Genomes and Genes
Affiliation: Max Planck Institute for Experimental Medicine
- Neuron-glia signaling and the protection of axon function by Schwann cellsSusanne Quintes
Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Gottingen, Germany
J Peripher Nerv Syst 15:10-6. 2010..Understanding the cross talk between neurons and Schwann cells will help to further define the role of glia in preserving axonal integrity and to develop therapeutic strategies for peripheral neuropathies such as CMT1A...
- Elevated phosphatidylinositol 3,4,5-trisphosphate in glia triggers cell-autonomous membrane wrapping and myelinationSandra Goebbels
Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany or
J Neurosci 30:8953-64. 2010..That myelin synthesis is not restricted to early development but can occur later in life is relevant to developmental disorders and myelin disease...
- Genetic disruption of Pten in a novel mouse model of tomaculous neuropathySandra Goebbels
Max Planck Institute of Experimental Medicine, Gottingen, Germany
EMBO Mol Med 4:486-99. 2012..We suggest that regions of non-compact myelin are under lifelong protection by PTEN against abnormal membrane outgrowth, and that dysregulated phosphoinositide levels play a critical role in the pathology of tomaculous neuropathies...
- Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre miceSandra Goebbels
Max Planck Institute of Experimental Medicine, Goettingen, Germany
Genesis 44:611-21. 2006..The NEX-Cre mouse will be a valuable tool for behavioral research and the conditional inactivation of target genes in pyramidal neurons of the dorsal telencephalon...
- Neuronal basic helix-loop-helix proteins Neurod2/6 regulate cortical commissure formation before midline interactionsIngo Bormuth
Max Planck Institute of Experimental Medicine, Department of Neurogenetics, D 37075 Gottingen, Germany
J Neurosci 33:641-51. 2013..Our findings define a new stage in corpus callosum development and demonstrate that neocortical projection neurons require transcriptional specification by neuronal bHLH proteins to execute an intrinsic program of remote connectivity...
- Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongueNicolas Snaidero
Max Planck Institute of Experimental Medicine, Cellular Neuroscience, Hermann Rein Strasse, 3, 37075 Gottingen, Germany Department of Neurology, University of Gottingen, Robert Koch Strasse, 40, 37075 Gottingen, Germany
Cell 156:277-90. 2014..Our model can explain assembly of myelin as a multilayered structure, abnormal myelin outfoldings in neurological disease, and plasticity of myelin biogenesis observed in adult life...
- Neuroinflammation in white matter tracts of Cnp1 mutant mice amplified by a minor brain injuryGeorg L Wieser
Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075, Gottingen, Germany
Glia 61:869-80. 2013..This interaction of genetic and environmental factors may be relevant for neuropsychiatric diseases associated with secondary neuroinflammation...
- In vivo imaging and noninvasive ablation of pyramidal neurons in adult NEX-CreERT2 miceAmit Agarwal
Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Goettingen, Germany
Cereb Cortex 22:1473-86. 2012..This marks a striking difference from similar studies, in which dying oligodendrocytes failed to recruit cells of the adaptive immune system...
- Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous systemBastian G Brinkmann
Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen 37075, Germany
Neuron 59:581-95. 2008..Thus, NRG1/ErbB signaling is markedly different between Schwann cells and oligodendrocytes that have evolved an NRG/ErbB-independent mechanism of myelination control...
- Glycolytic oligodendrocytes maintain myelin and long-term axonal integrityUrsula Funfschilling
Max Planck Institute of Experimental Medicine, Department of Neurogenetics, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
Nature 485:517-21. 2012..Because myelinated axons can use lactate when energy-deprived, our findings suggest a model in which axon-glia metabolic coupling serves a physiological function...
- Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelinationCorinna Lappe-Siefke
Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Goettingen, Germany
Nat Genet 33:366-74. 2003..Oligodendrocyte dysfunction, such as that in multiple sclerosis lesions, may suffice to cause secondary axonal loss...
- Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite developmentHiroshi Kawabe
Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
Neuron 65:358-72. 2010..We conclude that a Nedd4-1/Rap2A/TNIK signaling pathway regulates neurite growth and arborization in mammalian neurons...
- Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conductionJulia Patzig
Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen, Germany
elife 5:. 2016..We propose that pathological or aging-associated diminishment of the septin/anillin-scaffold causes myelin outfoldings that impair the normal nerve conduction velocity...
- Cre/loxP-mediated inactivation of the bHLH transcription factor gene NeuroD/BETA2Sandra Goebbels
Max Planck Institute of Experimental Medicine, Goettingen, Germany
Genesis 42:247-52. 2005..The NeuroD(loxP) mouse mutant will be a valuable tool to study the developmental and adult function of NeuroD in nervous system and pancreas...
- Hippocampal cGMP-dependent protein kinase I supports an age- and protein synthesis-dependent component of long-term potentiation but is not essential for spatial reference and contextual memoryThomas Kleppisch
Institut fur Pharmakologie und Toxikologie, 80802 Munchen, Germany, Max Planck Institut fur Psychiatrie, 80804 München, Germany
J Neurosci 23:6005-12. 2003..These results suggest that hippocampal cGKI supports an age- and protein synthesis-dependent form of hippocampal LTP, whereas it is dispensable for hippocampus-dependent spatial reference and contextual memory...
- A myelin gene causative of a catatonia-depression syndrome upon agingNora Hagemeyer
Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
EMBO Mol Med 4:528-39. 2012..Analogously, in man, diffusion tensor imaging points to axonal loss in the frontal corpus callosum. To conclude, subtle white matter abnormalities inducing neurodegenerative changes can cause/amplify psychiatric diseases...
- Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in miceSiv Vingill
Cellular and Molecular Neurobiology, Max Planck Institute of Experimental Medicine, G ttingen, Germany Neuroscience, International Max Planck Research School, G ttingen, Germany
EMBO J 35:2008-25. 2016..Taken together, our study establishes a vital role for FBXO7 in neurons, which is required for proper motor control and accentuates the importance of FBXO7 in proteasome function...