Rita Rosenthal

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. doi Myrrh exerts barrier-stabilising and -protective effects in HT-29/B6 and Caco-2 intestinal epithelial cells
    Rita Rosenthal
    Department of Gastroenterology, Rheumatology and Infectious Diseases, Section Nutritional Medicine Clinical Physiology, Charite, Campus Benjamin Franklin, 12200, Berlin, Germany
    Int J Colorectal Dis . 2016
  2. doi The effect of chitosan on transcellular and paracellular mechanisms in the intestinal epithelial barrier
    Rita Rosenthal
    Institute of Clinical Physiology, Charite, Campus Benjamin Franklin, Freie Universität and Humboldt Universität, 12200 Berlin, Germany
    Biomaterials 33:2791-800. 2012
  3. ncbi Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration
    Rita Rosenthal
    Augenklinik und Augenpoliklinik, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Biochem Biophys Res Commun 323:1203-8. 2004
  4. ncbi Effects of ML-7 and Y-27632 on carbachol- and endothelin-1-induced contraction of bovine trabecular meshwork
    Rita Rosenthal
    Augenklinik und Augenpoliklinik, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Exp Eye Res 80:837-45. 2005
  5. ncbi The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells
    Rita Rosenthal
    Augenklinik und Hochschulambulanz, Charite Universitatsmedizin, Berlin Campus Benjamin Franklin, Berlin, Germany
    Biochem Biophys Res Commun 337:241-7. 2005
  6. ncbi Endothelin receptor B in trabecular meshwork
    Rita Rosenthal
    Institut für Klinische Physiologie, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Exp Eye Res 85:482-91. 2007
  7. doi Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes
    Susanne Milatz
    Institute of Clinical Physiology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Biochim Biophys Acta 1798:2048-57. 2010
  8. ncbi Endothelin antagonism: effects of FP receptor agonists prostaglandin F2alpha and fluprostenol on trabecular meshwork contractility
    Hagen Thieme
    Augenklinik und Augenpoliklinik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    Invest Ophthalmol Vis Sci 47:938-45. 2006
  9. doi Aerolysin from Aeromonas hydrophila perturbs tight junction integrity and cell lesion repair in intestinal epithelial HT-29/B6 cells
    Roland Bücker
    Department of Gastroenterology, Infectious Diseases, and Rheumotology, Charite Berlin, Germany
    J Infect Dis 204:1283-92. 2011
  10. doi Claudin-17 forms tight junction channels with distinct anion selectivity
    Susanne M Krug
    Institute of Clinical Physiology, Campus Benjamin Franklin, Charite, Freie Universität and Humboldt Universität, Hindenburgdamm 30, 12203 Berlin, Germany
    Cell Mol Life Sci 69:2765-78. 2012

Collaborators

Detail Information

Publications30

  1. doi Myrrh exerts barrier-stabilising and -protective effects in HT-29/B6 and Caco-2 intestinal epithelial cells
    Rita Rosenthal
    Department of Gastroenterology, Rheumatology and Infectious Diseases, Section Nutritional Medicine Clinical Physiology, Charite, Campus Benjamin Franklin, 12200, Berlin, Germany
    Int J Colorectal Dis . 2016
    ..Thus, this study investigates the effect of myrrh on paracellular barrier function in the absence or presence of the pro-inflammatory cytokine TNFα...
  2. doi The effect of chitosan on transcellular and paracellular mechanisms in the intestinal epithelial barrier
    Rita Rosenthal
    Institute of Clinical Physiology, Charite, Campus Benjamin Franklin, Freie Universität and Humboldt Universität, 12200 Berlin, Germany
    Biomaterials 33:2791-800. 2012
    ..These results suggest that the rapid and reversible absorption-enhancing chitosan effect is due to changes in intracellular pH caused by the activation of a chloride-bicarbonate exchanger resulting in the opening of the TJ...
  3. ncbi Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration
    Rita Rosenthal
    Augenklinik und Augenpoliklinik, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Biochem Biophys Res Commun 323:1203-8. 2004
    ..Thus, in RPE cells IGF-1 stimulates the second messenger Ca(2+) and increases VEGF secretion which, in turn, induces neovascularization...
  4. ncbi Effects of ML-7 and Y-27632 on carbachol- and endothelin-1-induced contraction of bovine trabecular meshwork
    Rita Rosenthal
    Augenklinik und Augenpoliklinik, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Exp Eye Res 80:837-45. 2005
    ..According to our concept of aqueous humor outflow regulation, trabecular meshwork relaxing substances appear to be ideal antiglaucomatous drugs, leading to increased outflow facility...
  5. ncbi The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells
    Rita Rosenthal
    Augenklinik und Hochschulambulanz, Charite Universitatsmedizin, Berlin Campus Benjamin Franklin, Berlin, Germany
    Biochem Biophys Res Commun 337:241-7. 2005
    ..Our findings support the hypothesis that there are two different FGFR-1- and FGFR-2-dependent pathways that modulate the role of bFGF in induction of neovascularisation in AMD...
  6. ncbi Endothelin receptor B in trabecular meshwork
    Rita Rosenthal
    Institut für Klinische Physiologie, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Exp Eye Res 85:482-91. 2007
    ..Currently, there is no evidence for ET-1 synthesis in HTM cells. Further investigations are necessary to clarify the physiological function of ET-BR in TM and the source of ET-1 at this tissue...
  7. doi Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes
    Susanne Milatz
    Institute of Clinical Physiology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Biochim Biophys Acta 1798:2048-57. 2010
    ..Thus, in a kidney model epithelium, claudin-3 acts as a general barrier-forming protein...
  8. ncbi Endothelin antagonism: effects of FP receptor agonists prostaglandin F2alpha and fluprostenol on trabecular meshwork contractility
    Hagen Thieme
    Augenklinik und Augenpoliklinik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    Invest Ophthalmol Vis Sci 47:938-45. 2006
    ..Contractility of TM is induced by endothelin (ET)-1, a possible pathogenic factor in glaucoma. The involvement of FP receptor agonists in the ET-1 effects on TM function was studied...
  9. doi Aerolysin from Aeromonas hydrophila perturbs tight junction integrity and cell lesion repair in intestinal epithelial HT-29/B6 cells
    Roland Bücker
    Department of Gastroenterology, Infectious Diseases, and Rheumotology, Charite Berlin, Germany
    J Infect Dis 204:1283-92. 2011
    ..Pathogenesis of Aeromonas hydrophila and its hemolysin has been characterized, but the mechanism of the epithelial barrier dysfunction is currently poorly understood...
  10. doi Claudin-17 forms tight junction channels with distinct anion selectivity
    Susanne M Krug
    Institute of Clinical Physiology, Campus Benjamin Franklin, Charite, Freie Universität and Humboldt Universität, Hindenburgdamm 30, 12203 Berlin, Germany
    Cell Mol Life Sci 69:2765-78. 2012
    ..In conclusion, claudin-17 forms channels within tight junctions with distinct anion preference...
  11. doi Claudin-2, a component of the tight junction, forms a paracellular water channel
    Rita Rosenthal
    Institute of Clinical Physiology, Charite, Campus Benjamin Franklin, Freie Universität and Humboldt Universität, 12200 Berlin, Germany
    J Cell Sci 123:1913-21. 2010
    ..By contrast, claudin-10b transfection did not alter water flux. We conclude that claudin-2, but not claudin-10b, forms a paracellular water channel and thus mediates paracellular water transport in leaky epithelia...
  12. ncbi Pharmacological and functional characterization of endothelin receptors in bovine trabecular meshwork and ciliary muscle
    Lars Choritz
    Institut für Klinische Physiologie, Charite, Universitätmedizin Berlin, Berlin, Deutschland
    Ophthalmic Res 37:179-87. 2005
    ..Thus, although both receptors are present, the ET-A receptor appears to play the predominant role in mediating contraction in both the TM and CM, while the ET-B receptor seems to contribute little to the overall ET-1 effect...
  13. doi High-resolution analysis of barrier function
    Michael Fromm
    Institute of Clinical Physiology, Charite, Berlin, Germany
    Ann N Y Acad Sci 1165:74-81. 2009
    ..Third, three-dimensional confocal fluorescence imaging for depicting transepithelial transport processes is introduced. Using this method the transepithelial translocation of bacteria which generate focal leaks was discovered...
  14. pmc Ca2+ channels in retinal pigment epithelial cells regulate vascular endothelial growth factor secretion rates in health and disease
    Rita Rosenthal
    Institut für Klinische Physiologie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Mol Vis 13:443-56. 2007
    ..Since RPE cells express neuroendocrine L-type Ca2+ channels we investigated their involvement in VEGF secretion in normal RPE cells and RPE cells from patients with CNV...
  15. doi Yersinia enterocolitica induces epithelial barrier dysfunction through regional tight junction changes in colonic HT-29/B6 cell monolayers
    Nina A Hering
    Department of Gastroenterology, Infectious Diseases and Rheumatology, Charite Campus Benjamin Franklin, Berlin, Germany
    Lab Invest 91:310-24. 2011
    ..enterocolitica infection is due to circumscribed epithelial TJ protein changes and necrotic cell loss, as a consequence of which leak flux diarrhea and antigen-uptake provoking extraintestinal arthritis may be triggered...
  16. doi Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function
    Dorothee Gunzel
    Institute of Clinical Physiology, Charite, 12200 Berlin, Germany
    J Cell Sci 122:1507-17. 2009
    ..The extent of all these effects strongly depended on the endogenous claudins of the transfected cells...
  17. ncbi Voltage-dependent ion channels in the mouse RPE: comparison with Norrie disease mice
    Guido Wollmann
    Institut fuer Klinische Physiologie, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Germany
    Vision Res 46:688-98. 2006
    ..Although no significant differences were observed, our study provides a base for future studies on ion channel function and dysfunction in transgenic mouse models...
  18. ncbi Effects of unoprostone and endothelin 1 on L-type channel currents in human trabecular meshwork cells
    Hagen Thieme
    Augenklinik und Hochschulambulanz, Berlin, Germany
    Ophthalmic Res 37:293-300. 2005
    ..Since L-type channel currents are known to influence the contractility of TM, we examined the effects of unoprostone and ET-1 on L-type channel currents of TM cells...
  19. doi Analysis of absorption enhancers in epithelial cell models
    Rita Rosenthal
    Institute of Clinical Physiology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Freie Universität and Humboldt Universität, Berlin, Germany
    Ann N Y Acad Sci 1258:86-92. 2012
    ..The majority of members of the claudin protein family seal the paracellular pathway. This paper focuses on recent approaches concerning absorption-enhancing effects, with regard to selectivity and mechanism...
  20. ncbi Investigations of RPE cells of choriodal neovascular membranes from patients with age-related macula degeneration
    Rita Rosenthal
    Department of Clinical Physiology, Benjamin Franklin University Hospital, Free University Berlin, 12200 Berlin, Germany
    Adv Exp Med Biol 533:107-13. 2003
  21. ncbi Effects of protein kinase C on delayed rectifier K+ channel regulation by tyrosine kinase in rat retinal pigment epithelial cells
    Olaf Strauss
    Institute for Clinical Physiology, Benjamin Franklin University Clinic, Free University of Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    Invest Ophthalmol Vis Sci 43:1645-54. 2002
    ..Investigation of the regulation of delayed rectifier potassium channels by protein kinases in retinal pigment epithelial (RPE) cells...
  22. ncbi Electrophysiological response of cultured trabecular meshwork cells to synthetic ion channels
    Pawel Fidzinski
    Institut für Klinische Physiologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    Chem Biol 10:35-43. 2003
    ..Thus, THF-gramicidin hybrids form a basis for the use of synthetic ion channels in biological systems, which eventually may lead to new therapeutic approaches...
  23. ncbi Expression of bestrophin-1, the product of the VMD2 gene, modulates voltage-dependent Ca2+ channels in retinal pigment epithelial cells
    Rita Rosenthal
    Augenklinik, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    FASEB J 20:178-80. 2006
    ....
  24. ncbi Ca2+-channels in the RPE
    Rita Rosenthal
    Institut für Klinische Physiologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, 12200 Berlin, Germany
    Adv Exp Med Biol 514:225-35. 2002
    ..Thus, voltage-dependent Ca2+ channels in the retinal pigment epithelium are of importance for the function of photoreceptors...
  25. doi The ginger component 6-shogaol prevents TNF-α-induced barrier loss via inhibition of PI3K/Akt and NF-κB signaling
    Julia Luettig
    Nutritional Medicine and Clinical Physiology, Department of Gastroenterology, Rheumatology and Infectious Diseases, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Mol Nutr Food Res 60:2576-2586. 2016
    ..Purpose of this study was to characterize the influence of 6-SG on inflammation-related intestinal barrier dysfunction, especially its paracellular component...
  26. doi Tight junctions and differentiation--a chicken or the egg question?
    Nina Kirschner
    Department of Dermatology and Venerology, University Hospital Hamburg Eppendorf, Germany Institute of Clinical Physiology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Exp Dermatol 21:171-5. 2012
    ..In addition, the concept is introduced that both processes are going on at the same time, which means that while one specific TJ protein/barrier component might be influenced by differentiation, the other may influence differentiation...
  27. pmc Endothelin antagonism as an active principle for glaucoma therapy
    Rita Rosenthal
    Institute of Clinical Physiology, Charite, Campus Benjamin Franklin, Freie Universität and Humboldt Universität Berlin, Berlin, Germany
    Br J Pharmacol 162:806-16. 2011
    ..In sum, inhibition of endothelin signalling leads to lowering of intraocular pressure and exerts neuroprotective effects. Thus, endothelin antagonism in the eye represents a promising approach for pharmacological treatment of glaucoma...
  28. doi Effects of endothelin-1 on calcium-independent contraction of bovine trabecular meshwork
    Giulia Renieri
    Department of Ophthalmology, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55101, Mainz, Germany
    Graefes Arch Clin Exp Ophthalmol 246:1107-15. 2008
    ..This study investigates the role of ET-1 and its receptors ET-A and ET-B (ET-AR and ET-BR) in TM Ca(2+)-independent contractility...
  29. doi Expression profile of voltage-dependent Ca2+ channel subunits in the human retinal pigment epithelium
    Sönke Wimmers
    Experimentelle Ophthalmologie, Klinik und Poliklinik für Augenheilkunde, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Graefes Arch Clin Exp Ophthalmol 246:685-92. 2008
    ..In order to provide a better base for the understanding of the underlying Ca(2+) signalling in these cells, we investigated the expression profile of voltage-dependent Ca(2+) channel subunits in RPE cells...
  30. ncbi Stimulation of cannabinoid (CB1) and prostanoid (EP2) receptors opens BKCa channels and relaxes ocular trabecular meshwork
    Friederike Stumpff
    Department of Veterinary Physiology, Free University of Berlin, Germany
    Exp Eye Res 80:697-708. 2005
    ..This effect may contribute to the relaxant activity of EP2 and CB1 agonists in isolated TM strips, modulating ocular outflow...