Karin Klingel

Summary

Country: Germany

Publications

  1. doi Predictors of outcome in patients with suspected myocarditis
    Ingrid Kindermann
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, Germany
    Circulation 118:639-48. 2008
  2. pmc Proteomic analyses of age related changes in A.BY/SnJ mouse hearts
    Krishnatej Nishtala
    Proteome Sci 11:29. 2013
  3. pmc Cardiovascular magnetic resonance risk stratification in patients with clinically suspected myocarditis
    Julia Schumm
    Department of Cardiology, Robert Bosch Medical Center, Stuttgart, Germany
    J Cardiovasc Magn Reson 16:14. 2014
  4. pmc Left ventricular functional assessment in murine models of ischemic and dilated cardiomyopathy using [18 F]FDG-PET: comparison with cardiac MRI and monitoring erythropoietin therapy
    Stefan Brunner
    Department of Nuclear Medicine, Ludwig Maximilians University, Klinikum Grosshadern, Marchioninistr 15, Munich, 81377, Germany
    EJNMMI Res 2:43. 2012
  5. pmc beta2-microglobulin-associated regulation of interferon-gamma and virus-specific immunoglobulin G confer resistance against the development of chronic coxsackievirus myocarditis
    Karin Klingel
    Department of Molecular Pathology, University Hospital Tuebingen, Tuebingen, Germany
    Am J Pathol 162:1709-20. 2003
  6. ncbi Molecular pathology of inflammatory cardiomyopathy
    Karin Klingel
    Department of Molecular Pathology, University Hospital of Tubingen, Liebermeisterstr 8, 72076, Tuebingen, Germany
    Med Microbiol Immunol 193:101-7. 2004
  7. doi Osteopontin: a biomarker to predict the outcome of inflammatory heart disease
    Karin Klingel
    Department of Molecular Pathology, University Hospital Tubingen, Tubingen, Germany
    Semin Thromb Hemost 36:195-202. 2010
  8. ncbi Molecular pathology and structural features of enteroviral replication. Toward understanding the pathogenesis of viral heart disease
    K Klingel
    Department of Molecular Pathology, Institute for Pathology, University of Tubingen, Germany
    Herz 25:216-20. 2000
  9. doi Osteopontin: a fibrosis-related marker molecule in cardiac remodeling of enterovirus myocarditis in the susceptible host
    Gudrun Szalay
    Department of Molecular Pathology, Institute for Pathology, University Hospital, Tubingen, Germany
    Circ Res 104:851-9. 2009
  10. ncbi Fatal parvovirus B19-associated myocarditis clinically mimicking ischemic heart disease: an endothelial cell-mediated disease
    Burkhard D Bültmann
    Institute of Pathology, University of Tubingen, Tubingen, Germany
    Hum Pathol 34:92-5. 2003

Detail Information

Publications95

  1. doi Predictors of outcome in patients with suspected myocarditis
    Ingrid Kindermann
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, Germany
    Circulation 118:639-48. 2008
    ..The objective of this study was to identify the prognostic indicators in patients with suspected myocarditis who underwent endomyocardial biopsy...
  2. pmc Proteomic analyses of age related changes in A.BY/SnJ mouse hearts
    Krishnatej Nishtala
    Proteome Sci 11:29. 2013
    ..BY/SnJ mice aged 1 and 4 months was comparatively studied using two dimensional-differential in-gel electrophoresis (2D-DIGE) and liquid chromatography tandem mass spectrometry (LC-MS/MS)...
  3. pmc Cardiovascular magnetic resonance risk stratification in patients with clinically suspected myocarditis
    Julia Schumm
    Department of Cardiology, Robert Bosch Medical Center, Stuttgart, Germany
    J Cardiovasc Magn Reson 16:14. 2014
    ....
  4. pmc Left ventricular functional assessment in murine models of ischemic and dilated cardiomyopathy using [18 F]FDG-PET: comparison with cardiac MRI and monitoring erythropoietin therapy
    Stefan Brunner
    Department of Nuclear Medicine, Ludwig Maximilians University, Klinikum Grosshadern, Marchioninistr 15, Munich, 81377, Germany
    EJNMMI Res 2:43. 2012
    ....
  5. pmc beta2-microglobulin-associated regulation of interferon-gamma and virus-specific immunoglobulin G confer resistance against the development of chronic coxsackievirus myocarditis
    Karin Klingel
    Department of Molecular Pathology, University Hospital Tuebingen, Tuebingen, Germany
    Am J Pathol 162:1709-20. 2003
    ..Moreover, CVB3-induced cardiac injury and prevention of chronic myocarditis was found to be unrelated to perforin-mediated cytotoxicity in our model system...
  6. ncbi Molecular pathology of inflammatory cardiomyopathy
    Karin Klingel
    Department of Molecular Pathology, University Hospital of Tubingen, Liebermeisterstr 8, 72076, Tuebingen, Germany
    Med Microbiol Immunol 193:101-7. 2004
    ....
  7. doi Osteopontin: a biomarker to predict the outcome of inflammatory heart disease
    Karin Klingel
    Department of Molecular Pathology, University Hospital Tubingen, Tubingen, Germany
    Semin Thromb Hemost 36:195-202. 2010
    ..Thus cardiac OPN expression might be considered as a biomarker indicating ongoing cardiac inflammation preceding fibrosis and remodeling of the heart...
  8. ncbi Molecular pathology and structural features of enteroviral replication. Toward understanding the pathogenesis of viral heart disease
    K Klingel
    Department of Molecular Pathology, Institute for Pathology, University of Tubingen, Germany
    Herz 25:216-20. 2000
    ..In summary, these data indicate that mutual influences of virus replication and subsequent modifications of the host cell metabolism are crucial for cardiac injury and dysfunction during acute and chronic disease...
  9. doi Osteopontin: a fibrosis-related marker molecule in cardiac remodeling of enterovirus myocarditis in the susceptible host
    Gudrun Szalay
    Department of Molecular Pathology, Institute for Pathology, University Hospital, Tubingen, Germany
    Circ Res 104:851-9. 2009
    ..Thus, OPN may serve as a diagnostic tool as well as a potential therapeutic target to limit cardiac remodeling in chronic myocarditis...
  10. ncbi Fatal parvovirus B19-associated myocarditis clinically mimicking ischemic heart disease: an endothelial cell-mediated disease
    Burkhard D Bültmann
    Institute of Pathology, University of Tubingen, Tubingen, Germany
    Hum Pathol 34:92-5. 2003
    ..We speculate that, due to the high viral load in cardiac ECs, PVB19 infection of endothelial cells was sufficient to induce impaired coronary microcirculation with secondary cardiac myocyte necrosis...
  11. pmc Effective chemokine secretion by dendritic cells and expansion of cross-presenting CD4-/CD8+ dendritic cells define a protective phenotype in the mouse model of coxsackievirus myocarditis
    Andreas Oliver Weinzierl
    Department of Molecular Pathology, University of Tubingen, Liebermeisterstrasse 8, 72076 Tubingen, Germany
    J Virol 82:8149-60. 2008
    ..We conclude that MHC-independent genetic factors involving DC-related IP-10 secretion and TLR3 expression are beneficial in the prevention of chronic coxsackievirus myocarditis...
  12. doi EMMPRIN and its ligand cyclophilin A as novel diagnostic markers in inflammatory cardiomyopathy
    Peter Seizer
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Universitatsklinikum Tubingen, Otfried Muller Strasse 10, Tubingen, Germany
    Int J Cardiol 163:299-304. 2013
    ..Therefore, a series of 102 human endomyocardial biopsies were analyzed for the expression of EMMPRIN and CyPA and correlated with histological and immunohistological findings...
  13. ncbi Connective tissue growth factor: a crucial cytokine-mediating cardiac fibrosis in ongoing enterovirus myocarditis
    Christine Lang
    Department of Molecular Pathology, Institute for Pathology, University Hospital Tubingen, Tubingen, Germany
    J Mol Med (Berl) 86:49-60. 2008
    ..Thus, downregulation of cardiac CTGF expression may open novel therapeutic approaches counteracting the development of cardiac fibrosis and subsequent heart muscle dysfunction...
  14. doi A cryptic vascular endothelial growth factor T-cell epitope: identification and characterization by mass spectrometry and T-cell assays
    Andreas O Weinzierl
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Germany
    Cancer Res 68:2447-54. 2008
    ..In the future, T cells directed against VEGF as a tumor-associated antigen may represent a possible way of combining peptide-based anti-VEGF immunotherapy with already existent anti-VEGF cancer therapies...
  15. ncbi SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment
    Volker Vallon
    Department of Pharmacology and Toxicology, University of Tubingen, Tubingen, Germany
    J Mol Med (Berl) 84:396-404. 2006
    ..Our results suggest that SGK1 plays a decisive role in mineralocorticoid-induced CTGF expression and cardiac fibrosis...
  16. ncbi Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury
    Almut Grenz
    Department of Pharmacology and Toxicology, Tubingen University Hospital, Tubingen, Germany
    FASEB J 21:2863-73. 2007
    ..Moreover, the present studies suggest apyrase treatment as a novel pharmacological approach to renal diseases precipitated by limited oxygen availability...
  17. doi Identification of HLA-A*01- and HLA-A*02-restricted CD8+ T-cell epitopes shared among group B enteroviruses
    Andreas O Weinzierl
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    J Gen Virol 89:2090-7. 2008
    ..All four epitopes were homologous in 36-92% of group B enteroviruses, providing a strong basis for monitoring the divergence of T-cell-based immune responses in enterovirus-induced acute and chronic diseases...
  18. doi Identification of HLA ligands and T-cell epitopes for immunotherapy of lung cancer
    Anneke Neumann
    Department of Immunology, Interfaculty Institute for Cell Biology, University of Tubingen, Auf der Morgenstelle 15, Tubingen, 72076, Germany
    Cancer Immunol Immunother 62:1485-97. 2013
    ..g. peptide vaccines that are able to induce a CTL response against the tumor, might be a promising approach...
  19. pmc Ongoing coxsackievirus myocarditis is associated with increased formation and activity of myocardial immunoproteasomes
    Gudrun Szalay
    Department of Molecular Pathology, University Hospital Tubingen, Germany
    Am J Pathol 168:1542-52. 2006
    ..Thus, we propose that increased formation of immunoproteasomes in susceptible mice affects the generation of antigenic peptides and the subsequent T-cell-mediated immune responses...
  20. doi Lack of the serum and glucocorticoid-inducible kinase SGK1 attenuates the volume retention after treatment with the PPARgamma agonist pioglitazone
    Ferruh Artunc
    Department of Physiology, University of Tubingen, Gmelinstr 5, 72076 Tubingen, Germany
    Pflugers Arch 456:425-36. 2008
    ..We conclude that SGK1 contributes to but does not fully account for the volume retention during treatment with the PPARgamma agonist pioglitazone...
  21. doi The prostacyclin agonist iloprost aggravates fibrosis and enhances viral replication in enteroviral myocarditis by modulation of ERK signaling and increase of iNOS expression
    Stefan Gruhle
    Department of Molecular Pathology, Institute for Pathology and Neuropathology, University Hospital Tubingen, Liebermeisterstrasse 8, Tubingen, Germany
    Basic Res Cardiol 107:287. 2012
    ..In conclusion, these results suggest a critical reflection of the clinical use of iloprost, especially in patients possibly suffering from an enteroviral myocarditis...
  22. pmc Sustained nitric oxide synthesis contributes to immunopathology in ongoing myocarditis attributable to interleukin-10 disorders
    Gudrun Szalay
    Dept of Molecular Pathology, Institute for Pathology, University Hospital Tubingen, Liebermeisterstr 8, D 72076 Tubingen, Germany
    Am J Pathol 169:2085-93. 2006
    ..Moreover, lack of regulatory IL-10 leads to uncontrolled iNOS mRNA production, thus contributing to ongoing myocardial injury...
  23. doi Persistent troponin elevation in a patient with cardiac amyloidosis
    Bjoern F Kraemer
    Medizische Klinik III, University Hospital of Tubingen, Otfried Müller Str, Tubingen 72076, Germany
    Clin Cardiol 32:E39-42. 2009
    ..It is important to consider cardiac amyloidosis in patients with troponin elevation and heart failure since the clinical management differs significantly from other causes of heart failure...
  24. doi Capture of endothelial progenitor cells by a bispecific protein/monoclonal antibody molecule induces reendothelialization of vascular lesions
    Harald F Langer
    Medical Clini III, Department of Cardiovascular Medicine, Eberhard Karls University of Tubingen, Tubingen, Germany
    J Mol Med (Berl) 88:687-99. 2010
    ..In vivo, GPVI-CD133 augments reendothelialization of vascular lesions. Thus, this bifunctional protein could be a potential new therapeutic option for cardiovascular diseases...
  25. pmc Comparison of Ventricular Inducibility with Late Gadolinium Enhancement and Myocardial Inflammation in Endomyocardial Biopsy in Patients with Dilated Cardiomyopathy
    Karin A L Mueller
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Universitaetsklinikum der Eberhard Karls Universitaet, Tuebingen, Germany
    PLoS ONE 11:e0167616. 2016
    ..Risk stratification of patients with non-ischemic dilated cardiomyopathy remains a matter of debate in the era of device implantation...
  26. doi Endomyocardial expression of SDF-1 predicts mortality in patients with suspected myocarditis
    Christine S Zuern
    Department of Cardiology and Cardiovascular Medicine, University of Tuebingen, Otfried Mueller Str 10, 72076, Tuebingen, Germany
    Clin Res Cardiol 104:1033-43. 2015
    ..Therefore, we aimed to investigate whether endomyocardial expression of SDF-1 identifies high-risk patients with suspected myocarditis...
  27. pmc Quantification of HLA class I molecules on renal cell carcinoma using Edman degradation
    Juliane S Stickel
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Germany
    BMC Urol 11:1. 2011
    ..HLA loss or down-regulation have often been reported and might interfere with immunotherapeutic approaches aimed at the recognition of HLA-presented peptides...
  28. doi Targeting of protease 2A genome by single and multiple siRNAs as a strategy to impair CVB3 life cycle in permissive HeLa cells
    Giorgia Racchi
    Department of Molecular Pathology, Institute for Pathology, University Hospital of Tubingen, Germany
    Methods Find Exp Clin Pharmacol 31:63-70. 2009
    ..In addition to placing the selected siRNA 3626 among the most effective anti-CVB3 agents so far described, these data fully justify future attempts to further optimize the siRNA-mediated approach to CVB3-induced myocarditis...
  29. ncbi DOCA-induced phosphorylation of glycogen synthase kinase 3beta
    Amanda W Wyatt
    Department of Physiology, University of Tubingen, Germany
    Cell Physiol Biochem 17:137-44. 2006
    ..The inactivation of GSK3 may play a permissive role in the stimulation of cardiac fibrosis but may by itself not be sufficient to trigger cardiac fibrosis...
  30. doi Highly pathogenic influenza virus infection of the thymus interferes with T lymphocyte development
    Annette B Vogel
    Friedrich Loeffler Institute, Institute of Immunology, University Hospital, Tuebingen, Germany
    J Immunol 185:4824-34. 2010
    ..Moreover, this exceptional mechanism might not only be found in influenza virus infection, but also might be the reason for the increased immune evasion of some new emerging pathogens...
  31. ncbi High prevalence of viral genomes and inflammation in peripartum cardiomyopathy
    Burkhard D Bültmann
    Institute of Pathology, University Hospital of Tubingen, Germany
    Am J Obstet Gynecol 193:363-5. 2005
    ..7%) that were associated immunohistologically with interstitial inflammation. These findings indicate a high prevalence of virus-associated inflammatory changes in peripartum cardiomyopathy...
  32. pmc Cardiovascular magnetic resonance patterns of biopsy proven cardiac involvement in systemic sclerosis
    Patrick Krumm
    Department of Radiology, Diagnostic and Interventional Radiology, University of Tubingen, Hoppe Seyler Str 3, Tubingen, 72076, Germany
    J Cardiovasc Magn Reson 18:70. 2016
    ..To determine morphological and functional cardiovascular magnetic resonance (CMR) patterns in histopathologically confirmed myocardial involvement in patients with systemic sclerosis (SSc)...
  33. ncbi Parvovirus B19: a pathogen responsible for more than hematologic disorders
    Burkhard D Bültmann
    Institute of Pathology, University of Tubingen, Liebermeisterstrasse 8, D 72076 Tubingen, Germany
    Virchows Arch 442:8-17. 2003
    ..Because treatment of lytic PVB19 infection has been successfully applied, the pathologist should be alerted to include PVB19 into the diagnostic spectrum of viral disease, especially in immunocompromised patients...
  34. ncbi Distorted relation between mRNA copy number and corresponding major histocompatibility complex ligand density on the cell surface
    Andreas O Weinzierl
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Tubingen, Germany
    Mol Cell Proteomics 6:102-13. 2007
    ....
  35. ncbi Upregulation of the water channel aquaporin-4 as a potential cause of postischemic cell swelling in a murine model of myocardial infarction
    Arne Warth
    Institute of Pathology, University Hospital Tubingen, Tubingen, Germany
    Cardiology 107:402-10. 2007
    ....
  36. doi The immunoadhesin glycoprotein VI-Fc regulates arterial remodelling after mechanical injury in ApoE-/- mice
    Tanja Schonberger
    DVM, Medizinische Klinik III, Abt Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    Cardiovasc Res 80:131-7. 2008
    ..In this study, we examined binding of soluble platelet collagen receptor GPVI-Fc to atherosclerotic lesions and its effect on platelet-triggered athero-progression and neointima formation after wire-induced carotid injury...
  37. doi Low-dose dexamethasone-supplemented fluid resuscitation reverses endotoxin-induced acute renal failure and prevents cortical microvascular hypoxia
    Tanja Johannes
    Department of Physiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Shock 31:521-8. 2009
    ..Therefore, low-dose DEX might have potential application in the prevention of septic acute renal failure...
  38. doi Iloprost preserves renal oxygenation and restores kidney function in endotoxemia-related acute renal failure in the rat
    Tanja Johannes
    Department of Physiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Crit Care Med 37:1423-32. 2009
    ..To investigate that exogenous prostacyclin would counterbalance an endotoxemia-induced intrarenal vasoconstriction and would therefore have beneficial effects on kidney function...
  39. pmc Disrupting the EMMPRIN (CD147)-cyclophilin A interaction reduces infarct size and preserves systolic function after myocardial ischemia and reperfusion
    Peter Seizer
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Germany
    Arterioscler Thromb Vasc Biol 31:1377-86. 2011
    ..The aim of the study was to characterize the role of the CD147 and CyPA interplay in myocardial ischemia/reperfusion (I/R) injury...
  40. ncbi Tropism of human cytomegalovirus for endothelial cells is determined by a post-entry step dependent on efficient translocation to the nucleus
    C Sinzger
    Department of Medical Virology, and Department of Molecular Pathology, University of Tubingen, D 72076 Tubingen, Germany
    J Gen Virol 81:3021-35. 2000
    ..Simultaneous staining of viral particles and viral IE antigen revealed that interstrain differences in the transport of penetrated capsids towards the nucleus of endothelial cells determine the EC tropism of HCMV...
  41. ncbi Up-regulation of the human serum and glucocorticoid-dependent kinase 1 in glomerulonephritis
    B Friedrich
    Department of Physiology, University of Tubingen, Germany
    Kidney Blood Press Res 25:303-7. 2002
    ..In conclusion, glomerulonephritis leads to glomerular and in some cases to epithelial up-regulation of hSGK1 transcription...
  42. ncbi Mechanisms and consequences of enterovirus persistence in cardiac myocytes and cells of the immune system
    R Kandolf
    Department of Molecular Pathology, Institute for Pathology, University Hospital of Tubingen, Germany
    Virus Res 62:149-58. 1999
    ....
  43. ncbi Protein and mRNA expression of serum and glucocorticoid-dependent kinase 1 in metanephrogenesis
    S M Huber
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Dev Dyn 221:464-9. 2001
    ....
  44. ncbi h-sgk serine-threonine protein kinase gene as transcriptional target of transforming growth factor beta in human intestine
    S Waldegger
    Institute of Physiology, University of Tubingen, Tubingen, Germany
    Gastroenterology 116:1081-8. 1999
    ..The aim of this study was to localize h-sgk messenger RNA (mRNA) expression in normal and inflamed intestinal mucosa and to identify potential transcriptional regulators...
  45. doi [Molecular mechanisms and consequences of cardiac viral infections]
    R Kandolf
    Abteilung Molekulare Pathologie, Universitatsklinikum Tubingen, Liebermeisterstrasse 8, 72076 Tubingen
    Pathologe 29:112-7. 2008
    ..These cellular interactions may contribute to mechanisms by which B19 establishes persistent infection in endothelial cells and play a critical role in viral pathogenesis of inflammatory cardiomyopathy...
  46. ncbi Coxsackie B virus and its interaction with permissive host cells
    H C Selinka
    Department of Molecular Pathology, University of Tubingen, Germany
    Clin Diagn Virol 9:115-23. 1998
    ....
  47. ncbi [Serious clinical course of myocarditis with "apical ballooning": first presentation of pathogenicity of HHV6 subtype A in myocarditis]
    B Bigalke
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen
    Internist (Berl) 46:1259-64. 2005
    ..This case presents for the first time the cross-link of myocarditis with HHV6A infection and the appearance of "apical ballooning"...
  48. pmc Pathogenesis of murine enterovirus myocarditis: virus dissemination and immune cell targets
    K Klingel
    Institute for Pathology, Department of Molecular Pathology, University of Tubingen, Germany
    J Virol 70:8888-95. 1996
    ..These data indicate that immune cells are important targets of CVB3 infection, providing a noncardiac reservoir for viral RNA during acute and persistent myocardial enterovirus infection...
  49. ncbi Central nervous system Hodgkin's lymphoma without systemic manifestation: case report and review of the literature
    U Herrlinger
    Department of Neurology, University of Tubingen, Germany
    Acta Neuropathol 99:709-14. 2000
    ..Moreover, EBV-encoded RNA-1 (EBER-1) sequences and a monoclonal rearrangement of the immunoglobulin heavy chain CDR2 locus were detected...
  50. ncbi Human parvovirus B19: a new emerging pathogen of inflammatory cardiomyopathy
    C T Bock
    Department of Molecular Pathology, Institute of Pathology, University Hospital of Tuebingen, Tuebingen, Germany
    J Vet Med B Infect Dis Vet Public Health 52:340-3. 2005
    ....
  51. ncbi [Recurrent transient ischaemic attacks in a patient with pansinusitis]
    C S Zürn
    Medizinische Klinik III, Universitatsklinikum Tubingen, Tubingen
    Internist (Berl) 47:1165-71. 2006
    ..The cardiac biopsy demonstrated the findings of Loeffler's endocarditis. In conclusion the diagnosis of hypereosinophilic syndrome was made and identified as the cause of the neurological deficits...
  52. doi The activating receptor NKG2D of natural killer cells promotes resistance against enterovirus-mediated inflammatory cardiomyopathy
    Karin Klingel
    Department of Molecular Pathology, University Hospital Tubingen, Germany
    J Pathol 234:164-77. 2014
    ....
  53. doi CXCL16 is a novel diagnostic marker and predictor of mortality in inflammatory cardiomyopathy and heart failure
    Oliver Borst
    Department of Cardiology and Cardiovascular Medicine, University of Tubingen, Germany Department of Physiology, University of Tubingen, Germany
    Int J Cardiol 176:896-903. 2014
    ..The present study evaluates the diagnostic and prognostic relevance of CXCL16 expression in endomyocardial biopsies of consecutive patients with congestive HF...
  54. doi Heme oxygenase-1 mediates oxidative stress and apoptosis in coxsackievirus B3-induced myocarditis
    Oana N Ursu
    Institute for Pathology and Neuropathology, Department of Molecular Pathology, University Hospital Tubingen, Tubingen, Germany
    Cell Physiol Biochem 33:52-66. 2014
    ....
  55. ncbi The expression of the carboxyl ester lipase gene in pancreas and pancreatic adenocarcinomas
    Reinhard Reuss
    Division of Molecular Genetics, Institute of Anthropology and Human Genetics, University Hospital Tubingen, Eberhard Karls University Tubingen, D 72076 Tubingen, Germany
    Int J Oncol 29:649-54. 2006
    ....
  56. doi Downregulation of angiogenin transcript levels and inhibition of colonic carcinoma by gum arabic (Acacia senegal)
    Omaima Nasir
    Department of Physiology, University of Tuebingen, Gmelinstrasse 5, Tuebingen, Germany
    Nutr Cancer 62:802-10. 2010
    ..The observations disclose a powerful anticarcinogenic effect of GA. The nutrient could thus be used for the prophylaxis against colon carcinoma particularly in individuals at enhanced risk...
  57. ncbi Acute hemorrhagic leukoencephalitis (Hurst's disease) linked to Epstein-Barr virus infection
    Markus Hofer
    Department of Neuropathology, Institute for Pathology, University Hospital Freiburg, Breisacherstr 64, 79106, Freiburg, Germany
    Acta Neuropathol 109:226-30. 2005
    ..Serological results, in situ hybridization and PCR analysis demonstrated an acute Epstein-Barr virus (EBV) infection of the central nervous system. To our knowledge, this is the first reported case of Hurst's disease linked to EBV...
  58. pmc Mice deficient for the ets transcription factor elk-1 show normal immune responses and mildly impaired neuronal gene activation
    Francesca Cesari
    Abteilung Molekularbiologie, Universitatsklinikum Tubingen, Tubingen, Germany
    Mol Cell Biol 24:294-305. 2004
    ..This was not accompanied by altered patterns of neuronal apoptosis. Collectively, our data indicate that Elk-1 is essential neither for mouse development nor for adult life, suggesting compensatory activities by other TCFs...
  59. pmc Human herpesvirus 6 subtype A-associated myocarditis with 'apical ballooning'
    Boris Bigalke
    Medizinische Klinik III, University Hospital of Tubingen, Tubingen, Germany
    Can J Cardiol 23:393-5. 2007
    ..The present case report links, for the first time, myocarditis with a human herpesvirus 6 subtype A infection and the appearance of apical ballooning...
  60. ncbi Progressive bicytopenia due to persistent parvovirus B19 infection after immunochemotherapy with fludarabine/cyclophosphamide and rituximab for relapsed B cell lymphoma
    Jorg T Hartmann
    Dept of Medical Oncology Hematology Immunology Rheumatology Pulmology, Medical Center II, Eberhard Karls University, Tuebingen, Germany
    Haematologica 91:ECR49. 2006
    ..Treatment with IVIG treatment resulted in normalization of peripheral blood counts within 7 weeks...
  61. ncbi A new monoclonal antibody (Cox mAB 31A2) detects VP1 protein of coxsackievirus B3 with high sensitivity and specificity
    Nicole Ettischer-Schmid
    Institute for Pathology, Department of Molecular Pathology, University Hospital of Tuebingen, Liebermeisterstrasse 8, D 72076, Tuebingen, Germany
    Virchows Arch 469:553-562. 2016
    ..The new antibody was characterized and was found to function well in immunohistochemistry, immunofluorescence staining, Western blotting, ELISA and FACS analyses...
  62. pmc Clinical and histopathological features of patients with systemic sclerosis undergoing endomyocardial biopsy
    Karin A L Mueller
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitaetsklinikum Tuebingen, Tuebingen, Germany
    PLoS ONE 10:e0126707. 2015
    ..The aim of the present study was to evaluate clinical characteristics, histopathological findings and outcome of patients with SSc and a clinical phenotype suggesting cardiac involvement...
  63. pmc The Novel Extracellular Cyclophilin A (CyPA) - Inhibitor MM284 Reduces Myocardial Inflammation and Remodeling in a Mouse Model of Troponin I -Induced Myocarditis
    David Heinzmann
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    PLoS ONE 10:e0124606. 2015
    ..Our data suggest a new pharmacological approach for the treatment of myocardial inflammation and reduction of cardiac fibrosis by inhibition of extracellular CyPA. ..
  64. doi Acute normovolemic hemodilution in the pig is associated with renal tissue edema, impaired renal microvascular oxygenation, and functional loss
    Franziska M Konrad
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Tubingen, Tubingen
    Anesthesiology 119:256-69. 2013
    ..The authors investigated the impact of acute normovolemic hemodilution (ANH) on intrarenal oxygenation and its functional short-term consequences in pigs...
  65. doi Increased susceptibility to Yersinia enterocolitica Infection of Tff2 deficient mice
    Aftab A Shah
    Division of Molecular Genetics, Institute of Human Genetics, University of Tuebingen, Tuebingen, Germany
    Cell Physiol Biochem 30:853-62. 2012
    ..enterocolitica...
  66. ncbi Expression and localization of S-adenosylhomocysteine-hydrolase in the rat kidney following carbon monoxide induced hypoxia
    Doris Kloor
    Department of Pharmacology and Toxicology, Faculty of Medicine, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 19:57-66. 2007
    ....
  67. ncbi Role of renal nerves and salt intake on erythropoietin secretion in rats following carbon monoxide exposure
    Catherine Gebhard
    Department of Pharmacology and Toxicology, University Hospital Tuebingen, D 72074 Tuebingen, Germany
    J Pharmacol Exp Ther 319:111-6. 2006
    ..In summary, our data suggest that renal nerves contribute to the half-maximal EPO secretory response to CO exposure, possibly via NPY receptors...
  68. ncbi Comparative analysis of two coxsackievirus B3 strains: putative influence of virus-receptor interactions on pathogenesis
    H C Selinka
    Department of Molecular Pathology, University Hospital Tubingen, Tubingen, Germany
    J Med Virol 67:224-33. 2002
    ..Together these data suggest that even small differences in virus-receptor interactions, influencing virus binding and virus spread, may have an impact on the pathogenesis of CVB-induced diseases...
  69. ncbi Serum- and glucocorticoid-dependent kinase, cell volume, and the regulation of epithelial transport
    S Fillon
    Department of Physiology, , Germany
    Comp Biochem Physiol A Mol Integr Physiol 130:367-76. 2001
    ..Thus, hsgk1 participates in the regulation of transport by steroids and secretagogues increasing intracellular Ca2+-activity. The stimulation of hsgk1 transcription by TGF-beta1 may further bear pathophysiological relevance...
  70. pmc Regulated on activation, normal T-cell-expressed and -secreted mRNA expression in normal endometrium and endometriotic implants: assessment of autocrine/paracrine regulation by in situ hybridization
    D Hornung
    Departments of Obstetrics and Gynecology and Molecular Pathology, University of Tuebingen, Tuebingen, Germany
    Am J Pathol 158:1949-54. 2001
    ..Production of this chemokine, in turn, stimulates recruitment of CD68-positive macrophages into these tissues...
  71. ncbi Unexpected abundance of HLA class II presented peptides in primary renal cell carcinomas
    Jörn Dengjel
    Immatics Biotechnologies GmbH, University of Tubingen, Germany
    Clin Cancer Res 12:4163-70. 2006
    ....
  72. ncbi Expression of the serine/threonine kinase hSGK1 in chronic viral hepatitis
    Sophie Fillon
    Department for Physiology, University of Tubingen, Gmelinstrasse 5, D 72076 Tubingen, Germany
    Cell Physiol Biochem 12:47-54. 2002
    ..In conclusion hSGK1 is upregulated by TGF-beta1 during hepatitis and may contribute to enhanced matrix formation during fibrosing liver disease...
  73. ncbi Chorioamnionitis and inflammation of the fetal lung
    B Schmidt
    Department of Neonatology, , Tubingen, Germany
    Am J Obstet Gynecol 185:173-7. 2001
    ....
  74. ncbi Posttransplant lymphoproliferative disorder in a kidney-pancreas transplanted recipient: simultaneous development of clonal lymphoid B-cell proliferation of host and donor origin
    Roland Heyny-von Haussen
    Department of Pathology, Klinikum Darmstadt, Grafenstrasse 9, 64276 Darmstadt, Germany
    Am J Surg Pathol 30:900-5. 2006
    ..The recipient died in consequence of the CNS involvement, after intracerebral hemorrhage with uncal and tonsillar herniation...
  75. pmc Impaired renal Na(+) retention in the sgk1-knockout mouse
    Peer Wulff
    Zentrum für Molekulare Neurobiologie, University of Hamburg, Hamburg, Germany
    J Clin Invest 110:1263-8. 2002
    ....
  76. ncbi Cardiovascular magnetic resonance assessment of human myocarditis: a comparison to histology and molecular pathology
    Heiko Mahrholdt
    Division of Cardiology, Robert Bosch Medical Center, Stuttgart, Germany
    Circulation 109:1250-8. 2004
    ..Because the initial onset is difficult to recognize clinically and the diagnostic tools available are unsatisfactory, new strategies to diagnose myocarditis are needed...
  77. ncbi Virus-receptor interactions of coxsackie B viruses and their putative influence on cardiotropism
    Hans Christoph Selinka
    Institut fur Medizinische Mikrobiologie und Hygiene, Johannes Gutenberg Universitat Mainz, Hochhaus am Augustusplatz, 55101 Mainz, Germany
    Med Microbiol Immunol 193:127-31. 2004
    ....
  78. doi Cardiovascular magnetic resonance in clinically suspected cardiac amyloidosis: noninvasive imaging compared to endomyocardial biopsy
    Holger Vogelsberg
    Division of Cardiology, Robert Bosch Medical Center, Stuttgart, Germany
    J Am Coll Cardiol 51:1022-30. 2008
    ..We sought to evaluate the diagnostic performance of cardiovascular magnetic resonance imaging (CMRI) for detection of cardiac amyloidosis compared with endomyocardial biopsy (EMB) in a clinical routine setting...
  79. ncbi Molecular cloning of mouse amino acid transport system B0, a neutral amino acid transporter related to Hartnup disorder
    Angelika Bröer
    School of Biochemistry and Molecular Biology, Australian National University, Canberra ACT 0200, Australia
    J Biol Chem 279:24467-76. 2004
    ..Thus, the human homologue of this transporter is an excellent functional and positional candidate for Hartnup disorder...
  80. ncbi Parvovirus B19
    Burkhard D Bültmann
    N Engl J Med 350:2006-7; author reply 2006-7. 2004
  81. ncbi Immunomodulation by interleukin-4 suppresses matrix metalloproteinases and improves cardiac function in murine myocarditis
    Jun Li
    Department of Internal Medicine II, Charite Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Eur J Pharmacol 554:60-8. 2007
    ..A significant suppression of MMPs may mainly contribute to an improvement of left ventricular dysfunction in acute murine CVB3-induced myocarditis...
  82. ncbi Analysing myocardial tissue from explanted hearts of heart transplant recipients and multi-organ donors for the presence of parvovirus B19 DNA
    Oliver Donoso Mantke
    Robert Koch Institut, Nordufer 20, D 13353 Berlin, Germany
    J Clin Virol 31:32-9. 2004
    ..Reports of PVB19 infection as a causative agent of paediatric or adult inflammatory cardiac diseases, or of cardiac transplant rejection are rare...
  83. ncbi Presentation, patterns of myocardial damage, and clinical course of viral myocarditis
    Heiko Mahrholdt
    Division of Cardiology, Robert Bosch Medical Center, Auerbachstrasse 110, 70376 Stuttgart, Germany
    Circulation 114:1581-90. 2006
    ..Enteroviruses and adenoviruses have been considered the most common causes of viral myocarditis, but parvovirus B19 (PVB19) and human herpesvirus 6 (HHV6) are increasingly found in endomyocardial biopsy samples...
  84. ncbi Late constrictive involvement of the pericardium in a case of previous myocarditis
    Rainer Wessely
    Deutsches Herzzentrum und 1 Medizinische Klinik, Technische Universitat, Munich, Germany
    Cardiovasc Pathol 13:327-9. 2004
    ....
  85. pmc The reno-vascular A2B adenosine receptor protects the kidney from ischemia
    Almut Grenz
    Department of Pharmacology and Toxicology, Tubingen University Hospital, Tubingen, Germany Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    PLoS Med 5:e137. 2008
    ..Here, we identified a novel pathway of renal protection from ischemia using ischemic preconditioning (IP)...
  86. ncbi Expression and regulation of CCR1 in peritoneal macrophages from women with and without endometriosis
    Fritz Wieser
    Center for Reproductive Sciences, Department of Obstetrics and Gynecology, University of California, San Francisco, California, USA
    Fertil Steril 83:1878-81. 2005
    ....
  87. ncbi A geographical mystery: do cardiotropic viruses respect national borders?
    Ali Yilmaz
    J Am Coll Cardiol 52:82; author reply 82-3. 2008
  88. ncbi Parvovirus B19 infection mimicking acute myocardial infarction
    Uwe Kuhl
    Medical Clinic II, Department of Cardiology, University Hospital Benjamin Franklin, Berlin, Germany
    Circulation 108:945-50. 2003
    ..In the present study, we report on the association of parvovirus B19 (PVB19) genomes in the clinical setting of acute myocarditis...
  89. ncbi Excessive transcription of the human serum and glucocorticoid dependent kinase hSGK1 in lung fibrosis
    Simone Waerntges
    Department for Physiology, University of Tuebingen, Germany
    Cell Physiol Biochem 12:135-42. 2002
    ..In conclusion, in lung fibrosis, the serine/threonine kinase hSGK1 is upregulated, an effect at least partially accounted for by TGFbeta1. The full effect of TGFbeta1 requires the activation of p38 kinase...
  90. doi Potential role of antibodies against cardiac Kv channel-interacting protein 2 in dilated cardiomyopathy
    Martin Landsberger
    Department of Internal Medicine B, Ernst Moritz Arndt University, Greifswald, Germany
    Am Heart J 156:92-99.e2. 2008
    ..Growing evidence suggests participation of autoimmune mechanisms in the pathogenesis of dilated cardiomyopathy (DCM)...
  91. doi Giant cell myocarditis mimicking idiopathic fascicular ventricular tachycardia
    Michael Weidenbach
    Department of Pediatric Cardiology, Heart Center, University of Leipzig, Leipzig, Germany
    J Heart Lung Transplant 27:238-41. 2008
    ..The patient rapidly deteriorated and required support using extracorporeal membrane oxygenation (ECMO). Biopsy revealed GCM with massive myocyte necrosis. He was successfully heart transplanted 6 days after admission...
  92. ncbi [Rare case of enterovirus myocarditis with consecutive acute heart failure and subsequent "rescue therapy" with biventricular assist device]
    Norbert Augustin
    Deutsches Herzzentrum Munchen, Klinik für Herz und Gefässchirurgie an der Technischen Universität München, Munich
    Herz 28:457-60. 2003
    ..Examinations included left-and right-heart catheter evaluation with removal of right ventricular biopsies. Histology and molecular pathology revealed the diagnosis of an enteroviral myocarditis...
  93. doi Simultaneous PET-MRI: a new approach for functional and morphological imaging
    Martin S Judenhofer
    Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, Department of Radiology, Eberhard Karls University of Tubingen, Röntgenweg 13, 72076 Tubingen, Germany
    Nat Med 14:459-65. 2008
    ..Combining fMRI and spectroscopy with PET paves the way for a new perspective in molecular imaging...
  94. ncbi Serum and glucocorticoid-inducible kinase in pulmonary tissue of preterm fetuses exposed to chorioamnionitis
    Johannes Wirbelauer
    University Children s Hospital, University of Wurzburg, Germany
    Neonatology 93:257-62. 2008
    ....
  95. ncbi Dissemination of a localized cutaneous infection with Mycobacterium chelonae under immunosuppressive treatment
    Wolfram Hoetzenecker
    Arch Dermatol 143:951-2. 2007