Rudolf Martini

Summary

Country: Germany

Publications

  1. pmc Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse
    Chi Wang Ip
    Department of Neurology, Section of Developmental Neurobiology, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 7:e42554. 2012
  2. ncbi request reprint Macrophage colony stimulating factor is a crucial factor for the intrinsic macrophage response in mice heterozygously deficient for the myelin protein P0
    Marcus Müller
    Department of Neurology, University of Munster, Albert Schweitzer Str 33, D 48129 Munster, Germany
    Exp Neurol 203:55-62. 2007
  3. doi request reprint Tacrolimus (FK506) causes disease aggravation in models for inherited peripheral myelinopathies
    Chi Wang Ip
    Department of Neurology, Developmental Neurobiology, University of Wuerzburg, Josef Schneider Str 11, D 97080 Wuerzburg, Germany
    Neurobiol Dis 33:207-12. 2009
  4. ncbi request reprint Neuroprotective effect of the immune system in a mouse model of severe dysmyelinating hereditary neuropathy: enhanced axonal degeneration following disruption of the RAG-1 gene
    Martin Berghoff
    Section of Developmental Neurobiology, Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    Mol Cell Neurosci 28:118-27. 2005
  5. pmc PD-1 regulates neural damage in oligodendroglia-induced inflammation
    Antje Kroner
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    PLoS ONE 4:e4405. 2009
  6. ncbi request reprint Role of immune cells in animal models for inherited peripheral neuropathies
    Chi Wang Ip
    Department of Neurology, Developmental Neurobiology, University of Wuerzburg, Josef Schneider Str 11, D 97080 Wuerzburg, Germany
    Neuromolecular Med 8:175-90. 2006
  7. ncbi request reprint Monocyte chemoattractant protein-1 is a pathogenic component in a model for a hereditary peripheral neuropathy
    Stefan Fischer
    Department of Neurology, Developmental Neurobiology, University of Wuerzburg, Wuerzburg, Germany
    Mol Cell Neurosci 37:359-66. 2008
  8. doi request reprint Lack of evidence for a pathogenic role of T-lymphocytes in an animal model for Charcot-Marie-Tooth disease 1A
    Bianca Kohl
    Department of Neurology, Section of Developmental Neurobiology, University of Wuerzburg, Josef Schneider Strasse 11, D 97080 Wuerzburg, Germany
    Neurobiol Dis 38:78-84. 2010
  9. ncbi request reprint Visualization of degenerating axons in a dysmyelinating mouse mutant with axonal loss
    Birgit Ey
    Department of Neurology, Developmental Neurobiology, University of Wuerzburg, Josef Schneiderstr 11, D 97080 Wuerzburg, Germany
    Mol Cell Neurosci 35:153-60. 2007
  10. ncbi request reprint Attenuated demyelination in the absence of the macrophage-restricted adhesion molecule sialoadhesin (Siglec-1) in mice heterozygously deficient in P0
    Igor Kobsar
    Department of Neurology, Developmental Neurobiology, University of Wuerzburg, Josef Schneider Str 11, D 97080 Wuerzburg, Germany
    Mol Cell Neurosci 31:685-91. 2006

Collaborators

Detail Information

Publications33

  1. pmc Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse
    Chi Wang Ip
    Department of Neurology, Section of Developmental Neurobiology, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 7:e42554. 2012
    ..Based on our observations, so far not attended molecular and cellular players belonging to the immune system should be considered to understand pathogenesis in inherited myelin disorders with progressive axonal damage...
  2. ncbi request reprint Macrophage colony stimulating factor is a crucial factor for the intrinsic macrophage response in mice heterozygously deficient for the myelin protein P0
    Marcus Müller
    Department of Neurology, University of Munster, Albert Schweitzer Str 33, D 48129 Munster, Germany
    Exp Neurol 203:55-62. 2007
    ..M-CSF is, therefore, considered as a target candidate for therapeutic strategies to treat human demyelinating neuropathies...
  3. doi request reprint Tacrolimus (FK506) causes disease aggravation in models for inherited peripheral myelinopathies
    Chi Wang Ip
    Department of Neurology, Developmental Neurobiology, University of Wuerzburg, Josef Schneider Str 11, D 97080 Wuerzburg, Germany
    Neurobiol Dis 33:207-12. 2009
    ..Furthermore, when used as an immunosuppressant, the drug may generate detrimental neurological side effects in patients with an additional hereditary neuropathy...
  4. ncbi request reprint Neuroprotective effect of the immune system in a mouse model of severe dysmyelinating hereditary neuropathy: enhanced axonal degeneration following disruption of the RAG-1 gene
    Martin Berghoff
    Section of Developmental Neurobiology, Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    Mol Cell Neurosci 28:118-27. 2005
    ..These data suggest a neuroprotective net effect of T-lymphocytes on axon survival in inherited, early onset dysmyelination...
  5. pmc PD-1 regulates neural damage in oligodendroglia-induced inflammation
    Antje Kroner
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    PLoS ONE 4:e4405. 2009
    ..Our finding may have implications for understanding the mechanisms leading to the high clinical variability of polygenic or even monogenic disorders of the nervous system...
  6. ncbi request reprint Role of immune cells in animal models for inherited peripheral neuropathies
    Chi Wang Ip
    Department of Neurology, Developmental Neurobiology, University of Wuerzburg, Josef Schneider Str 11, D 97080 Wuerzburg, Germany
    Neuromolecular Med 8:175-90. 2006
    ..In the present review, we discuss the influence of the immune system on inherited de- and dysmyelination regarding disease mechanisms and possible clinical implications...
  7. ncbi request reprint Monocyte chemoattractant protein-1 is a pathogenic component in a model for a hereditary peripheral neuropathy
    Stefan Fischer
    Department of Neurology, Developmental Neurobiology, University of Wuerzburg, Wuerzburg, Germany
    Mol Cell Neurosci 37:359-66. 2008
    ..Our findings show that reducing but not eliminating chemokine expression can rescue genetically caused demyelination that may be an interesting target in treating demyelinating diseases of the peripheral nervous system...
  8. doi request reprint Lack of evidence for a pathogenic role of T-lymphocytes in an animal model for Charcot-Marie-Tooth disease 1A
    Bianca Kohl
    Department of Neurology, Section of Developmental Neurobiology, University of Wuerzburg, Josef Schneider Strasse 11, D 97080 Wuerzburg, Germany
    Neurobiol Dis 38:78-84. 2010
    ..We suggest that - in contrast to myelin phagocytosing macrophages - T-lymphocytes are not a promising target for treatment of CMT1A...
  9. ncbi request reprint Visualization of degenerating axons in a dysmyelinating mouse mutant with axonal loss
    Birgit Ey
    Department of Neurology, Developmental Neurobiology, University of Wuerzburg, Josef Schneiderstr 11, D 97080 Wuerzburg, Germany
    Mol Cell Neurosci 35:153-60. 2007
    ....
  10. ncbi request reprint Attenuated demyelination in the absence of the macrophage-restricted adhesion molecule sialoadhesin (Siglec-1) in mice heterozygously deficient in P0
    Igor Kobsar
    Department of Neurology, Developmental Neurobiology, University of Wuerzburg, Josef Schneider Str 11, D 97080 Wuerzburg, Germany
    Mol Cell Neurosci 31:685-91. 2006
    ..Our findings are potentially important in the development of future treatment strategies for inherited demyelinating neuropathies...
  11. doi request reprint Attenuation of MCP-1/CCL2 expression ameliorates neuropathy in a mouse model for Charcot-Marie-Tooth 1X
    Janos Groh
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    Hum Mol Genet 19:3530-43. 2010
    ..Thus, attenuation of MCP-1 upregulation by inhibiting ERK phosphorylation might be a promising approach to treat CMT1X and other so far untreatable inherited peripheral neuropathies in humans...
  12. doi request reprint Origin of CD11b+ macrophage-like cells in the CNS of PLP-overexpressing mice: low influx of haematogenous macrophages and unchanged blood-brain-barrier in the optic nerve
    Chi Wang Ip
    Department of Neurology, Developmental Neurobiology, University of Wuerzburg, Josef Schneider Str 11, D 97080 Wuerzburg, Germany
    Mol Cell Neurosci 38:489-94. 2008
    ..Our study demonstrates an intrinsic origin of CD11b+ cells in the presence of an unchanged blood-brain-barrier in a CNS myelin mutant...
  13. pmc Ectopic T-cell specificity and absence of perforin and granzyme B alleviate neural damage in oligodendrocyte mutant mice
    Antje Kroner
    Department of Neurology, Section of Developmental Neurobiology, University of Wuerzburg, Josef Schneider Str 11, D 97080 Wuerzburg, Germany
    Am J Pathol 176:549-55. 2010
    ..These findings have high relevance with regard to our understanding of the pathogenesis of disorders primarily caused by genetically mediated oligodendropathy...
  14. doi request reprint The alpha-chemokine CXCL14 is up-regulated in the sciatic nerve of a mouse model of Charcot-Marie-Tooth disease type 1A and alters myelin gene expression in cultured Schwann cells
    Elena M Barbaria
    Molecular Neurobiology Laboratory, Department of Neurology, Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Neurobiol Dis 33:448-58. 2009
    ..Our findings demonstrate that early overexpression of PMP22, in a mouse model of CMT1A, results in a strong up-regulation of CXCL14, which seems to play a novel regulatory role in Schwann cell differentiation...
  15. ncbi request reprint Sialoadhesin deficiency ameliorates myelin degeneration and axonopathic changes in the CNS of PLP overexpressing mice
    Chi Wang Ip
    Department of Neurology, Section of Developmental Neurobiology, University of Wuerzburg, Josef Schneider Str 11, D 97080 Wuerzburg, Germany
    Neurobiol Dis 25:105-11. 2007
    ..These findings may have substantial impact on treatment strategies for leukodystrophic disorders and some forms of multiple sclerosis...
  16. ncbi request reprint Evidence for macrophage-mediated myelin disruption in an animal model for Charcot-Marie-Tooth neuropathy type 1A
    Igor Kobsar
    Developmental Neurobiology, Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Neurosci Res 81:857-64. 2005
    ....
  17. pmc Accelerated course of experimental autoimmune encephalomyelitis in PD-1-deficient central nervous system myelin mutants
    Antje Kroner
    Clinical Research Group for MS and Neuroimmunology, Department of Neurology, University of Wuerzburg, Josef Schneider Strasse 11, 97080 Wuerzburg, Germany
    Am J Pathol 174:2290-9. 2009
    ....
  18. ncbi request reprint Heterozygous P0 deficiency protects mice from vincristine-induced polyneuropathy
    Nurcan Uceyler
    Department of Neurology, Julius Maximilians Universitat, Wurzburg, Germany
    J Neurosci Res 84:37-46. 2006
    ..Thus, the P0(+/-) phenotype seems to be protected against VIN-induced neuropathy. The mechanism of this neuroprotection remains elusive...
  19. doi request reprint Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease
    Rudolf Martini
    Department of Neurology, Developmental Neurobiology, University of Wuerzburg, Josef Schneider Strabetae 11, Wuerzburg, Germany
    Glia 56:1566-77. 2008
    ..Knowledge of the molecular mechanisms underlying Schwann cell-macrophage interaction under pathological conditions is an important prerequisite to develop effective treatment strategies for various peripheral nerve disorders...
  20. ncbi request reprint Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes
    Chi Wang Ip
    Department of Neurology, University of Wuerzburg, D 97080 Wuerzburg, Germany
    J Neurosci 26:8206-16. 2006
    ..These findings provide strong evidence that a primary glial damage can cause secondary immune reactions of pathological significance as it has been suggested for some forms of multiple sclerosis and other leukodystrophies...
  21. ncbi request reprint Origin of pathogenic macrophages and endoneurial fibroblast-like cells in an animal model of inherited neuropathy
    Mathias Maurer
    Department of Neurology, Bayerische Julius Maximilians Universität Würzburg, D 97080 Wurzburg, Germany
    Mol Cell Neurosci 23:351-9. 2003
    ..These blood-borne fibroblast-like cells express the common hematopoetic stem cell marker CD34 and might comprise another cell type of potential importance for immune regulation in hereditary demyelinating neuropathies...
  22. doi request reprint Increase of MCP-1 (CCL2) in myelin mutant Schwann cells is mediated by MEK-ERK signaling pathway
    Stefan Fischer
    Department of Neurology, Developmental Neurobiology, University of Wuerzburg, Wuerzburg, Germany
    Glia 56:836-43. 2008
    ..These findings may have important implications for the treatment of inherited peripheral neuropathies in humans...
  23. doi request reprint Similarities between inherited demyelinating neuropathies and Wallerian degeneration: an old repair program may cause myelin and axon perturbation under nonlesion conditions
    Rudolf Martini
    Section of Developmental Neurobiology, Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Am J Pathol 183:655-60. 2013
    ..These novel insights into the pathogenesis of CMT1 might be instrumental for the development of new therapeutic options in humans. ..
  24. pmc Colony-stimulating factor-1 mediates macrophage-related neural damage in a model for Charcot-Marie-Tooth disease type 1X
    Janos Groh
    Department of Neurology, Section of Developmental Neurobiology, University of Wurzburg, Josef Schneiderstr 11, 97080 Wurzburg, Germany
    Brain 135:88-104. 2012
    ..Thus, colony-stimulating factor-1 or its cognate receptor are promising target molecules for treating the detrimental, low-grade inflammation of several inherited neuropathies in humans...
  25. doi request reprint Immune cells perturb axons and impair neuronal survival in a mouse model of infantile neuronal ceroid lipofuscinosis
    Janos Groh
    Department of Neurology, Developmental Neurobiology, Josef Schneider Str 11, D 97080 Wuerzburg, Germany
    Brain 136:1083-101. 2013
    ..Finally, reconstitution experiments revealed a crucial role of CD8+ T-lymphocytes in pathogenesis. Our study provides novel pathomechanistic insights that may be crucial for developing treatment strategies...
  26. ncbi request reprint Immune-mediated components of hereditary demyelinating neuropathies: lessons from animal models and patients
    Rudolf Martini
    Department of Neurology, University of Wuerzburg, Germany
    Lancet Neurol 3:457-65. 2004
    ..We conclude that in patients with typical CMT1 and in animal models, a cryptic and mild inflammatory process not responsive to standard anti-inflammatory treatment fosters genetically mediated demyelination...
  27. ncbi request reprint Triple knock-out of CNTF, LIF, and CT-1 defines cooperative and distinct roles of these neurotrophic factors for motoneuron maintenance and function
    Bettina Holtmann
    The Institute for Clinical Neurobiology, Department of Neurology, D 97080 Wuerzburg, Germany
    J Neurosci 25:1778-87. 2005
    ....
  28. ncbi request reprint Altered expression of ion channel isoforms at the node of Ranvier in P0-deficient myelin mutants
    Jochen C Ulzheimer
    Section of Developmental Neurobiology, Department of Neurology, University of Wuerzburg, D 97080 Wuerzburg, Germany
    Mol Cell Neurosci 25:83-94. 2004
    ..Thus, deficiency of P0 leads to dysregulation of nodal VGSC isoforms and to altered localization of paranodal and juxtaparanodal components of the nodal complex...
  29. ncbi request reprint The Wlds mutation delays robust loss of motor and sensory axons in a genetic model for myelin-related axonopathy
    Mohtashem Samsam
    Department of Neurology, University of Wurzburg, D 97080 Wurzburg, Germany
    J Neurosci 23:2833-9. 2003
    ..We conclude that myelin-related axonal loss is a process having some features in common with Wallerian degeneration. Introducing the Wld(s) gene would be a promising approach to delaying detrimental axonal loss in myelin disorders...
  30. ncbi request reprint Long-lasting significant functional improvement in chronic severe spinal cord injury following scar resection and polyethylene glycol implantation
    Veronica Estrada
    Molecular Neurobiology Laboratory, Department of Neurology, Heinrich Heine University Medical Center Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
    Neurobiol Dis 67:165-79. 2014
    ..In conclusion, scar resection and subsequent implantation of PEG into the generated cavity leads to tissue recovery, axon regeneration, myelination and functional improvement that have not been achieved before in severe chronic SCI...
  31. doi request reprint Nonuniform molecular features of myelinating Schwann cells in models for CMT1: distinct disease patterns are associated with NCAM and c-Jun upregulation
    Dennis Klein
    Department of Neurology, Developmental Neurobiology, University of Wurzburg, Josef Schneider Str 11, D 97080, Wurzburg, Germany
    Glia 62:736-50. 2014
    ....
  32. pmc Role of immune cells in animal models for inherited neuropathies: facts and visions
    Mathias Maurer
    Department of Neurology, University of Wurzburg, Germany
    J Anat 200:405-14. 2002
    ..We conclude that the involvement of T-lymphocytes and macrophages is a common pathogenetic feature in various forms of slowly progressive inherited neuropathies...
  33. pmc Non-invasive assessment of retinal alterations in mouse models of infantile and juvenile neuronal ceroid lipofuscinosis by spectral domain optical coherence tomography
    Janos Groh
    Department of Neurology, Developmental Neurobiology, University of Wuerzburg, Josef Schneider Str, 11, D 97080 Wuerzburg, Germany
    Acta Neuropathol Commun 2:54. 2014
    ....