F C Luft

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. doi [Resistant hypertension : What is it?]
    F C Luft
    Experimental and Clinical Research Center, Kooperation zwischen dem Max Delbrück Centrum für Molekulare Medizin und der Medizinischen Fakultät der Charité, Lindenbergerweg 80, 13125, Berlin, Deutschland
    Internist (Berl) 56:224-9. 2015
  2. doi Clinical salt deficits
    Friedrich C Luft
    Experimental and Clinical Research Center, a joint cooperation between the Max Delbrück Center for Molecular Medicine and the Charité Medical Faculty, Lindenbergerweg 80, 13125, Berlin, Germany
    Pflugers Arch 467:559-63. 2015
  3. doi Activating autoantibodies and cardiovascular disease
    Friedrich C Luft
    Experimental and Clinical Research Center and Max Delbrück Center for Molecular Medicine and Charité Medical Faculty, Berlin, Germany
    Physiology (Bethesda) 28:254-61. 2013
  4. doi Molecular mechanisms of arterial stiffness: new insights
    Friedrich C Luft
    Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité Medical Faculty, Berlin, Germany
    J Am Soc Hypertens 6:436-8. 2012
  5. doi Immune mechanisms in angiotensin II-induced target-organ damage
    Friedrich C Luft
    Experimental and Clinical Research Center, a joint cooperation between Charité Medical Faculty and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Ann Med 44:S49-54. 2012
  6. doi Neural regulation of the immune system modulates hypertension-induced target-organ damage
    Friedrich C Luft
    Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, Germany
    J Am Soc Hypertens 6:23-6. 2012
  7. doi Rats, salt, and history
    Friedrich C Luft
    Experimental and Clinical Research Center, Charité Medical Faculty and Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany
    Cell Metab 15:129-30. 2012
  8. doi The laminated hearts
    Friedrich C Luft
    Experimental and Clinical Research Center, Franz Volhard Clinic at the Max Delbruck Center, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Mol Med (Berl) 86:243-5. 2008
  9. ncbi Soluble endoglin (sEng) joins the soluble fms-like tyrosine kinase (sFlt) receptor as a pre-eclampsia molecule
    Friedrich C Luft
    Franz Volhard Clinic, Medical Faculty of the Charite, HELIOS Klinikum Berlin, Max Delbruck Center for Molecular Medicine, Berlin Buch, Wiltberg Strasse 50, 13125 Berlin, Germany
    Nephrol Dial Transplant 21:3052-4. 2006
  10. ncbi Antihypertensive therapy with aliskiren
    F C Luft
    Experimental and Clinical Research Center, Medical Faculty of the Charité and Max Delbrück Center for Molecular Medicine, Helios Klinikum Berlin Buch, Berlin, Germany
    Kidney Int 73:679-83. 2008

Collaborators

Detail Information

Publications146 found, 100 shown here

  1. doi [Resistant hypertension : What is it?]
    F C Luft
    Experimental and Clinical Research Center, Kooperation zwischen dem Max Delbrück Centrum für Molekulare Medizin und der Medizinischen Fakultät der Charité, Lindenbergerweg 80, 13125, Berlin, Deutschland
    Internist (Berl) 56:224-9. 2015
    ..The prevalence of such patients can be substantially reduced by means of a thorough history and physical examination, determining drug serum concentrations, and excluding secondary causes. ..
  2. doi Clinical salt deficits
    Friedrich C Luft
    Experimental and Clinical Research Center, a joint cooperation between the Max Delbrück Center for Molecular Medicine and the Charité Medical Faculty, Lindenbergerweg 80, 13125, Berlin, Germany
    Pflugers Arch 467:559-63. 2015
    ..Molecular genetics has given us important new insights into salt deficit syndromes. Recent recognition of a novel sodium storage compartment involving sodium binding to proteoglycans adds to the overall complexity of these syndromes. ..
  3. doi Activating autoantibodies and cardiovascular disease
    Friedrich C Luft
    Experimental and Clinical Research Center and Max Delbrück Center for Molecular Medicine and Charité Medical Faculty, Berlin, Germany
    Physiology (Bethesda) 28:254-61. 2013
    ..Their existence and actions appear to be established. Lacking are mechanistic studies of receptor activation and translational studies to document receptor-stimulating antibodies as worthwhile therapeutic targets. ..
  4. doi Molecular mechanisms of arterial stiffness: new insights
    Friedrich C Luft
    Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité Medical Faculty, Berlin, Germany
    J Am Soc Hypertens 6:436-8. 2012
    ..New information regarding genetic factors and molecular mechanisms involved in altering vascular responses are reviewed as a preview of emerging information in this area...
  5. doi Immune mechanisms in angiotensin II-induced target-organ damage
    Friedrich C Luft
    Experimental and Clinical Research Center, a joint cooperation between Charité Medical Faculty and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Ann Med 44:S49-54. 2012
    ..Neural mechanisms interact with and regulate these processes. Understanding the mechanisms could direct us to novel therapies...
  6. doi Neural regulation of the immune system modulates hypertension-induced target-organ damage
    Friedrich C Luft
    Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, Germany
    J Am Soc Hypertens 6:23-6. 2012
    ..Vagal stimulation, either electrical or pharmacological, could provide additional protection. The field of neuroimmunology will become increasingly important to cardiovascular clinicians...
  7. doi Rats, salt, and history
    Friedrich C Luft
    Experimental and Clinical Research Center, Charité Medical Faculty and Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany
    Cell Metab 15:129-30. 2012
    ..How does salt increase blood pressure? One hypothesis put forward is the involvement of reactive oxygen species produced in the renal outer medulla. A novel rat gene-deletion model in this issue of Cell Metabolism supports this argument...
  8. doi The laminated hearts
    Friedrich C Luft
    Experimental and Clinical Research Center, Franz Volhard Clinic at the Max Delbruck Center, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Mol Med (Berl) 86:243-5. 2008
  9. ncbi Soluble endoglin (sEng) joins the soluble fms-like tyrosine kinase (sFlt) receptor as a pre-eclampsia molecule
    Friedrich C Luft
    Franz Volhard Clinic, Medical Faculty of the Charite, HELIOS Klinikum Berlin, Max Delbruck Center for Molecular Medicine, Berlin Buch, Wiltberg Strasse 50, 13125 Berlin, Germany
    Nephrol Dial Transplant 21:3052-4. 2006
  10. ncbi Antihypertensive therapy with aliskiren
    F C Luft
    Experimental and Clinical Research Center, Medical Faculty of the Charité and Max Delbrück Center for Molecular Medicine, Helios Klinikum Berlin Buch, Berlin, Germany
    Kidney Int 73:679-83. 2008
    ..Studies with primary cardiovascular and renal end points to address these possibilities are in progress...
  11. pmc Commentary: Shoot the renals!
    F C Luft
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin Brandenburg, Berlin, Germany
    Heart 93:1530-2. 2007
    ..Since this phraseology includes practically every patient with atherosclerosis, these guidelines appear ill advised...
  12. doi Divergent effects of central and peripheral renin on body weight and metabolism
    Friedrich C Luft
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Cell Metab 12:423-4. 2010
    ..2010) provide convincing evidence for a new role for brain renin in metabolic rate and weight loss. Renin overexpression or deletion peripherally from other studies suggests the opposite effect...
  13. ncbi Are we getting closer to a Nobel prize for unraveling preeclampsia?
    Ralf Dechend
    Max Delbruck Center for Molecular Medicine, Building 84, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Curr Cardiol Rep 10:440-7. 2008
    ..The prize will go to the affected women and their afflicted children. For the investigators in the area, such a prize would be welcome...
  14. ncbi Cachexia has only one meaning
    Friedrich C Luft
    HELIOS Kliniken Berlin, Franz Volhard Clinic at the Max Delbrück Center Medical Faculty of the Charité, 13122, Berlin, Germany
    J Mol Med (Berl) 85:783-5. 2007
  15. ncbi Dysferlin, dystrophy, and dilatative cardiomyopathy
    Friedrich C Luft
    Medical Faculty of the Charite, HELIOS Kliniken Berlin, Franz Volhard Clinic at the Max Delbruck Center, Berlin, Germany
    J Mol Med (Berl) 85:1157-9. 2007
  16. ncbi The renin-angiotensin and "drinking" behavior
    Friedrich C Luft
    Medical Faculty of the Charite, HELIOS Kliniken Berlin, Franz Volhard Clinic at the Max Delbruck Center, Wiltbergstr 50, 13122, Berlin, Germany
    J Mol Med (Berl) 85:1043-5. 2007
  17. ncbi Cerivastatin prevents angiotensin II-induced renal injury independent of blood pressure- and cholesterol-lowering effects
    J K Park
    Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
    Kidney Int 58:1420-30. 2000
    ..We used an angiotensin II (Ang II)-dependent model to test the hypothesis that cerivastatin prevents leukocyte adhesion and infiltration, induction of inducible nitric oxide synthase (iNOS), and ameliorates end-organ damage...
  18. ncbi Severely impaired baroreflex-buffering in patients with monogenic hypertension and neurovascular contact
    J Jordan
    Clinical Research Center, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 102:2611-8. 2000
    ..Neurovascular contact of the ventrolateral medulla may lead to arterial hypertension by interfering with baroreflex function...
  19. doi Neurohumoral and metabolic response to exercise in water
    S Wiesner
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Horm Metab Res 42:334-9. 2010
    ..Even though water immersion blunts exercise-induced sympathoadrenal activation, lipid mobilization and lipid oxidation rate are maintained or even improved. The response may be explained by augmented ANP release...
  20. ncbi Interaction between beta-adrenergic receptor stimulation and nitric oxide release on tissue perfusion and metabolism
    J Jordan
    Clinical Research Center, Franz Volhard Clinic, Max Delbruck Center, Medical Faculty of the Charite, Humboldt University, 13125 Berlin, Germany
    J Clin Endocrinol Metab 86:2803-10. 2001
    ..The data are consistent with the idea that in humans, NO is important in modulating and ameliorating sympathetic effects in peripheral tissues...
  21. pmc Immunosuppressive treatment protects against angiotensin II-induced renal damage
    Dominik N Muller
    HELIOS Klinikum Berlin, Franz Volhard Clinic and Medical Faculty of the Charité, Humboldt University of Berlin, Germany
    Am J Pathol 161:1679-93. 2002
    ..Ang II induces dendritic migration directly, whereas in vivo TNF-alpha is involved in dendritic cell infiltration and maturation. Thus, Ang II may initiate events leading to innate and acquired immune response...
  22. ncbi Limited effect of systemic beta-blockade on sympathetic outflow
    J Tank
    Clinical Research Center, HELIOS Kliniken, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Hypertension 38:1377-81. 2001
    ..This, observation is not consistent with an important tonic stimulatory effect of beta-adrenoreceptors in the brain...
  23. doi Pacemaker current inhibition in experimental human cardiac sympathetic activation: a double-blind, randomized, crossover study
    C Schroeder
    1 Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany 2 Experimental Clinical Research Center, Charité Medical Faculty and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Clin Pharmacol Ther 95:601-7. 2014
    ..Ivabradine attenuates sympathetic influences on HR at the sinus node level, leaving myocardial sympathetic activation unopposed. Reversal of parasympathetic dysfunction by ivabradine appears limited. ..
  24. ncbi Left ventricular function in mice lacking the AT2 receptor
    V Gross
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    J Hypertens 19:967-76. 2001
    ..Given the putative opposing functions of the AT1 and AT2 receptor, we also analysed AT1 receptor expression in the left ventricle...
  25. ncbi Normal blood pressure and renal function in mice lacking the bradykinin B(2) receptor
    A F Milia
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Hypertension 37:1473-9. 2001
    ..We hold the latter possibility to be more likely and to be a fruitful possibility for future research...
  26. ncbi Genetic influences on baroreflex function in normal twins
    J Tank
    Clinical Research Center, , , Humboldt University, Berlin, Germany
    Hypertension 37:907-10. 2001
    ..36 to 0.44). The genetic influence on BRS remained strong after correction for BMI and blood pressure. Therefore, BRS is strongly genetically determined, probably by different genes than are resting blood pressure and BMI...
  27. ncbi Regulator of G protein signalling 2 ameliorates angiotensin II-induced hypertension in mice
    Hantz C Hercule
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Exp Physiol 92:1014-22. 2007
    ..Our findings suggest that RGS2 deletion promotes Ang II-dependent hypertension primarily through an increase of myogenic tone and vasoreactivity, probably by sensitization of AT(1) receptors...
  28. ncbi Adipose tissue and circulating endothelial cell specific molecule-1 in human obesity
    J Janke
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Germany
    Horm Metab Res 38:28-33. 2006
    ..Circulating ESM-1 levels are reduced in the overweight and obese, consistent with the notion that ESM-1 may play some role in obesity-associated vascular disease...
  29. ncbi Ca2+ channels, Ca2+ sparks, and regulation of arterial smooth muscle function
    M Gollasch
    Franz Volhard Clinic, Humboldt University Berlin, Germany
    Z Kardiol 89:15-9. 2000
    ..Our findings suggest that "elementary" Ca2+ release units may represent novel, important therapeutic targets for regulating function of the intact arterial smooth muscle tissue...
  30. ncbi Myocardial adrenergic dysfunction in rats with transgenic, human renin-dependent hypertension
    J Bohlender
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    J Hypertens 19:1453-63. 2001
    ..We investigated cardiac function in rats transgenic for the human renin and angiotensinogen genes (TGR) to test the hypothesis that elevated local angiotensin II precipitates adrenergic dysfunction and abnormal contractile function...
  31. ncbi Endothelial adhesion molecules and leukocyte integrins in preeclamptic patients
    H Haller
    Franz Volhard Clinic, Berlin, Germany
    Hypertension 29:291-6. 1997
    ..The effect on cultured endothelial cells and the rapid decrease after delivery suggests the presence of a circulating serum factor which increases endothelial cell [Ca2+]i and enhances adhesion molecule expression...
  32. ncbi Role of mitogen-activated protein kinases in activation of human neutrophils by antineutrophil cytoplasmic antibodies
    R Kettritz
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    J Am Soc Nephrol 12:37-46. 2001
    ..However, both pathways show differential effects, whereby p38-MAPK controls the translocation of ANCA antigens to the cell surface...
  33. ncbi Heterogeneous responses to changes in dietary salt intake: the salt-sensitivity paradigm
    F C Luft
    Franz Volhard Clinic, Rudolf Virchow University Hospital, Free University of Berlin, Germany
    Am J Clin Nutr 65:612S-617S. 1997
    ....
  34. ncbi Tyramine in the assessment of regional adrenergic function
    F Adams
    Universitary Medicine, Charite Campus Buch, Franz Volhard Clinical Research Center and HELIOS Klinikum, Berlin, Germany
    Biochem Pharmacol 72:1724-9. 2006
    ..Tyramine applied through a microdialysis probe in concentrations up to 3.5 mM can be used to assess pre- and post-synaptic mechanisms regulating lipid mobilization...
  35. ncbi Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats
    Bernhard Pilz
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Hypertension 46:569-76. 2005
    ..We conclude that in dTGR, equieffective antihypertensive doses of Val or aliskiren attenuated end-organ damage. Thus, renin inhibition compares favorably to angiotensin receptor blockade in reversing organ damage in dTGR...
  36. ncbi Long-term blood pressure telemetry in AT2 receptor-disrupted mice
    V Gross
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    J Hypertens 18:955-61. 2000
    ..Therefore, we investigated the influence of dietary salt loading and deoxycorticosterone (DOCA)-salt treatment on blood pressure and diurnal patterns of blood pressure in these mice by radiotelemetry...
  37. ncbi Ostial renal artery stent placement for atherosclerotic renal artery stenosis in patients with coronary artery disease
    C M Gross
    Franz Volhard Clinic, Max Delbruck Center for Molecular Medicine, Virchow Klinikum, Humboldt University of Berlin, Germany
    Cathet Cardiovasc Diagn 45:1-8. 1998
    ..Serum creatinine changed from 1.46+/-0.7 mg/dl to 1.39+/-0.58 mg/dl (P = ns). Three patients showed restenosis (12.5%). Ostial stenting lowers blood pressure, decreases antihypertensive drugs and increases medication flexibility...
  38. pmc The use of small molecule high-throughput screening to identify inhibitors of the proteinase 3-NB1 interaction
    M Choi
    Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité Medical Faculty, Berlin, Germany
    Clin Exp Immunol 161:389-96. 2010
    ..The findings suggest that small inhibitory compounds provide a potential therapeutic tool to reduce mPR3 by preventing its binding to NB1...
  39. ncbi Antisense oligodesoxynucleotide strategies in renal and cardiovascular disease
    H Haller
    Franz Volhard Clinic, Max Delbruck Center for Molecular Medicine, Virchow Klinikum Charité Humboldt University of Berlin, Germany
    Kidney Int 53:1550-8. 1998
    ..Liposomes may not provide sufficient transfer efficiency. Coating liposomes with viral fusion proteins may offer an ideal way with which to deliver the goods into the cytoplasm of the target cell...
  40. ncbi Alpha-2 adrenergic transmission and human baroreflex regulation
    Jens Tank
    Department of Nephrology and Hypertension, Franz Volhard Clinic, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 43:1035-41. 2004
    ..alpha-2 Adrenoceptor stimulation greatly augments baroreflex-mediated bradycardia, most likely by parasympathetic activation...
  41. ncbi Hemodynamic and metabolic responses to valsartan and atenolol in obese hypertensive patients
    Jens Jordan
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    J Hypertens 23:2313-8. 2005
    ..Treatment recommendations for lean hypertensives may not be simply extrapolated to obese hypertensive persons...
  42. pmc Angiotensin II induced inflammation in the kidney and in the heart of double transgenic rats
    Juergen Theuer
    Franz Volhard Clinic, Charite and Max Delbrück Center for Molecular Medicine, Berlin, Humboldt University of Berlin, Germany
    BMC Cardiovasc Disord 2:3. 2002
    ..Leukocyte infiltration in the vascular wall accompanies PAI-1, MCP-1, iNOS and Tissue Factor expression. Furthermore we show evidence that Ang II causes the upregulation of NF-kB in our model...
  43. ncbi Influences of norepinephrine transporter function on the distribution of sympathetic activity in humans
    Antje F Mayer
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Max Delbrueck Centrum, and HELIOS Klinikum, Berlin, Germany
    Hypertension 48:120-6. 2006
    ..All of these changes are physiologically relevant because they lead to corresponding changes in organ function...
  44. ncbi Influences of AT1 receptor blockade on tissue metabolism in obese men
    Michael Boschmann
    Franz Volhard Clinical Research Center, Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 290:R219-23. 2006
    ..Endogeneous ANG II may slightly increase adipose tissue lipolysis. The mechanism may promote the redistribution of triglycerides from adipose tissue toward other organs...
  45. doi Cardiovascular autonomic regulation in Non-Obese Diabetic (NOD) mice
    Volkmar Gross
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Auton Neurosci 138:108-13. 2008
    ..In conclusion the use of diabetic NOD mice as a functional model for human diabetes may be questioned...
  46. ncbi Megalin antagonizes activation of the parathyroid hormone receptor
    J Hilpert
    Franz Volhard Clinic, Humboldt University, 13125 Berlin, Germany
    J Biol Chem 274:5620-5. 1999
    ..These data provide evidence that megalin is involved in the renal catabolism of PTH and potentially antagonizes PTH/PTHrP receptor activity in the proximal tubular epithelium...
  47. ncbi Workshop: mechanisms and cardiovascular damage in hypertension
    F C Luft
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Hypertension 37:594-8. 2001
    ..Anti-inflammatory interventions may have therapeutic utility...
  48. ncbi Autonomic nervous system function in patients with monogenic hypertension and brachydactyly: a field study in north-eastern Turkey
    J Tank
    Clinical Research Center, Franz Volhard Clinic, , Berlin, Germany
    J Hum Hypertens 15:787-92. 2001
    ....
  49. ncbi Prolonged cold preservation augments vascular injury independent of renal transplant immunogenicity and function
    D Dragun
    , , Humboldt University, Berlin, Germany
    Kidney Int 60:1173-81. 2001
    ..CONCLUSIONS: Because of the prominent vascular injury, strategies for endothelial protection should be attempted in grafts with long preservation times in clinical renal transplantation...
  50. ncbi Insights into angiotensin II receptor function through AT2 receptor knockout mice
    V Gross
    Franz Volhard Clinic HELIOS Klinikum Berlin and Max Delbrück Center, Medical Faculty of the Charite, Berlin, Germany
    Acta Physiol Scand 181:487-94. 2004
    ..Technical advances that have allowed us to adapt methods for the rat to the much smaller mouse have facilitated our studies...
  51. doi Energy metabolism in human renin-gene transgenic rats: does renin contribute to obesity?
    Petra Gratze
    Franz Volhard Clinical Research Center, Helios Klinikum Berlin Buch, Berlin Buch, Germany
    Hypertension 53:516-23. 2009
    ..The mechanisms are independent of any currently known renin-related effects...
  52. pmc A peroxisome proliferator-activated receptor-alpha activator induces renal CYP2C23 activity and protects from angiotensin II-induced renal injury
    Dominik N Muller
    HELIOS Klinikum Berlin, Franz Volhard Clinic, and Medical Faculty of the Charité, Humboldt University of Berlin, Berlin
    Am J Pathol 164:521-32. 2004
    ..We propose that CYP-dependent EET/HEET production may serve as an anti-inflammatory control mechanism...
  53. ncbi Weight loss and the renin-angiotensin-aldosterone system
    Stefan Engeli
    Medical Faculty of the Charite, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, HELIOS Klinikum, Berlin, Germany
    Hypertension 45:356-62. 2005
    ..These data suggest that a 5% reduction in body weight can lead to a meaningfully reduced renin-angiotensin-aldosterone system in plasma and adipose tissue, which may contribute to the reduced blood pressure...
  54. ncbi Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage
    Anette Fiebeler
    Medical Faculty of the Charite, HELIOS Klinikum Berlin, Franz Volhard Clinic, Berlin, Germany
    Circulation 111:3087-94. 2005
    ..We tested the hypothesis that reducing aldosterone by inhibiting CYP11B2 or by adrenalectomy (ADX) may ameliorate organ damage. Furthermore, we investigated how much local cardiac aldosterone originates from the adrenal gland...
  55. ncbi Paradoxical effect of sibutramine on autonomic cardiovascular regulation in obese hypertensive patients--sibutramine and blood pressure
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Clin Auton Res 15:200-6. 2005
    ..This notion has not been tested in overweight and obese patients...
  56. doi Cytoprotective Actions of FTY720 Modulate Severe Preservation Reperfusion Injury in Rat Renal Transplants
    T Florian Fuller
    Department of Urology, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Transplantation 89:402-8. 2010
    ..The purpose of this study was to explore the role of FTY720 in ischemic injury and regeneration using a clinically relevant rat renal transplant model with 24 hr of cold ischemia...
  57. doi Growth arrest specific protein 6 participates in DOCA-induced target-organ damage
    Joon Keun Park
    Robert Rossle Str 10, 13125 Berlin, Germany
    Hypertension 54:359-64. 2009
    ..Gas 6 appears to play a role in mineralocorticoid receptor-mediated target organ damage. Furthermore, because warfarin interferes with Gas 6 protein expression, the findings could be of clinical relevance for anticoagulant choices...
  58. pmc Activation of the peripheral endocannabinoid system in human obesity
    Stefan Engeli
    Franz Volhard Clinical Research Center, Charite Campus Buch, 13125 Berlin, Germany
    Diabetes 54:2838-43. 2005
    ..Our findings support the presence of a peripheral endocannabinoid system that is upregulated in human obesity...
  59. pmc NO-dependent blood pressure regulation in RGS2-deficient mice
    Michael Obst
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 290:R1012-9. 2006
    ..The MAP increases during the active phase in RGS2(-/-) mice may be related to central sympathetic activation and increased vascular adrenergic responsiveness...
  60. ncbi Paradoxical effect of sibutramine on autonomic cardiovascular regulation
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 106:2459-65. 2002
    ..Norepinephrine reuptake inhibition with sibutramine conceivably could exacerbate arterial hypertension and promote cardiovascular disease...
  61. doi Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide
    Sandra Feldt
    Medical Faculty of the Charite, Experimental and Clinical Research Center, Franz Volhard Clinic and HELIOS Klinikum, Berlin Buch, Germany
    Hypertension 51:682-8. 2008
    ..Aliskiren has no (P)RR blocking effect and did not inhibit ERK 1/2 phosphorylation or kinase activity. Finally, we found no evidence that HRP affects renin or prorenin binding and signaling...
  62. doi (Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in Goldblatt rats
    Dominik N Muller
    Medical Faculty of the Charite, Experimental and Clinical Research Center, Franz Volhard Clinic, and HELIOS Klinikum Berlin Buch, and Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Hypertension 51:676-81. 2008
    ..Our results indicate that blockade of the (P)RR with HRP does not improve target organ damage in renovascular hypertensive rats...
  63. doi Diabetic hypertensive leptin receptor-deficient db/db mice develop cardioregulatory autonomic dysfunction
    Andrey C da Costa Goncalves
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Hypertension 53:387-92. 2009
    ..Our data suggest that db/db mice exhibit features found in humans with type 2 diabetic autonomic neuropathy and could serve as a model for this complication...
  64. ncbi Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage
    Norbert Henke
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Germany
    Circ Res 101:268-76. 2007
    ..We conclude that in vivo NF-kappaB suppression in endothelial cells stops a signaling cascade leading to reduced hypertension-induced renal damage despite high blood pressure...
  65. ncbi Phenotypical evidence for a gender difference in cardiac norepinephrine transporter function
    Christoph Schroeder
    Franz Volhard Clinical Research Center, Haus 129, Medical Faculty of the Charité Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 286:R851-6. 2004
    ..Our observations suggest that the NET contribution to cardiac norepinephrine turnover may be decreased in women. The gender difference in NET function may not be expressed in tissues that are less NET dependent than the heart...
  66. ncbi Selective impairment in sympathetic vasomotor control with norepinephrine transporter inhibition
    Jens Tank
    Clinical Research Center, HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University, 13125 Berlin, Germany
    Circulation 107:2949-54. 2003
    ..Norepinephrine transporter (NET) inhibition increases the responsiveness to vasoactive medications and attenuates the response to sympathetic stimuli. The phenomenon may be a result of impaired regulation of sympathetic vasomotor tone...
  67. ncbi Angiotensin blockade prevents type 2 diabetes by formation of fat cells
    Arya M Sharma
    HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Humboldt University of Berlin, and Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Hypertension 40:609-11. 2002
    ..Increased formation of adipocytes would counteract the ectopic deposition of lipids in other tissues (muscle, liver, pancreas), thereby improving insulin sensitivity and preventing the development of type 2 diabetes...
  68. ncbi Molecular genetics of human hypertension
    F C Luft
    Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Curr Opin Nephrol Hypertens 9:259-66. 2000
    ....
  69. ncbi Angiotensin-induced inflammation and novel approaches to treatment
    D N Muller
    Max Delbruck Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin
    Adv Nephrol Necker Hosp 31:89-103. 2001
    ..The subsequent NF-kappa B activation probably involves participation of endothelin signaling and, perhaps, NF-AT3 activation. It is possible that other compounds can also modulate Ang II-induced inflammatory responses...
  70. ncbi Expression analysis using oligonucleotide microarrays in mice lacking bradykinin type 2 receptors
    J Monti
    , Berlin, Germany
    Hypertension 38:E1-3. 2001
    ..The findings were verified by an independent method. We suggest that microarray analysis has usefulness in elucidating otherwise unappreciated compensatory signaling pathways...
  71. ncbi Genetic and environmental influences on coping styles: a twin study
    A Busjahn
    Franz Volhard Clinic, Max Delbruck Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Psychosom Med 61:469-75. 1999
    ..Coping styles are generally considered to be environmentally driven, primarily by family influences. However, because personality traits are commonly influenced by genetic effects, we hypothesized that heredity is also important for coping...
  72. ncbi The effect of oral glucose loads on tissue metabolism during angiotensin II receptor and beta-receptor blockade in obese hypertensive subjects
    M Boschmann
    Franz Volhard Clinical Research Center, Charité Campus Buch and HELIOS Klinikum, Berlin, Berlin, Germany
    Horm Metab Res 38:323-9. 2006
    ..The exact mechanism by which inhibition of the renin-angiotensin-aldosterone system decreases the diabetes risk remains unresolved and requires further study...
  73. doi Genetic influences on the pharmacokinetics of orally and intravenously administered digoxin as exhibited by monozygotic twins
    A L Birkenfeld
    Experimental and Clinical Research Center, Franz Volhard Clinic, Helios Klinikum Berlin and Medical Faculty of the Charité, Berlin, Germany
    Clin Pharmacol Ther 86:605-8. 2009
    ..Our study suggests that studies involving twins could be more widely applied to elucidate pharmacogenetics...
  74. ncbi Regulation of the nitric oxide system in human adipose tissue
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Charite University Medicine in Berlin, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Lipid Res 45:1640-8. 2004
    ..Increased eNOS and iNOS expression in adipocytes and local effects of insulin and Ang II may increase adipose tissue production of NO in obesity...
  75. ncbi Bound leptin and sympathetic outflow in nonobese men
    Jens Tank
    HELIOS Kliniken Berlin, Franz Volhard Cardiovascular Research Center, Medical Faculty of the Charite, Humboldt University, 13125 Berlin, Germany
    J Clin Endocrinol Metab 88:4955-9. 2003
    ..This relationship cannot be explained by a direct central nervous effect of protein-bound leptin. Instead, protein-bound leptin may increase sympathetic vasomotor tone indirectly via a baroreflex mechanism...
  76. doi Effects of circulating and local uteroplacental angiotensin II in rat pregnancy
    Lydia Hering
    HELIOS Klinikum, Schwanebecker Chaussee 50, 13125 Berlin, Germany
    Hypertension 56:311-8. 2010
    ..Conceivably, upregulation of tissue Ang II in the maternal part of the placenta represents an important growth factor for trophoblast invasion and migration...
  77. ncbi Sympathetic vasomotor tone determines blood pressure response to long-term sibutramine treatment
    Karsten Heusser
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    J Clin Endocrinol Metab 92:1560-3. 2007
    ..The serotonin and norepinephrine transporter inhibitor sibutramine is a widely used antiobesity drug. In acute studies, the peripheral sympathomimetic effect of sibutramine was counteracted by a central sympatholytic action...
  78. ncbi Mature adipocytes inhibit in vitro differentiation of human preadipocytes via angiotensin type 1 receptors
    Jurgen Janke
    Max Delbruck Center for Molecular Medicine, HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
    Diabetes 51:1699-707. 2002
    ..Because AGT secretion and Ang II generation are characteristic features of adipogenesis, we postulate a paracrine negative-feedback loop that inhibits further recruitment of preadipocytes by maturing adipocytes...
  79. doi Phosphoinositol 3-kinase-gamma mediates antineutrophil cytoplasmic autoantibody-induced glomerulonephritis
    Adrian Schreiber
    Department of Nephrology and Hypertension, Medical Faculty of the Charite, Franz Volhard Clinic, Max Delbruck Center for Molecular Medicine, Schwanebecker Chaussee 50, Berlin, Germany
    Kidney Int 77:118-28. 2010
    ..We found that PI3Kgamma plays a pivotal role in ANCA-induced NCGN and suggest that its specific inhibition may provide a novel treatment target...
  80. ncbi Autonomic nervous system and blood pressure regulation in RGS2-deficient mice
    Volkmar Gross
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 288:R1134-42. 2005
    ..A central nervous system mechanism might be implicated by an increased sympathetic tone. This state of affairs could lead to a baroreceptor-HR reflex resetting, while BRS remains unimpaired...
  81. ncbi Inducible NOS inhibition, eicosapentaenoic acid supplementation, and angiotensin II-induced renal damage
    Jurgen Theuer
    Medical Faculty of the Charite, Franz Volhard Clinic HELIOS Klinikum Berlin, Berlin, Germany
    Kidney Int 67:248-58. 2005
    ....
  82. ncbi Influence of sibutramine treatment on sympathetic vasomotor tone in obese subjects
    Karsten Heusser
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinkum, Berlin, Germany
    Clin Pharmacol Ther 79:500-8. 2006
    ..Direct measurements of muscle sympathetic nerve activity (MSNA) in sibutramine-treated patients have not been conducted...
  83. ncbi Yohimbine attenuates baroreflex-mediated bradycardia in humans
    Jens Tank
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 50:899-903. 2007
    ..In contrast, yohimbine did not alter the sympathetic baroreflex curve. Yohimbine selectively attenuates baroreflex heart rate control in normotensive young men possibly through parasympathetic mechanisms...
  84. pmc Neutrophil surface presentation of the anti-neutrophil cytoplasmic antibody-antigen proteinase 3 depends on N-terminal processing
    S von Vietinghoff
    Medical Faculty of the Charite, Experimental and Clinical Research Center, Franz Volhard Clinic at the Max Delbruck Center, HELIOS Klinikum Berlin, Berlin, Germany
    Clin Exp Immunol 152:508-16. 2008
    ..ProPR3 display on the plasma membrane may influence the bone marrow microenvironment. NB1-mediated PR3 presentation depended on PR3 N-terminal processing implicating the PR3-N-terminus as NB1-binding site...
  85. ncbi Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor
    C Schmitz
    Max Delbruck Center for Molecular Medicine, Department of Molecular Biology and Biochemistry, Free University, D 13125 Berlin, Germany
    J Biol Chem 275:15357-62. 2000
    ..However, RnBP knockout mice excrete an abnormal pattern of carbohydrates in the urine, indicating a role of the protein in renal carbohydrate metabolism...
  86. ncbi Determination of renal arterial stenosis severity: comparison of pressure gradient and vessel diameter
    C M Gross
    Franz Volhard Clinic, Max Delbruck Center for Molecular Medicine, Charite, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin, Germany
    Radiology 220:751-6. 2001
    ..To determine the hemodynamic significance of arteriographically detected renal arterial stenosis by obtaining pressure gradients with a miniaturized pressure guide wire...
  87. ncbi Farnesol blocks the L-type Ca2+ channel by targeting the alpha 1C subunit
    U C Luft
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Virchow Klinikum Charite, Humboldt University of Berlin, Berlin, Germany
    Arterioscler Thromb Vasc Biol 19:959-66. 1999
    ..Finally, farnesol has a blood pressure-lowering action that may be relevant in vivo...
  88. ncbi Angiotensin, inflammation, hypertension, and cardiovascular disease
    F C Luft
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Wiltberg Strasse 50, 13125 Berlin, Germany
    Curr Hypertens Rep 3:61-7. 2001
    ..It stimulates the proliferation of lymphocytes and contributes to their activation via calcineurin-related pathways. Knowledge of these mechanisms may provide additional therapeutic avenues...
  89. ncbi Direct renin inhibition with aliskiren in hypertension and target organ damage
    Dominik N Muller
    Medical Faculty of the Charite, Max Delbruck Center for Molecular Medicine, Franz Volhard Clinic, HELIOS Klinikum Berlin, Berlin 13125, Germany
    Clin J Am Soc Nephrol 1:221-8. 2006
    ..Because angiotensin receptor blockade, angiotensin-converting enzyme inhibition, calcium channel blockade, and diuretic therapy all lead to sharp increases in plasma renin activity, aliskiren offers a novel circumvention...
  90. ncbi Adapting renal and cardiovascular physiology to the genetically hypertensive mouse
    Volkmar Gross
    Max Delbrück Center for Molecular Medicine and Franz Volhard Clinic, HELIOS Klinikum, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Semin Nephrol 22:172-9. 2002
    ..Imaging techniques for the mouse including ultrasound and magnetic resonance imaging are currently feasible. Thus, we will be able to characterize the physiology of any hypertensive mouse model that may become available...
  91. pmc Beta-adrenergic and atrial natriuretic peptide interactions on human cardiovascular and metabolic regulation
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    J Clin Endocrinol Metab 91:5069-75. 2006
    ..Atrial natriuretic peptide (ANP) has well-known cardiovascular effects and modifies lipid and carbohydrate metabolism in humans...
  92. ncbi p38 mitogen-activated protein kinase inhibition ameliorates angiotensin II-induced target organ damage
    Joon Keun Park
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum, Berlin, Germany
    Hypertension 49:481-9. 2007
    ..In conclusion, BIRB796 improved survival, target organ damage, and arrhythmogenic potential in angiotensin II-induced target organ damage...
  93. doi Interaction between P450 eicosanoids and nitric oxide in the control of arterial tone in mice
    Hantz C Hercule
    Charite Campus Buch, Franz Volhard Clinic ECRC, Berlin, Germany
    Arterioscler Thromb Vasc Biol 29:54-60. 2009
    ..We identified a novel interaction between EETs and endothelial NO release using soluble epoxide hydrolase (sEH) -/- and +/+ mice...
  94. doi Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease
    Jan Monti
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Nat Genet 40:529-37. 2008
    ..We further demonstrated differential regulation of EPHX2 in human heart failure, suggesting a cross-species role for Ephx2 in this complex disease...
  95. doi Uterine vascular function in a transgenic preeclampsia rat model
    Stefan Verlohren
    Department of Obstetrics, Franz Volhard Clinic, Berlin, Germany
    Hypertension 51:547-53. 2008
    ..Renin-angiotensin system activation-induced preeclampsia is associated with altered placentation, modified resistance index, and endothelial dysfunction. A disturbed prostacyclin:thromboxane ratio could be an important mediator...
  96. pmc The putative (pro)renin receptor blocker HRP fails to prevent (pro)renin signaling
    Sandra Feldt
    Experimental and Clinical Research Center, Max Delbruck Center, Lindenberger Weg 80, 13125 Berlin, Germany
    J Am Soc Nephrol 19:743-8. 2008
    ..In addition, the in vitro data do not support the use of the HRP to block AngII-independent prorenin- or renin-mediated effects...
  97. doi Hormonal influences on cardiovascular norepinephrine transporter responses in healthy women
    Iryna Moldovanova
    Medical University Charité, Franz Volhard Clinical Research Center, Helios Klinikum Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Hypertension 51:1203-9. 2008
    ..The phenomenon may be explained by an effect of female sex hormones on norepinephrine transporter function, on compensatory cardiovascular responses, or both...
  98. ncbi Baroreflex buffering and susceptibility to vasoactive drugs
    Jens Jordan
    Franz Volhard Clinical Research Center and HELIOS Klinikum, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 105:1459-64. 2002
    ..Differences in baroreflex function affect the responsiveness to vasoactive medications, particularly baroreflex buffering of blood pressure; however, the magnitude is not known...
  99. ncbi Baroreflex failure
    Karsten Heusser
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 45:834-9. 2005
    ..Both had muscle sympathetic nerve activity that was increased even while resting. Treating these patients was a stochastic challenge. The therapy is frequently based on medicines that are no longer commonly prescribed...
  100. ncbi Lectin-like oxidized low-density lipoprotein (LDL) receptor (LOX-1)-mediated pathway and vascular oxidative injury in older-age rat renal transplants
    Jan Hinrich Bräsen
    HELIOS Klinikum Berlin, Franz Volhard Clinic at the Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Kidney Int 67:1583-94. 2005
    ..Reactive oxygen species participate in aging and in chronic vascular disease. We investigated how mediators of oxidative stress may increase allograft susceptibility to vascular injury...
  101. ncbi Agonistic autoantibodies to the AT1 receptor in a transgenic rat model of preeclampsia
    Ralf Dechend
    Medical Faculty of the Charite, Franz Volhard Clinic and Department of Pathology, HELIOS Klinikum Berlin, Germany
    Hypertension 45:742-6. 2005
    ..Finally, we observed an atherosis-like lesion in the spiral arteries of the placental bed, which we called placental-bed arteriolosclerosis. Our model may be relevant to preeclampsia in humans...