H Koepsell

Summary

Affiliation: Institute of Anatomy and Cell Biology
Country: Germany

Publications

  1. doi request reprint The Na+-D-glucose cotransporters SGLT1 and SGLT2 are targets for the treatment of diabetes and cancer
    Hermann Koepsell
    Department of Molecular Plant Physiology and Biophysics, Julius von Sachs Institute, University of Wurzburg, 97082 Wurzburg, Germany Electronic address
    Pharmacol Ther . 2016
  2. doi request reprint Role of organic cation transporters in drug-drug interaction
    Hermann Koepsell
    a University Würzburg, Julius von Sachs Institute, Department of Molecular Plant Physiology and Biophysics, Botanik 1, Julius von Sachs Platz 2, Würzburg 97082, Germany
    Expert Opin Drug Metab Toxicol 11:1619-33. 2015
  3. pmc Sodium glucose cotransporter 1 ligand BLF501 as a novel tool for management of gastrointestinal mucositis
    Diego Cardani
    Department of Pharmacology and Biomolecular Sciences, Universita degli Studi di Milano, Via Trentacoste 2, 20133 Milan, Italy
    Mol Cancer 13:23. 2014
  4. doi request reprint Polyspecific organic cation transporters and their biomedical relevance in kidney
    Hermann Koepsell
    Institute of Anatomy and Cell Biology and Department of Molecular Plant Physiology and Biophysics, Julius von Sachs Institute, University of Wurzburg, Wurzburg, Germany
    Curr Opin Nephrol Hypertens 22:533-8. 2013
  5. doi request reprint The SLC22 family with transporters of organic cations, anions and zwitterions
    Hermann Koepsell
    University of Wurzburg, Institute of Anatomy and Cell Biology, Koellikerstr 6, 97070 Wurzburg, Germany
    Mol Aspects Med 34:413-35. 2013
  6. pmc Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse
    Wolfgang Kummer
    Institute for Anatomy and Cell Biology, Justus Liebig University, 35385 Giessen, Germany
    Respir Res 7:65. 2006
  7. ncbi request reprint Organic cation transporters
    H Koepsell
    Institut fur Anatomie und Zellbiologie, Bayerischen Julius Maximilians Universität, Koellikerstr 6, 97070 Wurzburg, Germany
    Rev Physiol Biochem Pharmacol 150:36-90. 2003
  8. pmc Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion
    Valentin Gorboulev
    Institute of Anatomy and Cell Biology, University of Wurzburg, Wurzburg, Germany
    Diabetes 61:187-96. 2012
  9. ncbi request reprint In vivo two-photon fluorescence microscopy opens a new area for investigation of the excretion of cationic drugs in the kidney
    H Koepsell
    Institut fur Anatomie und Zellbiologie, Julius Maximilians Universitat, Wurzburg, Germany
    Kidney Int 72:387-8. 2007
  10. ncbi request reprint The SLC22 drug transporter family
    Hermann Koepsell
    Institute of Anatomy and Cell Biology, Bayerische Maximilians Universität Würzburg, Koellikerstr 6, 97070, Wurzburg, Germany
    Pflugers Arch 447:666-76. 2004

Collaborators

Detail Information

Publications55

  1. doi request reprint The Na+-D-glucose cotransporters SGLT1 and SGLT2 are targets for the treatment of diabetes and cancer
    Hermann Koepsell
    Department of Molecular Plant Physiology and Biophysics, Julius von Sachs Institute, University of Wurzburg, 97082 Wurzburg, Germany Electronic address
    Pharmacol Ther . 2016
    ..SGLT1 and SGLT2 are expressed in various tumors where they supply the tumor cells with glucose for euglycemic glycolysis. Tumor growth of carcinoma expressing SGLT2 can be slowed down by an SGLT2 inhibitor...
  2. doi request reprint Role of organic cation transporters in drug-drug interaction
    Hermann Koepsell
    a University Würzburg, Julius von Sachs Institute, Department of Molecular Plant Physiology and Biophysics, Botanik 1, Julius von Sachs Platz 2, Würzburg 97082, Germany
    Expert Opin Drug Metab Toxicol 11:1619-33. 2015
    ..Knowledge about physiological and biomedical functions of OCTs and the molecular mechanisms of transport and inhibition is required to anticipate drug-drug interactions and their potential biomedical impact...
  3. pmc Sodium glucose cotransporter 1 ligand BLF501 as a novel tool for management of gastrointestinal mucositis
    Diego Cardani
    Department of Pharmacology and Biomolecular Sciences, Universita degli Studi di Milano, Via Trentacoste 2, 20133 Milan, Italy
    Mol Cancer 13:23. 2014
    ..We tested whether SGLT-1 engagement might protect the intestinal mucosa from doxorubicin (DXR)- and 5-fluorouracil (5-FU)-induced injury in animal models mimicking acute or chronic mucositis...
  4. doi request reprint Polyspecific organic cation transporters and their biomedical relevance in kidney
    Hermann Koepsell
    Institute of Anatomy and Cell Biology and Department of Molecular Plant Physiology and Biophysics, Julius von Sachs Institute, University of Wurzburg, Wurzburg, Germany
    Curr Opin Nephrol Hypertens 22:533-8. 2013
    ..Recent research concerning properties of these transporters and their clinical significance for nephrology is summarized...
  5. doi request reprint The SLC22 family with transporters of organic cations, anions and zwitterions
    Hermann Koepsell
    University of Wurzburg, Institute of Anatomy and Cell Biology, Koellikerstr 6, 97070 Wurzburg, Germany
    Mol Aspects Med 34:413-35. 2013
    ..Drug-drug interactions at individual transporters may change pharmacokinetics and toxicities of drugs...
  6. pmc Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse
    Wolfgang Kummer
    Institute for Anatomy and Cell Biology, Justus Liebig University, 35385 Giessen, Germany
    Respir Res 7:65. 2006
    ..Hence, the hypothesis emerged that 5-HT evokes bronchoconstriction by inducing release of ACh from epithelial cells via OCTs...
  7. ncbi request reprint Organic cation transporters
    H Koepsell
    Institut fur Anatomie und Zellbiologie, Bayerischen Julius Maximilians Universität, Koellikerstr 6, 97070 Wurzburg, Germany
    Rev Physiol Biochem Pharmacol 150:36-90. 2003
    ..Finally, we discuss the clinical potential of the increasing knowledge about polymorphisms and mutations in polyspecific organic cation transporters...
  8. pmc Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion
    Valentin Gorboulev
    Institute of Anatomy and Cell Biology, University of Wurzburg, Wurzburg, Germany
    Diabetes 61:187-96. 2012
    ..The data indicate that SGLT1 is 1) pivotal for intestinal mass absorption of d-glucose, 2) triggers the glucose-induced secretion of GIP and GLP-1, and 3) triggers the upregulation of GLUT2...
  9. ncbi request reprint In vivo two-photon fluorescence microscopy opens a new area for investigation of the excretion of cationic drugs in the kidney
    H Koepsell
    Institut fur Anatomie und Zellbiologie, Julius Maximilians Universitat, Wurzburg, Germany
    Kidney Int 72:387-8. 2007
    ..In combination with specific inhibitors, the contribution of individual cation transporters can be determined...
  10. ncbi request reprint The SLC22 drug transporter family
    Hermann Koepsell
    Institute of Anatomy and Cell Biology, Bayerische Maximilians Universität Würzburg, Koellikerstr 6, 97070, Wurzburg, Germany
    Pflugers Arch 447:666-76. 2004
    ..Defect mutations of transporters of the SLC22 family may cause specific diseases such as "primary systemic carnitine deficiency" or "idiopathic renal hypouricemia" or change drug absorption or excretion...
  11. ncbi request reprint Polyspecific organic cation transporters: their functions and interactions with drugs
    Hermann Koepsell
    Institute of Anatomy und Cell Biology, University Wurzburg, Koellikerstrasse 6, 97070 Wurzburg, Germany
    Trends Pharmacol Sci 25:375-81. 2004
  12. ncbi request reprint Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications
    Hermann Koepsell
    Institute of Anatomy and Cell Biology, Julius Maximilians University, Wurzburg, Germany
    Pharm Res 24:1227-51. 2007
    ..Transport studies with expressed OCTs will help to optimize pharmacokinetics during development of new drugs...
  13. ncbi request reprint Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1
    P Arndt
    , Koellikerstr. 6, , Germany
    Am J Physiol Renal Physiol 281:F454-68. 2001
    ..Inhibition experiments at different pH levels strongly suggest that the weak base quinine passively permeates the plasma membrane at physiological pH and inhibits rOCT2 from the intracellular side...
  14. ncbi request reprint The plasma membrane-associated protein RS1 decreases transcription of the transporter SGLT1 in confluent LLC-PK1 cells
    T Korn
    Institute of Anatomy of the Bayerische Julius Maximilians Universität, 97070 Wurzburg, Germany
    J Biol Chem 276:45330-40. 2001
    ..The data suggest that RS1 participates in transcriptional up-regulation of SGLT1 after confluence but not in down-regulation by D-glucose...
  15. ncbi request reprint The transport modifier RS1 is localized at the inner side of the plasma membrane and changes membrane capacitance
    M Valentin
    Anatomical Institute, University of Wurzburg, Koellikerstrasse 6, 97070 Wurzburg, Germany
    Biochim Biophys Acta 1468:367-80. 2000
    ..The data suggest that RS1 is an intracellular regulatory protein that associates with the plasma membrane. Overexpression of RS1 may effect the incorporation and/or retrieval of transporters into the plasma membrane...
  16. ncbi request reprint Membrane localization of the electrogenic cation transporter rOCT1 in rat liver
    F Meyer-Wentrup
    Anatomisches Institut, Bayerischen Julius Maximilians Universität, Wurzburg, Germany
    Biochem Biophys Res Commun 248:673-8. 1998
    ..Translational regulation is suggested since the message of rOCT1 was distributed throughout the liver lobuli, whereas rOCT1 protein was observed only in hepatocytes surrounding the central veins...
  17. ncbi request reprint Localization of organic cation transporters OCT1 and OCT2 in rat kidney
    U Karbach
    Institute of Anatomy of the Bayerische Julius Maximilians Universität, 97070 Wurzburg, Germany
    Am J Physiol Renal Physiol 279:F679-87. 2000
    ..The data suggest that rOCT1 and rOCT2 are responsible for basolateral cation uptake in the proximal tubule, which represents the first step in cation secretion...
  18. ncbi request reprint Downregulation of the Na(+)- D-glucose cotransporter SGLT1 by protein RS1 (RSC1A1) is dependent on dynamin and protein kinase C
    M Veyhl
    Institut fur Anatomie und Zellbiologie, Bayerische Julius Maximilians Universität, Koellikerstr 6, D 97070 Wurzburg, Germany
    J Membr Biol 196:71-81. 2003
    ..Taken together, these data indicate that hRS1 modulates dynamin-dependent trafficking of intracellular vesicles containing hSGLT1 in Xenopus oocytes, and modulates PKC-dependent short-term regulation of this transporter...
  19. ncbi request reprint Cloning and characterization of the transport modifier RS1 from rabbit which was previously assumed to be specific for Na+-D-glucose cotransport
    J Reinhardt
    Anatomisches Institut der Bayerischen Julius Maximilians Universität, Koellikerstr 6, Wurzburg, Germany
    Biochim Biophys Acta 1417:131-43. 1999
    ..The data show that RS1 can modulate the function of transporters with non-homologous primary structures...
  20. ncbi request reprint Cloning and characterization of two human polyspecific organic cation transporters
    V Gorboulev
    Anatomisches Institut der Bayerischen Julius Maximilians Universität, Wurzburg, Germany
    DNA Cell Biol 16:871-81. 1997
    ..Cation transport in distal tubules is indicated for the first time. Here hOCT2 mediates the first step in cation reabsorption. hOCT1 may participate in hepatic excretion of organic cations...
  21. ncbi request reprint Organic cation transporter capable of transporting serotonin is up-regulated in serotonin transporter-deficient mice
    A Schmitt
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Neurosci Res 71:701-9. 2003
    ....
  22. ncbi request reprint Drug excretion mediated by a new prototype of polyspecific transporter
    D Gründemann
    Anatomisches Institut, Bayerische Julius Maximilians Universität, Wurzburg, Germany
    Nature 372:549-52. 1994
    ..As OCT1 translocates hydrophobic and hydrophilic organic cations of different structures, it is considered to be a new prototype of polyspecific transporters that are important for drug elimination...
  23. ncbi request reprint The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26
    M R Koehler
    Department of Human Genetics, University of Wurzburg, Biozentrum, Germany
    Cytogenet Cell Genet 79:198-200. 1997
    ..We have localized the OCT1 and OCT2 genes (SLC22A1, SLC22A2) on chromosome 6q26...
  24. ncbi request reprint Organic cation transporters in intestine, kidney, liver, and brain
    H Koepsell
    Anatomisches Institut Bayerischen Julius Maximilians Universität, Wurzburg, Germany
    Annu Rev Physiol 60:243-66. 1998
    ....
  25. pmc Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1
    M Veyhl
    Institute of Anatomy of the Bayerische Julius Maximilians Universität, Koellikerstr 6, 97070 Wurzburg, Germany
    Proc Natl Acad Sci U S A 95:2914-9. 1998
    ..The data suggest that the Na+-D-glucose cotransporter SAAT1 transports beta-D-Glc-IPM into human tumor cells and may accumulate the drug in the cells. They provide an example for drug targeting by employing a plasma membrane transporter...
  26. doi request reprint Charge-to-substrate ratio during organic cation uptake by rat OCT2 is voltage dependent and altered by exchange of glutamate 448 with glutamine
    Bernhard M Schmitt
    Institute of Anatomy and Cell Biology, Koellikerstr 6, 97070 Wurzburg, Germany
    Am J Physiol Renal Physiol 296:F709-22. 2009
    ..Substitution of Glu448 by glutamine reduced the charge-to-TEA(+) ratio at 0 mV to unity. The observed charge excess associated with organic cation uptake into depolarized cells may contribute to tubular damage in renal failure...
  27. doi request reprint Protein kinase C-dependent trafficking of glutamate transporters excitatory amino acid carrier 1 and glutamate transporter 1b in cultured cerebellar granule cells
    U Karatas-Wulf
    University of Wurzburg, Institute of Anatomy and Cell Biology, Wurzburg, Germany
    Neuroscience 161:794-805. 2009
    ..The findings suggest that PKC is similarly involved in regulation of surface trafficking of GLT1b and EAAC1 and that PKC stimulated increase in surface location of GLT1b and EAAC1 in glutamatergic CGCs...
  28. ncbi request reprint Alkali cation binding and permeation in the rat organic cation transporter rOCT2
    Bernhard M Schmitt
    Department of Anatomy and Cell Biology, University of Wurzburg, Koellikerstrasse 6, 97070 Wurzburg, Germany
    J Biol Chem 280:24481-90. 2005
    ..Our data show that selective permeability of rOCT2 is not determined by ligand affinity but might rather be understood in terms of the ion channel concept of a distinct "selectivity filter."..
  29. ncbi request reprint Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity
    Alexander Sturm
    Institute of Anatomy and Cell Biology, University of Wurzburg, Wurzburg, Germany
    Am J Physiol Renal Physiol 293:F767-79. 2007
    ..They indicate that cysteine 451 in rOCT1 interacts with the large intracellular loop and that cysteine 451 in both rOCT1 and rOCT2 is critical for the affinity of choline...
  30. ncbi request reprint Different affinities of inhibitors to the outwardly and inwardly directed substrate binding site of organic cation transporter 2
    Christopher Volk
    Institut fur Anatomie und Zellbiologie, Koellikerstr 6, 97070 Wurzburg, Germany
    Mol Pharmacol 64:1037-47. 2003
    ..A model is proposed that describes how substrates and inhibitors might interact with rOCT2. The data provide a theoretical basis to understand drug-drug interactions at polyspecific transporters for organic cations...
  31. ncbi request reprint Subtype-specific affinity for corticosterone of rat organic cation transporters rOCT1 and rOCT2 depends on three amino acids within the substrate binding region
    Valentin Gorboulev
    Institute of Anatomy and Cell Biology, University of Wurzburg, Germany
    Mol Pharmacol 67:1612-9. 2005
    ....
  32. ncbi request reprint RS1 (RSC1A1) regulates the exocytotic pathway of Na+-D-glucose cotransporter SGLT1
    Maike Veyhl
    Institut für Anatomie und Zellbiologie der Universität Würzburg, Koellikerstr 6, 97070 Wurzburg, Germany
    Am J Physiol Renal Physiol 291:F1213-23. 2006
    ..The data suggest that hRS1 protein exhibits glucose-dependent, short-term inhibition of hSGLT1 and hOCT2 by inhibiting the release of vesicles from the trans-Golgi network...
  33. pmc Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity
    Christina Osswald
    Institute of Anatomy and Cell Biology, Bavarian Julius Maximilians University, Koellikerstrasse 6, 97070 Wurzburg, Germany
    Mol Cell Biol 25:78-87. 2005
    ..At this age, serum leptin was increased, whereas food intake was the same as for wild-type mice. The data suggest that the removal of RS1 leads to leptin-independent up-regulation of food intake, which causes obesity...
  34. ncbi request reprint Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium
    Katrin Susanne Lips
    Institute of Anatomy and Cell Biology, Justus Liebig University, Giessen, Germany
    Am J Respir Cell Mol Biol 33:79-88. 2005
    ..7 microM). The data show that OCT1 and OCT2 mediate luminal ACh release in human airways and suggest that ACh release is blocked after inhalation of budesonide...
  35. doi request reprint Cell free expression and functional reconstitution of eukaryotic drug transporters
    Thorsten Keller
    Institute of Anatomy and Cell Biology, University of Wurzburg, Koellikerstrasse 6, 97070 Wurzburg, Germany
    Biochemistry 47:4552-64. 2008
    ..The V max of PAH (-)/KG (2-) antiport was increased by Cl (-) in a manner independent of gradients, and PAH (-)/KG (2-) antiport was independent of membrane potential in the absence or presence of Cl (-)...
  36. ncbi request reprint High-affinity cation binding to organic cation transporter 1 induces movement of helix 11 and blocks transport after mutations in a modeled interaction domain between two helices
    Dmitry Gorbunov
    Institute of Anatomy and Cell Biology, Koellikerstr 6, 97070 Wurzburg, Germany
    Mol Pharmacol 73:50-61. 2008
    ..We propose that cations bound to high-affinity sites may be translocated together with cations bound to low-affinity sites or that they may block the translocation mechanism...
  37. ncbi request reprint Na(+)-D-glucose cotransporter in muscle capillaries increases glucose permeability
    Katrin Elfeber
    Institut für Anatomie und Zellbiologie der Bayerischen Julius Maximilians Universität, Koellikerstrasse 6, 97070 Wurzburg, Germany
    Biochem Biophys Res Commun 314:301-5. 2004
    ..The data show that SGLT1 in capillaries of skeletal muscle is required for the action of insulin on D-glucose supply of myocytes...
  38. ncbi request reprint Characterization of regulatory mechanisms and states of human organic cation transporter 2
    Jürgen Biermann
    Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Universitatsklinikum Munster, Domagkstrasse 3a, D 48149 Munster, Germany
    Am J Physiol Cell Physiol 290:C1521-31. 2006
    ..Inhibition of the Ca2+/CaM complex causes changes in transport capacity via hOCT2 trafficking...
  39. ncbi request reprint Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid
    Harunobu Tahara
    Graduate School of Pharmaceutical Sciences University of Tokyo Hongo, Tokyo, 113 0033, Japan
    Drug Metab Dispos 34:743-7. 2006
    ..These results suggest that the renal drug-drug interaction between fexofenadine and probenecid is probably explained by an inhibition of the renal uptake of fexofenadine via hOAT3, at least in part...
  40. ncbi request reprint A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters
    Harunobu Tahara
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    J Pharmacol Exp Ther 315:337-45. 2005
    ....
  41. ncbi request reprint 3-Hydroxyglutaric acid is transported via the sodium-dependent dicarboxylate transporter NaDC3
    Franziska Stellmer
    Department of Pediatrics, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    J Mol Med (Berl) 85:763-70. 2007
    ..The data demonstrate for the first time the membrane translocation of 3OH-GA mediated by NaDC3 and the cis-inhibitory effect on OCT2-mediated transport of cations...
  42. pmc A glucose sensor hiding in a family of transporters
    Ana Diez-Sampedro
    Department of Physiology, David Geffen School of Medicine, University of California, 10833 Le Conte Avenue, Los Angeles, CA 90095 1751, USA
    Proc Natl Acad Sci U S A 100:11753-8. 2003
    ..This points to an unexpected role of glucose and SLC5 proteins in physiology, and highlights the importance of determining the tissue expression and function of new members of gene families...
  43. ncbi request reprint Synthesis and biologic evaluation of (11)c-methyl-d-glucoside, a tracer of the sodium-dependent glucose transporters
    Guy M Bormans
    Faculty of Pharmaceutical Sciences and Department of Nuclear Medicine, University of Leuven, Leuven, Belgium
    J Nucl Med 44:1075-81. 2003
    ..This study aimed to synthesize and to evaluate the biologic characteristics of (11)C labeled methyl-D-glucoside, a nonmetabolizable tracer that is selectively transported by sodium-dependent glucose transporters (SGLTs)...
  44. ncbi request reprint Carriers involved in targeting the cytostatic bile acid-cisplatin derivatives cis-diammine-chloro-cholylglycinate-platinum(II) and cis-diammine-bisursodeoxycholate-platinum(II) toward liver cells
    Oscar Briz
    Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain
    Mol Pharmacol 61:853-60. 2002
    ..These results suggest a role for carriers of organic anions and cations in Bamet-R2 and Bamet-UD2 uptake, which may determine their ability to accumulate in liver tumor cells and/or be taken up and efficiently excreted by hepatocytes...
  45. ncbi request reprint Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases
    Ibrahim Cetinkaya
    Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, and Klinik und Poliklinik für Kinderheilkunde, Universitatsklinikum Munster, D 48149 Munster, Germany
    Am J Physiol Renal Physiol 284:F293-302. 2003
    ..In conclusion, we demonstrate that the hOCT2 is inhibited by PI3K and PKA and activated by a CaM-dependent signaling pathway, probably via a change in substrate affinity...
  46. ncbi request reprint The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules
    Kerry B Goralski
    Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada
    J Pharmacol Exp Ther 303:959-68. 2002
    ..TEA uptake by the basolateral membrane may be mediated mainly by rOCT1 and rOCT2, but these transporters may be in a different functional or regulatory state when expressed in cells or oocytes compared with expression in vivo...
  47. doi request reprint Revised immunolocalization of the Na+-D-glucose cotransporter SGLT1 in rat organs with an improved antibody
    Daniela Balen
    Molecular Toxicology, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, HR 10001 Zagreb, Croatia
    Am J Physiol Cell Physiol 295:C475-89. 2008
    ..Our improved rSGLT1-ab may be used to identify novel sites of SGLT1 localization and thus unravel additional physiological functions of this transporter in rat organs...
  48. ncbi request reprint Synthesis of 18F-fluoroalkyl-beta-D-glucosides and their evaluation as tracers for sodium-dependent glucose transporters
    Tjibbe J De Groot
    Laboratory for Radiopharmaceutical Chemistry and Department of Nuclear Medicine, Universitaire Ziekenhuizen Gasthuisberg, Leuven, Belgium
    J Nucl Med 44:1973-81. 2003
    ..Three omega-(18)F-fluoro-n-alkyl-beta-D-glucosides (alkyl = ethyl (5a)), n-butyl (5b), and n-octyl (5c)) were synthesized and evaluated as potential substrates for the sodium/D-glucose cotransporter SGLT1...
  49. ncbi request reprint Regulation of the human organic cation transporter hOCT1
    Giuliano Ciarimboli
    Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Universitatsklinikum Munster, D 48149 Munster, Germany
    J Cell Physiol 201:420-8. 2004
    ..Regulation pathways were the same in the two expression systems. Since apparent substrate affinities depend on activity of regulatory pathways, the expression system plays a role in determining the substrate affinities...
  50. ncbi request reprint Down-regulation of the non-neuronal acetylcholine synthesis and release machinery in acute allergic airway inflammation of rat and mouse
    Katrin S Lips
    Institute for Anatomy and Cell Biology, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
    Life Sci 80:2263-9. 2007
    ....
  51. ncbi request reprint Transporter regulator RS1 (RSC1A1) coats the trans-Golgi network and migrates into the nucleus
    Matthias Kroiss
    Institut für Anatomie und Zellbiologie der Universität Würzburg, Koellikerstr 6 97070 Würzburg, Germany
    Am J Physiol Renal Physiol 291:F1201-12. 2006
    ..Furthermore, we assigned SGLT1 to microtubule-associated tubulovesicular structures and dynamin-containing parts of the TGN. The data indicate that RS1 inhibits the dynamin-dependent release of SGLT1-containing vesicles from the TGN...
  52. pmc Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2
    Giuliano Ciarimboli
    Medizinische Klinik und Poliklinik D, Universitatsklinikum Munster, Germany
    Am J Pathol 167:1477-84. 2005
    ..A combination of cis-platin with other substrates that compete for hOCT2 offers an effective option to decrease nephrotoxicity in the clinical setting...
  53. ncbi request reprint Drug specificity and intestinal membrane localization of human organic cation transporters (OCT)
    Johanna Müller
    Membrane Transport Group, Biozentrum of the Martin Luther University Halle Wittenberg, Weinbergweg 22, D 06120 Halle, Germany
    Biochem Pharmacol 70:1851-60. 2005
    ..More importantly, immunocytochemical analyses of human jejunum revealed for the first time that hOCT3 is localized to the brush border membrane whereas hOCT1 immunolabeling was mainly observed at the lateral membranes of the enterocytes...
  54. ncbi request reprint Rat renal glucose transporter SGLT1 exhibits zonal distribution and androgen-dependent gender differences
    Ivan Sabolic
    Unit of Molecular Toxicology, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10001 Zagreb, Croatia
    Am J Physiol Renal Physiol 290:F913-26. 2006
    ....
  55. ncbi request reprint Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permease
    Christian Popp
    Institute of Anatomy and Cell Biology, University of Wurzburg, Germany
    Mol Pharmacol 67:1600-11. 2005
    ..The dimensions of TEA in comparison with the interacting amino acids in the modeled cleft suggest that more than one TEA molecule can bind in parallel to the modeled conformation of the transporter...