Carsten Tschope

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Mesenchymal stromal cells: a promising cell source for the treatment of inflammatory cardiomyopathy
    C Tschope
    Department of Cardiology and Pneumology, Charite University Medicine, Berlin Campus, Benjamin Franklin Hindenburgdamm 30, 12200 Berlin
    Curr Pharm Des 17:3295-307. 2011
  2. ncbi request reprint [Cardiovascular risk of androgen deprivation therapy for treatment of hormone-dependent prostate cancer : Differences between GnRH antagonists and GnRH agonists]
    C Tschope
    Abteilung fur Kardiologie, Universitatsmedizin Berlin, Campus Virchow Klinikum CVK, Augustenburger Platz 1, 13353, Berlin, Deutschland
    Herz 41:697-705. 2016
  3. doi request reprint [New therapy concepts for heart failure with preserved ejection fraction]
    C Tschope
    Abteilung fur Kardiologie, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum CVK, Augustenburger Platz 1, 13353, Berlin, Deutschland
    Herz 40:194-205. 2015
  4. pmc New insights in (inter)cellular mechanisms by heart failure with preserved ejection fraction
    Carsten Tschope
    Department of Cardiology and Pneumology, Charite, University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
    Curr Heart Fail Rep 11:436-44. 2014
  5. pmc Mesenchymal stem cells improve murine acute coxsackievirus B3-induced myocarditis
    S Van Linthout
    Berlin Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Campus Virchow, Berlin, Germany
    Eur Heart J 32:2168-78. 2011
  6. pmc Mesenchymal stem cells and inflammatory cardiomyopathy: cardiac homing and beyond
    S Van Linthout
    Berlin Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Campus Virchow, 13353 Berlin, Germany
    Cardiol Res Pract 2011:757154. 2011
  7. pmc Increased left ventricular stiffness impairs exercise capacity in patients with heart failure symptoms despite normal left ventricular ejection fraction
    David Sinning
    Department of Cardiology and Pulmonology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Cardiol Res Pract 2011:692862. 2011
  8. pmc Mesenchymal stromal cells but not cardiac fibroblasts exert beneficial systemic immunomodulatory effects in experimental myocarditis
    Konstantinos Savvatis
    Department of Cardiology and Pneumology, Campus Benjamin Franklin CBF, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e41047. 2012
  9. ncbi request reprint Diastolic heart failure and LV dyssynchrony
    Mario Kasner
    Department of Cardiology and Pneumology, Benjamin Franklin Campus, Charite University Hospital, Berlin, Germany
    Curr Pharm Biotechnol 13:2539-44. 2012
  10. doi request reprint Diastolic heart failure: What we still don't know. Looking for new concepts, diagnostic approaches, and the role of comorbidities
    C Tschope
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany
    Herz 37:875-9. 2012

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint Mesenchymal stromal cells: a promising cell source for the treatment of inflammatory cardiomyopathy
    C Tschope
    Department of Cardiology and Pneumology, Charite University Medicine, Berlin Campus, Benjamin Franklin Hindenburgdamm 30, 12200 Berlin
    Curr Pharm Des 17:3295-307. 2011
    ....
  2. ncbi request reprint [Cardiovascular risk of androgen deprivation therapy for treatment of hormone-dependent prostate cancer : Differences between GnRH antagonists and GnRH agonists]
    C Tschope
    Abteilung fur Kardiologie, Universitatsmedizin Berlin, Campus Virchow Klinikum CVK, Augustenburger Platz 1, 13353, Berlin, Deutschland
    Herz 41:697-705. 2016
    ..The GnRH antagonists have a different mode of action compared with GnRH agonists and may be preferred in ADT for patients with cardiovascular disease...
  3. doi request reprint [New therapy concepts for heart failure with preserved ejection fraction]
    C Tschope
    Abteilung fur Kardiologie, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum CVK, Augustenburger Platz 1, 13353, Berlin, Deutschland
    Herz 40:194-205. 2015
    ....
  4. pmc New insights in (inter)cellular mechanisms by heart failure with preserved ejection fraction
    Carsten Tschope
    Department of Cardiology and Pneumology, Charite, University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
    Curr Heart Fail Rep 11:436-44. 2014
    ..The potential importance of reciprocal interactions of the endothelium with cardiac fibroblasts and cardiomyocytes and with the cardiac neurohumoral response in this cardiac remodeling process is outlined. ..
  5. pmc Mesenchymal stem cells improve murine acute coxsackievirus B3-induced myocarditis
    S Van Linthout
    Berlin Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Campus Virchow, Berlin, Germany
    Eur Heart J 32:2168-78. 2011
    ..Finally, we investigated whether MSC application could improve murine acute CVB3-induced myocarditis...
  6. pmc Mesenchymal stem cells and inflammatory cardiomyopathy: cardiac homing and beyond
    S Van Linthout
    Berlin Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Campus Virchow, 13353 Berlin, Germany
    Cardiol Res Pract 2011:757154. 2011
    ..This paper gives an overview about how inflammation triggers the functionality of MSCs and how it induces cardiac homing. Finally, the potential of intravenous application of MSCs by inflammatory cardiomyopathy is discussed...
  7. pmc Increased left ventricular stiffness impairs exercise capacity in patients with heart failure symptoms despite normal left ventricular ejection fraction
    David Sinning
    Department of Cardiology and Pulmonology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Cardiol Res Pract 2011:692862. 2011
    ..Increased LV stiffness impairs exercise capacity in HFNEF...
  8. pmc Mesenchymal stromal cells but not cardiac fibroblasts exert beneficial systemic immunomodulatory effects in experimental myocarditis
    Konstantinos Savvatis
    Department of Cardiology and Pneumology, Campus Benjamin Franklin CBF, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e41047. 2012
    ..In conclusion, modulation of the immune response in extracardiac organs is associated with cardiobeneficial effects in experimental inflammatory cardiomyopathy after systemic application of MSCs...
  9. ncbi request reprint Diastolic heart failure and LV dyssynchrony
    Mario Kasner
    Department of Cardiology and Pneumology, Benjamin Franklin Campus, Charite University Hospital, Berlin, Germany
    Curr Pharm Biotechnol 13:2539-44. 2012
    ..However, up to date it is not clear to what degree LV dyssynchrony is involved in the pathomechanisms of this subpopulation of DHF...
  10. doi request reprint Diastolic heart failure: What we still don't know. Looking for new concepts, diagnostic approaches, and the role of comorbidities
    C Tschope
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany
    Herz 37:875-9. 2012
    ..In conclusion, HFPEF is still an enigma. New pathophysiological concepts, improved diagnostic strategies, and a better understanding of patient factors are needed to generate new therapeutic options in the future...
  11. ncbi request reprint Cardiac effects of HDL and its components on diabetic cardiomyopathy
    Frank Spillmann
    Department of Cardiology and Pneumology, Charite, University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Endocr Metab Immune Disord Drug Targets 12:132-47. 2012
    ....
  12. ncbi request reprint Coronary vasospasm-induced acute diastolic dysfunction in a patient with Raynaud's phenomenon
    Carsten Tschope
    Charite University Medicine Berlin, Campus Benjamin Franklin, Department of Cardiology and Pneumology, Hindenburgdamm 30, 12200, Berlin, Germany
    Clin Res Cardiol 95:344-8. 2006
    ..Thus, episodes of dyspnea in patients with Raynaud's phenomenon might be also interpreted as a coronary ischemia equivalent, which may belong to a visceral form of Raynaud's phenomenon and which are sensitive to iloprost infusions...
  13. ncbi request reprint [Microalbuminuria in patients with hypertension and cardiovascular comorbidity, REAL observational study of treatment with Irbesartan/HCTZ]
    C Tschope
    Univ Medizin Berlin, Campus Benjamin Franklin Medizinische Klinik I, Abteilung für Kardiologie und Pulmologie, Hindenburgdamm 30, D 1222o Berlin
    MMW Fortschr Med 148:48. 2006
  14. ncbi request reprint [Cardioprotection by means of Candesartan in cardiac insufficiency. CHARM overall partial evaluation (Candesartan in heart failure assessment of reduction in mortality and morbidity)]
    C Tschope
    Abteilung für Kardiologie und Pulmologie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
    Internist (Berl) 47:1084-6. 2006
  15. doi request reprint Development of diabetic cardiomyopathy and the kallikrein-kinin system--new insights from B1 and B2 receptor signaling
    Carsten Tschope
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, D 12200 Berlin, Germany
    Biol Chem 389:707-11. 2008
    ..Some recent findings suggest that the B1 receptor mediates cardiac inflammation and therefore may be detrimental for cardiac function in the setting of diabetic cardiomyopathy...
  16. doi request reprint Heart failure with normal ejection fraction. Pathophysiology, diagnosis, and treatment
    Carsten Tschope
    Department of Cardiology and Pneumology, Benjamin Franklin Campus, Charite University Hospital, Hindenburgdamm 30, 12200 Berlin, Germany
    Herz 34:89-96. 2009
    ..Treatment options will be reviewed including the recent clinical trials for this group of patients...
  17. pmc Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathy
    Dirk Westermann
    Department of Cardiology and Pneumology, Charité Universitä tsmedizinBerlin, Campus Benjamin Franklin, Berlin, Germany
    Diabetes 58:1373-81. 2009
    ..The underlying pathology of this disease is still under discussion. We studied the role of the kinin B1 receptor on the development of experimental diabetic cardiomyopathy...
  18. ncbi request reprint Protection against oxidative stress in diabetic rats: role of angiotensin AT(1) receptor and beta 1-adrenoceptor antagonism
    Marc Dorenkamp
    Department of Cardiology and Pneumonology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Eur J Pharmacol 520:179-87. 2005
    ..05). Angiotensin AT(1) receptor antagonism, but not beta(1)-adrenoceptor antagonism, ameliorates diabetes-generated oxidative stress, indicating a pivotal role of the renin-angiotensin system in the development of diabetic complications...
  19. ncbi request reprint Tumor necrosis factor-alpha antagonism protects from myocardial inflammation and fibrosis in experimental diabetic cardiomyopathy
    Dirk Westermann
    Dept of Cardiology and Pneumonology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Basic Res Cardiol 102:500-7. 2007
    ..TNFalpha-antagonism attenuates the development of experimental diabetic cardiomyopathy associated with a reduction of intramyocardial inflammation and cardiac fibrosis...
  20. ncbi request reprint Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction and oxidative stress in experimental diabetic cardiomyopathy
    Carsten Tschope
    Department of Cardiology and Pneumonology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    FASEB J 19:2057-9. 2005
    ..These insights might have therapeutic implications also for human diabetic cardiomyopathy...
  21. ncbi request reprint Toll-like receptor-4 modulates survival by induction of left ventricular remodeling after myocardial infarction in mice
    Alexander Riad
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Immunol 180:6954-61. 2008
    ..0001). TLR4 deficiency led to improved survival after MI mediated by attenuated left ventricular remodeling...
  22. doi request reprint Renin inhibition improves cardiac function and remodeling after myocardial infarction independent of blood pressure
    Dirk Westermann
    Department of Cardiology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Hypertension 52:1068-75. 2008
    ..Aliskiren improved LV dysfunction after MI in a dose that did not affect blood pressure. This was associated with the amelioration of cardiac remodelling, hypertrophy, and apoptosis...
  23. doi request reprint Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure
    Dirk Westermann
    Department of Cardiology and Pneumology, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Basic Res Cardiol 104:499-509. 2009
    ..Diastolic heart failure is a rising problem with a high incidence and similar mortality and morbidity compared to patients with systolic heart failure. Nevertheless, the underlying pathophysiology is still debated...
  24. ncbi request reprint Cardiac function and remodeling is attenuated in transgenic rats expressing the human kallikrein-1 gene after myocardial infarction
    Matthias Koch
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12220 Berlin, Germany
    Eur J Pharmacol 550:143-8. 2006
    ..Further studies have to show whether these results can be caused by other therapeutically options. Long acting bradykinin receptor agonists might be an alternative option to improve ischemic heart disease...
  25. ncbi request reprint Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: the role of angiotensin type 1 receptor antagonism
    Dirk Westermann
    Department of Cardiology, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Diabetes 56:641-6. 2007
    ..These findings present evidence that AT-1 receptor antagonists attenuate cardiac failure by decreasing cardiac inflammation and normalizing MMP activity, leading to normalized cardiac fibrosis in STZ-induced diabetic cardiomyopathy...
  26. doi request reprint Myeloid differentiation factor-88 contributes to TLR9-mediated modulation of acute coxsackievirus B3-induced myocarditis in vivo
    Alexander Riad
    Dept of Cardiology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, Berlin 12203, Germany
    Am J Physiol Heart Circ Physiol 298:H2024-31. 2010
    ..In conclusion, the MyD88/TNF-alpha axis due to TLR9 activation in the heart contributes the development of acute myocarditis but not of chronic myocarditis...
  27. ncbi request reprint Rational of the use of aliskiren in hypertension and beyond
    D Westermann
    Department of Cardiology and Pneumology, Charite School of Medicine, Campus Benjamin Franklin, Berlin, Germany
    Minerva Cardioangiol 57:761-72. 2009
    ..Therefore, we review here the major effects of this new drug not only in regard to hypertension but also in regard to target organ damage reduction and possible changes in morbidity and mortality, which future trials will investigate...
  28. ncbi request reprint Elevated NT-ProBNP levels in patients with increased left ventricular filling pressure during exercise despite preserved systolic function
    Carsten Tschope
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Germany
    J Card Fail 11:S28-33. 2005
    ..We therefore investigated the plasma levels of the N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with heart failure symptoms during exercise, despite preserved systolic cardiac function...
  29. doi request reprint Role of left ventricular stiffness in heart failure with normal ejection fraction
    Dirk Westermann
    Department of Cardiology and Pneumology, Benjamin Franklin Campus, Charite University Hospital, Hindenburgdamm 30, 12200 Berlin, Germany
    Circulation 117:2051-60. 2008
    ....
  30. ncbi request reprint Carvedilol improves left ventricular function in murine coxsackievirus-induced acute myocarditis association with reduced myocardial interleukin-1beta and MMP-8 expression and a modulated immune response
    Matthias Pauschinger
    Department of Internal Medicine II, Cardiology and Pneumonology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Eur J Heart Fail 7:444-52. 2005
    ..Beta-adrenergic receptor stimulation influences the production of cytokines heralding the possibility of modulating cytokine production by beta-adrenergic blockers...
  31. ncbi request reprint Immunomodulation by interleukin-4 suppresses matrix metalloproteinases and improves cardiac function in murine myocarditis
    Jun Li
    Department of Internal Medicine II, Charite Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Eur J Pharmacol 554:60-8. 2007
    ..A significant suppression of MMPs may mainly contribute to an improvement of left ventricular dysfunction in acute murine CVB3-induced myocarditis...
  32. ncbi request reprint Low-dose treatment with atorvastatin leads to anti-oxidative and anti-inflammatory effects in diabetes mellitus
    Alexander Riad
    Department of Cardiology and Pneumology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12206 Berlin, Germany
    Eur J Pharmacol 569:204-11. 2007
    ..05). Lipid-independent anti-oxidative and anti-inflammatory effects of low-dose atorvastatin involving the ERK1/2/NF-kappaB-pathway are sufficient to improve endothelial function under experimental diabetic conditions...
  33. ncbi request reprint Upregulation of the cardiac bradykinin B2 receptors after myocardial infarction
    C Tschope
    Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Free University of Berlin, Germany
    Immunopharmacology 44:111-7. 1999
    ..Our data show clearly that the described increase in BK during myocardial ischemia is accompanied by an elevated B2-receptor expression in the infarcted and non-infarcted parts of cardiac ventricles...
  34. ncbi request reprint Cardiac kinin level in experimental diabetes mellitus: role of kininases
    Matthias Koch
    Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Free University of Berlin, Berlin, Germany
    Am J Physiol Heart Circ Physiol 285:H418-23. 2003
    ....
  35. ncbi request reprint Diltiazem treatment prevents diastolic heart failure in mice with familial hypertrophic cardiomyopathy
    Dirk Westermann
    Department of Cardiology and Pneumonology, Charite Universiätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30 12220, Berlin, Germany
    Eur J Heart Fail 8:115-21. 2006
    ..The pathology underlying this mechanism has not yet been identified...
  36. ncbi request reprint Cardioprotective and anti-inflammatory effects of interleukin converting enzyme inhibition in experimental diabetic cardiomyopathy
    Dirk Westermann
    Department of Cardiology, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
    Diabetes 56:1834-41. 2007
    ..We investigated the effect of pharmacological inhibition of the interleukin converting enzyme (ICE) on cardiac inflammation, apoptosis, fibrosis, and left ventricular function in an animal model of diabetes...
  37. pmc Human cardiac-derived adherent proliferating cells reduce murine acute Coxsackievirus B3-induced myocarditis
    Kapka Miteva
    Berlin Brandenburg Center for Regenerative Therapies, Charite, University Medicine Berlin, Campus Virchow, Berlin, Germany
    PLoS ONE 6:e28513. 2011
    ..We explored whether CAPs application could be a novel strategy to improve acute Coxsackievirus B3 (CVB3)-induced myocarditis...
  38. doi request reprint Role of heart rate reduction in the prevention of experimental heart failure: comparison between If-channel blockade and β-receptor blockade
    Peter Moritz Becher
    Department of Cardiology and Pneumology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Hypertension 59:949-57. 2012
    ..Behind heart rate reduction, additional beneficial cardiac effects contribute to heart failure prevention with I(f)-channel inhibition...
  39. ncbi request reprint Myocardial bradykinin B2-receptor expression at different time points after induction of myocardial infarction
    C Tschope
    Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Free University of Berlin, Germany
    J Hypertens 18:223-8. 2000
    ....
  40. ncbi request reprint Inhibition of p38 mitogen-activated protein kinase attenuates left ventricular dysfunction by mediating pro-inflammatory cardiac cytokine levels in a mouse model of diabetes mellitus
    D Westermann
    Department of Cardiology and Pneumology, Charite University Hospital, Benjamin Franklin Campus, Berlin, Germany
    Diabetologia 49:2507-13. 2006
    ..We investigated the effect of SB 203580, a pharmacological inhibitor of p38 mitogen-activated protein kinase (MAPK), on cardiac inflammation, cardiac fibrosis, and left ventricular function using an animal model of diabetic cardiomyopathy...
  41. doi request reprint The angiotensin-(1-7) receptor agonist AVE0991 is cardioprotective in diabetic rats
    Linda Ebermann
    Department of Cardiology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Eur J Pharmacol 590:276-80. 2008
    ....
  42. doi request reprint Prevention of cardiac dysfunction in acute coxsackievirus B3 cardiomyopathy by inducible expression of a soluble coxsackievirus-adenovirus receptor
    Sandra Pinkert
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite University Medicine Berlin, Hindenburgdamm 30, Berlin, Germany
    Circulation 120:2358-66. 2009
    ..Here, we analyze the therapeutic potential of a soluble (s) virus receptor molecule against CVB3 myocarditis using a gene therapy approach...
  43. ncbi request reprint Angiotensin deficiency in mice leads to dilated cardiomyopathy
    Thomas Walther
    Department Cardiology, Campus Benjamin Franklin, Charite Berlin, Hindenburgdamm, Germany
    Eur J Pharmacol 493:161-5. 2004
    ....
  44. doi request reprint Vascular-protective effects of high-density lipoprotein include the downregulation of the angiotensin II type 1 receptor
    Sophie Van Linthout
    Department of Cardiology and Pneumology, Charite University Medicine of Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Hypertension 53:682-7. 2009
    ..In conclusion, vascular-protective effects of HDL include the downregulation of the AT1R...
  45. doi request reprint Immunosuppression with an interleukin-2 fusion protein leads to improved LV function in experimental ischemic cardiomyopathy
    Matthias Koch
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Int Immunopharmacol 10:207-12. 2010
    ..LV contractile dysfunction after experimental MI is improved after treatment with an IL-2-IgG2b fusion protein...
  46. doi request reprint Left ventricular enlargement in coxsackievirus-B3 induced chronic myocarditis--ongoing inflammation and an imbalance of the matrix degrading system
    Susanne Rutschow
    Department of Cardiology and Pneumonology, Medizinische Klinik II, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Eur J Pharmacol 630:145-51. 2010
    ..Viral persistence induces chronic myocardial inflammation and an imbalance of the matrix degrading system, associated with the development of left ventricular dysfunction and dilatation in chronic murine myocarditis...
  47. pmc Down-regulation of endothelial TLR4 signalling after apo A-I gene transfer contributes to improved survival in an experimental model of lipopolysaccharide-induced inflammation
    Sophie Van Linthout
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
    J Mol Med (Berl) 89:151-60. 2011
    ..In conclusion, HDL reduces TLR4 expression and signalling in endothelial cells, which may contribute significantly to the protective effects of HDL in LPS-induced inflammation and lethality...
  48. ncbi request reprint Improvement of defective sarcoplasmic reticulum Ca2+ transport in diabetic heart of transgenic rats expressing the human kallikrein-1 gene
    Carsten Tschope
    Department of Cardiology and Pneumology, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12220 Berlin, Germany
    FASEB J 18:1967-9. 2004
    ..An increased phosphorylation of the SERCA2 regulatory protein phospholamban at threonine17 via a B2 receptor-mediated mechanism is thereby involved...
  49. ncbi request reprint Up-regulation of PPARgamma in myocardial infarction
    Daniela Fliegner
    Cardiovascular Disease in Women, Charite, Center for Cardiovascular Research, Charite, University of Medicine Berlin, Germany
    Eur J Heart Fail 10:30-8. 2008
    ..We hypothesized, that PPARs are regulated in myocardial infarction (MI) and their activity is modulated by angiotensin receptor blockers (ARBs)...
  50. doi request reprint Pretreatment with statin attenuates the cardiotoxicity of Doxorubicin in mice
    Alexander Riad
    Department of Cardiology and Pulmology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Med Klinik II, Berlin, Germany
    Cancer Res 69:695-9. 2009
    ..Statin pretreatment attenuates doxorubicin-induced cardiotoxicity via antioxidative and anti-inflammatory effects...
  51. doi request reprint Kinins in cardiac inflammation and regeneration: insights from ischemic and diabetic cardiomyopathy
    Konstantinos Savvatis
    Charite Universitatsmedizin Berlin, Department of Cardiology and Pneumonology, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Neuropeptides 44:119-25. 2010
    ..The kinin receptors could therefore constitute potential therapeutic targets in the treatment of myocardial ischemia and diabetic cardiomyopathy...
  52. doi request reprint Simultaneous estimation of NT-proBNP on top to mitral flow Doppler echocardiography as an accurate strategy to diagnose diastolic dysfunction in HFNEF
    Mario Kasner
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Int J Cardiol 149:23-9. 2011
    ..Therefore NT-proBNP on top to conventional mitral flow Doppler might improve the diagnostic of diastolic dysfunction in patients with heart failure despite normal EF (HFNEF) without using tissue Doppler...
  53. doi request reprint Impact of HDL on adipose tissue metabolism and adiponectin expression
    Sophie Van Linthout
    Charite, University Medicine Berlin, Campus Benjamin Franklin, Department of Cardiology, Berlin, Germany
    Atherosclerosis 210:438-44. 2010
    ....
  54. doi request reprint Cardiac inflammation contributes to changes in the extracellular matrix in patients with heart failure and normal ejection fraction
    Dirk Westermann
    Department of Cardiology and Pneumology, Charite, Universititäts Medizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Germany
    Circ Heart Fail 4:44-52. 2011
    ..The pathophysiology of heart failure with normal ejection fraction (HFNEF) is still under discussion. Here we report the influence of cardiac inflammation on extracellular matrix (ECM) remodeling in patients with HFNEF...
  55. doi request reprint Immune attributes of cardiac-derived adherent proliferating (CAP) cells in cardiac therapy
    Marion Haag
    Berlin Brandenburg Centre for Regenerative Therapies, Charite Universitatsmedizin Berlin, Germany Tissue Engineering Laboratory, Charite Universitatsmedizin Berlin, Germany
    J Tissue Eng Regen Med 7:362-70. 2013
    ..The results indicate that CAP cells have low immunogenicity and could be advantageous in cardiac repair by reducing inflammatory cytokines and inducing regulatory T cells...
  56. doi request reprint Selective PDE5A inhibition with sildenafil rescues left ventricular dysfunction, inflammatory immune response and cardiac remodeling in angiotensin II-induced heart failure in vivo
    Dirk Westermann
    Department of Cardiology and Pneumology, Campus Benjamin Franklin CBF, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany
    Basic Res Cardiol 107:308. 2012
    ..PDE5A inhibition with sildenafil may provide a new treatment strategy for cardiac hypertrophy and adverse remodeling in the hypertensive heart...
  57. doi request reprint Interleukin-23 deficiency leads to impaired wound healing and adverse prognosis after myocardial infarction
    Konstantinos Savvatis
    Department of Cardiology and Pneumology, Campus Benjamin Franklin
    Circ Heart Fail 7:161-71. 2014
    ..We sought to investigate the role of interleukin-23 (IL-23) deficiency, a cytokine important in differentiation of CD4+ cells, in scar formation of the ischemic heart...
  58. ncbi request reprint Myocardial expression of rat bradykinin receptors and two tissue kallikrein genes in experimental diabetes
    C Tschope
    Department of Cardiology and Pneumology, University Hospital Benjamin Franklin UKBF, Free University of Berlin, Germany
    Immunopharmacology 44:35-42. 1999
    ..This reduction is not compensated by elevated BK receptor levels. We suggest that alterations of the KKS may contribute to myocardial dysfunction in diabetes mellitus...
  59. ncbi request reprint Prevention of cardiac fibrosis and left ventricular dysfunction in diabetic cardiomyopathy in rats by transgenic expression of the human tissue kallikrein gene
    Carsten Tschope
    Department of Cardiology and Pneumonology, Campus Benjamin Franklin, Charite University Medicine, Free University of Berlin, Germany
    FASEB J 18:828-35. 2004
    ..Transgenic expression of hKLK1 counteracts the progression of LV contractile dysfunction and extracellular matrix remodeling in STZ-induced diabetic cardiomyopathy via a BK B2 receptor-dependent pathway...
  60. ncbi request reprint Angiotensin AT2 receptor deficiency after myocardial infarction: its effects on cardiac function and fibrosis depend on the stimulus
    Carsten Tschope
    Department of Cardiology, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Cell Biochem Biophys 43:45-52. 2005
    ..Thus, hypertension-induced fibrosis is probably triggered by other control mechanisms than fibrosis induced by MI...
  61. ncbi request reprint Utility of Doppler echocardiography and tissue Doppler imaging in the estimation of diastolic function in heart failure with normal ejection fraction: a comparative Doppler-conductance catheterization study
    Mario Kasner
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Circulation 116:637-47. 2007
    ....
  62. doi request reprint Cardiac-targeted RNA interference mediated by an AAV9 vector improves cardiac function in coxsackievirus B3 cardiomyopathy
    Henry Fechner
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Mol Med (Berl) 86:987-97. 2008
    ..5 vs. 16.2 +/- 1.1 ms (p < 0.01). The data show, for the first time, that intravenously injected AAV9 has the potential to target RNAi to the heart and suggest AAV9-shRNA vectors as a novel therapeutic approach for cardiac disorders...
  63. doi request reprint Doxorubicin cardiomyopathy-induced inflammation and apoptosis are attenuated by gene deletion of the kinin B1 receptor
    Dirk Westermann
    Charite Universitatsmedizin Berlin, Department of Cardiology and Pneumology, Campus Benjamin Franklin, D 12200 Berlin, Germany
    Biol Chem 389:713-8. 2008
    ..These insights might have useful implications for future studies utilizing B1R antagonists for treatment of human DOX cardiomyopathy...
  64. pmc Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy
    Lennart Suckau
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Germany
    Circulation 119:1241-52. 2009
    ..Whereas gene therapy rests on recombinant protein expression as its basic principle, RNAi therapy uses regulatory RNAs to achieve its effect...
  65. doi request reprint Global strain rate imaging for the estimation of diastolic function in HFNEF compared with pressure-volume loop analysis
    Mario Kasner
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Eur J Echocardiogr 11:743-51. 2010
    ..We therefore correlated global strain with pressure-volume (PV) loop analysis and compared it with flow and tissue Doppler measurements...
  66. doi request reprint Reduced degradation of the chemokine MCP-3 by matrix metalloproteinase-2 exacerbates myocardial inflammation in experimental viral cardiomyopathy
    Dirk Westermann
    Department of Cardiology and Pneumology, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany
    Circulation 124:2082-93. 2011
    ..The present study investigated whether gene deletion of matrix metalloproteinase-2 influences cardiac inflammation and function in murine coxsackievirus B3 (CVB3)-induced myocarditis...
  67. doi request reprint Functional iron deficiency and diastolic function in heart failure with preserved ejection fraction
    Mario Kasner
    Department of Cardiology and Pneumology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Int J Cardiol 168:4652-7. 2013
    ..We aimed to investigate the impact of FID on cardiac performance determined by pressure-volume loop analysis in HFPEF...
  68. ncbi request reprint The role of NT-proBNP in the diagnostics of isolated diastolic dysfunction: correlation with echocardiographic and invasive measurements
    Carsten Tschope
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Eur Heart J 26:2277-84. 2005
    ..Diastolic heart failure is a frequent entity but difficult to diagnose. N-terminal pro-B type natriuretic peptide (NT-proBNP) was therefore investigated as a possible non-invasive parameter to diagnose isolated diastolic dysfunction...
  69. doi request reprint Human apolipoprotein A-I gene transfer reduces the development of experimental diabetic cardiomyopathy
    Sophie Van Linthout
    Abteilung für Kardiologie und Pneumologie, Charité Universitätsklinikum Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Circulation 117:1563-73. 2008
    ....
  70. doi request reprint Attenuation of left ventricular dysfunction by an ACE inhibitor after myocardial infarction in a kininogen-deficient rat model
    Matthias Koch
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Biol Chem 389:719-23. 2008
    ..However, ACE inhibition is sufficient to improve LV function despite kininogen deficiency...
  71. pmc New echocardiographic findings correlate with intramyocardial inflammation in endomyocardial biopsies of patients with acute myocarditis and inflammatory cardiomyopathy
    Felicitas Escher
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Berlin, Germany
    Mediators Inflamm 2013:875420. 2013
    ..The diagnosis of acute myocarditis (AMC) and inflammatory cardiomyopathy (DCMi) can be difficult. Speckle tracking echocardiography with accurate assessments of regional contractility could have an outstanding importance for the diagnosis...
  72. ncbi request reprint Hemodynamic characterization of left ventricular function in experimental coxsackieviral myocarditis: effects of carvedilol and metoprolol
    Carsten Tschope
    Department of Cardiology and Pneumonology, Charite University Medicine of Berlin, Campus Benjamin Franklin UKBF, Hindenburgdamm 30, Berlin D 12220, Germany
    Eur J Pharmacol 491:173-9. 2004
    ..Therefore, we determined the effects of carvedilol and metoprolol on left ventricular function in a murine model of coxsackievirus B3 (CVB3)-induced myocarditis...
  73. ncbi request reprint Cardioprotective mechanisms of the kallikrein-kinin system in diabetic cardiopathy
    Frank Spillmann
    Department of Cardiology and Pneumology, Charite University Medicine of Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Curr Opin Nephrol Hypertens 15:22-9. 2006
    ..In this review, we will discuss the hypothesis that the stimulation of the kallikrein-kinin system could be a promising target for the treatment of diabetic cardiopathy...
  74. doi request reprint Reduced MMP-2 activity contributes to cardiac fibrosis in experimental diabetic cardiomyopathy
    Sophie Van Linthout
    Dept of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin Hindenburgdamm 30, 12200, Berlin, Germany
    Basic Res Cardiol 103:319-27. 2008
    ..To evaluate the regulation of matrix metalloproteinase (MMP)-2 in diabetic cardiomyopathy...
  75. doi request reprint Diastolic tissue Doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction
    Mario Kasner
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite Universitaetsmedizin Berlin, Berlin, Germany
    J Am Coll Cardiol 57:977-85. 2011
    ..We attempted to correlate echocardiographic analysis of diastolic function with changes of myocardial collagen in middle-aged patients with heart failure (HF) despite normal ejection fraction (EF)...
  76. doi request reprint Left ventricular dysfunction induced by nonsevere idiopathic pulmonary arterial hypertension: a pressure-volume relationship study
    Mario Kasner
    Department of Cardiology and Pneumology, Charite Universitatsmedizin Berlin, CBF, Hindenburgdamm 30, 12200 Berlin, Germany
    Am J Respir Crit Care Med 186:181-9. 2012
    ..Severe increase in right ventricular pressure can compromise left ventricular (LV) function because of impaired interventricular interaction and aggravate the symptoms...
  77. ncbi request reprint Anti-inflammatory effects of atorvastatin improve left ventricular function in experimental diabetic cardiomyopathy
    S Van Linthout
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite University Medicine Berlin, Hindenburgdamm 30, 12200, Berlin, Germany
    Diabetologia 50:1977-86. 2007
    ..We investigated whether atorvastatin influences the development of left ventricular (LV) dysfunction, independently of cholesterol-lowering, in an experimental model of type 1 diabetes mellitus cardiomyopathy...
  78. doi request reprint The cardiovascular influence of interleukin-1 beta on the expression of bradykinin B1 and B2 receptors
    A Riad
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Department of Cardiology and Pneumology, Germany
    Int Immunopharmacol 8:222-30. 2008
    ..Our data suggest that a causal link exists between cardiac IL-1ss content and B1R regulation after MI...
  79. ncbi request reprint Opposite regulation of brain and C-type natriuretic peptides in the streptozotocin-diabetic cardiopathy
    T Walther
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Mol Endocrinol 24:391-5. 2000
    ..This may contribute to cardiac dysfunction in diabetes mellitus and suggests that stimulation of CNP expression could provide cardiac protection in such cases...
  80. ncbi request reprint Functional, biochemical, and molecular investigations of renal kallikrein-kinin system in diabetic rats
    C Tschope
    Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Free University of Berlin, D 12200 Berlin
    Am J Physiol 277:H2333-40. 1999
    ..Thus, despite reduced renal kallikrein synthesis, renal KKS is activated in the advanced stage of diabetic nephropathy...
  81. doi request reprint Enhancement of endothelial nitric oxide synthase production reverses vascular dysfunction and inflammation in the hindlimbs of a rat model of diabetes
    A Riad
    Department of Cardiology and Pneumology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12206, Berlin, Germany
    Diabetologia 51:2325-32. 2008
    ..In the present study we investigated whether a pharmacological increase of endothelial NO synthase (eNOS) production can restore the impaired hindlimb flow in a rat model of severe diabetes...
  82. pmc Upregulation of bradykinin B1-receptor expression after myocardial infarction
    C Tschope
    Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Free University of Berlin, Germany
    Br J Pharmacol 129:1537-8. 2000
    ..6 h). Six days post-MI, B1R expression returned to levels found 6 h after MI. These data are the first demonstration for an induced myocardial B1R expression in an in vivo model of MI...
  83. doi request reprint Assessment of cardiac inflammation and remodeling during the development of streptozotocin-induced diabetic cardiomyopathy in vivo: a time course analysis
    P M Becher
    Department of Cardiology and Pneumology, Charite University Hospital Berlin, Campus Benjamin Franklin, D 12200 Berlin, Germany
    Int J Mol Med 32:158-64. 2013
    ..Our results suggest that the model of STZ-induced diabetic cardiomyopathy is a robust model for investigating cardiac immune response and LV remodeling processes under diabetic conditions...
  84. doi request reprint A distinct subgroup of cardiomyopathy patients characterized by transcriptionally active cardiotropic erythrovirus and altered cardiac gene expression
    U Kuhl
    Department of Cardiology and Pneumology, Charité Centrum 11 Cardiovascular Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
    Basic Res Cardiol 108:372. 2013
    ..Virus genome detection is insufficient to assess pathogenic potential, but additional transcriptional mapping should be incorporated into future pathogenetic and therapeutic studies both in cardiology and transplantation medicine. ..
  85. doi request reprint Fractalkine in human inflammatory cardiomyopathy
    F Escher
    Department of Cardiology and Pneumonology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Heart 97:733-9. 2011
    ..Cardiac inflammation is important for the prognosis of patients with inflammatory cardiomyopathy (CMi), but the mechanisms leading to it are not fully elucidated...
  86. ncbi request reprint Impaired angiotensin II regulation of renal C-type natriuretic peptide mRNA expression in experimental diabetes mellitus
    T Walther
    Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Free University of Berlin, Hindenburgdamm 30, D 12200, Berlin, Germany
    Cardiovasc Res 51:562-6. 2001
    ..We investigated levels of mRNA for the vasodilator C-type natriuretic peptide (CNP) in the renal cortex of streptozotocin (STZ)-diabetic rats and the influence of an angiotensin II inhibition...
  87. ncbi request reprint Effects of mesenchymal stromal cells on diabetic cardiomyopathy
    S Van Linthout
    Berlin Brandenburg Center for Regenerative Therapies, Charite, University Medicine Berlin, Campus Virchow, Berlin, Germany
    Curr Pharm Des 17:3341-7. 2011
    ..Furthermore, the dysfunctionality of (bone marrow-derived) mesenchymal stromal cells under diabetes mellitus and potential strategies to overcome this impairment in cell functionality are outlined...
  88. ncbi request reprint Role of gender in heart failure with normal left ventricular ejection fraction
    Vera Regitz-Zagrosek
    Center for Cardiovascular Research, CCR, Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Prog Cardiovasc Dis 49:241-51. 2007
    ..Thus, a number of molecular mechanisms can contribute to the gender differences in HF-NEF...
  89. ncbi request reprint Secretory sphingomyelinase is upregulated in chronic heart failure: a second messenger system of immune activation relates to body composition, muscular functional capacity, and peripheral blood flow
    Wolfram Doehner
    Division of Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Eur Heart J 28:821-8. 2007
    ....
  90. pmc Quantification of circulating endothelial progenitor cells using the modified ISHAGE protocol
    Caroline Schmidt-Lucke
    Department of Molecular Cardiology, Internal Medicine III, J W Goethe University, Frankfurt, Germany
    PLoS ONE 5:e13790. 2010
    ..We, therefore developed a novel protocol adapted from the standardised so-called ISHAGE protocol for enumeration of haematopoietic stem cells to enable comparison of clinical and laboratory data...
  91. ncbi request reprint Accelerated mitochondrial adenosine diphosphate/adenosine triphosphate transport improves hypertension-induced heart disease
    Thomas Walther
    Charite Universitatsmedizin, Campus Benjamin Franklin, Department of Cardiology and Pneumonology, Hindenburgdamm 30, 12200 Berlin, Germany
    Circulation 115:333-44. 2007
    ..An adequate exchange of ATP and ADP over the inner mitochondrial membrane by the adenine nucleotide translocase (ANT) is thereby essential to guarantee the cellular energy supply...
  92. doi request reprint Endomyocardial biopsy derived adherent proliferating cells - a potential cell source for cardiac tissue engineering
    Marion Haag
    Tissue Engineering Laboratory, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Tucholskystr 2, 10117 Berlin, Germany
    J Cell Biochem 109:564-75. 2010
    ..Results indicate that these cells rather support angiogenesis than cardiomyocyte differentiation...
  93. doi request reprint Interferon beta modulates endothelial damage in patients with cardiac persistence of human parvovirus b19 infection
    Caroline Schmidt-Lucke
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Infect Dis 201:936-45. 2010
    ..In a phase 1 study, we investigated whether interferon beta reduced endothelial damage in patients with cardiac persistence of human parvovirus B19 (B19V) infection...
  94. ncbi request reprint High-density lipoprotein at the interface of type 2 diabetes mellitus and cardiovascular disorders
    Sophie Van Linthout
    Department of Cardiology and Pneumology, Charite, University Medicine Berlin, Campus Benjamin Franklin, 12200 Berlin Germany
    Curr Pharm Des 16:1504-16. 2010
    ..The second part of the review focuses on describing the newest insights in the impact of HDL on glucose metabolism and on diabetes-associated cardiovascular complications...
  95. doi request reprint Biglycan is required for adaptive remodeling after myocardial infarction
    D Westermann
    Abteilung für Kardiologie und Pneumologie, Charité Universitätsklinikum Berlin, Campus Benjamin Franklin, Berlin, Germany
    Circulation 117:1269-76. 2008
    ..The present study investigates the role of the small leucine-rich proteoglycan biglycan during cardiac extracellular matrix remodeling and cardiac hemodynamics after MI...
  96. ncbi request reprint A thrombocyte-induced myocardial dysfunction in the ischemic and reperfused guinea pig heart is mediated by reactive oxygen species
    C Seligmann
    Department of Cardiology, University Hospital Benjamin Franklin, Free University of Berlin, Berlin, Germany
    Free Radic Biol Med 29:1244-51. 2000
    ..We conclude that thrombocytes under conditions of ischemia and reperfusion are able to induce a myocardial dysfunction mediated by reactive oxygen species. Superoxide seems to play a major role in this respect...
  97. ncbi request reprint High prevalence of cardiac parvovirus B19 infection in patients with isolated left ventricular diastolic dysfunction
    C Tschope
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Circulation 111:879-86. 2005
    ..The etiology of left ventricular (LV) isolated diastolic dysfunction often remains unclear. In the present study, we report a strong association between parvovirus B19 (PVB19) genomes and isolated LV diastolic dysfunction...
  98. pmc Genomic expression profiling of human inflammatory cardiomyopathy (DCMi) suggests novel therapeutic targets
    F Wittchen
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany
    J Mol Med (Berl) 85:257-71. 2007
    ....
  99. doi request reprint Adiponectin promotes coxsackievirus B3 myocarditis by suppression of acute anti-viral immune responses
    A Jenke
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
    Basic Res Cardiol 109:408. 2014
    ....
  100. ncbi request reprint Altered heart rate and blood pressure variability in mice lacking the Mas protooncogene
    T Walther
    Max Delbruck Center for Molecular Medicine, Free University of Berlin, Berlin, Germany
    Braz J Med Biol Res 33:1-9. 2000
    ..The marked alterations detected in Mas-deficient mice of both genders suggest that the Mas-protooncogene is an important determinant of heart rate and blood pressure variability...
  101. ncbi request reprint Fibrosis rather than blood pressure determines cardiac BNP expression in mice
    Thomas Walther
    Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Free University of Berlin, Hindenburgdamm 30, D 12200, Berlin, Germany
    Regul Pept 116:95-100. 2003
    ....