Alexander Kurz

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. doi request reprint Disconnection of frontal and parietal areas contributes to impaired attention in very early Alzheimer's disease
    Susanne Neufang
    Department of Neuroradiology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
    J Alzheimers Dis 25:309-21. 2011
  2. ncbi request reprint Disease stage in Alzheimer disease and treatment effects of rivastigmine
    Alexander Kurz
    Technische Universitat Munchen, Munich, Germany
    Alzheimer Dis Assoc Disord 18:123-8. 2004
  3. doi request reprint Fluoro-deoxy-glucose positron emission tomography correlates of impaired activities of daily living in dementia with Lewy bodies: implications for cognitive reserve
    Robert Perneczky
    Departments of Psychiatry and Psychotherapy, Technical University Munich, Ismaninger Strasse 22, Munich, Germany
    Am J Geriatr Psychiatry 17:188-95. 2009
  4. doi request reprint Activities of daily living, cerebral glucose metabolism, and cognitive reserve in Lewy body and Parkinson's disease
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Dement Geriatr Cogn Disord 26:475-81. 2008
  5. doi request reprint Amyloid cascade and tau pathology cerebrospinal fluid markers in mild cognitive impairment with regards to Alzheimer's disease cerebral metabolic signature
    Panagiotis Alexopoulos
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    J Alzheimers Dis 36:401-8. 2013
  6. doi request reprint β-Site amyloid precursor protein-cleaving enzyme 1 activity is related to cerebrospinal fluid concentrations of sortilin-related receptor with A-type repeats, soluble amyloid precursor protein, and tau
    Amalia Tsolakidou
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Alzheimers Dement 9:386-91. 2013
  7. doi request reprint Quantitative longitudinal interrelationships between brain metabolism and amyloid deposition during a 2-year follow-up in patients with early Alzheimer's disease
    Stefan Forster
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    Eur J Nucl Med Mol Imaging 39:1927-36. 2012
  8. doi request reprint Caregiver burden and needs in frontotemporal dementia
    Janine Diehl-Schmid
    Department of Psychiatry, Technische Universitat Munchen, Munchen, Germany
    J Geriatr Psychiatry Neurol 26:221-9. 2013
  9. ncbi request reprint The usefulness of amyloid imaging in predicting the clinical outcome after two years in subjects with mild cognitive impairment
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Möhlstr 26, 81675 Munchen, Germany
    Curr Alzheimer Res 10:82-5. 2013
  10. doi request reprint Interrelations between CSF soluble AβPPβ, amyloid-β 1-42, SORL1, and tau levels in Alzheimer's disease
    Panagiotis Alexopoulos
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Alzheimers Dis 28:543-52. 2012

Detail Information

Publications87

  1. doi request reprint Disconnection of frontal and parietal areas contributes to impaired attention in very early Alzheimer's disease
    Susanne Neufang
    Department of Neuroradiology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
    J Alzheimers Dis 25:309-21. 2011
    ..We conclude that, at very early stages of AD, the reduction of effective connectivity in fronto-parietal circuits is related to regional gray matter volume and contributes to impairments in top-down attentional control...
  2. ncbi request reprint Disease stage in Alzheimer disease and treatment effects of rivastigmine
    Alexander Kurz
    Technische Universitat Munchen, Munich, Germany
    Alzheimer Dis Assoc Disord 18:123-8. 2004
    ..Activities of daily living showed statistically significant benefits with rivastigmine across all severity cohorts...
  3. doi request reprint Fluoro-deoxy-glucose positron emission tomography correlates of impaired activities of daily living in dementia with Lewy bodies: implications for cognitive reserve
    Robert Perneczky
    Departments of Psychiatry and Psychotherapy, Technical University Munich, Ismaninger Strasse 22, Munich, Germany
    Am J Geriatr Psychiatry 17:188-95. 2009
    ....
  4. doi request reprint Activities of daily living, cerebral glucose metabolism, and cognitive reserve in Lewy body and Parkinson's disease
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Dement Geriatr Cogn Disord 26:475-81. 2008
    ....
  5. doi request reprint Amyloid cascade and tau pathology cerebrospinal fluid markers in mild cognitive impairment with regards to Alzheimer's disease cerebral metabolic signature
    Panagiotis Alexopoulos
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    J Alzheimers Dis 36:401-8. 2013
    ..g., soluble AβPPα and β (sAβPPα and sAβPPβ, respectively); sortilin-related receptor with A-type repeats (SORL1, also called LR11 or SORLA)] are factors crucially implicated in the formation of pathological hallmarks of AD...
  6. doi request reprint β-Site amyloid precursor protein-cleaving enzyme 1 activity is related to cerebrospinal fluid concentrations of sortilin-related receptor with A-type repeats, soluble amyloid precursor protein, and tau
    Amalia Tsolakidou
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Alzheimers Dement 9:386-91. 2013
    ..Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) activity determines the rate of APP cleavage and is therefore the main driver of amyloid β production, which is a pathological hallmark of Alzheimer's disease (AD)...
  7. doi request reprint Quantitative longitudinal interrelationships between brain metabolism and amyloid deposition during a 2-year follow-up in patients with early Alzheimer's disease
    Stefan Forster
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    Eur J Nucl Med Mol Imaging 39:1927-36. 2012
    ..Based on this finding we now hypothesize that in early AD patients quantitative longitudinal decline in hypometabolism may be related to the amount of baseline amyloid deposition during a follow-up period of 2 years...
  8. doi request reprint Caregiver burden and needs in frontotemporal dementia
    Janine Diehl-Schmid
    Department of Psychiatry, Technische Universitat Munchen, Munchen, Germany
    J Geriatr Psychiatry Neurol 26:221-9. 2013
    ..However, little is known about the specific problems, the factors that contribute to caregiver burden, and the needs of the FTD caregivers-particularly those needs that are accessible by external support strategies...
  9. ncbi request reprint The usefulness of amyloid imaging in predicting the clinical outcome after two years in subjects with mild cognitive impairment
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Möhlstr 26, 81675 Munchen, Germany
    Curr Alzheimer Res 10:82-5. 2013
    ..Amyloid imaging enables to visualize a hallmark pathology of Alzheimer's disease (AD). Therefore we aimed to assess the usefulness of [(11)C]PiB PET for predicting clinical outcome of MCI patients after an interval of 2 years...
  10. doi request reprint Interrelations between CSF soluble AβPPβ, amyloid-β 1-42, SORL1, and tau levels in Alzheimer's disease
    Panagiotis Alexopoulos
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Alzheimers Dis 28:543-52. 2012
    ....
  11. doi request reprint Brain metabolic correlates of cerebrospinal fluid beta-amyloid 42 and tau in Alzheimer's disease
    Ruth Vukovich
    Department of Psychiatry and Psychotherapy, Neurochemistry and Neurogenetics Laboratory, Technische Universitat Munchen, Munchen, Germany
    Dement Geriatr Cogn Disord 27:474-80. 2009
    ..Their topographic origin and their association with synaptic dysfunction are still not well understood...
  12. ncbi request reprint Prediction of individual clinical outcome in MCI by means of genetic assessment and (18)F-FDG PET
    Alexander Drzezga
    Department of Nuclear Medicine, Technische Universitat, Munchen, Munich, Germany
    J Nucl Med 46:1625-32. 2005
    ....
  13. ncbi request reprint Metabolic correlates of brain reserve in dementia with Lewy bodies: an FDG PET study
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technical University Munich, Munich, Germany
    Dement Geriatr Cogn Disord 23:416-22. 2007
    ..Research has been mainly focussed on Alzheimer's disease and no studies exist on patients with dementia with Lewy bodies (DLB). The aim of this study was to provide evidence for brain reserve in DLB...
  14. ncbi request reprint Male gender is associated with greater cerebral hypometabolism in frontotemporal dementia: evidence for sex-related cognitive reserve
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technical University Munich, Munich, Germany
    Int J Geriatr Psychiatry 22:1135-40. 2007
    ..This suggests that men can compensate more pathology than women...
  15. pmc Education attenuates the effect of medial temporal lobe atrophy on cognitive function in Alzheimer's disease: the MIRAGE study
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munchen, Germany
    J Alzheimers Dis 17:855-62. 2009
    ..Most interestingly, the interaction term between education and MTA was significant suggesting that education modifies the relation of MTA to cognition. At any level of pathology, cognition remained higher for better educated individuals...
  16. doi request reprint Cerebral metabolic dysfunction in patients with dementia with Lewy bodies and visual hallucinations
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technical University Munich, Munich, Germany
    Dement Geriatr Cogn Disord 25:531-8. 2008
    ..To identify the pattern of cerebral hypometabolism in patients with dementia with Lewy bodies (DLB) and visual hallucinations (VH)...
  17. doi request reprint Clinical and neurobiological correlates of soluble amyloid precursor proteins in the cerebrospinal fluid
    Panagiotis Alexopoulos
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Alzheimers Dement 8:304-11. 2012
    ..The levels of the α-secretase-cleaved soluble APP (sAPPα) and β-secretase-cleaved soluble APP (sAPPβ) in cerebrospinal fluid (CSF) are likely to reflect these competing mechanisms...
  18. pmc Cerebrospinal fluid BACE1 activity and brain amyloid load in Alzheimer's disease
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Street 22, 81675 Munchen, Germany
    ScientificWorldJournal 2012:712048. 2012
    ..Associations were found in areas close to the brain ventricles, which may have important implications for the use of BACE1 in CSF as a marker for AD pathology and for antiamyloid treatment monitoring...
  19. ncbi request reprint Non-fluent progressive aphasia: cerebral metabolic patterns and brain reserve
    Robert Perneczky
    Departments of Psychiatry and Psychotherapy, Technische Universitat Munchen, Germany
    Brain Res 1133:178-85. 2007
    ..05). We conclude that brain reserve is also present in NFPA...
  20. doi request reprint A 6-month, open-label study of memantine in patients with frontotemporal dementia
    Janine Diehl-Schmid
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Int J Geriatr Psychiatry 23:754-9. 2008
    ..To evaluate safety and effects on cognition and behavior of memantine 20 mg/day in the treatment of patients with frontotemporal dementia (FTD)...
  21. doi request reprint Accelerated clinical decline in well-educated patients with frontotemporal lobar degenerations
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, 81675 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 259:362-7. 2009
    ..There was a significant positive association between education and CDR-SOB monthly rate of change, indicating a faster decline in the well-educated. Education was the only significant predictor of clinical deterioration...
  22. doi request reprint Increased Intrinsic Activity of Medial-Temporal Lobe Subregions is Associated with Decreased Cortical Thickness of Medial-Parietal Areas in Patients with Alzheimer's Disease Dementia
    Lorenzo Pasquini
    Department of Neuroradiology, Technische Universitat Munchen, Munich, Germany
    J Alzheimers Dis 51:313-26. 2016
    ..Results fit a model in which medial-parietal degeneration contributes to MTL dysconnectivity from medial-parietal cortices, potentially underpinning disinhibition-like changes in MTL activity. ..
  23. doi request reprint Regional expansion of hypometabolism in Alzheimer's disease follows amyloid deposition with temporal delay
    Stefan Forster
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    Biol Psychiatry 71:792-7. 2012
    ..The aim of this study was to examine longitudinal regional patterns of amyloid deposition and hypometabolism in the same population of mild AD subjects and to establish their regional relationship to each other...
  24. doi request reprint Asymmetric loss of parietal activity causes spatial bias in prodromal and mild Alzheimer's disease
    Christian Sorg
    Department of Psychiatry, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Biol Psychiatry 71:798-804. 2012
    ....
  25. doi request reprint Age-related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling
    Christine Preibisch
    Department of Neuroradiology, Technische Universitat Munchen, Munich, Germany Department of Neurology, Technische Universitat Munchen, Munchen, Germany
    J Magn Reson Imaging 34:1295-302. 2011
    ..To investigate age-related regional perfusion changes focused on the medial temporal lobes and related parietal areas using a pulsed arterial spin labeling technique...
  26. ncbi request reprint Complex activities of daily living in mild cognitive impairment: conceptual and diagnostic issues
    Robert Perneczky
    Department of Psychiatry, Technische Universitat Munchen, Germany
    Age Ageing 35:240-5. 2006
    ..The concept of an ADL threshold that separates MCI from dementia, however, appears to be improbable for several reasons...
  27. ncbi request reprint Brain reserve capacity in frontotemporal dementia: a voxel-based 18F-FDG PET study
    Robert Perneczky
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Technische Universitat Munchen, Ismaningerstr 22, 81675 Munchen, Germany
    Eur J Nucl Med Mol Imaging 34:1082-7. 2007
    ..The results suggest that brain reserve capacity (BRC) allows patients with more years of schooling to cope better with AD pathology. The objective of this study was to provide initial evidence for BRC in frontotemporal dementia (FTD)...
  28. doi request reprint Cognitive decline in the behavioral variant of frontotemporal dementia
    Janine Diehl-Schmid
    Department of Psychiatry of Technische Universität München, Munich, Germany
    Int Psychogeriatr 23:230-7. 2011
    ..This is surprising because knowledge about the progression of symptoms is a precondition for the design of clinical drug trials...
  29. doi request reprint Grey-matter atrophy in Alzheimer's disease is asymmetric but not lateralized
    Sabine Derflinger
    Department of Neurology, Technische Universitat Munchen, Munich, Germany
    J Alzheimers Dis 25:347-57. 2011
    ..We conclude that, in principle, brain atrophy in AD is asymmetric rather than lateralized. At the individual level however, asymmetry contributes to cognitive deficits...
  30. pmc Progressively Disrupted Intrinsic Functional Connectivity of Basolateral Amygdala in Very Early Alzheimer's Disease
    Marion Ortner
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Front Neurol 7:132. 2016
    ..Data suggest that early AD disrupts intrinsic connectivity of medial temporal lobe key regions, including that of amygdala...
  31. doi request reprint Visual Versus Fully Automated Analyses of 18F-FDG and Amyloid PET for Prediction of Dementia Due to Alzheimer Disease in Mild Cognitive Impairment
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    J Nucl Med 57:204-7. 2016
    ..It is a matter of debate whether to analyze these images visually or using automated techniques. Therefore, we compared the usefulness of both imaging methods and both analyzing strategies to predict dementia due to AD...
  32. doi request reprint Brain size and the compensation of Alzheimer's disease symptoms: a longitudinal cohort study
    Liang Hao Guo
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Alzheimers Dement 9:580-6. 2013
    ..In this study we examine whether ICV modulates the association between clinical disease progression on the one hand and brain atrophy or the apolipoprotein E genotype on the other...
  33. pmc Plasma proteomics for the identification of Alzheimer disease
    Liang Hao Guo
    Department of Psychiatry and Psychotherapy Institute for Medical Statistics and Epidemiology, Technische Universitat Munchen, Munich, Germany Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology, and Medicine, London, UK
    Alzheimer Dis Assoc Disord 27:337-42. 2013
    ..The study provides a piece of evidence in support of the feasibility of a blood-based biomarker approach in AD diagnostics; however, further research is required because of issues with replicability. ..
  34. pmc Prediction of Alzheimer's disease using individual structural connectivity networks
    Junming Shao
    Department of Neuroradiology of Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Neurobiol Aging 33:2756-65. 2012
    ..Our finding provides evidence that ISCNs are sensitive to the impact of earliest stages of AD. ISCNs may be useful as a white matter-based imaging biomarker to distinguish healthy aging from AD...
  35. pmc Impact of SORL1 single nucleotide polymorphisms on Alzheimer's disease cerebrospinal fluid markers
    Panagiotis Alexopoulos
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany panos alexopoulos lrz tum de
    Dement Geriatr Cogn Disord 32:164-70. 2011
    ..Recently, genetic variants of the neuronal sortilin-related receptor with A-type repeats (SORL1, also called LR11 or sorLA) have emerged as risk factors for the development of Alzheimer's disease (AD)...
  36. ncbi request reprint Urinary incontinence and its functional anatomy in frontotemporal lobar degenerations
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technical University Munich Medical School, Munich, Germany
    Eur J Nucl Med Mol Imaging 35:605-10. 2008
    ..The aim of the present study was therefore to explore if functional brain lesions were associated with UIC in patients suffering from frontotemporal lobar degenerations (FTLD)...
  37. ncbi request reprint No association of chromatin-modifying protein 2B with sporadic frontotemporal dementia
    Axel Schumacher
    Laboratory of Neurochemistry and Neurogenetics, Department of Psychiatry and Psychotherapy, Munich, Germany
    Neurobiol Aging 28:1789-90. 2007
    ..Thus, we conclude that CHMP2B can be excluded as a susceptibility gene conferring risk to sporadic forms of FTD...
  38. doi request reprint Evaluation of a brief educational program for dementia carers: the AENEAS study
    Alexander Kurz
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Int J Geriatr Psychiatry 25:861-9. 2010
    ..To evaluate the efficacy of a practical, easily implemented, educational intervention in group format for informal carers of persons with dementia...
  39. doi request reprint Cognitive rehabilitation in patients with mild cognitive impairment
    Alexander Kurz
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, Germany
    Int J Geriatr Psychiatry 24:163-8. 2009
    ..To explore the benefits of a multi-component cognitive rehabilitation programme in patients with mild cognitive impairment (MCI)...
  40. doi request reprint Link between hippocampus' raised local and eased global intrinsic connectivity in AD
    Lorenzo Pasquini
    Department of Neuroradiology, Technische Universitat Munchen, Munich, Germany TUM Neuroimaging Center, Technische Universitat Munchen, Munich, Germany
    Alzheimers Dement 11:475-84. 2015
    ..Because of widespread network degeneration, it has been suggested that increasing HP disconnection from the DMN may lead to progressive disinhibition of intra-HP synchronized activity...
  41. pmc Within-patient correspondence of amyloid-β and intrinsic network connectivity in Alzheimer's disease
    Nicholas Myers
    1 Department of Neuroradiology, Technische Universitat Munchen, Ismaningerstr 22, 81675 Munich, Germany2 TUM Neuroimaging Centre, Technische Universitat Munchen, Ismaningerstr 22, 81675 Munich, Germany3 Department of Experimental Psychology, Oxford University, 9 South Parks Road, Oxford OX1 3UD, UK
    Brain 137:2052-64. 2014
    ....
  42. pmc Selective changes of resting-state networks in individuals at risk for Alzheimer's disease
    Christian Sorg
    Department of Psychiatry, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 104:18760-5. 2007
    ..We interpret our finding as a proof of principle, demonstrating that functional brain disorders can be characterized by functional-disconnectivity profiles of RSNs...
  43. ncbi request reprint Impact of Alzheimer's disease on the functional connectivity of spontaneous brain activity
    Christian Sorg
    Department of Psychiatry, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    Curr Alzheimer Res 6:541-53. 2009
    ..Finally, rs-fMRI seems to have the potential to produce connectivity-related biomarkers that distinguish AD and healthy aging...
  44. ncbi request reprint Impairment of activities of daily living requiring memory or complex reasoning as part of the MCI syndrome
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Int J Geriatr Psychiatry 21:158-62. 2006
    ..However, even mild degrees of cognitive deterioration are known to have negative effects on complex ADL...
  45. doi request reprint Limited agreement between biomarkers of neuronal injury at different stages of Alzheimer's disease
    Panagiotis Alexopoulos
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany Department of Psychiatry, University of Patras, Rion Patras, Greece
    Alzheimers Dement 10:684-9. 2014
    ..Prospective diagnostic criteria for AD should address the relative importance of markers of neuronal injury and elaborate a way of dealing with conflicting biomarker findings. ..
  46. pmc Intrinsic brain activity of cognitively normal older persons resembles more that of patients both with and at risk for Alzheimer's disease than that of healthy younger persons
    Lorenzo Pasquini
    1 Department of Neuroradiology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Brain Connect 4:323-36. 2014
    ..The observed link of aging and AD with intrinsic brain activity supports the view that lifespan intrinsic activity may contribute critically to the pathogenesis of AD...
  47. ncbi request reprint CORDIAL: cognitive rehabilitation and cognitive-behavioral treatment for early dementia in Alzheimer disease: a multicenter, randomized, controlled trial
    Alexander Kurz
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Alzheimer Dis Assoc Disord 26:246-53. 2012
    ..The findings of this study may be helpful for designing further studies that are needed to determine the potential of CR in older adults with dementia...
  48. ncbi request reprint Mapping scores onto stages: mini-mental state examination and clinical dementia rating
    Robert Perneczky
    Department of Psychiatry and Psychotherapy and the Institute of Medical Statistics and Epidemiology, Technische Universitat Munchen, Germany
    Am J Geriatr Psychiatry 14:139-44. 2006
    ..In the present study, the authors mapped Mini-Mental State Examination (MMSE) scores onto CDR categories to determine how well the MMSE performs as a surrogate of the CDR as a timesaving method of staging dementia...
  49. ncbi request reprint A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease
    Matthias Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Hum Mol Genet 15:2446-56. 2006
    ..Further functional investigations are warranted to elucidate the specific role of PLAU, respectively, PLAU variants in the metabolism of Abeta proteins...
  50. pmc Impaired cross-modal inhibition in Alzheimer disease
    Alexander Drzezga
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    PLoS Med 2:e288. 2005
    ....
  51. doi request reprint Guilty by suspicion? Criminal behavior in frontotemporal lobar degeneration
    Janine Diehl-Schmid
    Department of Psychiatry, Technische Universitat Munchen, Munich, Germany
    Cogn Behav Neurol 26:73-7. 2013
    ..Our aim was to compare the frequency of criminal conduct in patients with behavioral variant frontotemporal dementia (bvFTD), semantic dementia (SD), and Alzheimer disease...
  52. doi request reprint Patient participation in medical and social decisions in Alzheimer's disease
    Johannes Hamann
    Department of Psychiatry, Technische Universitat Munchen, Munchen, Germany
    J Am Geriatr Soc 59:2045-52. 2011
    ....
  53. doi request reprint Novel insights for the treatment of Alzheimer's disease
    Alexander Kurz
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 35:373-9. 2011
    ..Symptomatic treatments will continue to be needed, and psychosocial approaches will retain an essential role in supporting affected individuals and their families...
  54. doi request reprint Education, occupation, and dementia: the Bavarian school sisters study
    Horst Bickel
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munchen, Germany
    Dement Geriatr Cogn Disord 27:548-56. 2009
    ....
  55. doi request reprint Neurobiology of cognitive disorders
    Alexander Kurz
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Germany
    Curr Opin Psychiatry 22:546-51. 2009
    ..The consequences of these novel insights for therapeutic interventions are also explained...
  56. doi request reprint Mapping CSF biomarker profiles onto NIA-AA guidelines for Alzheimer's disease
    Panagiotis Alexopoulos
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 266:587-97. 2016
    ....
  57. pmc Which medical and social decision topics are important after early diagnosis of Alzheimer's Disease from the perspectives of people with Alzheimer's Disease, spouses and professionals?
    Katharina Bronner
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    BMC Res Notes 9:149. 2016
    ..The relevance of early decision making will rise with increasing availability of early detection of Alzheimer's disease (AD) using brain imaging or biomarkers...
  58. pmc Gaussian Mixture Models and Model Selection for [18F] Fluorodeoxyglucose Positron Emission Tomography Classification in Alzheimer's Disease
    Rui Li
    Institut fur Informatik I12, Technische Universitat Munchen, Garching bei Munchen, Germany
    PLoS ONE 10:e0122731. 2014
    ....
  59. doi request reprint Caregivers of patients with frontotemporal lobar degeneration: a review of burden, problems, needs, and interventions
    Sabine Nunnemann
    Department of Psychiatry, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Int Psychogeriatr 24:1368-86. 2012
    ..The aim of the current study is to systematically review publications on (1) burden, problems, and needs of FTLD caregivers, and (2) the feasibility and efficacy of caregiver interventions in FTLD...
  60. doi request reprint Survival in a German population with frontotemporal lobar degeneration
    Sabine Nunnemann
    Department of Psychiatry, Technische Universitat Munchen, Munchen, Germany
    Neuroepidemiology 37:160-5. 2011
    ..Furthermore, the objective of the study was to identify prognostic factors associated with survival and to examine causes of death...
  61. ncbi request reprint Effects of cholinesterase inhibitors on behavioural disturbances in Alzheimer's disease: a systematic review
    Timo Grimmer
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Drugs Aging 23:957-67. 2006
    ....
  62. ncbi request reprint The cathepsin D rs17571 polymorphism: effects on CSF tau concentrations in Alzheimer disease
    Matthias Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Hum Mutat 27:532-7. 2006
    ..The result may corroborate the implication of the lysosomal system in the pathogenesis of AD and is of particular importance if CSF tau is used as a diagnostic biomarker...
  63. ncbi request reprint Potential biological markers for cerebrovascular disease
    Alexander Kurz
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Int Psychogeriatr 15:89-97. 2003
    ..Among biochemical markers in the CSF, tau protein, phospho-tau, and beta amyloid protein are helpful to differentiate vascular dementia from Alzheimer's disease...
  64. doi request reprint Amyloid clearance as a treatment target against Alzheimer's disease
    Alexander Kurz
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Alzheimers Dis 24:61-73. 2011
    ..It may take longer than projected in ongoing trials for such neurobiological effects to translate into measurable changes of clinical progression...
  65. doi request reprint Efficacy of memantine hydrochloride once-daily in Alzheimer's disease
    Alexander Kurz
    Technische Universitat Munchen, Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Ismaninger Strasse 22, D 81675 Munich, Germany
    Expert Opin Pharmacother 15:1955-60. 2014
    ..It is commonly administered twice daily at a maximum dose of 20 mg. To improve medication adherence, convenience of use and to enable a higher daily dose, a 28 mg, extended-release formulation of memantine has been developed...
  66. ncbi request reprint Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study
    Alexander Drzezga
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675, Munchen, Germany
    Eur J Nucl Med Mol Imaging 30:1104-13. 2003
    ..A newly emerging reduction of rCMRglc in prefrontal cortical areas is associated with the transition from MCI to AD...
  67. doi request reprint Personal perspectives of persons with Alzheimer's disease and their carers: a global survey
    Alexander Kurz
    Munich University of Technology and Science, Munich, Germany
    Alzheimers Dement 4:345-52. 2008
    ..Alzheimer's disease (AD) impacts on persons with AD as well their families. This survey aimed to identify information/communication gaps, and quality of life and other issues, from both perspectives...
  68. ncbi request reprint Galantamine demonstrates efficacy and safety in elderly patients with Alzheimer disease
    Jan Marcusson
    Department of Geriatric Medicine, Linkoping University Hospital, Linkoping, Sweden
    Alzheimer Dis Assoc Disord 17:S86-91. 2003
    ..Prescribing approved therapies such as galantamine for older patients with AD is recommended...
  69. ncbi request reprint Cerebral metabolic correlates of the clinical dementia rating scale in mild cognitive impairment
    Robert Perneczky
    Department of Psychiatry, Medicine Technische Universität Munchen, Germany
    J Geriatr Psychiatry Neurol 20:84-8. 2007
    ..001, uncorrected for multiple comparisons), which was independent from demographical variables. The authors conclude that clinical severity of impairments is already correlated with deficits in glucose metabolism in the stage of MCI...
  70. ncbi request reprint Alpha2-macroglobulin, lipoprotein receptor-related protein and lipoprotein receptor-associated protein and the genetic risk for developing Alzheimer's disease
    Candan Depboylu
    Department of Neurology, Philipps University Marburg, Rudolph Bultmann Str 8, 35039 Marburg, Germany
    Neurosci Lett 400:187-90. 2006
    ..Although LRP as well as RAP seem to play an essential role in the metabolism of alpha2M and APOE, there is no increase in the genetic risk for AD in patients carrying the investigated polymorphisms...
  71. ncbi request reprint Weak independent association signals between IDE polymorphisms, Alzheimer's disease and cognitive measures
    Jakob C Mueller
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technical University Munich TUM, Ismaningerstr 22, 81675 Munchen, Germany
    Neurobiol Aging 28:727-34. 2007
    ..A subgroup analysis indicated more prominent associations with AD in younger, and with MMSE in older patients. There may be two independent effects mediated by IDE variants, risk for AD and modification of disease progression...
  72. ncbi request reprint [Associations between dementia and head circumference as a measure of brain reserve--results from the Bavarian School sisters study]
    Horst Bickel
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie der Technischen Universitat Munchen, Klinikum rechts der Isar
    Psychiatr Prax 33:138-44. 2006
    ..The aim of the study was to examine the relationship of head circumference as a marker of maximal attained brain size to late-life cognitive impairment and dementia...
  73. ncbi request reprint TNF polymorphisms in Alzheimer disease and functional implications on CSF beta-amyloid levels
    Simon M Laws
    Alzheimer s and Aging, School of Biomedical and Sports Science, Edith Cowan University, Joondalup, Australia
    Hum Mutat 26:29-35. 2005
    ..Further investigations are warranted to assess the significance of these novel findings...
  74. ncbi request reprint Clinical efficacy of piracetam in cognitive impairment: a meta-analysis
    Tony Waegemans
    Research and Development, UCB SA Pharma Sector, Braine l Alleud, Belgium
    Dement Geriatr Cogn Disord 13:217-24. 2002
    ....
  75. ncbi request reprint Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial
    Timo Erkinjuntti
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland
    Lancet 359:1283-90. 2002
    ..We investigated the effects of galantamine in patients with a diagnosis of probable vascular dementia or Alzheimer's disease combined with cerebrovascular disease...
  76. ncbi request reprint Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer's disease
    Alexander Drzezga
    Department of Nuclear Medicine, Technische Universitat, Munchen, Ismaninger Str 22, D 81675 Munich, Germany
    Neuroimage 39:619-33. 2008
    ....
  77. pmc Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias
    Lisa Mosconi
    Center for Brain Health, New York University School of Medicine, New York, New York 10016, USA
    J Nucl Med 49:390-8. 2008
    ....
  78. pmc Multivariate and univariate neuroimaging biomarkers of Alzheimer's disease
    Christian Habeck
    Taub Institute, Columbia University Medical Center, New York, NY 10032, USA
    Neuroimage 40:1503-15. 2008
    ..Multivariate measures of AD utilize the covariance structure of imaging data and provide complementary, clinically relevant information that may be superior to univariate measures...
  79. ncbi request reprint [Treatment of Alzheimer's disease. The status quo]
    Janine Diehl
    Klinik für Psychiatrie und Psychotherapie der Technischen Universität München, Ismaninger Str 22, 81675 Munchen
    Med Monatsschr Pharm 25:8-12. 2002
  80. ncbi request reprint A novel treatment for patients with Alzheimer's disease and with vascular dementia
    Alexander Kurz
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, D 81675 Munich, Germany
    Ann N Y Acad Sci 977:476-81. 2002
  81. ncbi request reprint [Study questions the benefit of the treatment. Aggressive Alzheimer patient -- a (not a) case for atypical neuroleptics?]
    Alexander Kurz
    MMW Fortschr Med 148:16. 2006
  82. ncbi request reprint Galantamine provides sustained benefits in patients with 'advanced moderate' Alzheimer's disease for at least 12 months
    Rafael Blesa
    Hospital Clinic Universitari, Barcelona, Spain
    Dement Geriatr Cogn Disord 15:79-87. 2003
    ..This drug has potential for broader use in clinical practice...
  83. ncbi request reprint Lack of association of interleukin-10 promoter region polymorphisms with Alzheimer's disease
    Candan Depboylu
    Department of Neurology, Friedrich Wilhelms University, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Neurosci Lett 342:132-4. 2003
    ..We conclude that polymorphisms in the IL-10 promoter region do not increase the risk of developing AD...
  84. ncbi request reprint An open-label extension trial of galantamine in patients with probable vascular dementia and mixed dementia
    Timo Erkinjuntti
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland
    Clin Ther 25:1765-82. 2003
    ....
  85. ncbi request reprint Do all patients with mild cognitive impairment progress to dementia?
    Panagiotis Alexopoulos
    J Am Geriatr Soc 54:1008-10. 2006
  86. ncbi request reprint [State of the art management of BPSD in dementia]
    Michael K Rainer
    Memory Klinik und Psychiatrische Abteilung, Donauspital, Sozialmedizinisches Zentrum Ost, Wien, Osterreich
    Psychiatr Prax 32:31-8. 2005
    ..To obtain a cross-sectional overview of therapeutic practice concerning non-cognitive, behavioral signs and symptoms of dementia (BPSD) in Germany, Austria, and Switzerland...
  87. ncbi request reprint Galantamine in the treatment of cognitive decline in patients with vascular dementia or Alzheimer's disease with cerebrovascular disease
    Gary Small
    Department of Psychiatry and Biobehavioral Sciences and Neuropsychiatric Institute, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90024, USA
    CNS Drugs 17:905-14. 2003
    ....