
  2. doi request reprint Elevated phosphatidylinositol 3,4,5-trisphosphate in glia triggers cell-autonomous membrane wrapping and myelination
    Sandra Goebbels
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany or
    J Neurosci 30:8953-64. 2010
    ..That myelin synthesis is not restricted to early development but can occur later in life is relevant to developmental disorders and myelin disease...
  3. pmc Genetic disruption of Pten in a novel mouse model of tomaculous neuropathy
    Sandra Goebbels
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    EMBO Mol Med 4:486-99. 2012
    ..We suggest that regions of non-compact myelin are under lifelong protection by PTEN against abnormal membrane outgrowth, and that dysregulated phosphoinositide levels play a critical role in the pathology of tomaculous neuropathies...
  4. ncbi request reprint Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre mice
    Sandra Goebbels
    Max Planck Institute of Experimental Medicine, Goettingen, Germany
    Genesis 44:611-21. 2006
    ..The NEX-Cre mouse will be a valuable tool for behavioral research and the conditional inactivation of target genes in pyramidal neurons of the dorsal telencephalon...
  5. doi request reprint Neuronal basic helix-loop-helix proteins Neurod2/6 regulate cortical commissure formation before midline interactions
    Ingo Bormuth
    Max Planck Institute of Experimental Medicine, Department of Neurogenetics, D 37075 Gottingen, Germany
    J Neurosci 33:641-51. 2013
    ..Our findings define a new stage in corpus callosum development and demonstrate that neocortical projection neurons require transcriptional specification by neuronal bHLH proteins to execute an intrinsic program of remote connectivity...
  6. pmc Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue
    Nicolas Snaidero
    Max Planck Institute of Experimental Medicine, Cellular Neuroscience, Hermann Rein Strasse, 3, 37075 Gottingen, Germany Department of Neurology, University of Gottingen, Robert Koch Strasse, 40, 37075 Gottingen, Germany
    Cell 156:277-90. 2014
    ..Our model can explain assembly of myelin as a multilayered structure, abnormal myelin outfoldings in neurological disease, and plasticity of myelin biogenesis observed in adult life...
  7. doi request reprint Neuroinflammation in white matter tracts of Cnp1 mutant mice amplified by a minor brain injury
    Georg L Wieser
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075, Gottingen, Germany
    Glia 61:869-80. 2013
    ..This interaction of genetic and environmental factors may be relevant for neuropsychiatric diseases associated with secondary neuroinflammation...
  8. doi request reprint In vivo imaging and noninvasive ablation of pyramidal neurons in adult NEX-CreERT2 mice
    Amit Agarwal
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Goettingen, Germany
    Cereb Cortex 22:1473-86. 2012
    ..This marks a striking difference from similar studies, in which dying oligodendrocytes failed to recruit cells of the adaptive immune system...
  9. pmc Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system
    Bastian G Brinkmann
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen 37075, Germany
    Neuron 59:581-95. 2008
    ..Thus, NRG1/ErbB signaling is markedly different between Schwann cells and oligodendrocytes that have evolved an NRG/ErbB-independent mechanism of myelination control...
  10. pmc Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
    Ursula Funfschilling
    Max Planck Institute of Experimental Medicine, Department of Neurogenetics, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    Nature 485:517-21. 2012
    ..Because myelinated axons can use lactate when energy-deprived, our findings suggest a model in which axon-glia metabolic coupling serves a physiological function...
  11. ncbi request reprint Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination
    Corinna Lappe-Siefke
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Goettingen, Germany
    Nat Genet 33:366-74. 2003
    ..Oligodendrocyte dysfunction, such as that in multiple sclerosis lesions, may suffice to cause secondary axonal loss...
  12. pmc Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development
    Hiroshi Kawabe
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Neuron 65:358-72. 2010
    ..We conclude that a Nedd4-1/Rap2A/TNIK signaling pathway regulates neurite growth and arborization in mammalian neurons...
  13. pmc Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction
    Julia Patzig
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen, Germany
    elife 5:. 2016
    ..We propose that pathological or aging-associated diminishment of the septin/anillin-scaffold causes myelin outfoldings that impair the normal nerve conduction velocity...
  14. ncbi request reprint Cre/loxP-mediated inactivation of the bHLH transcription factor gene NeuroD/BETA2
    Sandra Goebbels
    Max Planck Institute of Experimental Medicine, Goettingen, Germany
    Genesis 42:247-52. 2005
    ..The NeuroD(loxP) mouse mutant will be a valuable tool to study the developmental and adult function of NeuroD in nervous system and pancreas...
  15. ncbi request reprint Hippocampal cGMP-dependent protein kinase I supports an age- and protein synthesis-dependent component of long-term potentiation but is not essential for spatial reference and contextual memory
    Thomas Kleppisch
    Institut fur Pharmakologie und Toxikologie, 80802 Munchen, Germany, Max Planck Institut fur Psychiatrie, 80804 M√ľnchen, Germany
    J Neurosci 23:6005-12. 2003
    ..These results suggest that hippocampal cGKI supports an age- and protein synthesis-dependent form of hippocampal LTP, whereas it is dispensable for hippocampus-dependent spatial reference and contextual memory...
  16. pmc A myelin gene causative of a catatonia-depression syndrome upon aging
    Nora Hagemeyer
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    EMBO Mol Med 4:528-39. 2012
    ..Analogously, in man, diffusion tensor imaging points to axonal loss in the frontal corpus callosum. To conclude, subtle white matter abnormalities inducing neurodegenerative changes can cause/amplify psychiatric diseases...
  17. doi request reprint Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in mice
    Siv Vingill
    Cellular and Molecular Neurobiology, Max Planck Institute of Experimental Medicine, G ttingen, Germany Neuroscience, International Max Planck Research School, G ttingen, Germany
    EMBO J 35:2008-25. 2016
    ..Taken together, our study establishes a vital role for FBXO7 in neurons, which is required for proper motor control and accentuates the importance of FBXO7 in proteasome function...