F Hanisch

Summary

Affiliation: Martin Luther University
Country: Germany

Publications

  1. pmc Glycogenosome accumulation in the arrector pili muscle in Pompe disease
    Istvan Katona
    Institute of Neuropathology, RWTH Aachen University and JARA Brain Translational Medicine, Pauwelsstr, 30, 52074 Aachen, Germany
    Orphanet J Rare Dis 9:17. 2014
  2. doi request reprint The significance of pathological spontaneous activity in various myopathies
    F Hanisch
    Department of Neurology, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, D 06120 Halle Saale, Germany Electronic address
    Clin Neurophysiol 125:1485-90. 2014
  3. pmc Sialylation and muscle performance: sialic acid is a marker of muscle ageing
    Frank Hanisch
    Department of Neurology, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    PLoS ONE 8:e80520. 2013
  4. doi request reprint Diagnostic impact of myotonic discharges in myofibrillar myopathies
    Frank Hanisch
    Department of Neurology, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, D 06120 Halle Saale, Germany
    Muscle Nerve 47:845-8. 2013
  5. doi request reprint Unusual manifestations in two cases of necrotizing myopathy associated with SRP-antibodies
    F Hanisch
    Neurological Department, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, D 06120 Halle, Saale, Germany
    Clin Neurol Neurosurg 114:1104-6. 2012
  6. pmc Three novel mutations in KIF21A highlight the importance of the third coiled-coil stalk domain in the etiology of CFEOM1
    Wai Man Chan
    Program in Genomics, Children s Hospital Boston, Boston, MA 02115, USA
    BMC Genet 8:26. 2007
  7. ncbi request reprint Frequency of calpain-3 c.550delA mutation in limb girdle muscular dystrophy type 2 and isolated hyperCKemia in German patients
    F Hanisch
    Klinik und Poliklinik fur Neurologie, Universität Halle Wittenberg, Germany
    Clin Neuropathol 26:157-63. 2007
  8. doi request reprint AMP deaminase deficiency in skeletal muscle is unlikely to be of clinical relevance
    Frank Hanisch
    Dept of Neurology, Martin Luther Universitat, Halle Wittenberg, Ernst Grube Str 40, 06097, Halle Saale, Germany
    J Neurol 255:318-22. 2008
  9. pmc Mycophenolate mofetil as second line immunosuppressant in Myasthenia gravis--a long-term prospective open-label study
    F Hanisch
    Klinik und Poliklinik fur Neurologie, Martin Luther Universitat Halle Wittenberg, Ernst Grube Str 40, 06097 Halle Saale, Germany
    Eur J Med Res 14:364-6. 2009
  10. pmc Maintenance electroconvulsive therapy for comorbid pharmacotherapy-refractory obsessive-compulsive and schizoaffective disorder
    F Hanisch
    Klinik und Poliklinik fur Neurologie, Martin Luther Universitat Halle Wittenberg, Ernst Grube Str 40, 06097 Halle Saale, Germany
    Eur J Med Res 14:367-8. 2009

Collaborators

Detail Information

Publications34

  1. pmc Glycogenosome accumulation in the arrector pili muscle in Pompe disease
    Istvan Katona
    Institute of Neuropathology, RWTH Aachen University and JARA Brain Translational Medicine, Pauwelsstr, 30, 52074 Aachen, Germany
    Orphanet J Rare Dis 9:17. 2014
    ..Moreover, the failure of autophagy in Pompe disease could contribute to muscular atrophy and disease progression and is thought to compromise the efficacy of enzyme replacement therapy (ERT)...
  2. doi request reprint The significance of pathological spontaneous activity in various myopathies
    F Hanisch
    Department of Neurology, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, D 06120 Halle Saale, Germany Electronic address
    Clin Neurophysiol 125:1485-90. 2014
    ..Pathological spontaneous activity (PSA) in electromyography (EMG) has not yet been systematically analysed in various types of myopathies...
  3. pmc Sialylation and muscle performance: sialic acid is a marker of muscle ageing
    Frank Hanisch
    Department of Neurology, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    PLoS ONE 8:e80520. 2013
    ..Here we propose that increased Sia concentrations in muscles are a characteristic feature of ageing and could be used as a marker for age-related changes in muscle...
  4. doi request reprint Diagnostic impact of myotonic discharges in myofibrillar myopathies
    Frank Hanisch
    Department of Neurology, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, D 06120 Halle Saale, Germany
    Muscle Nerve 47:845-8. 2013
    ..Nevertheless, this peculiar type of spontaneous repetitive discharge has not attracted special interest in the genetically heterogeneous MFMs...
  5. doi request reprint Unusual manifestations in two cases of necrotizing myopathy associated with SRP-antibodies
    F Hanisch
    Neurological Department, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, D 06120 Halle, Saale, Germany
    Clin Neurol Neurosurg 114:1104-6. 2012
    ..The pathomechanism is not clear. Any otherwise unexplained evidence of necrotizing myopathy should prompt the screening for SRP antibodies...
  6. pmc Three novel mutations in KIF21A highlight the importance of the third coiled-coil stalk domain in the etiology of CFEOM1
    Wai Man Chan
    Program in Genomics, Children s Hospital Boston, Boston, MA 02115, USA
    BMC Genet 8:26. 2007
    ..To further define the spectrum of KIF21A mutations in CFEOM we have now identified all CFEOM probands newly enrolled in our study and determined if they harbor mutations in KIF21A...
  7. ncbi request reprint Frequency of calpain-3 c.550delA mutation in limb girdle muscular dystrophy type 2 and isolated hyperCKemia in German patients
    F Hanisch
    Klinik und Poliklinik fur Neurologie, Universität Halle Wittenberg, Germany
    Clin Neuropathol 26:157-63. 2007
    ..The c.550delA mutation in the CAPN3 gene was frequently identified in LGMD2A patients from Eastern Europe and is considered a Slavic founder mutation...
  8. doi request reprint AMP deaminase deficiency in skeletal muscle is unlikely to be of clinical relevance
    Frank Hanisch
    Dept of Neurology, Martin Luther Universitat, Halle Wittenberg, Ernst Grube Str 40, 06097, Halle Saale, Germany
    J Neurol 255:318-22. 2008
    ..It is controversial (i) whether AMPD deficiency is associated with exercise-induced complaints and (ii) whether an acquired form exists in which an underlying neuromuscular disorder additionally lowers the AMPD activity...
  9. pmc Mycophenolate mofetil as second line immunosuppressant in Myasthenia gravis--a long-term prospective open-label study
    F Hanisch
    Klinik und Poliklinik fur Neurologie, Martin Luther Universitat Halle Wittenberg, Ernst Grube Str 40, 06097 Halle Saale, Germany
    Eur J Med Res 14:364-6. 2009
    ..The preferred immunosuppressive drug for long term treatment of myasthenia gravis (MG) is azathioprine (AZA). Mycophenolate mofetil (MMF) was suggested as an effective and safe second line alternative to AZA...
  10. pmc Maintenance electroconvulsive therapy for comorbid pharmacotherapy-refractory obsessive-compulsive and schizoaffective disorder
    F Hanisch
    Klinik und Poliklinik fur Neurologie, Martin Luther Universitat Halle Wittenberg, Ernst Grube Str 40, 06097 Halle Saale, Germany
    Eur J Med Res 14:367-8. 2009
    ..There is a high comorbidity of schizophrenia and obsessive-compulsory disorder (OCD) associated with more severe symptoms. Standard pharmacotherapy achieve symptom improvement in approximately 60% only...
  11. doi request reprint Combined treatment with quetiapine and sertindole in therapy refractory insomnia after clozapine discontinuation
    F Hanisch
    Klinik und Poliklinik fur Neurologie, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    J Psychopharmacol 24:1725-6. 2010
    ..In conclusion, the combination of sertindole and quetiapine might be a safe and effective combination in therapy-refractory insomnia after clozapine discontinuation in schizophrenia...
  12. doi request reprint Phenotype variability and histopathological findings in centronuclear myopathy due to DNM2 mutations
    F Hanisch
    Klinik und Poliklinik fur Neurologie, Martin Luther Universitat Halle Wittenberg, Ernst Grube Str 40, 06097, Halle Saale, Germany
    J Neurol 258:1085-90. 2011
    ..Other genes than currently known seem to cause the clinical and histopathological phenotype of CNM...
  13. ncbi request reprint [Hauptmann-Thannhauser muscular dystrophy and differential diagnosis of myopathies associated with contractures]
    F Hanisch
    Klinik und Poliklinik für Neurologie der Martin Luther Universität Halle Wittenberg, Germany
    Nervenarzt 73:1004-11. 2002
    ..Other muscular diseases associated with contractures and congenital or childhood onset are reviewed...
  14. ncbi request reprint Lactate production upon short-term non-ischemic forearm exercise in mitochondrial disorders and other myopathies
    Frank Hanisch
    Klinik und Poliklinik fur Neurologie, Martin Luther Universitat, Halle Wittenberg, Ernst Grube Strasse 40, 06097 Halle Saale, Germany
    J Neurol 253:735-40. 2006
    ..Recently, the lactate increase normalized to the mechanical energy production in NIFET was suggested to have a intermediate sensitivity and satisfactory specifity for the screening of mitochondrial disorders...
  15. ncbi request reprint [Congenital fibrosis of extraocular muscles (CFEOM) and other phenotypes of congenital cranial dysinnervation syndromes (CCDD)]
    Frank Hanisch
    Klinik und Poliklinik fur Neurologie, Martin Luther Universitat Halle Wittenberg, Halle Saale
    Nervenarzt 76:395-402. 2005
    ..There are 13 different known gene loci for one of these phenotypes. Five gene products have been identified: the kinesin motor protein Kif21a, the transcription factors ARIX and SALL4, and the carboxypeptidase CPAH...
  16. ncbi request reprint Stroke following variceal sclerotherapy
    Frank Hanisch
    Neurologische Klinik, Martin Luther Universitat Halle Wittenberg, Ernst Grube Str 40, D 06097 Halle Saale, Germany
    Eur J Med Res 9:282-4. 2004
    ..Such occurrences are associated with risk factors for deep vein thrombosis (DVT), e. g. pregnancy, immobilisation, and surgery of the lower limbs...
  17. ncbi request reprint Only transient increase of serum CoQ subset 10 during long-term CoQ10 therapy in mitochondrial ophthalmoplegia
    Frank Hanisch
    Neurological Departement, University of Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    Eur J Med Res 8:485-91. 2003
    ..Coenzyme Q10 (CoQ10) is frequently administered in mitochondrial diseases. Mitochondrial dysfunction and CoQ10 treatment was also proposed in neurodegenerative disorders as amyotrophic lateral sclerosis and Parkinsons disease...
  18. ncbi request reprint Genotype-phenotype analysis in early-onset Alzheimer's disease due to presenilin-1 mutations at codon 139
    Frank Hanisch
    Neurological Department, University of Halle Wittenberg, Halle Saale, Germany
    Eur J Med Res 9:361-4. 2004
    ..Onset and duration were not correlated to the amino acid exchanged. Another modifying genetic or environmental factor is probable...
  19. ncbi request reprint Congenital fibrosis of extraocular muscles type 1 with progression of ophthalmoplegia
    F Hanisch
    Klinik und Poliklinik fur Neurologie, Martin Luther Universitat Halle Wittenberg, D 06097 Halle Saale, Germany
    Eur J Med Res 10:366-8. 2005
    ..Congenital fibrosis of the extraocular muscles type 1 (CFEOM1) is a congenital, non-progressive autosomal-dominant disorder with bilateral oculomotor nerve palsy due to mutations in the kinesin motor protein gene KIF21A. -..
  20. ncbi request reprint Ecto- and cytosolic 5'-nucleotidases in normal and AMP deaminase-deficient human skeletal muscle
    Frank Hanisch
    Neurological Department, Martin Luther University of Halle Wittenberg, Ernst Grube Str 40, D 06097 Halle Saale, Germany
    Biol Chem 387:53-8. 2006
    ....
  21. ncbi request reprint Lactate increase and oxygen desaturation in mitochondrial disorders--evaluation of two diagnostic screening protocols
    Frank Hanisch
    Klinik und Poliklinik fur Neurologie, Martin Luther Universitat, Halle Wittenberg, Ernst Grube Str 40, 06097, Halle Saale, Germany
    J Neurol 253:417-23. 2006
    ..Therefore, both parameters (lactate and oxygen saturation) can be used as screening tests in mitochondrial disorders. However, conflicting results regarding sensitivities and specifities of both tests have been reported...
  22. ncbi request reprint [Ocular involvement in MuSK antibody-positive myasthenia gravis]
    V Bau
    Klinik und Poliklinik für Augenheilkunde, Martin Luther Universitat Halle Wittenberg, Halle Saale
    Klin Monbl Augenheilkd 223:81-3. 2006
    ..Furthermore, Ab against the muscle-specific receptor tyrosine kinase (MuSK) were detected in 38 - 54 % of patients with AChR-Ab-negative ("seronegative") MG, but not in pure ocular MG...
  23. doi request reprint [Muscular dystrophy due to mutations in anoctamin 5: clinical and molecular genetic findings]
    M Deschauer
    Klinik und Poliklinik fur Neurologie, Martin Luther Universitat Halle Wittenberg, Ernst Grube Str 40, 06097 Halle Saale, Deutschland
    Nervenarzt 82:1596-603. 2011
    ..Mutations in the ANO5 gene seem to be a relatively common cause of muscular dystrophy in Germany. Cases with late onset or asymptomatic hyperCKemia can occur. Clinically, asymmetric manifestation is typical...
  24. ncbi request reprint Endothelin-1 and cerebral blood flow in a porcine model
    Dirk Henze
    Department of Anaesthesiology and Intensive Care Medicine, Martin Luther University Halle Wittenberg, Dryanderstr 4 7, 06108 Halle Saale, Germany
    J Clin Neurosci 14:650-7. 2007
    ..These data imply that with increasingly pathological changes of the cerebral metabolism endothelin becomes progressively more important in the regulation of cerebral vascular tone...
  25. ncbi request reprint Influence of moderate and profound hyperventilation on cerebral blood flow, oxygenation and metabolism
    Tobias Clausen
    Department of Anesthesiology and Intensive Care Medicine, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, Halle Saale, 06120, Germany
    Brain Res 1019:113-23. 2004
    ..The aim of the present study was to examine the impact of moderate and profound hyperventilation on regional cerebral blood flow (rCBF), oxygenation and metabolism...
  26. doi request reprint [Treatability of sporadic late onset nemaline myopathy]
    F Hanisch
    Klinik und Poliklinik fur Neurologie, Universitatsklinikum, Martin Luther Universitat Halle Wittenberg, Ernst Grube Str 40, 06120, Halle Saale, Deutschland
    Nervenarzt 84:955-61. 2013
    ....
  27. pmc Morphology and function of cerebral arteries in adults with pompe disease
    Ole Hensel
    Department of Neurology, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, 06120, Halle Saale, Germany
    JIMD Rep 20:27-33. 2015
    ....
  28. doi request reprint Characterization of monoclonal gammopathy in patients with amyotrophic lateral sclerosis
    H H Wolf
    Department of Internal Medicine IV, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Acta Neurol Scand 132:212-5. 2015
    ..Recently, new guidelines for the monitoring and the risk evaluation of monoclonal gammopathy with undetermined significance (MGUS) became available and the light chain MGUS subtype was defined...
  29. pmc Risk factors for osteoporosis, falls and fractures in hereditary myopathies and sporadic inclusion body myositis - A cross sectional survey
    F Danckworth
    Department of Neurology, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, 06120 Halle Saale, Germany
    Mol Genet Metab Rep 1:85-97. 2014
    ..The risk of osteoporosis is known in myopathies requiring long-term steroid treatment and Pompe disease, but not in other hereditary myopathies or sporadic inclusion body myositis (sIBM)...
  30. doi request reprint The checklist individual strength (CIS20-R) in patients with amyotrophic lateral sclerosis - a longitudinal study
    S Panitz
    Department of Neurology, Martin Luther University Halle Wittenberg, Halle, Saale, Germany
    Acta Neurol Scand 131:372-80. 2015
    ..Fatigue may be underestimated symptom in amyotrophic lateral sclerosis (ALS). The self-administered checklist individual strength (CIS20-R) was used to measure both physical and mental fatigue in ALS...
  31. ncbi request reprint ["Seronegative" myasthenia with antibodies against muscle-specific tyrosine-kinase]
    B Hain
    Klinik und Poliklinik fur Neurologie, Martin Luther Universitat Halle Wittenberg, Halle Saale, Deutschland
    Nervenarzt 75:362-7. 2004
    ..Finally, they illustrate the therapeutic difficulties with less response to pyridostigmine and immunosuppressive drugs...
  32. ncbi request reprint Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1)
    Koki Yamada
    Department of Medicine Genetics, Enders 5, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Genet 35:318-21. 2003
    ..We identified six different mutations in 44 of 45 probands. The primary mutational hotspots are in the stalk domain, highlighting an important new role for KIF21A and its stalk in the formation of the oculomotor axis...
  33. ncbi request reprint Frequent low penetrance mutations in the Lamin A/C gene, causing Emery Dreifuss muscular dystrophy
    Michal Vytopil
    Institute of Molecular Genetics CNR, Via Abbiategrasso, 207, 27100, Pavia, Italy
    Neuromuscul Disord 12:958-63. 2002
    ....
  34. ncbi request reprint Myofiber degeneration in autosomal dominant Emery-Dreifuss muscular dystrophy (AD-EDMD) (LGMD1B)
    Michel Mittelbronn
    Institute of Brain Research, University of Tubingen, Tubingen, Germany
    Brain Pathol 16:266-72. 2006
    ....