Robert Sabat

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Cutting edge: immune cells as sources and targets of the IL-10 family members?
    Kerstin Wolk
    Department of Experimental Dermatology, Schering AG, and Institute of Medical Immunology, Medical School Charite, Humboldt University, Berlin, Germany
    J Immunol 168:5397-402. 2002
  2. doi request reprint Biology of interleukin-10
    Robert Sabat
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany
    Cytokine Growth Factor Rev 21:331-44. 2010
  3. pmc Increased prevalence of metabolic syndrome in patients with acne inversa
    Robert Sabat
    Department of Dermatology and Allergy, University Hospital Charite, Berlin, Germany
    PLoS ONE 7:e31810. 2012
  4. ncbi request reprint Immunopathogenesis of psoriasis
    Robert Sabat
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany
    Exp Dermatol 16:779-98. 2007
  5. doi request reprint Research in practice: IL-22 and IL-20: significance for epithelial homeostasis and psoriasis pathogenesis
    Robert Sabat
    Psoriasis Research and Treatment Center, Department of Dermatology, University Hospital Charite, Berlin, Germany
    J Dtsch Dermatol Ges 9:518-23. 2011
  6. doi request reprint IL-10 family of cytokines
    Robert Sabat
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany
    Cytokine Growth Factor Rev 21:315-24. 2010
  7. ncbi request reprint IL-19 and IL-20: two novel cytokines with importance in inflammatory diseases
    Robert Sabat
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Campus Charite Mitte, Berlin, Germany
    Expert Opin Ther Targets 11:601-12. 2007
  8. ncbi request reprint Three decades of psoriasis research: where has it led us?
    Robert Sabat
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, D 10117 Berlin, Germany
    Clin Dermatol 25:504-9. 2007
  9. doi request reprint The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis
    Kerstin Wolk
    Interdisciplinary Department of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany
    Eur J Immunol 39:3570-81. 2009
  10. doi request reprint IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not
    Kerstin Wolk
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Chariteplatz 1, 10117, Berlin, Germany
    J Mol Med (Berl) 87:523-36. 2009

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Cutting edge: immune cells as sources and targets of the IL-10 family members?
    Kerstin Wolk
    Department of Experimental Dermatology, Schering AG, and Institute of Medical Immunology, Medical School Charite, Humboldt University, Berlin, Germany
    J Immunol 168:5397-402. 2002
    ..In these cells, IL-20R2 might be part of a still-unknown receptor complex. Therefore, immune cells may represent a major source but a minor target of the novel IL-10 family members...
  2. doi request reprint Biology of interleukin-10
    Robert Sabat
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany
    Cytokine Growth Factor Rev 21:331-44. 2010
    ..At the same time, IL-10 strengthens the "scavenger"-function and contributes to induced tolerance. This review provides an overview about the cellular sources, molecular mechanisms, effects, and biological role of IL-10...
  3. pmc Increased prevalence of metabolic syndrome in patients with acne inversa
    Robert Sabat
    Department of Dermatology and Allergy, University Hospital Charite, Berlin, Germany
    PLoS ONE 7:e31810. 2012
    ..So far, the association of AI with systemic metabolic alterations is largely unexplored...
  4. ncbi request reprint Immunopathogenesis of psoriasis
    Robert Sabat
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany
    Exp Dermatol 16:779-98. 2007
    ..Our model helps to explain the varied effectiveness of the currently tested immune modulating therapies and may enable the prediction of the success of future therapies...
  5. doi request reprint Research in practice: IL-22 and IL-20: significance for epithelial homeostasis and psoriasis pathogenesis
    Robert Sabat
    Psoriasis Research and Treatment Center, Department of Dermatology, University Hospital Charite, Berlin, Germany
    J Dtsch Dermatol Ges 9:518-23. 2011
    ..A therapy counteracting IL-22 and IL-20 would be an innovative treatment with the potential for few side effects that would act on the final phase of psoriasis pathogenesis...
  6. doi request reprint IL-10 family of cytokines
    Robert Sabat
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany
    Cytokine Growth Factor Rev 21:315-24. 2010
    ..This review provides an overview of the most important and common aspects of the IL-10 family members...
  7. ncbi request reprint IL-19 and IL-20: two novel cytokines with importance in inflammatory diseases
    Robert Sabat
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Campus Charite Mitte, Berlin, Germany
    Expert Opin Ther Targets 11:601-12. 2007
    ..For this reason, the authors have reviewed the facts known at present regarding these cytokines and postulate that IL-19 and IL-20 are pharmacologically interesting distal elements of an inflammatory cascade...
  8. ncbi request reprint Three decades of psoriasis research: where has it led us?
    Robert Sabat
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, D 10117 Berlin, Germany
    Clin Dermatol 25:504-9. 2007
    ..This hypothesis is also supported by the very recent discoveries about interleukin (IL)-22, IL-20, and IL-23...
  9. doi request reprint The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis
    Kerstin Wolk
    Interdisciplinary Department of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany
    Eur J Immunol 39:3570-81. 2009
    ..This study demonstrates that a T-cell mediator induces a tissue cell mediator with similar effects to its own and therefore suggests the existence of a novel type of pathogenetic cascade...
  10. doi request reprint IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not
    Kerstin Wolk
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Chariteplatz 1, 10117, Berlin, Germany
    J Mol Med (Berl) 87:523-36. 2009
    ..This study suggests that different cytokines are players in the psoriasis pathogenesis although only the IL-10 family members IL-22 and IL-20 directly cause the characteristic epidermal alterations...
  11. ncbi request reprint Interleukin (IL)-19, IL-20 and IL-24 are produced by and act on keratinocytes and are distinct from classical ILs
    Stefanie Kunz
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany
    Exp Dermatol 15:991-1004. 2006
    ..In summary, these data support the notion that IL-19, IL-20 and IL-24 are distinct from classical ILs and constitute a separate subfamily of mediators within the IL-10 family...
  12. ncbi request reprint Expression profiling of IL-10-regulated genes in human monocytes and peripheral blood mononuclear cells from psoriatic patients during IL-10 therapy
    Mechthild Jung
    Institute of Medical Immunology, Charite, Humboldt University Berlin, Berlin, Germany
    Eur J Immunol 34:481-93. 2004
    ..We could confirm a recently reported up-regulation of heme oxygenase-1 (HO-1). However, we demonstrate that the anti-inflammatory mechanisms of IL-10 remain functional even when HO-1 is irreversibly inhibited...
  13. ncbi request reprint Ultraviolet B radiation-mediated inhibition of interferon-gamma-induced keratinocyte activation is independent of interleukin-10 and other soluble mediators but associated with enhanced intracellular suppressors of cytokine-signaling expression
    Markus Friedrich
    Department for Dermatology and Allergology, Medical School Charite, Humboldt University Berlin, Berlin, Germany
    J Invest Dermatol 121:845-52. 2003
    ....
  14. ncbi request reprint IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis
    Kerstin Wolk
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany
    Eur J Immunol 36:1309-23. 2006
    ..In summary, despite similarities, IFN-gamma primarily amplifies inflammation, while IL-22 may be important in the innate immunity and reorganization of epithelia...
  15. doi request reprint Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes
    Kerstin Wolk
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany
    J Leukoc Biol 83:1181-93. 2008
    ..However, the strongest response to TLR2 and TLR3 activation showed keratinocytes in the simultaneous presence of IL-20 and IL-29...
  16. doi request reprint IL-29 is produced by T(H)17 cells and mediates the cutaneous antiviral competence in psoriasis
    Kerstin Wolk
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, 10117 Berlin, Germany
    Sci Transl Med 5:204ra129. 2013
    ..These data suggest that T(H)17 cell-derived IL-29, which is absent in AD, mediates the robust antiviral state on psoriatic skin, and demonstrate a new function of T(H)17 cells...
  17. ncbi request reprint IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease
    Kerstin Wolk
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, Campus Charite Mitte, University Hospital Charite, Chariteplatz 1, Berlin, Germany
    J Immunol 178:5973-81. 2007
    ..These data suggest that systemic IL-22 may contribute to the prevention of systemic inflammation provoked by LPS present in the blood of CD patients through its induction of hepatic LBP...
  18. doi request reprint Deficiency of IL-22 contributes to a chronic inflammatory disease: pathogenetic mechanisms in acne inversa
    Kerstin Wolk
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, D 10117 Berlin, Germany
    J Immunol 186:1228-39. 2011
    ..We conclude that IL-22 deficiency may contribute to the pathogenesis of certain chronic disorders as postulated in this paper for AI...
  19. doi request reprint Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice
    Snehlata Kumari
    Department of Dermatology, University of Cologne, Kerpener Strasse 62, 50931 Cologne, Germany Institute for Genetics, Center for Molecular Medicine CMMC, and Cologne Excellence Cluster on Cellular Stress Responses in Aging associated Diseases CECAD, University of Cologne, Zülpicher Str 47a, 50674 Cologne, Germany
    Immunity 39:899-911. 2013
    ..Therefore, our results expand current views on psoriasis pathogenesis by revealing a new keratinocyte-intrinsic mechanism that links TNFR1, NF-κB, ERK, IL-24, IL-22R1, and STAT3 signaling to disease initiation. ..
  20. doi request reprint Interleukin-29 induces epithelial production of CXCR3A ligands and T-cell infiltration
    Ellen Witte
    Psoriasis Research and Treatment Center, University Hospital Charite, Berlin, Germany
    J Mol Med (Berl) 94:391-400. 2016
    ..In summary, the Th17-cytokine IL-29 induces specific chemokines and, in consequence, provokes skin infiltration of potentially pathogenic T-cells...
  21. doi request reprint IL-19 is a component of the pathogenetic IL-23/IL-17 cascade in psoriasis
    Ellen Witte
    1 Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany 2 Psoriasis Research and Treatment Center, University Hospital Charite, Berlin, Germany
    J Invest Dermatol 134:2757-67. 2014
    ..In summary, IL-19 as a component of the IL-23/IL-17 axis strengthens the IL-17A action and might be a biomarker for the activity of this axis in chronic inflammatory disorders. ..
  22. ncbi request reprint Interleukin-10 enhances the CD14-dependent phagocytosis of bacteria and apoptotic cells by human monocytes
    Marcel Lingnau
    Institute of Medical Immunology, University Hospital Charite, Berlin, Germany
    Hum Immunol 68:730-8. 2007
    ..TGF-beta, however, may be an inhibitor of both systems...
  23. ncbi request reprint The evaluation of psoriasis therapy with biologics leads to a revision of the current view of the pathogenesis of this disorder
    Sandra Philipp
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Chariteplatz 1, D 10117 Berlin, Germany
    Expert Opin Ther Targets 10:817-31. 2006
    ..For this reason, the authors critically re-evaluated the view of psoriasis pathogenesis and postulate that in the majority of patients the T1 cells do not play a dominant role in the clinical, visible stage of this disease...
  24. doi request reprint Interleukin-28 and interleukin-29: novel regulators of skin biology
    Kerstin Wolk
    Interdisciplinary Department of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany
    J Interferon Cytokine Res 30:617-28. 2010
    ..In summary, IL-28/IL-29 may play an important role in the skin in the clearance of viral and microbial infections and in the removal of tumors...
  25. doi request reprint Biology of interleukin-22
    Kerstin Wolk
    University Hospital Charite, Berlin, Germany
    Semin Immunopathol 32:17-31. 2010
    ....
  26. doi request reprint Immunological changes in psoriasis patients under long-term treatment with fumaric acid esters: risk of Kaposi sarcoma occurrence?
    Sandra Philipp
    Psoriasis Research and Treatment Center, Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology
    Eur J Dermatol 23:339-43. 2013
    ..Psoriasis is a chronic skin disorder. The most frequently used systemic anti-psoriatic therapy in Germany is fumaric acid esters (FAE)...
  27. ncbi request reprint Interleukin-10: an important immunoregulatory cytokine with major impact on psoriasis
    Khusru Asadullah
    Corporate Research Business Area Dermatology, Schering AG, Berlin, Germany
    Curr Drug Targets Inflamm Allergy 3:185-92. 2004
    ..Further investigations, in particular multicenter, placebo-controlled, double blind trials are required to fully determine whether IL-10 application will become a successful antipsoriatic therapy...
  28. ncbi request reprint Keratinocyte unresponsiveness towards interleukin-10: lack of specific binding due to deficient IL-10 receptor 1 expression
    Martina Seifert
    Institute of Medical Immunology, Medical School Charite, Humboldt University Berlin, Berlin, Germany
    Exp Dermatol 12:137-44. 2003
    ..Our data indicates that IL-10 unresponsiveness of keratinocytes could be explained by the lacking of functional IL-10 receptor expression and suggest that any IL-10 effects on these cells observed are indirectly mediated...
  29. pmc MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations
    Athanasia Tsaousi
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany Psoriasis Research and Treatment Center, University Hospital Charite, Berlin, Germany
    Mediators Inflamm 2016:4097574. 2016
    ..In summary, we demonstrate elevated MMP8 levels in AI lesions, suggest their role in skin destruction and metabolic alterations, and recommend the use of MMP8 as blood biomarker for AI disease activity assessment...
  30. ncbi request reprint Pan-selectin antagonism improves psoriasis manifestation in mice and man
    Markus Friedrich
    Department of Dermatology and Allergy, University Hospital Charite, Schumannstr 20 21, 10117 Berlin, Germany
    Arch Dermatol Res 297:345-51. 2006
    ..Assessment of safety parameters showed no abnormal findings. These data suggest that pan-selectin antagonism may be a promising strategy for the treatment of psoriasis and other inflammatory diseases...
  31. ncbi request reprint Reduced monocyte CD86 expression in postinflammatory immunodeficiency
    Kerstin Wolk
    Institute of Medical Immunology and Department of General, Visceral, Vascular, Thoracic Surgery, University Hospital Charite, Berlin, Germany
    Crit Care Med 35:458-67. 2007
    ..To further characterize the monocytic cells in this clinical state, we analyzed their expression of CD86, the most important co-stimulatory molecule...
  32. doi request reprint A simple assay to measure phagocytosis of live bacteria
    Heike Bicker
    Institute of Medical Immunology and Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany
    Clin Chem 54:911-5. 2008
    ..We sought to develop a flow cytometric assay to measure the engulfment and degradation of live bacteria by human blood monocytes and granulocytes...
  33. ncbi request reprint TIRC7 inhibits T cell proliferation by modulation of CTLA-4 expression
    Grit Carsta Bulwin
    Institut fur Medizinische Immunologie, Campus Charite Mitte, Humboldt Universitat zu Berlin, Berlin, Germany
    J Immunol 177:6833-41. 2006
    ..Splenocytes obtained from CTLA-4-deficient mice are not responsive to TIRC7 Ab targeting. Thus, TIRC7 acts as an upstream regulatory molecule of CTLA-4 expression...
  34. doi request reprint IL-28A, IL-28B, and IL-29: promising cytokines with type I interferon-like properties
    Katrin Witte
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Chariteplatz 1, 10117 Berlin, Germany
    Cytokine Growth Factor Rev 21:237-51. 2010
    ..These properties suggest that IL-28/IL-29 are potential therapeutic alternatives to type I interferons in terms of viral infections and tumors. This review describes the current knowledge about these cytokines...
  35. doi request reprint Depression is a frequent co-morbidity in patients with acne inversa
    Agata Kurek
    Department of Dermatology, Venerology and Allergology, University Hospital Charite, Berlin, Germany
    J Dtsch Dermatol Ges 11:743-9, 743-50. 2013
    ..Acne inversa (AI) is a common chronic inflammatory disease that has a profound impact on the patientsí quality of life. We hypothesized a higher level of depression in AI patients compared to controls...
  36. ncbi request reprint Multiple mechanisms of reduced major histocompatibility complex class II expression in endotoxin tolerance
    Kerstin Wolk
    Institute of Medical Immunology, Medical School Charite, Humboldt University Berlin, D 10117 Berlin, Germany
    J Biol Chem 278:18030-6. 2003
    ....
  37. doi request reprint Profound disturbances of sexual health in patients with acne inversa
    Agata Kurek
    Department of Dermatology and Allergy, University Hospital Charite, Berlin, Germany
    J Am Acad Dermatol 67:422-8, 428.e1. 2012
    ..Acne inversa (AI) leads chronically to painful eruptions and extensive scarring in predominantly intimate areas. We hypothesized an impairment of sexual life caused by the disease...
  38. doi request reprint Interleukin-22: a cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection
    Ellen Witte
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Chariteplatz 1, 10117 Berlin, Germany
    Cytokine Growth Factor Rev 21:365-79. 2010
    ....
  39. ncbi request reprint Naturally occurring anti-IFN-gamma autoantibody and severe infections with Mycobacterium cheloneae and Burkholderia cocovenenans
    Conny Höflich
    Institute for Medical Immunology, University Hospital Charite, Humboldt University Schumannstr 20 21, D 10098 Berlin, Germany
    Blood 103:673-5. 2004
    ..Screening for neutralizing anti-IFN-gamma autoantibodies should supplement testing for IFN-gamma and IL-12 pathway defects in patients with recurrent infections with intracellular pathogens, especially with nontuberculous mycobacteria...
  40. ncbi request reprint Interleukin-22: a novel T- and NK-cell derived cytokine that regulates the biology of tissue cells
    Kerstin Wolk
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Campus Charite Mitte, Chariteplatz 1, D 10117 Berlin, Germany
    Cytokine Growth Factor Rev 17:367-80. 2006
    ..Furthermore, IL-22 induces acute phase reactants. These findings indicate that IL-22 represents a novel type of immune mediator that, although produced by immune cells, regulates tissue protection and homeostasis...
  41. pmc The Pelargonium sidoides Extract EPs 7630 Drives the Innate Immune Defense by Activating Selected MAP Kinase Pathways in Human Monocytes
    Katrin Witte
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany Berlin Brandenburg Center for Regenerative Therapies, University Hospital Charite, Berlin, Germany
    PLoS ONE 10:e0138075. 2015
    ....
  42. doi request reprint Therapeutic opportunities of the IL-22-IL-22R1 system
    Robert Sabat
    1 Interdisciplinary Group of Molecular Immunopathology, Institute of Medical Immunology, Department of Dermatology and Allergy, University Medicine Charité, Chariteplatz 1, D 10117 Berlin, Germany 2 Research Center Immunosciences, University Hospital Charite, Hessische Strasse 3 4, D 10115 Berlin, Germany
    Nat Rev Drug Discov 13:21-38. 2014
    ....
  43. doi request reprint Deficient cutaneous antibacterial competence in cutaneous T-cell lymphomas: role of Th2-mediated biased Th17 function
    Kerstin Wolk
    Psoriasis Research and Treatment Center, University Hospital Charite, Berlin, Germany Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany Research Center Immunosciences, University Hospital Charite, Berlin, Germany
    Clin Cancer Res 20:5507-16. 2014
    ..Our aim was to investigate the mechanisms of elevated susceptibility to cutaneous infections in patients with CTCL...
  44. ncbi request reprint Interleukin-10 and articular cartilage: experimental therapeutical approaches in cartilage disorders
    Gundula Schulze-Tanzil
    Department for Trauma and Reconstructive Surgery, Charité University of Medicine, Campus Benjamin Franklin, Berlin, Germany
    Curr Gene Ther 9:306-15. 2009
    ..However, a crucial problem remains to be the optimisation of local and continuous therapeutic effective levels of IL-10 administration in the joint...
  45. ncbi request reprint Adipokines in psoriasis: An important link between skin inflammation and metabolic alterations
    Kerstin Wolk
    Psoriasis Research and Treatment Center, Department of Dermatology and Allergy and Institute of Medical Immunology, University Medicine Charité, Chariteplatz 1, 10117, Berlin, Germany
    Rev Endocr Metab Disord . 2016
    ..This article describes selected adipokines and their potential role in both metabolic comorbidity and skin inflammation in psoriasis...
  46. ncbi request reprint High Prevalence of Back Pain and Axial Spondyloarthropathy in Patients with Hidradenitis Suppurativa
    Sylke Schneider-Burrus
    Department of Dermatology and Allergy, Charite University Hospital, Berlin, Germany
    Dermatology . 2016
    ..Hidradenitis suppurativa (HS) is a chronic inflammatory disease, causing fistulating sinuses in the intertriginous skin of axillary, genitofemoral and perianal sites...
  47. doi request reprint Formation of reactive oxygen species in lung alveolar cells: effect of vitamin E deficiency
    Robert Sabat
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, Charite Universitatsmedizin Berlin, CCM, Berlin, Germany
    Lung 186:115-22. 2008
    ..E deficiency caused a preferentially nonmitochondria-mediated increase of ROS formation in type II pneumocytes, macrophages, and lymphocytes. However, the short-term supplementation of vit. E does not reverse these effects...
  48. ncbi request reprint Heme oxygenase-1 inhibits T cell-dependent skin inflammation and differentiation and function of antigen-presenting cells
    Joanna Listopad
    TRG Inflammation and Immunology, Bayer Schering Pharma AG, D 13442 Berlin, Germany
    Exp Dermatol 16:661-70. 2007
    ..Suppression of antigen-presenting cells may represent a main anti-inflammatory mechanism of HO-1...
  49. ncbi request reprint IL-22 increases the innate immunity of tissues
    Kerstin Wolk
    Corporate Research Business Area Dermatology, Schering AG, D 13342 Berlin, Germany
    Immunity 21:241-54. 2004
    ..Taken together, IL-22 does not serve the communication between immune cells but is a T cell mediator that directly promotes the innate, nonspecific immunity of tissues...
  50. ncbi request reprint A vaccine for hypertension based on virus-like particles: preclinical efficacy and phase I safety and immunogenicity
    Patrice M Ambuhl
    Renal Division, University Hospital, Zurich, Switzerland
    J Hypertens 25:63-72. 2007
    ..Here we describe the preclinical development and the phase I clinical trial testing of a virus-like particle (VLP)-based antihypertensive vaccine...