Genomes and Genes
Richard M Clark
Affiliation: Max Planck Institute for Biological Cybernetics
- Estimating a nucleotide substitution rate for maize from polymorphism at a major domestication locusRichard M Clark
Laboratory of Genetics, University of Wisconsin, USA
Mol Biol Evol 22:2304-12. 2005..We use rate estimates from the tb1 region to estimate the timing of expansion of transposable elements in the maize genome and suggest that this expansion occurred primarily within the last million years...
- A distant upstream enhancer at the maize domestication gene tb1 has pleiotropic effects on plant and inflorescent architectureRichard M Clark
Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA
Nat Genet 38:594-7. 2006..Our findings show that the large stretches of noncoding DNA that comprise the majority of many plant genomes can be a source of variation affecting gene expression and quantitative phenotypes...
- Major regulatory genes in maize contribute to standing variation in teosinte (Zea mays ssp. parviglumis)Allison Weber
Laboratory of Genetics, University of Wisconsin, Madison 53706, USA
Genetics 177:2349-59. 2007..Our data suggest that major regulatory genes in maize do play a role in the natural variation for complex traits in teosinte and that some of the minor variants we identified may have been targets of selection during domestication...
- Pattern of diversity in the genomic region near the maize domestication gene tb1Richard M Clark
Laboratory of Genetics, University of Wisconsin, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 101:700-7. 2004....
- The ABCG5 polymorphism contributes to individual responses to dietary cholesterol and carotenoids in eggsKristin L Herron
Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA
J Nutr 136:1161-5. 2006..These results, although obtained from a small number of subjects, suggest that the ABCG5 polymorphism may play a role in the plasma response to dietary cholesterol and carotenoids...
- Common sequence polymorphisms shaping genetic diversity in Arabidopsis thalianaRichard M Clark
Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
Science 317:338-42. 2007..Analyzing the polymorphisms we describe in larger sets of accessions will enable a detailed understanding of forces shaping population-wide sequence variation in A. thaliana...
- The evolution of selfing in Arabidopsis thalianaChunlao Tang
Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA
Science 317:1070-2. 2007..An analysis of the genome-wide pattern of linkage disequilibrium suggests that selfing most likely evolved roughly a million years ago or more...
- Detecting polymorphic regions in Arabidopsis thaliana with resequencing microarraysGeorg Zeller
Friedrich Miescher Laboratory of the Max Planck Society, Tübingen 72070, Germany
Genome Res 18:918-29. 2008..thaliana, and our method is applicable to similar data sets in other species. More broadly, our computational approach can be applied to other segmentation tasks related to the analysis of genomic variation...