Affiliation: Klinikum St. Georg
- Outcome in a hepatitis C (genotype 1b) single source outbreak in Germany--a 25-year multicenter studyManfred Wiese
University Affiliated Hospital St Georg, Leipzig, Germany
J Hepatol 43:590-8. 2005..The natural course of the hepatitis C virus genotype 1b (HCV-1b) infection is still unclear but important for therapeutic decisions. There are few unbiased long-term follow-up studies with known dates of infection...
- Interferon-alpha and ribavirin resistance of Huh7 cells transfected with HCV subgenomic repliconMarc Aus dem Siepen
Institute of Virology, Essen University Hospital, University of Duisburg Essen, Hufelandstr 55, Essen, Germany
Virus Res 125:109-13. 2007..This mutation, however, did not change the sensitivity of the replicon itself to this antiviral...
- Low frequency of cirrhosis in a hepatitis C (genotype 1b) single-source outbreak in germany: a 20-year multicenter studyM Wiese
University Affiliated Hospital St Georg of Leipzig, Departments of Medicine of the Universities, Germany
Hepatology 32:91-6. 2000..In conclusion, formerly healthy young women, without hepatic comorbidity, may clear HCV (1b) infection in half of the cases or develop mild chronic hepatitis C with low risk of progression to cirrhosis within 20 years...
- Hepatitis C virus mutation affects proteasomal epitope processingUlrike Seifert
Institute of Biochemistry, Charite, Humboldt University, Berlin, Germany
J Clin Invest 114:250-9. 2004....
- Influence of interleukin 12B (IL12B) polymorphisms on spontaneous and treatment-induced recovery from hepatitis C virus infectionTobias Mueller
Charite, Campus Virchow Klinikum, Medizinische Klinik mit Schwerpunkt, Hepatologie und Gastroenterologie, Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
J Hepatol 41:652-8. 2004..We investigated whether the IL12B polymorphisms within the promoter region (4 bp insertion/deletion) and the 3'-UTR (1188-A/C), which have been reported to influence IL-12 synthesis, are associated with the outcome of HCV infection...
- Reduced bone mineral density and altered bone turnover markers in patients with non-cirrhotic chronic hepatitis B or C infectionIngolf Schiefke
Department of Medicine II, University of Leipzig, Philipp Rosenthal Str 27, 04103 Leipzig, Germany
World J Gastroenterol 11:1843-7. 2005..However, little is known about the occurrence of bone disease in non-cirrhotic patients with chronic hepatitis B or C. Therefore, it was the aim of this study to evaluate this particular population for BMD and bone turnover markers...
- Nonstructural protein 5A does not contribute to the resistance of hepatitis C virus replication to interferon alpha in cell cultureMarc Aus dem Siepen
Institute of Virology, Essen University Hospital, Hufelandstr 55, 45122 Essen, Germany
Virology 336:131-6. 2005..Thus, these data provide no evidence that the NS5A protein contributes to the resistance of HCV replication to IFN-alpha...