Angelika Erhardt

Summary

Affiliation: Max Planck Institute of Psychiatry
Country: Germany

Publications

  1. doi request reprint Translational approaches to anxiety: focus on genetics, fear extinction and brain imaging
    Angelika Erhardt
    Max Planck Institute for Psychiatry, Kraepelinstr 2 10, 80804, Munich, Germany
    Curr Psychiatry Rep 15:417. 2013
  2. pmc Replication and meta-analysis of TMEM132D gene variants in panic disorder
    A Erhardt
    Max Planck Institute of Psychiatry, Munich, Germany
    Transl Psychiatry 2:e156. 2012
  3. doi request reprint TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies
    A Erhardt
    Max Planck Institute of Psychiatry, Munchen, Germany
    Mol Psychiatry 16:647-63. 2011
  4. doi request reprint Consequences of chronic social stress on behaviour and vasopressin gene expression in the PVN of DBA/2OlaHsd mice--influence of treatment with the CRHR1-antagonist R121919/NBI 30775
    A Erhardt
    MD Max Planck Institute of Psychiatry, Munich, Germany
    J Psychopharmacol 23:31-9. 2009
  5. ncbi request reprint Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders
    Angelika Erhardt
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804 München, Germany
    J Affect Disord 101:159-68. 2007
  6. pmc Gender-specific association of galanin polymorphisms with HPA-axis dysregulation, symptom severity, and antidepressant treatment response
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Munchen, Germany
    Neuropsychopharmacology 35:1583-92. 2010
  7. ncbi request reprint Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 München, Germany
    J Affect Disord 105:177-84. 2008
  8. ncbi request reprint Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Munchen, Germany
    Am J Med Genet B Neuropsychiatr Genet 144:424-9. 2007
  9. doi request reprint Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder
    Martin E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:1196-204. 2008
  10. doi request reprint Rare variants in TMEM132D in a case-control sample for panic disorder
    Carina Quast
    Max Planck Institute of Psychiatry, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 159:896-907. 2012

Detail Information

Publications27

  1. doi request reprint Translational approaches to anxiety: focus on genetics, fear extinction and brain imaging
    Angelika Erhardt
    Max Planck Institute for Psychiatry, Kraepelinstr 2 10, 80804, Munich, Germany
    Curr Psychiatry Rep 15:417. 2013
    ..Finally, connecting genetic and epigenetic data with functionally relevant imaging readouts will allow a comparison of overlap and differences across species in mechanistic pathways from genes to brain functioning and behaviour. ..
  2. pmc Replication and meta-analysis of TMEM132D gene variants in panic disorder
    A Erhardt
    Max Planck Institute of Psychiatry, Munich, Germany
    Transl Psychiatry 2:e156. 2012
    ..Our results also indicate that patient ascertainment and genetic background could be important sources of heterogeneity modifying this association signal in different populations...
  3. doi request reprint TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies
    A Erhardt
    Max Planck Institute of Psychiatry, Munchen, Germany
    Mol Psychiatry 16:647-63. 2011
    ..TMEM132D may thus be an important new candidate gene for PD as well as more generally for anxiety-related behavior...
  4. doi request reprint Consequences of chronic social stress on behaviour and vasopressin gene expression in the PVN of DBA/2OlaHsd mice--influence of treatment with the CRHR1-antagonist R121919/NBI 30775
    A Erhardt
    MD Max Planck Institute of Psychiatry, Munich, Germany
    J Psychopharmacol 23:31-9. 2009
    ....
  5. ncbi request reprint Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders
    Angelika Erhardt
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804 München, Germany
    J Affect Disord 101:159-68. 2007
    ..This region contains two candidate genes for purinergic ligand-gated ion channels, P2RX7 and P2RX4, and one gene coding for calmodulin-dependent protein kinase kinase b (CaMKKb)...
  6. pmc Gender-specific association of galanin polymorphisms with HPA-axis dysregulation, symptom severity, and antidepressant treatment response
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Munchen, Germany
    Neuropsychopharmacology 35:1583-92. 2010
    ..The reported associations in independent samples of AD and MDD support an estrogen-dependent function of GAL in pathophysiology of anxiety and depression, affecting response to antidepressant treatment...
  7. ncbi request reprint Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 München, Germany
    J Affect Disord 105:177-84. 2008
    ..Furthermore, GAL is involved in hypothalamic-hypophysiotropic signalling and cosecreted with luteinizing hormone-releasing hormone (LHRH), possibly acting as a mediator of estrogen action...
  8. ncbi request reprint Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Munchen, Germany
    Am J Med Genet B Neuropsychiatr Genet 144:424-9. 2007
    ..These results further underline a possible important role of genetic variations within the system controlling serotonergic neurotransmission for the development and course of disease in PD...
  9. doi request reprint Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder
    Martin E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:1196-204. 2008
    ..These data suggest that polymorphisms in the AVPR1B and the CRHR1 genes alter the susceptibility to panic disorder...
  10. doi request reprint Rare variants in TMEM132D in a case-control sample for panic disorder
    Carina Quast
    Max Planck Institute of Psychiatry, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 159:896-907. 2012
    ..Our data suggest that not only common but also putatively functional and/or rare variants within TMEM132D might contribute to the risk to develop anxiety disorders...
  11. ncbi request reprint Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks
    Christoph K Thoeringer
    Max Planck Institute of Psychiatry, Munich 80804, Germany
    J Psychiatr Res 41:579-84. 2007
    ..43; 95% CI: 0.19-0.95). In conclusion, these results suggest a central role of DBI genetic variants in the susceptibility for the development of anxiety disorders that are characterized by the occurrence of panic attacks...
  12. ncbi request reprint Regulation of the hypothalamic-pituitary-adrenocortical system in patients with panic disorder
    Angelika Erhardt
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 31:2515-22. 2006
    ..However, differences in the suppression effects and psychopathological correlation patterns between depressed and panic patients suggest different biological mechanisms of HPA system dysregulation in both disorders...
  13. doi request reprint Polymorphisms in the GAD2 gene-region are associated with susceptibility for unipolar depression and with a risk factor for anxiety disorders
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Munchen, Germany
    Am J Med Genet B Neuropsychiatr Genet 150:1100-9. 2009
    ..However, data from expression studies imply that these polymorphisms could tag functional effects on the neighboring gene MYO3A, which is also expressed in the brain, including the cingulate cortex and the amygdala...
  14. ncbi request reprint The temporal dynamics of intrahippocampal corticosterone in response to stress-related stimuli with different emotional and physical load: an in vivo microdialysis study in C57BL/6 and DBA/2 inbred mice
    Christoph K Thoeringer
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 32:746-57. 2007
    ..In addition, our study highlights the use of in vivo microdialysis to assess the neuroendocrine endophenotype of animal models via profiling of stimulus-response patterns of stress hormones...
  15. pmc Functional coding variants in SLC6A15, a possible risk gene for major depression
    Carina Quast
    Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 8:e68645. 2013
    ..As statistically significant association for rare variants might only be achieved in extremely large samples (N >70,000) functional exploration may shed light on putatively disease-relevant variants...
  16. ncbi request reprint Association between genes on chromosome 19p13.2 and panic disorder
    Noomi O Gregersen
    aTranslational Neuropsychiatry Unit, Department of Clinical Medicine bDepartment of Biomedicine, Centre for Integrative Sequencing iSEQ, Aarhus University cThe Lundbeck Foundation Initiative for Integrative Psychiatric Research iPSYCH, Aarhus dAmplexa Genetics A S eDepartment of Clinical Genetics, University of Southern Denmark, Odense fPsychosis Research Unit, Aarhus University Hospital, Risskov gLaboratory of Neural Plasticity, Department of Neuroscience and Pharmacology, University of Copenhagen hCentre of Psychiatry Amager, Copenhagen University Hospital, Copenhagen, Denmark iDepartment of Psychiatry, The National Hospital, The Faroe Islands jDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
    Psychiatr Genet 26:287-292. 2016
    ..We show that associated variants may be sex specific, indicating the importance of carrying out a sex-specific association analysis of PD...
  17. doi request reprint Polymorphisms in the angiotensin-converting enzyme gene region predict coping styles in healthy adults and depressed patients
    Angela Heck
    Max Planck Institute of Psychiatry, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 150:104-14. 2009
    ..These results suggest that the ACE gene is involved in the development of coping strategies...
  18. pmc Unstable prefrontal response to emotional conflict and activation of lower limbic structures and brainstem in remitted panic disorder
    Natalya Chechko
    Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 4:e5537. 2009
    ..Higher sensitivity of patients to unspecific fear cues and similarities to conditioned fear suggest involvement of lower limbic and brainstem structures. We investigated if emotion perception is altered in remitted PD as a trait feature...
  19. ncbi request reprint Unstable prefrontal response to emotional conflict and activation of lower limbic structures and brainstem in remitted panic disorder
    Natalya Chechko
    Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 4:e5537. 2009
    ..Processing of non-panic related emotional stimuli is disturbed in PD patients despite clinical remission...
  20. ncbi request reprint Protein biomarkers in a mouse model of extremes in trait anxiety
    Claudia Ditzen
    Max Planck Institute of Psychiatry, D 80804 Munich, Germany
    Mol Cell Proteomics 5:1914-20. 2006
    ..The presence of both protein markers in red or white blood cells, respectively, creates the opportunity to screen for their expression in clinical blood specimens from patients suffering from anxiety...
  21. ncbi request reprint Temazepam triggers the release of vasopressin into the rat hypothalamic paraventricular nucleus: novel insight into benzodiazepine action on hypothalamic-pituitary-adrenocortical system activity during stress
    Tobias Welt
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 31:2573-9. 2006
    ..An increasingly released AVP of magnocellular origin seems to provide a negative tonus on ACTH secretion most probably via inhibiting the release of ACTH secretagogues from the median eminence into hypophyseal portal blood...
  22. ncbi request reprint Stress response regulation in panic disorder
    Marcus Ising
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Curr Pharm Des 18:5675-84. 2012
    ....
  23. doi request reprint Gender-specific association of variants in the AKR1C1 gene with dimensional anxiety in patients with panic disorder: additional evidence for the importance of neurosteroids in anxiety?
    Carina Quast
    Max Planck Institute of Psychiatry, Munich, Germany
    Depress Anxiety 31:843-50. 2014
    ..However, little is known about the contribution of genetic variants in genes relevant for the neurosteroidogenesis to anxiety disorders...
  24. doi request reprint Are TMEM genes potential candidate genes for panic disorder?
    Noomi O Gregersen
    aTranslational Neuropsychiatry Unit, Department of Clinical Medicine bDepartment of Biomedicine and Centre for Integrative Sequencing iSEQ, Aarhus University cThe Lundbeck Foundation Initiative for Integrative Psychiatric Research iPSYCH dResearch Department P, Aarhus University Hospital, Risskov eAmplexa Genetics A S fDepartment of Clinical Genetics, University of Southern Denmark, Odense gLaboratory of Neuropsychiatry, University of Copenhagen hDepartment of Psychiatry, HS Amager Hospital, Copenhagen University Hospital, Copenhagen, Denmark iDepartment of Psychiatry, The National Hospital, Torshavn, Faroe Islands jMax Planck Institute of Psychiatry, Munich, Germany
    Psychiatr Genet 24:37-41. 2014
    ..No nominal significant associations were observed between TMEM98 and PD. Our data indicate that TMEM132E might contribute moderately towards the risk of developing PD. ..
  25. pmc Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling
    Anthony S Zannas
    Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
    Genome Biol 16:266. 2015
    ..Chronic psychological stress is associated with accelerated aging and increased risk for aging-related diseases, but the underlying molecular mechanisms are unclear...
  26. pmc Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders
    Janine Arloth
    Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich 80804, Germany
    Neuron 86:1189-202. 2015
    ....
  27. ncbi request reprint Chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation: effects on stress hormone levels and adult hippocampal neurogenesis
    Boldizsar Czeh
    The German Primate Center, Division of Neurobiology, Gottingen, Germany
    Biol Psychiatry 52:1057-65. 2002
    ..The present study investigated the effect of chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation treatment on stress hormone regulation and hippocampal neurogenesis...