Genomes and Genes
Affiliation: Leibniz Institute for Age Research
- Strong population genetic structuring in an annual fish, Nothobranchius furzeri, suggests multiple savannah refugia in southern MozambiqueVeronika Bartáková
Institute of Vertebrate Biology, Academy of Sciences of the Czech Republic, Květná 8, Brno 603 65, Czech Republic
BMC Evol Biol 13:196. 2013..Here, we analysed the genetic structure, diversity, historical demography and temporal patterns of divergence in natural populations of N. furzeri across its entire distribution range...
- High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging researchKathrin Reichwald
Leibniz Institute for Age Research Fritz Lipmann Institute, Beutenbergstr, 07745 Jena, Germany
Genome Biol 10:R16. 2009..Treatment with resveratrol and low temperature significantly extends the maximum life span. These features make N. furzeri a promising new vertebrate model for age research...
- Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosaTimo Dirk Müller
Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
Child Adolesc Psychiatry Ment Health 2:33. 2008..The aim of this study was to analyse whether nucleotide sequence variations in the CNR1, FAAH, NAAA and MGLL genes are associated with anorexia nervosa (AN)...
- Chicken ovalbumin upstream promoter transcription factor II regulates uncoupling protein 3 gene transcription in Phodopus sungorusTobias Fromme
Department of Animal Physiology, Faculty of Biology, Philipps University, D 35043 Marburg, Germany
BMC Mol Biol 8:1. 2007..We therefore investigated whether Coup-TFII is a further player in the transcriptional control of the Ucp3 gene in rodents...
- The transcript catalogue of the short-lived fish Nothobranchius furzeri provides insights into age-dependent changes of mRNA levelsAndreas Petzold
Genome Analysis, Leibniz Institute for Age Research Fritz Lipmann Institute, Beutenbergstr 11, Jena 07745, Germany
BMC Genomics 14:185. 2013..To substantiate its role as an alternative vertebrate ageing model, a transcript catalogue is needed, which can serve e.g. as basis for identifying ageing-related genes...
- Mitochondrial DNA copy number and function decrease with age in the short-lived fish Nothobranchius furzeriNils Hartmann
Department of Molecular Genetics, Leibniz Institute for Age Research Fritz Lipmann Institute FLI, Beutenbergstrasse 11, Jena, Germany
Aging Cell 10:824-31. 2011..These findings suggest that despite the short lifespan, aging in N. furzeri is associated with a decline in mtDNA copy number, the downregulation of mtDNA-associated genes and an impairment of mitochondrial function...
- Allele-specific, age-dependent and BMI-associated DNA methylation of human MCHR1Stefanie Stepanow
Genome Analysis, Leibniz Institute for Age Research, Jena, Germany
PLoS ONE 6:e17711. 2011..In addition, 15 CpGs in close vicinity of these SNPs constitute a weak CpG island. Here, we studied whether DNA methylation in this sequence context may contribute to population- and age-specific effects of MCHR1 alleles in obesity...
- Method for preparing single-stranded DNA templates for Pyrosequencing using vector ligation and universal biotinylated primersMarco Groth
Genome Analysis, Leibniz Institute for Age Research Fritz Lipmann Institute, 07745 Jena, Germany
Anal Biochem 356:194-201. 2006..As a proof of principle, we used the method for genotyping two single-nucleotide polymorphisms in the human genes CARD15 and A2M and for characterization of four multisite variations in the human DEFB104 gene...
- Absence of replicative senescence in cultured cells from the short-lived killifish Nothobranchius furzeriMichael Graf
Molecular Genetics, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstr 11, 07745 Jena, Germany
Exp Gerontol 48:17-28. 2013..Hence, we propose that differences in maximum life span of different N. furzeri strains is not reflected by differences in proliferation speed or replicative potential of the respective cultured cells...
- Parallel evolution of senescence in annual fishes in response to extrinsic mortalityEva Terzibasi Tozzini
Fritz Lipmann Institute for Age Research, Leibniz Institute, Jena, Germany
BMC Evol Biol 13:77. 2013..We use 10 Nothobranchius populations from seasonal pools that differ in their duration to test how this parameter affects longevity and aging in two independent clades of these annual fishes...
- The age related markers lipofuscin and apoptosis show different genetic architecture by QTL mapping in short-lived Nothobranchius fishEnoch Ng'oma
Biology of Ageing, Leibniz Institute for Age Research Fritz Lipmann Institute, 07745 Jena, Germany
Aging (Albany NY) 6:468-80. 2014..001), showing additive and dominance effects, and two interacting loci. Our results show that lipofuscin and apoptosis are markers of different age-dependent biological processes controlled by different genetic mechanisms...
- Mapping of quantitative trait loci controlling lifespan in the short-lived fish Nothobranchius furzeri--a new vertebrate model for age researchJeanette Kirschner
Genome Analysis, Leibniz Institute for Age Research Fritz Lipmann Institute, Jena, Germany
Aging Cell 11:252-61. 2012..Our work provides first results on the way to identify loci controlling lifespan in N. furzeri and illustrates the potential of this vertebrate species as a genetic model for age research...
- Telomeres shorten while Tert expression increases during ageing of the short-lived fish Nothobranchius furzeriNils Hartmann
Leibniz Institute for Age Research Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany
Mech Ageing Dev 130:290-6. 2009..We further conclude that the extremely short lifespan of the GRZ strain is not caused by diminished telomerase activity or accelerated telomere shortening...
- Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequenceStefan Taudien
Genomanalyse, Institut fur Molekulare Biotechnologie, Jena, Germany
BMC Genomics 5:92. 2004..1. This DEF locus, however, represents one of the regions in the euchromatic part of the final human genome sequence which contains segmental duplications, and recalcitrant gaps indicating high structural dynamics...