Hiroaki Iwata

Summary

Country: Germany

Publications

  1. doi request reprint Bullous pemphigoid: role of complement and mechanisms for blister formation within the lamina lucida
    Hiroaki Iwata
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    Exp Dermatol 22:381-5. 2013
  2. doi request reprint GM-CSF modulates autoantibody production and skin blistering in experimental epidermolysis bullosa acquisita
    Unni Krishna S R L Samavedam
    Department of Dermatology, University of Lubeck, 23563 Lübeck, Germany
    J Immunol 192:559-71. 2014
  3. doi request reprint Radiosensitive Hematopoietic Cells Determine the Extent of Skin Inflammation in Experimental Epidermolysis Bullosa Acquisita
    Hiroaki Iwata
    Department of Dermatology, University of Lubeck, D 23538 Lubeck, Germany
    J Immunol 195:1945-54. 2015
  4. doi request reprint Autoantibodies to Multiple Epitopes on the Non-Collagenous-1 Domain of Type VII Collagen Induce Blisters
    Artem Vorobyev
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    J Invest Dermatol 135:1565-73. 2015
  5. pmc Persistent autoantibody-production by intermediates between short-and long-lived plasma cells in inflamed lymph nodes of experimental epidermolysis bullosa acquisita
    Benjamin Tiburzy
    Institute for Systemic Inflammation Research ISEF, University of Lubeck, Lubeck, Germany
    PLoS ONE 8:e83631. 2013
  6. doi request reprint B cells, dendritic cells, and macrophages are required to induce an autoreactive CD4 helper T cell response in experimental epidermolysis bullosa acquisita
    Hiroaki Iwata
    Department of Dermatology, University of Lubeck, 23538 Lubeck, Germany
    J Immunol 191:2978-88. 2013
  7. ncbi request reprint Animal models to investigate pathomechanisms and evaluate novel treatments for autoimmune bullous dermatoses
    Hiroaki Iwata
    Lubeck Institute of Experimental Dermatology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Curr Pharm Des 21:2422-39. 2015
  8. pmc Prevalence of pemphigus and pemphigoid autoantibodies in the general population
    Wiebke Prüßmann
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    Orphanet J Rare Dis 10:63. 2015
  9. doi request reprint Caspase-1-independent IL-1 release mediates blister formation in autoantibody-induced tissue injury through modulation of endothelial adhesion molecules
    Hengameh Sadeghi
    Department of Dermatology, University of Lubeck, 23538 Lubeck, Germany
    J Immunol 194:3656-63. 2015
  10. doi request reprint Genetic identification and functional validation of FcγRIV as key molecule in autoantibody-induced tissue injury
    Michael Kasperkiewicz
    Department of Dermatology, University of Lubeck, Germany
    J Pathol 228:8-19. 2012

Collaborators

Detail Information

Publications10

  1. doi request reprint Bullous pemphigoid: role of complement and mechanisms for blister formation within the lamina lucida
    Hiroaki Iwata
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    Exp Dermatol 22:381-5. 2013
    ....
  2. doi request reprint GM-CSF modulates autoantibody production and skin blistering in experimental epidermolysis bullosa acquisita
    Unni Krishna S R L Samavedam
    Department of Dermatology, University of Lubeck, 23563 Lübeck, Germany
    J Immunol 192:559-71. 2014
    ..We demonstrate that GM-CSF modulates both autoantibody production and skin blistering in a prototypical organ-specific autoimmune disease. ..
  3. doi request reprint Radiosensitive Hematopoietic Cells Determine the Extent of Skin Inflammation in Experimental Epidermolysis Bullosa Acquisita
    Hiroaki Iwata
    Department of Dermatology, University of Lubeck, D 23538 Lubeck, Germany
    J Immunol 195:1945-54. 2015
    ..Collectively, we demonstrate that radiosensitive cells determine the varying extent of skin inflammation and blistering in the end-stage effector phase of EBA...
  4. doi request reprint Autoantibodies to Multiple Epitopes on the Non-Collagenous-1 Domain of Type VII Collagen Induce Blisters
    Artem Vorobyev
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    J Invest Dermatol 135:1565-73. 2015
    ..In addition, using COL7-humanized mice, we provide in vivo evidence of pathogenicity of autoantibodies binding to human COL7. ..
  5. pmc Persistent autoantibody-production by intermediates between short-and long-lived plasma cells in inflamed lymph nodes of experimental epidermolysis bullosa acquisita
    Benjamin Tiburzy
    Institute for Systemic Inflammation Research ISEF, University of Lubeck, Lubeck, Germany
    PLoS ONE 8:e83631. 2013
    ..These results indicate that inflamed lymph nodes can harbor pathogenic plasma cells exhibiting distinct properties and hence may resemble a so far neglected site for chronic autoantibody production. ..
  6. doi request reprint B cells, dendritic cells, and macrophages are required to induce an autoreactive CD4 helper T cell response in experimental epidermolysis bullosa acquisita
    Hiroaki Iwata
    Department of Dermatology, University of Lubeck, 23538 Lubeck, Germany
    J Immunol 191:2978-88. 2013
    ..Collectively, we demonstrate the pathogenic relevance of Abs targeting the vWFA2 domain of COL7 and show the requirement of APC-induced CD4 T cells to induce experimental EBA. ..
  7. ncbi request reprint Animal models to investigate pathomechanisms and evaluate novel treatments for autoimmune bullous dermatoses
    Hiroaki Iwata
    Lubeck Institute of Experimental Dermatology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Curr Pharm Des 21:2422-39. 2015
    ..Overall we aim to foster a broader use of AIBD animal models, especially in translational biomedical research, to deepen our understanding of AIBD pathogenesis and to develop novel treatments for patients...
  8. pmc Prevalence of pemphigus and pemphigoid autoantibodies in the general population
    Wiebke Prüßmann
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    Orphanet J Rare Dis 10:63. 2015
    ..Hence, detection of specific autoantibodies has become a hallmark for AIBD diagnosis. Studies on prevalence of AIBD autoantibodies in healthy individuals yielded contradictory results...
  9. doi request reprint Caspase-1-independent IL-1 release mediates blister formation in autoantibody-induced tissue injury through modulation of endothelial adhesion molecules
    Hengameh Sadeghi
    Department of Dermatology, University of Lubeck, 23538 Lubeck, Germany
    J Immunol 194:3656-63. 2015
    ..e., when skin lesions had already developed) improved experimental EBA, IL-1 appears to be a potential therapeutic target for EBA and related AIBDs. ..
  10. doi request reprint Genetic identification and functional validation of FcγRIV as key molecule in autoantibody-induced tissue injury
    Michael Kasperkiewicz
    Department of Dermatology, University of Lubeck, Germany
    J Pathol 228:8-19. 2012
    ..Our findings both genetically and functionally identify a novel disease-related molecule, FcγRIV, in an autoantibody-mediated disorder, which may be of importance for the development of novel targeted therapies...