Dominik Linz

Summary

Country: Germany

Publications

  1. doi Impact of SERVE-HF on management of sleep disordered breathing in heart failure: a call for further studies
    Dominik Linz
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse 1, Geb 40, 66421, Homburg, Saarland, Germany
    Clin Res Cardiol 105:563-70. 2016
  2. doi Impact of obstructive and central apneas on ventricular repolarisation: lessons learned from studies in man and pigs
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421, Homburg Saar, Germany
    Clin Res Cardiol 105:639-47. 2016
  3. doi Atrial arrhythmogenesis in obstructive sleep apnea: Therapeutic implications
    Dominik Linz
    Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Germany Electronic address
    Sleep Med Rev 26:87-94. 2016
  4. doi The importance of sleep-disordered breathing in cardiovascular disease
    Dominik Linz
    Kardiologie, Angiologie und Internistische Intensivmedizin, Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Kirrberger Strasse 1, Geb 40, 66421, Homburg, Saarland, Germany
    Clin Res Cardiol 104:705-18. 2015
  5. doi Progression of kidney injury and cardiac remodeling in obese spontaneously hypertensive rats: the role of renal sympathetic innervation
    Dominik Linz
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Am J Hypertens 28:256-65. 2015
  6. doi Renal denervation: effects on atrial electrophysiology and arrhythmias
    Dominik Linz
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str 1, Geb 40, 66421, Homburg Saar, Germany
    Clin Res Cardiol 103:765-74. 2014
  7. doi Effect of obstructive respiratory events on blood pressure and renal perfusion in a pig model for sleep apnea
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Am J Hypertens 27:1293-300. 2014
  8. pmc Obstructive sleep apnea and atrial arrhythmogenesis
    Mathias Hohl
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str 1, Geb 40, D 66421 Homburg Saar, Germany
    Curr Cardiol Rev 10:362-8. 2014
  9. doi Atrial autonomic innervation: a target for interventional antiarrhythmic therapy?
    Dominik Linz
    Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg, Saarland, Germany Electronic address
    J Am Coll Cardiol 63:215-24. 2014
  10. doi Renal denervation suppresses ventricular arrhythmias during acute ventricular ischemia in pigs
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany Electronic address
    Heart Rhythm 10:1525-30. 2013

Detail Information

Publications55

  1. doi Impact of SERVE-HF on management of sleep disordered breathing in heart failure: a call for further studies
    Dominik Linz
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse 1, Geb 40, 66421, Homburg, Saarland, Germany
    Clin Res Cardiol 105:563-70. 2016
    ..Its close association with outcomes in chronic heart failure with reduced ejection fraction (HF-REF) suggests that it may be a potential treatment target. Herein, we provide an update on SDB and its treatment in HF-REF. ..
  2. doi Impact of obstructive and central apneas on ventricular repolarisation: lessons learned from studies in man and pigs
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421, Homburg Saar, Germany
    Clin Res Cardiol 105:639-47. 2016
    ..Compared to central apneas, obstructive apneas are associated with negative intrathoracic pressure swings inducing autonomic imbalance, which may disturb ventricular repolarisation resulting in arrhythmias...
  3. doi Atrial arrhythmogenesis in obstructive sleep apnea: Therapeutic implications
    Dominik Linz
    Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Germany Electronic address
    Sleep Med Rev 26:87-94. 2016
    ....
  4. doi The importance of sleep-disordered breathing in cardiovascular disease
    Dominik Linz
    Kardiologie, Angiologie und Internistische Intensivmedizin, Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Kirrberger Strasse 1, Geb 40, 66421, Homburg, Saarland, Germany
    Clin Res Cardiol 104:705-18. 2015
    ....
  5. doi Progression of kidney injury and cardiac remodeling in obese spontaneously hypertensive rats: the role of renal sympathetic innervation
    Dominik Linz
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Am J Hypertens 28:256-65. 2015
    ..Renal sympathetic denervation (RDN) decreases sympathetic renal efferent and afferent nerve activity...
  6. doi Renal denervation: effects on atrial electrophysiology and arrhythmias
    Dominik Linz
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str 1, Geb 40, 66421, Homburg Saar, Germany
    Clin Res Cardiol 103:765-74. 2014
    ..This review focuses on the potential atrial antiarrhythmic and antiremodeling effects of RDN in AF patients with hypertension, heart failure, and sleep apnea and discusses the possible role of RDN in the treatment of AF...
  7. doi Effect of obstructive respiratory events on blood pressure and renal perfusion in a pig model for sleep apnea
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Am J Hypertens 27:1293-300. 2014
    ..Obstructive sleep apnea (OSA) is associated with hypertension and the progression of chronic kidney disease (CKD). Renal sympathetic innervation contributes to either condition...
  8. pmc Obstructive sleep apnea and atrial arrhythmogenesis
    Mathias Hohl
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str 1, Geb 40, D 66421 Homburg Saar, Germany
    Curr Cardiol Rev 10:362-8. 2014
    ....
  9. doi Atrial autonomic innervation: a target for interventional antiarrhythmic therapy?
    Dominik Linz
    Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg, Saarland, Germany Electronic address
    J Am Coll Cardiol 63:215-24. 2014
    ....
  10. doi Renal denervation suppresses ventricular arrhythmias during acute ventricular ischemia in pigs
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany Electronic address
    Heart Rhythm 10:1525-30. 2013
    ..Increased sympathetic activation during acute ventricular ischemia is involved in the occurrence of life-threatening arrhythmias...
  11. doi Effect of renal denervation on neurohumoral activation triggering atrial fibrillation in obstructive sleep apnea
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421 Homburg, Saar, Germany
    Hypertension 62:767-74. 2013
    ..However, the generation of atrial oxidative stress was not modulated. ..
  12. doi Renal sympathetic denervation provides ventricular rate control but does not prevent atrial electrical remodeling during atrial fibrillation
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Hypertension 61:225-31. 2013
    ..Modulation of the autonomic nervous system by RDN might provide rate control and reduce susceptibility to AF. Whether RDN may provide rate control in a larger number of patients with AF deserves further clinical studies...
  13. pmc Cardiac remodeling and myocardial dysfunction in obese spontaneously hypertensive rats
    Dominik Linz
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar 66421, Germany
    J Transl Med 10:187. 2012
    ..The additive effects of obesity and metabolic syndrome on left ventricular (LV) maladaptive remodeling and function in hypertension are not characterized...
  14. doi Antihypertensive and laxative effects by pharmacological inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Hypertension 60:1560-7. 2012
    ..Intestinal NHE3 blockade could be a new treatment strategy for elderly patients suffering from high blood pressure and constipation...
  15. doi Renal sympathetic denervation suppresses postapneic blood pressure rises and atrial fibrillation in a model for sleep apnea
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Hypertension 60:172-8. 2012
    ..Renal denervation displays antiarrhythmic effects by reducing NTP-induced AERP shortening and inhibits postapneic BP rises associated with obstructive events...
  16. doi Combined blockade of early and late activated atrial potassium currents suppresses atrial fibrillation in a pig model of obstructive apnea
    Dominik Linz
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, Germany
    Heart Rhythm 8:1933-9. 2011
    ..The role of different atrial potassium channels under those conditions has not been investigated...
  17. doi Effects of renal sympathetic denervation on exercise blood pressure, heart rate, and capacity in patients with resistant hypertension
    Sebastian Ewen
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str, Geb 40, 66421 Homburg Saar, Germany
    Hypertension 63:839-45. 2014
    ..No changes were observed in the control group. In conclusion, renal denervation reduced blood pressure and heart rate during exercise, improved mean workload, and increased exercise time without impairing chronotropic competence. ..
  18. doi Expanding the indication spectrum: renal denervation in diabetes
    Felix Mahfoud
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    EuroIntervention 9:R117-21. 2013
    ..This review highlights the background of approaching the renal sympathetic nerves as a potential new therapeutic option to improve glycaemic control in patients with resistant hypertension...
  19. doi Inhibition of NHE3-mediated Sodium Absorption in the Gut Reduced Cardiac End-organ Damage Without Deteriorating Renal Function in Obese Spontaneously Hypertensive Rats
    Benedikt Linz
    Department of Cardiology, Universitatsklinikum des Saarlandes, Homburg, Germany
    J Cardiovasc Pharmacol 67:225-31. 2016
    ..Reduction of intestinal sodium absorption by selective NHE3 inhibition in the gut lowered high blood pressure and reduced LV remodeling without deteriorating renal functional and structural parameters in SHR-ob...
  20. doi Therapeutic potential of renal sympathetic denervation in patients with chronic heart failure
    Michael Bohm
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg, Germany
    EuroIntervention 9:R122-6. 2013
    ....
  21. doi Orthostatic function after renal sympathetic denervation in patients with resistant hypertension
    Matthias Lenski
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Int J Cardiol 169:418-24. 2013
    ..However, safety concerns exist concerning the development of orthostatic dysfunction after RDN...
  22. doi Improvements in left ventricular hypertrophy and diastolic function following renal denervation: effects beyond blood pressure and heart rate reduction
    Stephan H Schirmer
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany Electronic address
    J Am Coll Cardiol 63:1916-23. 2014
    ..This study sought to investigate the interaction between blood pressure (BP) and heart rate (HR) reduction and changes in left ventricular (LV) structure and function following renal sympathetic denervation (RDN)...
  23. doi Effects of electrical stimulation of carotid baroreflex and renal denervation on atrial electrophysiology
    Dominik Linz
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, Germany
    J Cardiovasc Electrophysiol 24:1028-33. 2013
    ..Increased vagal tone potentially shortens atrial refractoriness resulting in a stabilization of reentry circuits perpetuating atrial fibrillation (AF)...
  24. doi Renal sympathetic denervation: applications in hypertension and beyond
    Michael Bohm
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Straße 1, DE 66421 Homburg Saar, Germany
    Nat Rev Cardiol 10:465-76. 2013
    ....
  25. doi Effects of renal sympathetic denervation on heart rate and atrioventricular conduction in patients with resistant hypertension
    Christian Ukena
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Int J Cardiol 167:2846-51. 2013
    ..Renal sympathetic denervation (RDN) reduces sympathetic activity and blood pressure (BP) in patients with resistant hypertension. The present study aimed to investigate the effects of RDN on HR and other electrocardiographic parameters...
  26. doi Reduced effect of percutaneous renal denervation on blood pressure in patients with isolated systolic hypertension
    Sebastian Ewen
    From the Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin S E, C U, D L, I K, B C, U L, M B, F M and Institut für Medizinische Biometrie, Epidemiologie und Medizinische Informatik S W, Universitatsklinikum des Saarlandes, Homburg Saar, Germany and Medizinische Klinik 4, Nephrologie und Hypertensiologie, Universitatsklinikum Erlangen, Erlangen, Germany R E S
    Hypertension 65:193-9. 2015
    ..In conclusion, renal denervation reduces office and ambulatory blood pressure in patients with ISH. However, this reduction is less pronounced compared with patients with CH. ..
  27. doi Potential role of renal sympathetic denervation for the treatment of cardiac arrhythmias
    Christian Ukena
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    EuroIntervention 9:R110-6. 2013
    ..Furthermore, RDN may have a beneficial impact on ventricular arrhythmia, in particular in patients with coronary artery disease or heart failure...
  28. doi Negative tracheal pressure during obstructive respiratory events promotes atrial fibrillation by vagal activation
    Dominik Linz
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, Germany
    Heart Rhythm 8:1436-43. 2011
    ..Obstructive sleep apnea (OSA) causes negative tracheal pressure (NTP) and is associated with atrial fibrillation (AF)...
  29. doi The sympathetic nervous system in chronic kidney disease
    Sebastian Ewen
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse Geb 40, Homburg Saar, Germany
    Curr Hypertens Rep 15:370-6. 2013
    ..In this review current knowledge of the role of the sympathetic nervous system in the development and progression of CKD will be summarized, and novel treatment options targeting sympathetic nervous system activity will be discussed. ..
  30. doi Low-Level But Not High-Level Baroreceptor Stimulation Inhibits Atrial Fibrillation in a Pig Model of Sleep Apnea
    Dominik Linz
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Homburg, Saar, Germany
    J Cardiovasc Electrophysiol 27:1086-92. 2016
    ..The purpose of this study was to investigate the effect of autonomic nervous system modulation by low-level baroreceptor stimulation (LL-BRS) compared to high-level BRS (HL-BRS) on atrial arrhythmogenic changes in a pig model of OSA...
  31. pmc Modulation of the sympathetic nervous system by renal denervation prevents reduction of aortic distensibility in atherosclerosis prone ApoE-deficient rats
    Mathias Hohl
    Klinik fur Innere Medizin III, Universitat des Saarlandes, 66421, Homburg Saar, Germany
    J Transl Med 14:167. 2016
    ..This study investigates the impact of RDN on aortic compliance in a novel atherosclerosis prone ApoE(-/-)-rat model...
  32. ncbi Renal denervation reduces office and ambulatory heart rate in patients with uncontrolled hypertension: 12-month outcomes from the global SYMPLICITY registry
    Michael Bohm
    aUniversitätskliniken des Saarlandes und Universität des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, Germany bUniversitätsklinik für Innere Medizin II, Kardiologie, Internistische Intensivmedizin und Notaufnahme, SALK Paracelsus Universität Salzburg, Salzburg, Austria cDepartment of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland dHypertension Unit, Department of Nephrology, Hospital 12 de Octubre, Madrid, Spain eDobney Hypertension Centre, School of Medicine and Pharmacology Royal Perth Hospital Unit, The University of Western Australia, Perth, Australia fMedtronic, Santa Rosa, California, USA gUniversität Erlangen Nürnberg, Medizinische Klinik 4, Nurnberg, Germany hInstitute of Cardiovascular Science and NHR Biomedical Research Centre, University College London, London, UK iKlinikum der Stadt Ludwigshafen am Rhein, Ludwigshafen am Rhein, Germany jDepartment of Cardiology and Angiology, Universitäts Herzzentrum Freiburg, Bad Krozingen, Freiburg, Germany kCentro di Fisiologia Clinica e Ipertensione, University of Milano Bicocca, Milan, Italy
    J Hypertens 34:2480-2486. 2016
    ..Renal denervation (RDN) can reduce sympathetic activity and blood pressure (BP) in patients with hypertension. The effects on resting and ambulatory heart rate (HR), also regulated by the sympathetic nervous system, are not established...
  33. doi Impact of Lesion Placement on Efficacy and Safety of Catheter-Based Radiofrequency Renal Denervation
    Felix Mahfoud
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany Electronic address
    J Am Coll Cardiol 66:1766-75. 2015
    ..Insufficient procedural efficacy has been proposed to explain nonresponse to renal denervation (RDN)...
  34. doi Atrial Remodeling Following Catheter-Based Renal Denervation Occurs in a Blood Pressure- and Heart Rate-Independent Manner
    Stephan H Schirmer
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany Electronic address
    JACC Cardiovasc Interv 8:972-80. 2015
    ..This study sought to investigate left atrial (LA) remodeling in relation to blood pressure (BP) and heart rate (HR) after renal sympathetic denervation (RDN)...
  35. doi Blood pressure reductions following catheter-based renal denervation are not related to improvements in adherence to antihypertensive drugs measured by urine/plasma toxicological analysis
    Sebastian Ewen
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str, Geb 40, 66421, Homburg Saar, Germany
    Clin Res Cardiol 104:1097-105. 2015
    ..In conclusion, renal denervation can reduce office and ambulatory blood pressure in patients with resistant hypertension despite a significant reduction in adherence to antihypertensive treatment after 6 months. ..
  36. doi Obstructive respiratory events and premature atrial contractions after cardioversion
    Dominik Linz
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, Germany
    Eur Respir J 45:1332-40. 2015
    ..OREs are associated with increased occurrence of PACs and more early relapse of AF. OREs increase occurrence of PACs and vulnerability for reinduction of AF by sympathovagal imbalance. ..
  37. doi Catheter-based renal denervation reduces atrial nerve sprouting and complexity of atrial fibrillation in goats
    Dominik Linz
    From the Universitätsklinikum des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, Germany D L, M H, F M, M W, H R N, M B Department of Physiology, University Maastricht, Maastricht, The Netherlands A v H, S V, U S Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom B C, S N R
    Circ Arrhythm Electrophysiol 8:466-74. 2015
    ..Renal denervation (RDN) can reduce renal and whole-body sympathetic activity. Aim of this study was to determine the effect of sympathetic nervous system modulation by RDN on atrial arrhythmogenesis...
  38. doi Renal hemodynamics and renal function after catheter-based renal sympathetic denervation in patients with resistant hypertension
    Felix Mahfoud
    Klinik fur Innere Medizin III, Kardiologie, Angiologie, und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str, Geb 40, 66421 Homburg Saar, Germany
    Hypertension 60:419-24. 2012
    ....
  39. pmc Experimental Evidence Of The Role Of Renal Sympathetic Denervation For Treating Atrial Fibrillation
    Dominik Linz
    Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes
    J Atr Fibrillation 7:1128. 2014
    ..This review focuses on the potential effects of RDN on different arrhythmogenic mechanisms in the atrium and discusses potential anti-remodeling effects in hypertension, heart failure, and sleep apnea...
  40. ncbi Renal artery denervation for treatment of patients with self-reported obstructive sleep apnea and resistant hypertension: results from the Global SYMPLICITY Registry
    Dominik Linz
    aUniversitätskliniken des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, GermanybDepartment of Medicine, University of Milano Bicocca, ItalycDepartment of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, PolanddHypertension Unit, Department of Nephrology, Hospital 12 de Octubre, Madrid, SpaineFaculty of Medicine, Monash University, Baker IDI Heart and Diabetes Institute, Melbourne and Dobney Hypertension Centre, School of Medicine and Pharmacology Royal Perth Hospital Unit, University of Western Australia, Perth, AustraliafDepartment of Nephrology and Hypertension, University Hospital Erlangen, Erlangen, GermanygInstitute of Cardiovascular Science, University College London, London, UK
    J Hypertens 35:148-153. 2017
    ..This analysis of patients with and without OSA evaluated the blood pressure (BP)-lowering effect of sympathetic modulation by renal denervation (RDN) in a real-world setting...
  41. doi Effects of renal sympathetic denervation on urinary sodium excretion in patients with resistant hypertension
    Janine Pöss
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str, Geb 40, 66421, Homburg Saar, Germany
    Clin Res Cardiol 104:672-8. 2015
    ..Renal sympathetic denervation lowers blood pressure and reduces sympathetic activity in certain patients with resistant hypertension...
  42. doi Effects of renal denervation on atrial arrhythmogenesis
    Dominik Linz
    Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Germany
    Future Cardiol 10:813-22. 2014
    ....
  43. doi Renal denervation and heart failure
    Michael Bohm
    Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Eur J Heart Fail 16:608-13. 2014
    ..The first proof-of-concept studies are planned to evaluate the clinical effect of this pathophysiologically plausible method, which might be able to change clinical practice. ..
  44. doi Renal denervation: a novel non-pharmacological approach in heart failure
    Michael Bohm
    Universitatsklinikum des Saarlandes, Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Kirrberger Str 1, DE 66424, Homburg Saar, Germany
    J Cardiovasc Transl Res 7:330-7. 2014
    ..Altogether, renal denervation is a promising novel technique that may improve the outcome of patients with sympathetic hyperactivity and cardiovascular diseases. ..
  45. doi Cathepsin A mediates susceptibility to atrial tachyarrhythmia and impairment of atrial emptying function in Zucker diabetic fatty rats
    Dominik Linz
    Department of Physiology, University Maastricht, Maastricht, The Netherlands Universitätsklinikum des Saarlandes, Homburg Saar, Germany
    Cardiovasc Res 110:371-80. 2016
    ..This study sought to delineate the role of CatA for the development of atrial remodelling under diabetic conditions...
  46. doi Atrial fibrillation and gastroesophageal reflux disease: the cardiogastric interaction
    Dominik Linz
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str 1, Geb 40, Homburg, Saar D 66421, Germany
    Europace 19:16-20. 2017
    ..Data on GERD and oesophageal lesions after AF-ablation procedures will be reviewed. Treatment of GERD to avoid AF or to reduce AF burden might represent a future treatment perspective but needs to be scrutinized in prospective trials...
  47. doi Catheter-based radio-frequency renal nerve denervation lowers blood pressure in obese hypertensive swine model
    Felix Mahfoud
    aDepartment of Internal Medicine, Cardiology, Angiology and Intensive Care Medicine, Saarland University Hospital, Homburg, Saarland, Germany bSt Jude Medical, Inc, Saint Paul, Minnesota, USA cUniversité de Toulouse Paul Sabatier dDepartment of Cardiovascular Medicine, Hypertension and Heart Failure Unit, Clinique Pasteur, Toulouse, France eHypertension Research Clinic, VA Medical Center, Washington, DC, USA
    J Hypertens 34:1854-62. 2016
    ..Radio-frequency renal denervation (RDN) therapy is under investigation for the treatment of uncontrolled hypertension. Data in hypertensive, drug-naïve large animal models using RDN is limited...
  48. doi Drug therapy for the patient with resistant hypertension
    Luca Donazzan
    Klinik für Innere Medizin III Kardiologie, Angiologie and Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str 1, D 66421 Homburg Saar, Germany
    Future Cardiol 11:191-202. 2015
    ..Fourth line therapy is the use of an aldosterone antagonist. Renal denervation and baroreceptor stimulation can be considered in patients who remained uncontrolled despite optimal medical therapy...
  49. doi Novel and nonpharmacologic approaches to cardio-protection in hypertension
    Luca Donazzan
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str 1, Geb 40, 66421, Homburg, Saar, Germany
    Curr Hypertens Rep 16:430. 2014
    ..Their pleiotropic effects appear promising in cardiovascular remodeling, heart failure and arrhythmias and could potentially affect cardiovascular morbidity and mortality. ..
  50. doi Renal denervation for treatment of ventricular arrhythmias: data from an International Multicenter Registry
    Christian Ukena
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str 1, 66421, Homburg, Saar, Germany
    Clin Res Cardiol 105:873-9. 2016
    ..This study aimed to investigate catheter-based renal sympathetic denervation (RDN) as antiarrhythmic strategy in refractory VA...
  51. doi Efficacy and safety of catheter-based radiofrequency renal denervation in stented renal arteries
    Felix Mahfoud
    From the Klinik für Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany F M, B C, D L, M B Medtronic Cardiovascular, Santa Rosa, CA S T, J R, D S J, R J M Klinik für Kardiologie and Angiologie II, Universitäts Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany T Z Brigham and Women s Hospital Heart and Vascular Center and Harvard Medical School, Boston, MA D L B and Prairie Heart Institute at St John s Hospital, Springfield, IL K R S
    Circ Cardiovasc Interv 7:813-20. 2014
    ..Although catheter-based renal denervation (RDN) can reduce blood pressure in certain patients with resistant hypertension, there are no data on the feasibility and safety of RDN in stented RA...
  52. doi Renal denervation for the treatment of cardiovascular high risk-hypertension or beyond?
    Michael Bohm
    From the Klinik für Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany M B, D L, C U, F M and Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia M E
    Circ Res 115:400-9. 2014
    ....
  53. doi Hyperaldosteronism induces left atrial systolic and diastolic dysfunction
    Jan Christian Reil
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany Klinik für Innere Medizin II, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitäres Herzzentrum Lübeck, Universitatsklinikum Schleswig Holstein, Lubeck, Germany
    Am J Physiol Heart Circ Physiol 311:H1014-H1023. 2016
    ..The described model suggests a direct causal link between hyperaldosteronism and decreased atrial contractility and diastolic compliance...
  54. doi Effect of renal denervation on left ventricular mass and function in patients with resistant hypertension: data from a multi-centre cardiovascular magnetic resonance imaging trial
    Felix Mahfoud
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Eur Heart J 35:2224-31b. 2014
    ..The present multi-centre study aimed to investigate the effect of RDN on anatomic and functional myocardial parameters, assessed by cardiac magnetic resonance (CMR), in patients with resistant hypertension...
  55. doi [Sleep-disordered breathing and cardiac disease]
    Dominik Linz
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar
    Dtsch Med Wochenschr 140:1272-7. 2015
    ..An effective treatment of SDB can reduced blood pressure and can avoid arrhythmias. The effect of treatment of SDB in patients with congestive heart failure is currently investigated in clinical randomized trials...