L Schomburg

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. pmc Dietary Selenium and Human Health
    Lutz Schomburg
    Institute for Experimental Endocrinology, Charité Medical University Berlin, Suedring 10, CVK, D 13353 Berlin, Germany
    Nutrients 9:. 2016
  2. doi request reprint Gene-specific regulation of hepatic selenoprotein expression by interleukin-6
    J Martitz
    Institut für Experimentelle Endokrinologie, Charite Universitatsmedizin Berlin, CVK, Südring 10, D 13353 Berlin, Germany
    Metallomics 7:1515-21. 2015
  3. doi request reprint Strong induction of iodothyronine deiodinases by chemotherapeutic selenocompounds
    M Stoedter
    Institut für Experimentelle Endokrinologie, Charite Universitatsmedizin Berlin, CVK, Südring 10, D 13353 Berlin, Germany
    Metallomics 7:347-54. 2015
  4. pmc Selenoprotein P status correlates to cancer-specific mortality in renal cancer patients
    Hellmuth A Meyer
    Institute of Physiology, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e46644. 2012
  5. doi request reprint Hypoxia reduces and redirects selenoprotein biosynthesis
    Niels Peter Becker
    Institute for Experimental Endocrinology, Charite Universitatsmedizin Berlin, CVK, D 13353 Berlin, Germany
    Metallomics 6:1079-86. 2014
  6. doi request reprint Selenoprotein P is the essential selenium transporter for bones
    Nicole Pietschmann
    Institute for Experimental Endocrinology, Charite Universitatsmedizin Berlin, D 13353 Berlin, Germany
    Metallomics 6:1043-9. 2014
  7. pmc Impact of treatment planning target volumen (PTV) size on radiation induced diarrhoea following selenium supplementation in gynecologic radiation oncology--a subgroup analysis of a multicenter, phase III trial
    Ralph Muecke
    Department of Radiotherapy, Lippe Hospital, Lemgo, Germany
    Radiat Oncol 8:72. 2013
  8. doi request reprint Autoantibodies to the IGF1 receptor in Graves' orbitopathy
    Waldemar B Minich
    Institute for Experimental Endocrinology, Charite Universitatsmedizin Berlin, Suedring 10, D 13353 Berlin, Germany
    J Clin Endocrinol Metab 98:752-60. 2013
  9. doi request reprint Selenium, selenoproteins and the thyroid gland: interactions in health and disease
    Lutz Schomburg
    Institute for Experimental Endocrinology, Charite University Medicine Berlin, Südring 10, CVK, 13353 Berlin, Germany
    Nat Rev Endocrinol 8:160-71. 2011
  10. ncbi request reprint Synthesis and metabolism of thyroid hormones is preferentially maintained in selenium-deficient transgenic mice
    Lutz Schomburg
    Institut für Experimentelle Endokrinologie, Charite Universitaetsmedizin Berlin, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Endocrinology 147:1306-13. 2006

Collaborators

Detail Information

Publications40

  1. pmc Dietary Selenium and Human Health
    Lutz Schomburg
    Institute for Experimental Endocrinology, Charité Medical University Berlin, Suedring 10, CVK, D 13353 Berlin, Germany
    Nutrients 9:. 2016
    ..It is obvious from the contributions that the bicentennial anniversary will celebrate a micronutrient still in its infancy with respect to being understood in terms of its biomedical importance...
  2. doi request reprint Gene-specific regulation of hepatic selenoprotein expression by interleukin-6
    J Martitz
    Institut für Experimentelle Endokrinologie, Charite Universitatsmedizin Berlin, CVK, Südring 10, D 13353 Berlin, Germany
    Metallomics 7:1515-21. 2015
    ..Accordingly, therapeutic IL-6 targeting may be effective for improving the Se and thyroid hormone status, adjuvant Se supplementation success and survival in sepsis. ..
  3. doi request reprint Strong induction of iodothyronine deiodinases by chemotherapeutic selenocompounds
    M Stoedter
    Institut für Experimentelle Endokrinologie, Charite Universitatsmedizin Berlin, CVK, Südring 10, D 13353 Berlin, Germany
    Metallomics 7:347-54. 2015
    ..Collectively, our data highlight that these selenocompounds may constitute interesting pharmacological compounds for modifying DIO expression potentially affecting the balance between cell differentiation and proliferation. ..
  4. pmc Selenoprotein P status correlates to cancer-specific mortality in renal cancer patients
    Hellmuth A Meyer
    Institute of Physiology, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e46644. 2012
    ..However, this assumption needs to be rigorously tested in prospective clinical trials...
  5. doi request reprint Hypoxia reduces and redirects selenoprotein biosynthesis
    Niels Peter Becker
    Institute for Experimental Endocrinology, Charite Universitatsmedizin Berlin, CVK, D 13353 Berlin, Germany
    Metallomics 6:1079-86. 2014
    ....
  6. doi request reprint Selenoprotein P is the essential selenium transporter for bones
    Nicole Pietschmann
    Institute for Experimental Endocrinology, Charite Universitatsmedizin Berlin, D 13353 Berlin, Germany
    Metallomics 6:1043-9. 2014
    ....
  7. pmc Impact of treatment planning target volumen (PTV) size on radiation induced diarrhoea following selenium supplementation in gynecologic radiation oncology--a subgroup analysis of a multicenter, phase III trial
    Ralph Muecke
    Department of Radiotherapy, Lippe Hospital, Lemgo, Germany
    Radiat Oncol 8:72. 2013
    ..Now, a potential relation between the planning target volume (PTV) of the RT and the Se effect concerning radiation induced diarrhoea was evaluated in detail...
  8. doi request reprint Autoantibodies to the IGF1 receptor in Graves' orbitopathy
    Waldemar B Minich
    Institute for Experimental Endocrinology, Charite Universitatsmedizin Berlin, Suedring 10, D 13353 Berlin, Germany
    J Clin Endocrinol Metab 98:752-60. 2013
    ..Graves' disease (GD) is maintained by stimulating antibodies against the TSH receptor. Graves' orbitopathy (GO) is the main extrathyroidal manifestation of GD, potentially involving autoimmunity against the IGF1 receptor (IGF1R)...
  9. doi request reprint Selenium, selenoproteins and the thyroid gland: interactions in health and disease
    Lutz Schomburg
    Institute for Experimental Endocrinology, Charite University Medicine Berlin, Südring 10, CVK, 13353 Berlin, Germany
    Nat Rev Endocrinol 8:160-71. 2011
    ..Selenium deficiency is likely to constitute a risk factor for a feedforward derangement of the immune system-thyroid interaction, while selenium supplementation appears to dampen the self-amplifying nature of this derailed interaction...
  10. ncbi request reprint Synthesis and metabolism of thyroid hormones is preferentially maintained in selenium-deficient transgenic mice
    Lutz Schomburg
    Institut für Experimentelle Endokrinologie, Charite Universitaetsmedizin Berlin, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Endocrinology 147:1306-13. 2006
    ..This indicates a top priority of the thyroid gland and its selenoenzymes with respect to the hierarchical Se supply within the organism...
  11. pmc Selenium supplementation fails to correct the selenoprotein synthesis defect in subjects with SBP2 gene mutations
    Lutz Schomburg
    Institute for Experimental Endocrinology, Charite University Medicine Berlin, Berlin, Germany
    Thyroid 19:277-81. 2009
    ..We have tried to improve selenoprotein biosynthesis and thyroid hormone metabolism in SBP2 deficient subjects by supplementing an organic and an inorganic Se form...
  12. ncbi request reprint Effect of age on sexually dimorphic selenoprotein expression in mice
    Lutz Schomburg
    Institute for Experimental Endocrinology, Charite University Medicine Berlin, D 10117 Berlin, Germany
    Biol Chem 388:1035-41. 2007
    ..These data highlight again the unique physiological regulatory mechanisms that have evolved to control Se metabolism according to the actual needs of the organism...
  13. ncbi request reprint [Selenium: benefits and risks]
    L Schomburg
    Institut für Experimentelle Endokrinologie, Campus Charite Mitte, Berlin
    MMW Fortschr Med 149:34-6. 2007
    ..Until further studies have confirmed the data indicating a positive effect of selenium supplementation, this highly potent substance must be applied only with great caution and only selectively in specific situations...
  14. doi request reprint Hierarchical regulation of selenoprotein expression and sex-specific effects of selenium
    Lutz Schomburg
    Institute for Experimental Endocrinology, Südring 10, CVK, Charite Universitatsmedizin Berlin, 13353 Berlin, Germany
    Biochim Biophys Acta 1790:1453-62. 2009
    ..This review tries to summarize these fascinating findings and highlights some interesting and surprising sex-specific differences...
  15. doi request reprint Genetics and phenomics of selenoenzymes--how to identify an impaired biosynthesis?
    Lutz Schomburg
    Institute for Experimental Endocrinology, Charite Universitatsmedizin Berlin, Südring 10, CVK, Augustenburger Platz 1, 13353 Berlin, Germany
    Mol Cell Endocrinol 322:114-24. 2010
    ..A careful diagnosis and thoughtful monitoring will help the affected individuals to minimize their predisposition to various diseases...
  16. ncbi request reprint Selenium and selenoproteins in mammals: extraordinary, essential, enigmatic
    L Schomburg
    Institut für Experimentelle Endokrinologie, Charite Universitatsmedizin Berlin, Schumannstrasse 20 21, 10117, Berlin, Germany
    Cell Mol Life Sci 61:1988-95. 2004
    ..It now holds great promises also for a better understanding of some key aspects of cancer, inflammation, fertility and prevention of age-associated diseases...
  17. ncbi request reprint Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp-knockout mice
    Kostja Renko
    Neurobiology of Selenium, Neuroscience Research Center, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    Biochem J 409:741-9. 2008
    ..Nevertheless, local Sepp expression is required to maintain selenium content in selenium-privileged tissues such as brain and testis during dietary selenium restriction...
  18. ncbi request reprint Neuronal and ependymal expression of selenoprotein P in the human brain
    M Scharpf
    Institut für Experimentelle Endokrinologie, Charite Universitatsmedizin, Berlin, Germany
    J Neural Transm (Vienna) 114:877-84. 2007
    ..Moreover, SePP-like immunoreactivity localizes to neurons and ependymal cells and thus appears strategically situated for maintenance and control of Se-dependent anti-oxidative defense systems...
  19. doi request reprint Selenium controls the sex-specific immune response and selenoprotein expression during the acute-phase response in mice
    Mette Stoedter
    Institute for Experimental Endocrinology, Charite Universitatsmedizin Berlin, Südring 10, D 13353 Berlin, Germany
    Biochem J 429:43-51. 2010
    ..The selenium status and sex control SepS expression and modify cytokine response patterns in serum, which might explain contradictory results on associations of SEPS genotype and inflammatory diseases in clinical studies...
  20. doi request reprint Interference of endocrine disrupters with thyroid hormone receptor-dependent transactivation
    Peter Josef Hofmann
    Institut für Experimentelle Endokrinologie, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, CVK, Campus Virchow Klinikum, D 13353 Berlin, Germany
    Toxicol Sci 110:125-37. 2009
    ..However, on basis of their high production volumes and potential bioaccumulation of some fat-soluble ED our data indicate the need to carefully monitor certain ED for potential disruption of the TH system in intact organisms and humans...
  21. doi request reprint Down-regulation of the hepatic selenoprotein biosynthesis machinery impairs selenium metabolism during the acute phase response in mice
    Kostja Renko
    Institute for Experimental Endocrinology, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    FASEB J 23:1758-65. 2009
    ..We conclude that hepatic translation of Sepp1 mRNA is specifically impaired during the APR. This deficit disrupts regular Se metabolism, transport, and supply to peripheral tissues and likely aggravates the pathological status...
  22. pmc Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues
    Lutz Schomburg
    Institut für Experimentelle Endokrinologie, Universitatsklinikum Charite, Schumannstrasse 20 21, 10117 Berlin, Germany
    Biochem J 370:397-402. 2003
    ..Selenium content was elevated in liver, but low in plasma and other tissues, and selenoenzyme activities changed accordingly. Our data reveal that SePP plays a pivotal role in delivering hepatic selenium to target tissues...
  23. doi request reprint Think globally: act locally. New insights into the local regulation of thyroid hormone availability challenge long accepted dogmas
    Ulrich Schweizer
    Institute for Experimental Endocrinology, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Mol Cell Endocrinol 289:1-9. 2008
    ..Finally, a link between Dio expression and energy metabolism has been delineated in mice that may hold great promise for the management of the adiposity pandemic...
  24. ncbi request reprint Selenoproteins of the thyroid gland: expression, localization and possible function of glutathione peroxidase 3
    Cornelia Schmutzler
    Institut für Experimentelle Endokrinologie, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Biol Chem 388:1053-9. 2007
    ..Particularly, GPx3 might use excess H2O2 and catalyze the polymerization of thyroglobulin to the highly cross-linked storage form present in the colloid...
  25. pmc Efficient selenium transfer from mother to offspring in selenoprotein-P-deficient mice enables dose-dependent rescue of phenotypes associated with selenium deficiency
    Ulrich Schweizer
    Neurobiologie des Selens, Neurowissenschaftliches Forschungszentrum, Charite Universitatsmedizin Berlin, Charite Campus Mitte, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Biochem J 378:21-6. 2004
    ....
  26. ncbi request reprint The neurobiology of selenium: lessons from transgenic mice
    Ulrich Schweizer
    Neurobiology of Selenium, Neuroscience Research Center, Charité University Medical School Berlin, Germany
    J Nutr 134:707-10. 2004
    ..Given that genes for at least 25 selenoproteins have been identified in the human genome, and most of these are expressed in the brain, their specific roles for normal brain function and neurological diseases remain to be elucidated...
  27. pmc Hepatically derived selenoprotein P is a key factor for kidney but not for brain selenium supply
    Ulrich Schweizer
    Neurobiologie des Selens, Neurowissenschaftliches Forschungszentrum, Charite Universitatsmedizin Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Biochem J 386:221-6. 2005
    ..This indicates that a transport function in plasma is exerted by hepatically derived SePP, while in brain SePP fulfils a second, hitherto unexpected, essential role...
  28. ncbi request reprint Hepatic deiodinase activity is dispensable for the maintenance of normal circulating thyroid hormone levels in mice
    Florian Streckfuss
    Neurobiology of Selenium, Neuroscience Research Center, Charite Universitatsmedizin, Berlin, Germany
    Biochem Biophys Res Commun 337:739-45. 2005
    ..However, mRNA and activity of ME were significantly increased in the same mice. Together, our results indicate that hepatic Dio1 activity is not absolutely required to sustain the euthyroid state in mice...
  29. ncbi request reprint New insights into the physiological actions of selenoproteins from genetically modified mice
    Ulrich Schweizer
    Neurobiology of Selenium, Neuroscience Research Center, Charite Universitatsmedizin Berlin, Germany
    IUBMB Life 57:737-44. 2005
    ..While some transgenic animals exhibit phenotypes that were expected from biochemical studies, in other instances the observed effects were a surprise in view of earlier hypotheses...
  30. doi request reprint Mutation of megalin leads to urinary loss of selenoprotein P and selenium deficiency in serum, liver, kidneys and brain
    Jazmin Chiu-Ugalde
    Institut für Experimentelle Endokrinologie und EnForCé, Charite Universitatsmedizin, Berlin, Germany
    Biochem J 431:103-11. 2010
    ..When fed on a low-Se diet, megalin-mutant mice developed impaired movement co-ordination, but no astrogliosis. These findings suggest that megalin prevents urinary SePP loss and participates in brain Se/SePP uptake...
  31. doi request reprint On the importance of selenium and iodine metabolism for thyroid hormone biosynthesis and human health
    Lutz Schomburg
    Institut für Experimentelle Endokrinologie und Endokrinologisches Forschungs Centrum der Charité EnForCé, Charite Campus Virchow Klinikum, Charite Universitatsmedizin, Berlin, Humboldt Universitat zu Berlin, Berlin, Germany
    Mol Nutr Food Res 52:1235-46. 2008
    ..Even though the underlying mechanisms are still largely uncharacterised, the effects of Se appear to be exerted via multiple different mechanisms that impact most pronounced on the endocrine and the immune systems...
  32. ncbi request reprint Real time RT-PCR analysis of thyroglobulin mRNA in peripheral blood in patients with congenital athyreosis and with differentiated thyroid carcinoma after stimulation with recombinant human thyrotropin
    Sarah Kaufmann
    Institut für Experimentelle Endokrinologie, Charite, Universtätsmedizin Berlin, 10117 Berlin, Germany
    Endocr Regul 38:41-9. 2004
    ..As a possible diagnostic alternative, we tested a real time RT-PCR protocol to determine Tg mRNA levels in peripheral blood...
  33. pmc Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration
    Eva K Wirth
    Institute for Experimental Endocrinology, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    FASEB J 24:844-52. 2010
    ..Schmitz, D., Bornkamm, G. W., Coppola, V., Tessarollo, L., Schomburg, L., Köhrle, J., Hatfield, D. L., Schweizer, U. Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration...
  34. doi request reprint Transgenic mice expressing small interfering RNA against Gata4 point to a crucial role of Gata4 in the heart and gonads
    Boris Thurisch
    Department of Neonatology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    J Mol Endocrinol 43:157-69. 2009
    ..Histology of the teratomas showed predominantly ectodermal and mesodermal structures. Our data demonstrate that Gata4 is critically involved in the function and integrity of the gonads in vivo...
  35. ncbi request reprint Altered apolipoprotein A-V expression during the acute phase response is independent of plasma triglyceride levels in mice and humans
    Steffi Becker
    Department of Medicine, Charite Campus Mitte, Berlin, Germany
    Biochem Biophys Res Commun 339:833-9. 2006
    ....
  36. ncbi request reprint Endocrine active compounds affect thyrotropin and thyroid hormone levels in serum as well as endpoints of thyroid hormone action in liver, heart and kidney
    Cornelia Schmutzler
    Institut für Experimentelle Endokrinologie und Endokrinologisches Forschungszentrum EnForCé, Charite, Universitatsmedizin Berlin, Campus Mitte, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Toxicology 205:95-102. 2004
    ....
  37. ncbi request reprint Selenium-dependent pre- and posttranscriptional mechanisms are responsible for sexual dimorphic expression of selenoproteins in murine tissues
    Cornelia Riese
    Institut fuer Experimentelle Endokrinologie, Charite Universitaetsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Endocrinology 147:5883-92. 2006
    ..Thus, we conclude that Se-dependent posttranscriptional mechanisms are operational that affect either translational efficiency or Dio1 stability in a sex- and tissue-specific manner...
  38. ncbi request reprint Mutations in SECISBP2 result in abnormal thyroid hormone metabolism
    Alexandra M Dumitrescu
    Department of Human Genetics, University of Chicago, MC 3090, 5841 S Maryland Ave, Chicago, Illinois 60637, USA
    Nat Genet 37:1247-52. 2005
    ..Because SBP2 is epistatic to selenoprotein synthesis, these defects had a generalized effect on selenoproteins. Incomplete loss of SBP2 function probably causes the mild phenotype...
  39. ncbi request reprint Selenium in intensive care (SIC) study: the XX files are still unresolved
    Lutz Schomburg
    Crit Care Med 35:995-6; author reply 996-7. 2007
  40. ncbi request reprint Selene, the goddess of the moon: does she shine on men only?
    Lutz Schomburg
    Eur Heart J 28:2043-4. 2007