Stephan Lindemann

Summary

Country: Germany

Publications

  1. ncbi request reprint The active platelet: translation and protein synthesis in an anucleate cell
    Stephan Lindemann
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Semin Thromb Hemost 33:144-50. 2007
  2. doi request reprint Oxidized LDL-activated platelets induce vascular inflammation
    Karin Daub
    Medizinische Klinik, Klinik für Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Germany
    Semin Thromb Hemost 36:146-56. 2010
  3. doi request reprint Junctional adhesion molecule A expressed on human CD34+ cells promotes adhesion on vascular wall and differentiation into endothelial progenitor cells
    Konstantinos Stellos
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Otfried Muller Strasse 10, 72076 Tubingen, Germany
    Arterioscler Thromb Vasc Biol 30:1127-36. 2010
  4. doi request reprint Platelet collagen receptor glycoprotein VI as a possible novel indicator for the acute coronary syndrome
    Boris Bigalke
    Medizinische Klinik, Klinik für Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Am Heart J 156:193-200. 2008
  5. doi request reprint High shear flow induces migration of adherent human platelets
    Bjoern F Kraemer
    Universitatsklinikum Tubingen, Medizinische Klinik III für Herz und Kreislauferkrankungen, Tubingen, Germany
    Platelets 22:415-21. 2011
  6. doi request reprint Inhibition of foam cell formation using a soluble CD68-Fc fusion protein
    Karin Daub
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    J Mol Med (Berl) 88:909-20. 2010
  7. doi request reprint Glycoprotein VI for diagnosis of acute coronary syndrome when ECG is ambiguous
    Boris Bigalke
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Germany
    Int J Cardiol 149:164-8. 2011
  8. doi request reprint Regulation of platelet glycoprotein VI (GPVI) surface expression and of soluble GPVI in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS)
    Boris Bigalke
    Medizinische Klinik III, Klinik für Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Basic Res Cardiol 104:352-7. 2009
  9. ncbi request reprint Platelet-leukocyte interactions in inflammation and atherothrombosis
    Andreas E May
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Semin Thromb Hemost 33:123-7. 2007
  10. ncbi request reprint The evil in atherosclerosis: adherent platelets induce foam cell formation
    Karin Daub
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Semin Thromb Hemost 33:173-8. 2007

Collaborators

Detail Information

Publications37

  1. ncbi request reprint The active platelet: translation and protein synthesis in an anucleate cell
    Stephan Lindemann
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Semin Thromb Hemost 33:144-50. 2007
    ..With more modern tools of investigation such as cDNA arrays and proteomics, we have discovered a cell that is becoming a more sophisticated libero that functions in the classic mechanisms of white blood cells--inflammation and immunity...
  2. doi request reprint Oxidized LDL-activated platelets induce vascular inflammation
    Karin Daub
    Medizinische Klinik, Klinik für Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Germany
    Semin Thromb Hemost 36:146-56. 2010
    ..Platelet oxLDL contributes significantly to vascular inflammation and is able to promote atherosclerosis...
  3. doi request reprint Junctional adhesion molecule A expressed on human CD34+ cells promotes adhesion on vascular wall and differentiation into endothelial progenitor cells
    Konstantinos Stellos
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Otfried Muller Strasse 10, 72076 Tubingen, Germany
    Arterioscler Thromb Vasc Biol 30:1127-36. 2010
    ..To investigate the role of junctional adhesion molecule A (JAM-A) on adhesion and differentiation of human CD34(+) cells into endothelial progenitor cells...
  4. doi request reprint Platelet collagen receptor glycoprotein VI as a possible novel indicator for the acute coronary syndrome
    Boris Bigalke
    Medizinische Klinik, Klinik für Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Am Heart J 156:193-200. 2008
    ....
  5. doi request reprint High shear flow induces migration of adherent human platelets
    Bjoern F Kraemer
    Universitatsklinikum Tubingen, Medizinische Klinik III für Herz und Kreislauferkrankungen, Tubingen, Germany
    Platelets 22:415-21. 2011
    ..Their migratory potential may enable platelets to cover intimal lesions and contribute to vascular repair...
  6. doi request reprint Inhibition of foam cell formation using a soluble CD68-Fc fusion protein
    Karin Daub
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    J Mol Med (Berl) 88:909-20. 2010
    ..Thus, CD68-Fc might offer a novel therapeutic strategy for patients with acute coronary syndrome by modulating the generation of vulnerable plaques...
  7. doi request reprint Glycoprotein VI for diagnosis of acute coronary syndrome when ECG is ambiguous
    Boris Bigalke
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Germany
    Int J Cardiol 149:164-8. 2011
    ....
  8. doi request reprint Regulation of platelet glycoprotein VI (GPVI) surface expression and of soluble GPVI in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS)
    Boris Bigalke
    Medizinische Klinik III, Klinik für Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Basic Res Cardiol 104:352-7. 2009
    ..This study examined patients with both ACS and stable coronary artery disease (CAD), which presented with atrial fibrillation (AF) and sinus rhythm (SR)...
  9. ncbi request reprint Platelet-leukocyte interactions in inflammation and atherothrombosis
    Andreas E May
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Semin Thromb Hemost 33:123-7. 2007
    ..They trigger autocrine and paracrine activation processes, leading to leukocyte recruitment (in)to the vascular wall. This article highlights the molecular basis and the inflammatory pathways initiated by platelet-leukocyte interactions...
  10. ncbi request reprint The evil in atherosclerosis: adherent platelets induce foam cell formation
    Karin Daub
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Semin Thromb Hemost 33:173-8. 2007
    ..These findings emphasize that the balance between endothelial cell regeneration and platelet-mediated foam cell generation derived from CD34 (+) progenitor cells may play a critical role in atherogenesis and atheroprogression...
  11. doi request reprint Expression of stromal-cell-derived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34+ progenitor cells
    Konstantinos Stellos
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Eur Heart J 30:584-93. 2009
    ..However, there are no clinical data available regarding platelet-bound SDF-1 in patients with acute coronary syndrome (ACS). The objective of this study was to evaluate the platelet-surface expression of SDF-1 in patients with ACS...
  12. doi request reprint EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation
    Peter Seizer
    Medizinische Klinik III, Eberhard Karls University Tuebingen, Germany
    Atherosclerosis 209:51-7. 2010
    ..Thus, we investigated the role of EMMPRIN (CD147) and its ligand cyclophilin A (CyPA) during foam cell formation originating from both monocytes/macrophages and CD34(+) progenitor cells...
  13. ncbi request reprint Platelet-derived stromal cell-derived factor-1 regulates adhesion and promotes differentiation of human CD34+ cells to endothelial progenitor cells
    Konstantinos Stellos
    Medizinische Klinik III, Eberhard Karls Universitätsklinikum Tübingen, Tubingen, Germany
    Circulation 117:206-15. 2008
    ..The chemokine stromal cell-derived factor-1 (SDF-1) regulates homing of CD34+ stem cells. We evaluated the role of platelet-derived SDF-1 in adhesion and differentiation of human CD34+ cells into endothelial progenitor cells...
  14. ncbi request reprint Influence of platelet count on the expression of platelet collagen receptor glycoprotein VI (GPVI) in patients with acute coronary syndrome
    Boris Bigalke
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    Thromb Haemost 101:911-5. 2009
    ....
  15. doi request reprint Diagnostic and therapeutic potentials of platelet glycoprotein VI
    Boris Bigalke
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Germany
    Semin Thromb Hemost 36:203-11. 2010
    ..Besides the therapeutical implication, radiolabeled GPVI gives us a valuable diagnostic means that may be used clinically for plaque imaging in the near future...
  16. doi request reprint Glycoprotein VI as a prognostic biomarker for cardiovascular death in patients with symptomatic coronary artery disease
    Boris Bigalke
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Germany
    Clin Res Cardiol 99:227-33. 2010
    ..Platelets play a critical role in arterial thrombosis, acute coronary syndrome (ACS) and stroke. Platelet collagen receptor glycoprotein VI (GPVI) is associated with acute coronary events and a poor clinical outcome...
  17. doi request reprint SGK1 sensitivity of platelet migration
    Eva Maria Schmidt
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 30:259-68. 2012
    ..In conclusion, SGK1 is a powerful regulator of platelet migration...
  18. ncbi request reprint Platelets induce differentiation of human CD34+ progenitor cells into foam cells and endothelial cells
    Karin Daub
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    FASEB J 20:2559-61. 2006
    ..The understanding and modulation of these mechanisms may offer new treatment strategies for patients at high risk for atherosclerotic diseases...
  19. doi request reprint PI3 kinase-dependent stimulation of platelet migration by stromal cell-derived factor 1 (SDF-1)
    Bjoern F Kraemer
    Abteilung III, Kardiologie und Kreislauferkrankungen, Medizinische Klinik, Universitatsklinikum Tubingen, Otfried Muller Strasse 10, 72076, Tubingen, Germany
    J Mol Med (Berl) 88:1277-88. 2010
    ..The potential of platelets to migrate in an SDF-1-mediated fashion may redefine the role of platelets in the pathophysiology of vascular inflammation, subsequent atherosclerotic degeneration, and vascular regeneration...
  20. ncbi request reprint Platelet interaction with progenitor cells: vascular regeneration or inquiry?
    Konstantinos Stellos
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Otfried Müller 10, Tubingen, Germany
    Pharmacol Rep 60:101-8. 2008
    ..Although further studies are needed to describe the mechanisms that lie underneath these observations, it seems that platelet interaction with progenitor cells is an essential step in both vascular regeneration and injury...
  21. doi request reprint Platelet lipoprotein interplay: trigger of foam cell formation and driver of atherosclerosis
    Dorothea Siegel-Axel
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Universitatsklinikum Tubingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
    Cardiovasc Res 78:8-17. 2008
    ..New data about platelet-mediated lipoprotein transport and consequent foam cell formation, however, provide proof of how platelets might contribute to atheromatous lesion formation...
  22. doi request reprint Ex vivoimaging of injured arteries in rabbits using fluorescence-labelled glycoprotein VI-Fc
    Boris Bigalke
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Germany
    Platelets 23:1-6. 2012
    ..021) and carotid (30.2 ± 7.6 vs. 7.9 ± 3.9; P = 0.005) arteries. This preclinical GPVI-Fc-based vascular lesion imaging approach may be the first step towards a method that allows identification of vascular lesions in vivo...
  23. ncbi request reprint Platelet response to clopidogrel is attenuated in diabetic patients undergoing coronary stent implantation
    Tobias Geisler
    Medizinische Klinik III, Universitatsklinikum Tubingen, Otfried Mullerstrasse 10, 72076 Tubingen, Germany
    Diabetes Care 30:372-4. 2007
  24. ncbi request reprint Platelet glycoprotein VI: a novel marker for acute coronary syndrome
    Boris Bigalke
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Semin Thromb Hemost 33:179-84. 2007
    ..We conclude that the determination of the platelet-specific thrombotic marker GPVI may help to identify patients at risk before myocardial ischemia is evident...
  25. ncbi request reprint Molecular pathways used by platelets to initiate and accelerate atherogenesis
    Stephan Lindemann
    Medical Clinic III, Cardiology and Circulatory Diseases, Eberhard Karls University, Tubingen, Germany
    Curr Opin Lipidol 18:566-73. 2007
    ..The involvement of platelets in the initiation of atherosclerotic lesion formation is critical in directing the atherosclerotic process into regeneration or ongoing vascular injury...
  26. doi request reprint Platelet function and response to aspirin: gender-specific features and implications for female thrombotic risk and management
    Christine S Zuern
    Abteilung Kardiologie und Kreislauferkrankungen, Medizinische Klinik III, Universitaetsklinikum Tuebingen, Germany
    Semin Thromb Hemost 35:295-306. 2009
    ..More studies focused on women are needed to optimize gender-specific therapy and, therefore, to improve clinical outcomes in women with atherosclerosis...
  27. ncbi request reprint Expression of platelet collagen receptor glycoprotein VI is associated with acute coronary syndrome
    Boris Bigalke
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
    Eur Heart J 27:2165-9. 2006
    ..In this observational study, we examined the platelet surface expression of GPVI in patients with symptomatic coronary artery disease (CAD)...
  28. ncbi request reprint [Role of platelets in atherosclerosis and inflammation]
    Dorothea Siegel-Axel
    Abteilung Kardiologie und Kreislauferkrankungen, Medizinische Klinik III, Eberhard Karls Universitat, Tubingen
    Med Klin (Munich) 101:467-75. 2006
    ..Platelet-induced chronic inflammatory processes at the vascular wall result in development of atherosclerotic lesions and atherothrombosis...
  29. pmc Effect of interleukin-15 on the course of myocarditis in Coxsackievirus B3-infected BALB/c mice
    Boris Bigalke
    Medizinische Klinik III, Klinik für Kardiologie und Kreislauferkrankungen, Eberhard Kearls Universität Tübingen, D 72076 Tubingen, Germany
    Can J Cardiol 25:e248-54. 2009
    ....
  30. ncbi request reprint Extracellular matrix metalloproteinase inducer (CD147) is a novel receptor on platelets, activates platelets, and augments nuclear factor kappaB-dependent inflammation in monocytes
    Roland Schmidt
    Deutsches Herzzentrum und I Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Lazarettstr 36, 80636 München, Germany
    Circ Res 102:302-9. 2008
    ..Thus, EMMPRIN may represent a novel target to diminish the burden of protease activity and inflammation in atherosclerosis...
  31. ncbi request reprint Prostacyclin inhibits adhesion of polymorphonuclear leukocytes to human vascular endothelial cells due to adhesion molecule independent regulatory mechanisms
    Stephan Lindemann
    Department of Medicine II, Johannes Gutenberg University, Langenbeckstr 1, D 55101 Mainz, Germany
    Basic Res Cardiol 98:8-15. 2003
    ..These prostacyclin analogs inhibit PMN-adhesion despite maximal adhesion molecule expression by regulating the balance of - yet to be determined - endothelial-derived mediators...
  32. pmc Activated polymorphonuclear leukocytes rapidly synthesize retinoic acid receptor-alpha: a mechanism for translational control of transcriptional events
    Christian C Yost
    Department of Pediatrics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    J Exp Med 200:671-80. 2004
    ..Rapid expression of a transcription factor under translational control is a previously unrecognized mechanism in human PMNs that indicates unexpected diversity in gene regulation in this critical innate immune effector cell...
  33. ncbi request reprint Change in protein phenotype without a nucleus: translational control in platelets
    Andrew S Weyrich
    Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84112, USA
    Semin Thromb Hemost 30:491-8. 2004
    ..We highlight the molecular machinery and pathways used by platelets to translate mRNA into protein and offer insight into how these synthesized products may regulate thrombotic and inflammatory events...
  34. pmc Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets
    Melvin M Denis
    Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Cell 122:379-91. 2005
    ..While this mechanism may be unique to platelets, it also suggests previously unrecognized diversity regarding the functional roles of the spliceosome in eukaryotic cells...
  35. ncbi request reprint Elevated monocyte chemoattractant protein-1 serum levels in patients at risk for coronary artery disease
    Ivo Martinovic
    Department of Heart Surgery, Philipps University Marburg Medical Center, Mainz, Germany
    Circ J 69:1484-9. 2005
    ..Monocyte chemoattractant protein-1 (MCP-1) is involved in the recruitment of monocytes into the arterial vessel wall as one of the major events leading to atherosclerotic vascular diseases, such as coronary artery disease (CAD)...
  36. ncbi request reprint SCUBE1--a new scoop in vascular biology?
    Stephan Lindemann
    Cardiovasc Res 71:414-5. 2006
  37. ncbi request reprint Outside-in signals delivered by matrix metalloproteinase-1 regulate platelet function
    Spencer W Galt
    Departments of Vascular Surgery, Internal Medicine, Program in Human Molecular Genetics, University of Utah, Salt Lake City, USA
    Circ Res 90:1093-9. 2002
    ..The finding that MMP-1 is rapidly activated in platelets and controls functional responses identifies a new role for this metalloproteinase as a signaling molecule that regulates thrombotic events...