Florian R Greten

Summary

Affiliation: Klinikum rechts der Isar
Country: Germany

Publications

  1. pmc Cell Autonomous and Non-Autonomous Functions of IKKβ and NF-κB during the Pathogenesis of Gastrointestinal Tumors
    Hsin Yu Fang
    Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str 22, Munich 81675, Germany
    Cancers (Basel) 3:2214-22. 2011
  2. pmc NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta
    Florian R Greten
    Second Department of Medicine, Klinikum rechts der Isar, Technical University Munich, 81675 Germany
    Cell 130:918-31. 2007
  3. doi TAK1: Another mesh in the NF-κB - JNK controlled network causing hepatocellular carcinoma
    Florian R Greten
    Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, Ismaningerstr 22, 81675 Munich, Germany
    J Hepatol 55:721-3. 2011
  4. doi IKKα promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells
    Serkan I Göktuna
    Institute of Molecular Immunology, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munich, Germany Unit of Signal Transduction GIGA ST, GIGA R, University of Liege and WELBIO, CHU, Sart Tilman, 4000 Liege, Belgium
    Cell Rep 7:1914-25. 2014
  5. doi Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties
    Sarah Schwitalla
    Institute of Molecular Immunology, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munich, Germany
    Cell 152:25-38. 2013
  6. pmc TNF-alpha-dependent loss of IKKbeta-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis
    Arun K Mankan
    Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 108:6567-72. 2011
  7. doi Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors
    Sarah Schwitalla
    Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
    Cancer Cell 23:93-106. 2013
  8. pmc High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity
    Manon D Schulz
    1 Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany 2
    Nature 514:508-12. 2014
  9. pmc The gastrointestinal tumor microenvironment
    Michael Quante
    II Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Gastroenterology 145:63-78. 2013
  10. pmc IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis
    Julia Bollrath
    2nd Department of Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    EMBO Rep 10:1314-9. 2009

Collaborators

Detail Information

Publications32

  1. pmc Cell Autonomous and Non-Autonomous Functions of IKKβ and NF-κB during the Pathogenesis of Gastrointestinal Tumors
    Hsin Yu Fang
    Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str 22, Munich 81675, Germany
    Cancers (Basel) 3:2214-22. 2011
    ..Therefore, specific NF-κB inhibition in combination with cytotoxic drugs and/or irradiation represents a very promising strategy for cancer therapy. ..
  2. pmc NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta
    Florian R Greten
    Second Department of Medicine, Klinikum rechts der Isar, Technical University Munich, 81675 Germany
    Cell 130:918-31. 2007
    ..These results unravel an unanticipated role for IKKbeta-dependent NF-kappaB signaling in the negative control of IL-1beta production and highlight potential complications of long-term IKKbeta inhibition...
  3. doi TAK1: Another mesh in the NF-κB - JNK controlled network causing hepatocellular carcinoma
    Florian R Greten
    Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, Ismaningerstr 22, 81675 Munich, Germany
    J Hepatol 55:721-3. 2011
    ..Therefore, TAK1 serves as a gatekeeper for a protumorigenic, NF-kappaB-independent function of NEMO in parenchymal liver cells...
  4. doi IKKα promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells
    Serkan I Göktuna
    Institute of Molecular Immunology, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munich, Germany Unit of Signal Transduction GIGA ST, GIGA R, University of Liege and WELBIO, CHU, Sart Tilman, 4000 Liege, Belgium
    Cell Rep 7:1914-25. 2014
    ..Because therapies aiming at the tumor microenvironment rather than directly at the mutated cancer cell may circumvent resistance development, we suggest IKKα as a promising target for colorectal cancer (CRC) therapy...
  5. doi Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties
    Sarah Schwitalla
    Institute of Molecular Immunology, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munich, Germany
    Cell 152:25-38. 2013
    ..Thus, our data support the concept of bidirectional conversion and highlight the importance of inflammatory signaling for dedifferentiation and generation of tumor-initiating cells in vivo...
  6. pmc TNF-alpha-dependent loss of IKKbeta-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis
    Arun K Mankan
    Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 108:6567-72. 2011
    ..These results unravel so far unanticipated direct and indirect functions for IKKβ in myeloid progenitor survival and maintenance of innate and Th17 immunity and raise concerns about long-term IKKβ inhibition in IL-17-mediated diseases...
  7. doi Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors
    Sarah Schwitalla
    Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
    Cancer Cell 23:93-106. 2013
    ..Thus, we propose a p53-controlled tumor-suppressive function that is independent of its well-established role in cell-cycle regulation, apoptosis, and senescence...
  8. pmc High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity
    Manon D Schulz
    1 Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany 2
    Nature 514:508-12. 2014
    ....
  9. pmc The gastrointestinal tumor microenvironment
    Michael Quante
    II Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Gastroenterology 145:63-78. 2013
    ....
  10. pmc IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis
    Julia Bollrath
    2nd Department of Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    EMBO Rep 10:1314-9. 2009
    ..By contrast, in tumorigenic cells, both NF-kappaB and STAT3 control apoptosis, and STAT3 can also enhance proliferation. Consequently, inflammation should be considered as a valuable target for cancer prevention and therapy...
  11. doi Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors
    Arun K Mankan
    Institute of Molecular Immunology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstr 22, 81675 Munchen, Germany
    Expert Opin Investig Drugs 20:1263-75. 2011
    ..Several genetic studies have proven its central role in the regulation of apoptosis, proliferation, angiogenesis and immune responses making it an attractive target for cancer therapy...
  12. doi Selective in vivo imaging of syngeneic, spontaneous, and xenograft tumors using a novel tumor cell-specific hsp70 peptide-based probe
    Stefan Stangl
    Department of Radiation Oncology, Klinikum rechts der Isar, TU München and CCG Innate Immunity in Tumor Biology, Helmholtz Zentrum München HMGU, Munich, Germany
    Cancer Res 74:6903-12. 2014
    ..TPP might also be a promising platform for tumor-specific drug delivery and other Hsp70-based targeted therapies...
  13. doi Concurrent video-rate color and near-infrared fluorescence laparoscopy
    Jürgen Glatz
    Technical University Munich, Chair for Biological Imaging, Munich, Germany
    J Biomed Opt 18:101302. 2013
    ....
  14. doi IKK- and NF-κB-mediated functions in carcinogenesis
    Melek C Arkan
    2nd Department of Medicine, Klinikum rechts der Isar, Technical University Munich, Ismaningerstr 22, 81675, Munich, Germany
    Curr Top Microbiol Immunol 349:159-69. 2011
    ..Here, we review molecular evidence that demonstrates the various functions of NF-κB during different tumor stages and that supports the rationale to target NF-κB in cancer prevention and therapy...
  15. doi Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis
    Moritz Bennecke
    2nd Department of Medicine, Klinikum rechts der Isar, Technical University Munich, Germany
    Cancer Cell 18:135-46. 2010
    ....
  16. doi gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis
    Julia Bollrath
    2nd Department of Medicine, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
    Cancer Cell 15:91-102. 2009
    ....
  17. pmc IkappaBbeta is an essential co-activator for LPS-induced IL-1beta transcription in vivo
    Melanie Scheibel
    II Medizinische Klinik, Technische Universitat Munchen, 81675 Munchen, Germany
    J Exp Med 207:2621-30. 2010
    ..Collectively, these findings provide an essential proinflammatory role for IκBβ in vivo, and establish a critical function for IκBβ as a transcriptional coactivator under inflammatory conditions...
  18. pmc Opposing functions of IKKbeta during acute and chronic intestinal inflammation
    Lars Eckmann
    Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:15058-63. 2008
    ..Our findings caution against the therapeutic use of IKKbeta/NF-kappaB inhibitors in acute inflammatory settings dominated by cell loss and ulceration...
  19. ncbi The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion
    Lee Wei Chen
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, California, USA
    Nat Med 9:575-81. 2003
    ..These results show the dual function of the NF-kappaB system, which is responsible for both tissue protection and systemic inflammation, and underscore the caution that should be exerted in using NF-kappaB and IKK inhibitors...
  20. ncbi IKK-beta links inflammation to obesity-induced insulin resistance
    Melek C Arkan
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nat Med 11:191-8. 2005
    ..We suggest that inhibition of IKK-beta, especially in myeloid cells, may be used to treat insulin resistance...
  21. ncbi Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators
    Jin Mo Park
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA
    Immunity 23:319-29. 2005
    ..Here we describe key roles for transcription factor CREB, a target for p38 signaling, and the plasminogen activator 2 (PAI-2) gene, a target for CREB, in maintenance of macrophage survival...
  22. ncbi Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition
    Jin Mo Park
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0636, USA
    Science 297:2048-51. 2002
    ..This dismantling of the p38 MAPK module represents a strategy used by B. anthracis to paralyze host innate immunity...
  23. pmc IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium
    Laurence J Egan
    Laboratory of Mucosal Immunology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 101:2452-7. 2004
    ..Selective preactivation of NF-kappaB through IKKbeta in intestinal epithelial cells could provide a therapeutic modality that allows higher doses of radiation to be tolerated during cancer radiotherapy...
  24. ncbi Cyclosporine inhibits growth through the activating transcription factor/cAMP-responsive element-binding protein binding site in the cyclin D1 promoter
    Gunter Schneider
    Department of Internal Medicine I, University of Ulm, Germany
    J Biol Chem 277:43599-607. 2002
    ..These results demonstrate that cyclosporine can inhibit proliferation of acinar cells by targeting the cyclin D1 promoter at the proximal CRE via a reduction of CREB protein abundance...
  25. ncbi Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis
    Florian R Greten
    Internal Medicine II, Technical University of Munich, Germany
    Gastroenterology 123:2052-63. 2002
    ..The aim of the present study was to explore regulation of proapoptotic and antiapoptotic signals during pancreatic tumor development in mice...
  26. ncbi Pattern of secondary genomic changes in pancreatic tumors of Tgf alpha/Trp53+/- transgenic mice
    Bettina Schreiner
    Department of Human Genetics, University of Ulm, Ulm, Germany
    Genes Chromosomes Cancer 38:240-8. 2003
    ..Together these data suggest the induction of a uniform pattern of secondary genomic changes in this transgenic tumor model for pancreatic cancer...
  27. ncbi The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer
    Florian R Greten
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Cancer Lett 206:193-9. 2004
    ..The investigation of the different NF-kappaB signaling pathways in different cell types and their role in certain diseases is therefore needed to evaluate the most successful therapeutic strategies...
  28. ncbi IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    Florian R Greten
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla 92093, USA
    Cell 118:285-96. 2004
    ..In addition to suppressing apoptosis in advanced tumors, IKKbeta may link inflammation to cancer...
  29. ncbi Regulation of cyclin D1 expression by autocrine IGF-I in human BON neuroendocrine tumour cells
    Gotz von Wichert
    Department of Internal Medicine I, University of Ulm, D 89081 Ulm, Germany
    Oncogene 24:1284-9. 2005
    ..In conclusion, our data provide the first comprehensive map of the signaling events elicited by endogenously released IGF-I leading to constitutive cyclin D1 expression in human neuroendocrine tumour cells...
  30. ncbi NF-kappaB: linking inflammation and immunity to cancer development and progression
    Michael Karin
    Laboratory of Gene Regulation and Signal Transduction, University of California at San Diego School of Medicine, Department of Pharmacology, 9500 Gilman Drive, La Jolla, California 92093 0723, USA
    Nat Rev Immunol 5:749-59. 2005
    ....
  31. ncbi Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis
    Colby Zaph
    Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 446:552-6. 2007
    ..These results indicate that the balance of IKK-beta-dependent gene expression in the intestinal epithelium is crucial in intestinal immune homeostasis by promoting mucosal immunity and limiting chronic inflammation...
  32. ncbi NF-kappaB in cancer: from innocent bystander to major culprit
    Michael Karin
    Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla 92093, USA
    Nat Rev Cancer 2:301-10. 2002
    ..NF-kappaB should therefore receive as much attention from cancer researchers as it has already from immunologists...