Steven A Johnsen

Summary

Country: Germany

Publications

  1. pmc Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer
    Steven A Johnsen
    Department of Molecular Oncology, Göttingen Center for Molecular Biosciences, University of Gottingen, Justus von Liebig Weg 11, 37077 Gottingen, Germany
    Cancer Res 69:128-36. 2009
  2. doi request reprint Phosphorylation by cyclin-dependent kinase-9 controls ubiquitin-conjugating enzyme-2A function
    Andrei Shchebet
    Department of Molecular Oncology, Universit of Göttingen Medical Center, Gottingen, Germany
    Cell Cycle 11:2122-7. 2012
  3. ncbi request reprint BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells
    Sankari Nagarajan
    Department of General, Visceral and Pediatric Surgery, Göttingen Center for Molecular Biosciences, University Medical Center Gottingen, 37077 Gottingen, Germany
    Nucleic Acids Res . 2016
  4. doi request reprint The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cells
    Oleksandra Karpiuk
    Department of Molecular Oncology, Göttingen Center for Molecular Biosciences, University Medical Center Gottingen, Göttingen 37077, Germany
    Mol Cell 46:705-13. 2012
  5. pmc A subset of histone H2B genes produces polyadenylated mRNAs under a variety of cellular conditions
    Vijayalakshmi Kari
    Department of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 8:e63745. 2013
  6. pmc Bromodomain protein BRD4 is required for estrogen receptor-dependent enhancer activation and gene transcription
    Sankari Nagarajan
    Department of General, Visceral and Pediatric Surgery, University Medical Center Gottingen, 37075 Gottingen, Germany Institute for Molecular Oncology, University Medical Center Gottingen, 37077 Gottingen, Germany Institute for Tumor Biology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Cell Rep 8:460-9. 2014
  7. pmc Cohesin is required for expression of the estrogen receptor-alpha (ESR1) gene
    Tanja Prenzel
    Department of Molecular Oncology, Göttingen Center for Molecular Biosciences, University Medical Center Gottingen, Ernst Caspari Haus, Justus von Liebig Weg 11, Göttingen 37077, Germany
    Epigenetics Chromatin 5:13. 2012
  8. pmc Epigenetic plasticity: a central regulator of epithelial-to-mesenchymal transition in cancer
    Upasana Bedi
    Department of Molecular Oncology, Göttingen Center for Molecular Biosciences, University Medical Center Gottingen, Gottingen, Germany
    Oncotarget 5:2016-29. 2014
  9. doi request reprint The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair
    Vijayalakshmi Kari
    Department of Molecular Oncology, Göttingen Center for Molecular Biosciences, University Medical Center Gottingen, Gottingen, Germany
    Cell Cycle 10:3495-504. 2011
  10. doi request reprint Estrogen-dependent gene transcription in human breast cancer cells relies upon proteasome-dependent monoubiquitination of histone H2B
    Tanja Prenzel
    Department of Molecular Oncology, Göttingen Center for Molecular Biosciences, Department of Medical Statistics, University Medical Center Gottingen, Germany
    Cancer Res 71:5739-53. 2011

Collaborators

  • Tim Beissbarth
  • Mikael Simons
  • Dirk Eick
  • Theresa Gorsler
  • Christina Scheel
  • Tanja Vogel
  • I Bach
  • K Pantel
  • J DAVID contact FURLOW
  • Moustapha Kassem
  • Baris Tursun
  • Sankari Nagarajan
  • Upasana Bedi
  • Vijayalakshmi Kari
  • Andrei Shchebet
  • Oleksandra Karpiuk
  • Tanja Prenzel
  • Zeynab Najafova
  • Yvonne Begus-Nahrmann
  • Frank Kramer
  • Vivek Kumar Mishra
  • Stefan Knapp
  • Daniela Indenbirken
  • Cheng Ming Chiang
  • Malik Alawi
  • Adam Grundhoff
  • Elisabeth Kremmer
  • Magali Hennion
  • Judith Pirngruber
  • Wanhua Xie
  • Florian Wegwitz
  • Feda H Hamdan
  • Anusha Budida
  • Sonja Loges
  • Tareq Hossan
  • David Wasilewski
  • Hanna Taipaleenmaki
  • Marina Scheller
  • Isabel Ben-Batalla
  • Eric Hesse
  • Ekkehard Dikomey
  • Bettina Tieg
  • Malte Kriegs
  • Heike Krebber
  • Nicolas Snaidero
  • Christina Galonska
  • Halyna Shcherbata
  • Annekatrin König
  • Chieh Hsu
  • Heinz Neumann
  • Corinna Hintermair
  • Yael Aylon
  • Lisa Schreiber
  • Efrat Shema
  • Neri Minsky
  • Rob D Chapman
  • Moshe Oren

Detail Information

Publications11

  1. pmc Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer
    Steven A Johnsen
    Department of Molecular Oncology, Göttingen Center for Molecular Biosciences, University of Gottingen, Justus von Liebig Weg 11, 37077 Gottingen, Germany
    Cancer Res 69:128-36. 2009
    ..Combined, these results indicate that LIM cofactors CLIM and RLIM regulate the biological activity of ERalpha during the development of human breast cancer...
  2. doi request reprint Phosphorylation by cyclin-dependent kinase-9 controls ubiquitin-conjugating enzyme-2A function
    Andrei Shchebet
    Department of Molecular Oncology, Universit of Göttingen Medical Center, Gottingen, Germany
    Cell Cycle 11:2122-7. 2012
    ....
  3. ncbi request reprint BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells
    Sankari Nagarajan
    Department of General, Visceral and Pediatric Surgery, Göttingen Center for Molecular Biosciences, University Medical Center Gottingen, 37077 Gottingen, Germany
    Nucleic Acids Res . 2016
    ..Together, our findings support a function for BRD4 in promoting basal mammary cell epithelial differentiation, at least in part, by regulating FOXO factor function on enhancers to activate TP63 and GRHL3 expression...
  4. doi request reprint The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cells
    Oleksandra Karpiuk
    Department of Molecular Oncology, Göttingen Center for Molecular Biosciences, University Medical Center Gottingen, Göttingen 37077, Germany
    Mol Cell 46:705-13. 2012
    ..Thus, these data indicate that H2Bub1 is required for maintaining multipotency of hMSCs and plays a central role in controlling stem cell differentiation...
  5. pmc A subset of histone H2B genes produces polyadenylated mRNAs under a variety of cellular conditions
    Vijayalakshmi Kari
    Department of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 8:e63745. 2013
    ..Thus, we propose that the production of polyadenylated histone mRNAs from replication-dependent histone genes is a regulated process induced under specific cellular circumstances...
  6. pmc Bromodomain protein BRD4 is required for estrogen receptor-dependent enhancer activation and gene transcription
    Sankari Nagarajan
    Department of General, Visceral and Pediatric Surgery, University Medical Center Gottingen, 37075 Gottingen, Germany Institute for Molecular Oncology, University Medical Center Gottingen, 37077 Gottingen, Germany Institute for Tumor Biology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Cell Rep 8:460-9. 2014
    ..These results uncover BRD4 as a central regulator of ERα function and potential therapeutic target...
  7. pmc Cohesin is required for expression of the estrogen receptor-alpha (ESR1) gene
    Tanja Prenzel
    Department of Molecular Oncology, Göttingen Center for Molecular Biosciences, University Medical Center Gottingen, Ernst Caspari Haus, Justus von Liebig Weg 11, Göttingen 37077, Germany
    Epigenetics Chromatin 5:13. 2012
    ..However, whether the cohesin and Mediator complexes function together to contribute to estrogen-regulated gene transcription remains unknown...
  8. pmc Epigenetic plasticity: a central regulator of epithelial-to-mesenchymal transition in cancer
    Upasana Bedi
    Department of Molecular Oncology, Göttingen Center for Molecular Biosciences, University Medical Center Gottingen, Gottingen, Germany
    Oncotarget 5:2016-29. 2014
    ..We propose that a more thorough understanding of the epigenetic mechanisms controlling EMT may provide new opportunities which may be harnessed for improved and individualized cancer therapy based on defined molecular mechanisms. ..
  9. doi request reprint The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair
    Vijayalakshmi Kari
    Department of Molecular Oncology, Göttingen Center for Molecular Biosciences, University Medical Center Gottingen, Gottingen, Germany
    Cell Cycle 10:3495-504. 2011
    ..These results provide important mechanistic insights into the tumor suppressor function of H2Bub1 and provide a rational basis for pursuing H2Bub1-based therapies in conjunction with traditional chemo- and radiotherapy...
  10. doi request reprint Estrogen-dependent gene transcription in human breast cancer cells relies upon proteasome-dependent monoubiquitination of histone H2B
    Tanja Prenzel
    Department of Molecular Oncology, Göttingen Center for Molecular Biosciences, Department of Medical Statistics, University Medical Center Gottingen, Germany
    Cancer Res 71:5739-53. 2011
    ..In supporting a tumor suppressor role for H2Bub1 in breast cancer, our findings offer a rational basis to pursue H2Bub1-based therapies for future management of breast cancer...
  11. pmc CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing
    Judith Pirngruber
    Department of Molecular Oncology, Göttingen Center for Molecular Biosciences, University of Gottingen, Gottingen, Germany
    EMBO Rep 10:894-900. 2009
    ..Thus, CDK9 acts to integrate phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing...