Patrick Meybohm

Summary

Affiliation: Johann Wolfgang Goethe University
Country: Germany

Publications

  1. ncbi request reprint Remote ischaemic preconditioning for heart surgery. The study design for a multi-center randomized double-blinded controlled clinical trial--the RIPHeart-Study
    Patrick Meybohm
    Clinic of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Theodor Stern Kai 7, Frankfurt am Main, Germany
    Eur Heart J 33:1423-6. 2012
  2. doi request reprint Patient Blood Management Bundles to Facilitate Implementation
    Patrick Meybohm
    Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt am Main, Germany Electronic address
    Transfus Med Rev . 2016
  3. doi request reprint [Tools for junior scientists support from medical societies: survey amongst members organized in the Association of the Scientific Medical Societies (AWMF)]
    Patrick Meybohm
    Klinik fur Anasthesiologie, Intensivmedizin und Schmerztherapie, Universitatsklinikum Frankfurt, Frankfurt, Deutschland Electronic address
    Z Evid Fortbild Qual Gesundhwes 109:632-41. 2015
  4. doi request reprint [Patient blood management: Current state of the literature]
    P Meybohm
    Klinik fur Anasthesiologie, Intensivmedizin und Schmerztherapie, Universitätsklinikum Frankfurt am Main, Theodor Stern Kai 7, 60590, Frankfurt am Main, Deutschland
    Chirurg 87:40-6. 2016
  5. pmc Should we restrict erythrocyte transfusion in early goal directed protocols?
    Patrick Meybohm
    Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    BMC Anesthesiol 15:75. 2015
  6. pmc Safety and effectiveness of a Patient Blood Management (PBM) program in surgical patients--the study design for a multi-centre prospective epidemiologic non-inferiority trial
    Patrick Meybohm
    Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    BMC Health Serv Res 14:576. 2014
  7. pmc SodiUm SeleniTe Adminstration IN Cardiac Surgery (SUSTAIN CSX-trial): study design of an international multicenter randomized double-blinded controlled trial of high dose sodium-selenite administration in high-risk cardiac surgical patients
    Christian Stoppe
    Department of Anesthesiology, University Hospital of the RWTH Aachen, Pauwelsstrase 30, 52074 Aachen, Germany
    Trials 15:339. 2014
  8. pmc Activities of cardiac tissue matrix metalloproteinases 2 and 9 are reduced by remote ischemic preconditioning in cardiosurgical patients with cardiopulmonary bypass
    Karina Zitta
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Kiel, Germany
    J Transl Med 12:94. 2014
  9. pmc Postoperative neurocognitive dysfunction in patients undergoing cardiac surgery after remote ischemic preconditioning: a double-blind randomized controlled pilot study
    Patrick Meybohm
    Clinic of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt am Main, Germany
    PLoS ONE 8:e64743. 2013
  10. pmc Aprotinin may increase mortality in low and intermediate risk but not in high risk cardiac surgical patients compared to tranexamic acid and ε-aminocaproic acid -- a meta-analysis of randomised and observational trials of over 30.000 patients
    Patrick Meybohm
    Clinic of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt am Main, Germany
    PLoS ONE 8:e58009. 2013

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Remote ischaemic preconditioning for heart surgery. The study design for a multi-center randomized double-blinded controlled clinical trial--the RIPHeart-Study
    Patrick Meybohm
    Clinic of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Theodor Stern Kai 7, Frankfurt am Main, Germany
    Eur Heart J 33:1423-6. 2012
    ..The purpose of this report is to describe the design and methods used in the "Remote Ischaemic Preconditioning for Heart Surgery (RIPHeart)-Study"...
  2. doi request reprint Patient Blood Management Bundles to Facilitate Implementation
    Patrick Meybohm
    Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt am Main, Germany Electronic address
    Transfus Med Rev . 2016
    ..A stepwise selection of the most feasible measures will facilitate the implementation of PBM. In this manner, PBM represents a new quality and safety standard...
  3. doi request reprint [Tools for junior scientists support from medical societies: survey amongst members organized in the Association of the Scientific Medical Societies (AWMF)]
    Patrick Meybohm
    Klinik fur Anasthesiologie, Intensivmedizin und Schmerztherapie, Universitatsklinikum Frankfurt, Frankfurt, Deutschland Electronic address
    Z Evid Fortbild Qual Gesundhwes 109:632-41. 2015
    ..A systematic survey of existing support tools and their dissemination among the medical societies has not yet been conducted...
  4. doi request reprint [Patient blood management: Current state of the literature]
    P Meybohm
    Klinik fur Anasthesiologie, Intensivmedizin und Schmerztherapie, Universitätsklinikum Frankfurt am Main, Theodor Stern Kai 7, 60590, Frankfurt am Main, Deutschland
    Chirurg 87:40-6. 2016
    ..Due to these serious deficits in patient care, in 2011 the World Health Organization recommended the implementation of a patient blood management (PBM)...
  5. pmc Should we restrict erythrocyte transfusion in early goal directed protocols?
    Patrick Meybohm
    Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    BMC Anesthesiol 15:75. 2015
    ..But more importantly, early goal-directed therapy also became standard care for non-septic critically ill patients and was adopted for high-risk surgical patients...
  6. pmc Safety and effectiveness of a Patient Blood Management (PBM) program in surgical patients--the study design for a multi-centre prospective epidemiologic non-inferiority trial
    Patrick Meybohm
    Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    BMC Health Serv Res 14:576. 2014
    ..Patient Blood Management (PBM) concepts aim to increase and preserve autologous erythrocyte volume and to optimise haemotherapy. They thus have great potential to benefit patients...
  7. pmc SodiUm SeleniTe Adminstration IN Cardiac Surgery (SUSTAIN CSX-trial): study design of an international multicenter randomized double-blinded controlled trial of high dose sodium-selenite administration in high-risk cardiac surgical patients
    Christian Stoppe
    Department of Anesthesiology, University Hospital of the RWTH Aachen, Pauwelsstrase 30, 52074 Aachen, Germany
    Trials 15:339. 2014
    ..Thus, a large-scale study is needed to investigate the effect of perioperative selenium supplementation on the occurrence of postoperative organ dysfunction...
  8. pmc Activities of cardiac tissue matrix metalloproteinases 2 and 9 are reduced by remote ischemic preconditioning in cardiosurgical patients with cardiopulmonary bypass
    Karina Zitta
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Kiel, Germany
    J Transl Med 12:94. 2014
    ..Here we investigated the effects of RIPC on the activities of heart tissue MMP-2/9 and their correlation with serum concentrations of cardiac troponin T (cTnT), a marker for myocardial damage...
  9. pmc Postoperative neurocognitive dysfunction in patients undergoing cardiac surgery after remote ischemic preconditioning: a double-blind randomized controlled pilot study
    Patrick Meybohm
    Clinic of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt am Main, Germany
    PLoS ONE 8:e64743. 2013
    ..We hypothesized that RIPC reduces postoperative neurocognitive dysfunction (POCD) in patients undergoing complex cardiac surgery...
  10. pmc Aprotinin may increase mortality in low and intermediate risk but not in high risk cardiac surgical patients compared to tranexamic acid and ε-aminocaproic acid -- a meta-analysis of randomised and observational trials of over 30.000 patients
    Patrick Meybohm
    Clinic of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt am Main, Germany
    PLoS ONE 8:e58009. 2013
    ..To compare the effect of aprotinin with the effect of lysine analogues (tranexamic acid and ε-aminocaproic acid) on early mortality in three subgroups of patients: low, intermediate and high risk of cardiac surgery...
  11. doi request reprint Patient Blood Management is Associated With a Substantial Reduction of Red Blood Cell Utilization and Safe for Patient's Outcome: A Prospective, Multicenter Cohort Study With a Noninferiority Design
    Patrick Meybohm
    Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt, Germany Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany Department of Anesthesiology, Intensive Care and Pain Medicine, University of Muenster, Muenster, Germany Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany Department of Medicine, Institute of Biostatistics and Mathematical Modelling, Goethe University Frankfurt, Germany German Red Cross Blood Transfusion Service Baden Wuerttemberg Hessen, Institute of Transfusion Medicine and Immunohematology, Frankfurt, Germany Central Laboratory, University Hospital Frankfurt, Germany Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Bonn, Germany Institute of Transfusion Medicine, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany Institute of Transfusion Medicine and Transplantation Immunology, University Hospital of Muenster, Muenster, Germany
    Ann Surg 264:203-11. 2016
    ..To determine whether the implementation of patient blood management (PBM) is effective to decrease the use of red blood cell without impairment of patient's safety...
  12. doi request reprint Patient blood management: is it worth to be employed?
    Suma Choorapoikayil
    Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt am Main, Germany
    Curr Opin Anaesthesiol 29:186-91. 2016
    ..This review will exemplify the need of patient centered treatments and highlight recent findings in the field of PBM...
  13. doi request reprint Antifactor Xa Activity for the Management of Anticoagulation during Cardiac Surgery
    Christian Reyher
    Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt am Main, Germany
    Thorac Cardiovasc Surg 64:494-500. 2016
    ..55 IU/mL (AUC: 0.85; inaccuracy rate: 13.3%) for ACT ≤ 100 seconds. Conclusion AXa activity is strongly correlated with ACT, and therefore may be feasible for managing anticoagulation with UFH during ECC. ..
  14. pmc Successful fast track protocol implementation for patients undergoing transapical transcatheter aortic valve implantation
    Nestoras Papadopoulos
    Division of Thoracic and Cardiovascular Surgery, Johann Wolfgang Goethe University Frankfurt Main, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    J Cardiothorac Surg 11:55. 2016
    ....
  15. pmc Influence of hypothermia and subsequent rewarming upon leukocyte-endothelial interactions and expression of Junctional-Adhesion-Molecules A and B
    Nicolai V Bogert
    Department of Thoracic and Cardiovascular Surgery, University Hospital Frankfurt, Goethe University, Frankfurt Main, Germany
    Sci Rep 6:21996. 2016
    ..Endothelial protection prior to warm reperfusion and mild hypothermic conditions reducing the difference between hypothermia and rewarming temperatures should be considered. ..
  16. pmc Washed cell salvage in surgical patients: A review and meta-analysis of prospective randomized trials under PRISMA
    Patrick Meybohm
    aDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt bInstitute for Anesthesiology, University and University Hospital Zurich, Zurich, Switzerland cInstitute of Biostatistics and Mathematical Modelling, Goethe University Frankfurt, Germany
    Medicine (Baltimore) 95:e4490. 2016
    ..Cell salvage is commonly used as part of a blood conservation strategy. However concerns among clinicians exist about the efficacy of transfusion of washed cell salvage...
  17. doi request reprint Multiple electrode aggregometry for the assessment of acquired platelet dysfunctions during extracorporeal circulation
    Haitham Mutlak
    Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt, Germany
    Thorac Cardiovasc Surg 63:21-7. 2015
    ..The aim of the present investigation was to study the capability of the multiple electrode aggregometry (MEA) using the Multiplate (Roche AG, Grenzach, Germany) device to reflect the extent of ECC-associated platelet dysfunctions...
  18. doi request reprint The Fibrin-Derived Peptide Bβ15-42 (FX06) Ameliorates Vascular Leakage and Improves Survival and Neurocognitive Recovery: Implications From Two Animal Models of Cardiopulmonary Resuscitation
    Stefan Bergt
    1Department of Anesthesiology and Critical Care Medicine, University Hospital Rostock, Rostock, Germany 2Department of Anesthesiology and Intensive Care Medicine, Schleswig Holstein University Hospital, Campus Kiel, Kiel, Germany 3Department of Anesthesiology and Intensive Care Medicine, University Hospital of Cologne, North Rhine Westphalia, Germany 4Institute for Experimental Surgery, Rostock University, Rostock, Germany 5Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt am Main, Germany 6Department of Anesthesiology and Intensive Care Medicine, Suedstadt Hospital, Rostock, Germany
    Crit Care Med 44:e988-95. 2016
    ..The fibrin-derived peptide Bβ15-42 (FX06) has been proven to attenuate ischemia/reperfusion injury. We tested the hypothesis that Bβ15-42 improves survival rate and neurocognitive recovery after cardiopulmonary resuscitation...
  19. doi request reprint [Hemorrhage after accidental overdosage of enoxaparin: monitoring and therapy]
    Christian Friedrich Weber
    Klinik fur Anasthesiologie, Intensivmedizin und Schmerztherapie, Universitatsklinikum Frankfurt, Frankfurt am Main
    Anasthesiol Intensivmed Notfallmed Schmerzther 49:368-73. 2014
    ..A few hours later an excessive coagulopathy developed and necessitated the transfusion of allogenic blood products. The present case report describes and discusses our diagnostic and therapeutic approaches...
  20. doi request reprint Contribution of Ninjurin1 to Toll-like receptor 4 signaling and systemic inflammation
    Carla Jennewein
    1 Department of Anesthesiology, Intensive Care Medicine, and Pain Therapy, University Hospital Frankfurt, Frankfurt am Main, Germany and
    Am J Respir Cell Mol Biol 53:656-63. 2015
    ..Our data contribute to a better understanding of the complex inflammatory mechanisms and add a novel therapeutic target for inflammatory conditions such as sepsis. ..
  21. doi request reprint Novel method to leukoreduce murine blood for transfusion: how to reduce animal usage
    Dania Fischer
    Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt Main, Germany
    Transfusion 56:146-52. 2016
    ..The commonly used neonatal LR filter (LRF) is associated with considerable animal numbers. A more efficient method would help support the guiding principles of "replacement, reduction, refinement" (3Rs)...
  22. ncbi request reprint Improving outcome of trauma patients by implementing patient blood management
    Christoph Füllenbach
    Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt am Main, Germany
    Curr Opin Anaesthesiol . 2016
    ....
  23. pmc IgM-Enriched Immunoglobulin Attenuates Systemic Endotoxin Activity in Early Severe Sepsis: A Before-After Cohort Study
    Saskia Wand
    Department of Anesthesia, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt am Main, Germany
    PLoS ONE 11:e0160907. 2016
    ....
  24. pmc Practice of hemodynamic monitoring and management in German, Austrian, and Swiss intensive care units: the multicenter cross-sectional ICU-CardioMan Study
    Sandra Funcke
    Department of Anaesthesiology, Centre of Anaesthesiology and Intensive Care Medicine, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    Ann Intensive Care 6:49. 2016
    ..Further, it is still unclear which factors trigger the use of extended hemodynamic monitoring...
  25. doi request reprint Pparγ Expression in T Cells as a Prognostic Marker of Sepsis
    Marco Brenneis
    Institute of Biochemistry I Pathobiochemistry, Faculty of Medicine, Goethe University Frankfurt Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology TMP Department of Anaethesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt Department of Nephrology, Medical Clinic III, University Hospital Frankfurt, Frankfurt, Germany
    Shock 45:591-7. 2016
    ..We suggest that both high PPARγ expression in T cells and low absolute T cell number in blood of septic patients may have the potential as a new prognostic marker for a poor sepsis outcome. ..
  26. doi request reprint [Management of extended blood loss and massive transfusion]
    Christian F Weber
    Klinik fur Anasthesiologie, Intensivmedizin und Schmerztherapie, Universitatsklinikum Frankfurt
    Anasthesiol Intensivmed Notfallmed Schmerzther 48:314-7. 2013
    ..Our guideline may be used as a template for other institutions...
  27. doi request reprint Methylene blue modulates adhesion molecule expression on microvascular endothelial cells
    Isabella Werner
    Department of Thoracic and Cardiovascular Surgery, University Hospital Frankfurt, Goethe University, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    Inflamm Res 63:649-56. 2014
    ....
  28. pmc Individual Organ Failure and Concomitant Risk of Mortality Differs According to the Type of Admission to ICU - A Retrospective Study of SOFA Score of 23,795 Patients
    Tobias M Bingold
    Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt am Main, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    PLoS ONE 10:e0134329. 2015
    ....